421 | id == 421
421 | category_id == 26
421 | category_order == 23
421 | category_name == Allergies
421 | category_color == #C47AC0
421 | slug == EMSY-interferons-allergies
421 | title == Can You Prevent Allergies by Targeting This Gene? (EMSY)
421 | meta_description == The EMSY gene controls interferon activity. Click to learn about its link with allergies and get tailored tips.
421 | summary == <p style="text-align:justify"><strong>What do most allergies have in common? The EMSY gene is involved in their development. Read this post to check your variants and get gene-based tips to relieve allergies.</strong></p>
421 | overall_score_text == Your Allergy Score (based on EMSY gene)
421 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/LRRC32-Allergies.jpg
421 | author_id == 9
421 | author_name == Aleksa Ristic
421 | author_title == MS (Pharmacy)
421 | author_order == 45
421 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
421 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
421 | reviewer == None
421 | medical_reviewer_id == 11
421 | medical_reviewer_name == Puya Yazdi
421 | medical_reviewer_title == MD
421 | publish_date == 2020
421 | publish_date == 10
421 | publish_date == 20
421 | avg_rating == 5.0
421 | tags_id == 97
421 | tags_name == Allergies
421 | tags_id == 98
421 | tags_name == Asthma
421 | tags_id == 852
421 | tags_name == EMSY gene
421 | tags_id == 343
421 | tags_name == Interferons
421 | tags_id == 853
421 | tags_name == Th2 dominance
421 | permissions_favorite == False
421 | permissions_rate == False
421 | content_article == <table style="height: 56px; width: 100%; border-collapse: collapse; margin-left: auto; margin-right: auto;" border="1" cellpadding="10"> <tbody> <tr> <td style="width: 100%; text-align: justify;"><strong>Note:</strong> We analyze the <em>EMSY (C11ORF30)</em> gene in our <em><strong><a href="https://get.selfdecode.com/gene-reports/inflammation/">Inflammation DNA Wellness Report</a></strong></em>, along with many other genes. If you're looking for a comprehensive genetic report on inflammation, make sure to check it out!</td> </tr> </tbody> </table> <p>&nbsp;</p> <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The EMSY gene controls the activity of interferons, which play a crucial role in allergy prevention.<br /><br /></strong><strong>Specific EMSY variants correlate with different allergic disorders, likely by suppressing interferons.<br /><br /></strong><strong>There are simple ways to prevent and relieve allergies by targeting your gene variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>The EMSY Gene in Allergic Reactions</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/EMSY/"><span style="font-weight: 400;">EMSY</span></a><span style="font-weight: 400;"> (C11ORF30) gene reduces the activity of interferon-stimulated genes [</span><a href="https://www.ncbi.nlm.nih.gov/gene/56946"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309773/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Typically, allergies are </span><a href="https://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">Th2-dominant</span></a><span style="font-weight: 400;"> states. </span><a href="https://www.selfhacked.com/blog/interferon-gamma-how-to-increase-decrease-high-low-levels/"><span style="font-weight: 400;">Interferon-gamma</span></a><span style="font-weight: 400;"> (IFN-gamma) and other interferons help prevent asthma and allergic reactions by shifting the immune response towards </span><a href="https://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1 dominance</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15962113/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15962113/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">EMSY variants can increase sensitivity to a range of indoor, outdoor and food allergens, making this gene a crucial factor in allergic diseases [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25546184/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">EMSY gene variants correlate with different allergic disorders, likely due to their potential to suppress interferons.</span></p> <p>&nbsp;</p> <h2><strong>Your EMSY Results for Allergies</strong></h2> <p>*5660599760124734*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs2155219/"><strong>rs2155219</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753407/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922420/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher odds of allergic diseases and food allergies</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with allergies</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele likely increases EMSY activity and suppresses interferons</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs55646091/"><strong>rs55646091</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with allergies</span></li> </ul> <p>*6758456481619133*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Relieve Allergies</strong></h2> <p>*4945022660053138*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Acupuncture</strong></h4> <p><span style="font-weight: 400;">Several clinical trials suggest that </span><a href="https://selfhacked.com/blog/acupuncture-benefits-mechanisms-risks/"><span style="font-weight: 400;">acupuncture</span></a><span style="font-weight: 400;"> may be a safe and effective way to improve allergic rhinitis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17874980/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15154290/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15291903/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25590322/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Acupuncture appears to help with allergic diseases by boosting IFN-gamma and changing the Th1/Th2 balance [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479426/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://scholar.google.com/scholar_lookup?journal=Journal+of+Acupuncture+and+Tuina+Science&amp;title=Effects+of+acupuncture-moxibustion+on+monocyte+Th1/Th2+cytokine+in+peripheral+blood+of+patients+with+perennial+allergic+rhinitis&amp;author=MF+Zheng&amp;author=C+Lin&amp;author=LP+Zheng&amp;author=FR+He&amp;volume=8&amp;issue=2&amp;publication_year=2010&amp;pages=85-88&amp;"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Acupuncture may relieve allergic reactions by targeting your EMSY variants.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Probiotics</strong></h4> <p><span style="font-weight: 400;">Several clinical trials have shown the potential of </span><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">probiotic</span></a><span style="font-weight: 400;"> supplementation to increase IFN-gamma levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18631345/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888046/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. In children, </span><a href="http://selfhacked.com/blog/l-fermentum/"><em><span style="font-weight: 400;">L. fermentum</span></em></a><span style="font-weight: 400;"> reduced atopic dermatitis severity by boosting IFN-gamma [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16393321/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Different probiotic strains may improve the symptoms of:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Allergic rhinitis (</span><a href="http://selfhacked.com/blog/l-acidophilus/"><em><span style="font-weight: 400;">L. acidophilus</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/health-benefits-l-plantarum/"><em><span style="font-weight: 400;">L. plantarum</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-casei/"><em><span style="font-weight: 400;">L. casei</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/b-longum/"><em><span style="font-weight: 400;">B. longum</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/b-animalis/"><em><span style="font-weight: 400;">B. animalis</span></em></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27442711/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16195581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18072744/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18510694/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Pollen and dust mites allergy ( </span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-johnsonii/"><em><span style="font-weight: 400;">L. johnsonii</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/c-butyricum/"><em><span style="font-weight: 400;">C. butyricum</span></em></a><span style="font-weight: 400;">) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27401319/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22513081/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Asthma (</span><a href="https://selfhacked.com/blog/l-salivarius/"><em><span style="font-weight: 400;">L.salivarius</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/b-breve/"><em><span style="font-weight: 400;">B. breve</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/c-butyricum/"><em><span style="font-weight: 400;">C. butyricum</span></em></a><span style="font-weight: 400;">) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446640/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746628/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Milk and peanut allergies (</span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-delbrueckii/"><em><span style="font-weight: 400;">L. delbrueckii</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-fermentum/"><em><span style="font-weight: 400;">L. fermentum</span></em></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10024217/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15241356/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370499/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23140691/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21385515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Probiotic supplementation may enhance interferon-gamma and help with different types of allergy.</span></p>
421 | content_snp_table_5660599760124734_key == 5660599760124734
421 | content_snp_table_5660599760124734_blur == True
421 | content_snp_table_5660599760124734_hidden == False
421 | content_learn_more_6758456481619133_key == 6758456481619133
421 | content_learn_more_6758456481619133_blur == True
421 | content_learn_more_6758456481619133_hidden == False
421 | content_learn_more_6758456481619133_text == Based on the variants we looked at, your EMSY gene is associated with slightly higher odds of allergies. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Consider supplementing with specific probiotic strains to relieve allergies by targeting your variants. Keep reading to learn more.
421 | content_recommendation_4945022660053138_key == 4945022660053138
421 | content_recommendation_4945022660053138_blur == True
421 | content_recommendation_4945022660053138_hidden == False
rsIDs = rs2155219,rs55646091
rsStatus = rs2155219,,chr11,76588150,G,T,,,4,17,HET
rsStatus = rs55646091,,chr11,76588387,G,A,,,24,0,Normal
