420 | id == 420
420 | category_id == 26
420 | category_order == 23
420 | category_name == Allergies
420 | category_color == #C47AC0
420 | slug == TRIM27-allergies
420 | title == The Relationship Between Histamine Release Inhibition & Allergies (TRIM27)
420 | meta_description == TRIM27 is involved in histamine release. Variants of TRIM27 have been associated with allergies. Read more here.
420 | summary == <p style="text-align:justify"><strong>The <em>TRIM27 </em>gene inhibits the release of a compound that induces allergic reactions. Read more to learn how a variant of <em>TRIM27 </em>may influence allergies.</strong></p>
420 | overall_score_text == Your Allergy Score (based on TRIM27 gene)
420 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/OR2B6-TRIM27-Allergies.jpg
420 | author_id == 14
420 | author_name == Shany Lahan
420 | author_title == MS (Neuroscience)
420 | author_order == 5
420 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
420 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
420 | reviewer == None
420 | medical_reviewer_id == 11
420 | medical_reviewer_name == Puya Yazdi
420 | medical_reviewer_title == MD
420 | publish_date == 2020
420 | publish_date == 10
420 | publish_date == 20
420 | avg_rating == 5.0
420 | tags_id == 849
420 | tags_name == Anaphylaxis
420 | tags_id == 98
420 | tags_name == Asthma
420 | tags_id == 851
420 | tags_name == FcεRI
420 | tags_id == 848
420 | tags_name == Hay Fever
420 | tags_id == 623
420 | tags_name == Histamine
420 | tags_id == 591
420 | tags_name == IgE Antibodies
420 | tags_id == 95
420 | tags_name == Immune System
420 | tags_id == 847
420 | tags_name == Mast Cell
420 | tags_id == 850
420 | tags_name == PI3KC2β
420 | tags_id == 846
420 | tags_name == TRIM27 Gene
420 | tags_id == 841
420 | tags_name == Ubiquitin
420 | permissions_favorite == False
420 | permissions_rate == False
420 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">TRIM27 </span></em><span style="font-weight: 400;">codes for zinc finger protein RFP, a protein required to inhibit the release of a compound that induces allergic reactions. A variant of </span><em><span style="font-weight: 400;">TRIM27 </span></em><span style="font-weight: 400;">may play a role in allergies by decreasing production of zinc finger protein RFP. Lifestyle and supplement modifications may counteract the effects of this variant by increasing production of zinc finger protein RFP.</span></span></p> <h2 style="text-align: justify;"><strong><em>TRIM27</em></strong><strong> and Allergies</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">In response to an allergen (allergy-causing substance), immune system cells can release a type of antibody called IgE. IgE can bind to and activate Fc&epsilon;RI, a receptor found on the surface of a type of immune system cell called a mast cell [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17259966/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Activation of Fc&epsilon;RI can stimulate the release of histamine from mast cells. Histamine is a compound well-known to trigger allergic reactions [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17259966/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The release of histamine depends on a number of factors, including the activity of an enzyme termed PI3KC2&beta; [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434511/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/trim27/"><em><span style="font-weight: 400;">TRIM27 </span></em><span style="font-weight: 400;">gene</span></a><span style="font-weight: 400;"> codes for zinc finger protein RFP. This protein is involved in the attachment of a ubiquitin molecule to PI3KC2&beta;. Upon its attachment, ubiquitin can physically block the actions of PI3KC2&beta; [</span><a href="https://www.ncbi.nlm.nih.gov/gene/5987"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434511/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A variant of </span><em><span style="font-weight: 400;">TRIM27 </span></em><span style="font-weight: 400;">has been associated with allergies, such as hay fever and anaphylaxis. This variant may decrease production or activity of zinc finger protein RFP, resulting in increased activity of PI3KC2&beta; and consequent excess histamine release [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>TRIM27</em></strong><strong> Results for Allergies</strong></h2> <p style="text-align: justify;">*3899760381338413*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>TRIM27 </em></strong><a href="https://selfdecode.com/snp/rs7767176/"><strong>rs7767176</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of allergies</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with allergies</span></li> </ul> <p style="text-align: justify;">*2870154702886027*</p> <h2 style="text-align: left;"><strong>Recommendations for Improving Allergies</strong></h2> <p style="text-align: justify;">*7562073250630138*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4><strong>Sun Exposure (Vitamin D)</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Exposure to </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sunlight</span></a><span style="font-weight: 400;"> is the best way to increase levels of </span><a href="https://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> in the blood. Vitamin D deficiency has been associated with asthma and allergies in children [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675563/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17919705/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Vitamin D supplements taken alongside an antihistamine improved symptoms of hay fever in people with vitamin D deficiency, in comparison to the antihistamine alone. However, this improvement was not significant until 8 weeks of supplementation, suggesting that symptom improvement might not occur until vitamin D has been adequately replenished in the body [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31332549/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a randomized controlled trial that took place in the winter (less sunlight than other seasons), the production of zinc finger protein RFP was found to significantly increase after 2 months of vitamin D supplementation. The production of other proteins related to immune system function was also found to increase [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604145/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Sunlight is the best source of vitamin D. Vitamin D may improve allergies by increasing production of zinc finger protein RFP.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Resveratrol</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/top-15-scientific-health-benefits-of-resveratrol-with-references/"><span style="font-weight: 400;">Resveratrol</span></a><span style="font-weight: 400;"> is an antioxidant found in high amounts in grapes and wine. It is also available in supplement form.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In 2 preliminary trials focused on adults and children with hay fever, resveratrol nose sprays improved associated symptoms, such as runny and stuffy nose, itching, and sneezing. Resveratrol also reduced the amount of antibodies in the blood, immune system cell counts, and levels of inflammatory markers [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24983742/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29539616/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Supplementation with a grape extract containing resveratrol was found to increase production of zinc finger protein RFP after 1 year [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23557933/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Resveratrol may improve allergies by increasing production of zinc finger protein RFP.&nbsp;</span></p>
420 | content_snp_table_3899760381338413_key == 3899760381338413
420 | content_snp_table_3899760381338413_blur == True
420 | content_snp_table_3899760381338413_hidden == False
420 | content_learn_more_2870154702886027_key == 2870154702886027
420 | content_learn_more_2870154702886027_blur == True
420 | content_learn_more_2870154702886027_hidden == False
420 | content_learn_more_2870154702886027_text == Based on the variants we looked at, your TRIM27 gene makes you somewhat more likely to develop allergies. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Exposure to sunlight and resveratrol supplements may help. Keep scrolling to find out more.
420 | content_recommendation_7562073250630138_key == 7562073250630138
420 | content_recommendation_7562073250630138_blur == True
420 | content_recommendation_7562073250630138_hidden == False
rsIDs = rs7767176
rsStatus = rs7767176,OR2B6,chr6,27957589,G,A,,,38,0,Normal
