422 | id == 422
422 | category_id == 26
422 | category_order == 23
422 | category_name == Allergies
422 | category_color == #C47AC0
422 | slug == TSLP-allergies
422 | title == The Role of a Th2 Cytokine in Allergic Reactions (TSLP)
422 | meta_description == TSLP is an important cytokine that activates B cells, mast cells, and eosinophils. Do you have the variants linked to allergies?
422 | summary == <p><strong><em>TSLP </em>is an important cytokine that activates B cells, mast cells, and eosinophils. Do you have the variants linked to allergies? Find out here.</strong></p>
422 | overall_score_text == Your Allergic Reaction Score (based on TSLP)
422 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TSLP-Allergies.jpg
422 | author_id == 1
422 | author_name == Jasmine Foster
422 | author_title == BSc, BEd
422 | author_order == 36
422 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
422 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
422 | reviewer == None
422 | medical_reviewer_id == 11
422 | medical_reviewer_name == Puya Yazdi
422 | medical_reviewer_title == MD
422 | publish_date == 2020
422 | publish_date == 10
422 | publish_date == 20
422 | avg_rating == 5.0
422 | tags_id == 97
422 | tags_name == Allergies
422 | tags_id == 98
422 | tags_name == Asthma
422 | tags_id == 96
422 | tags_name == Cytokines
422 | tags_id == 99
422 | tags_name == Eczema
422 | tags_id == 848
422 | tags_name == Hay Fever
422 | tags_id == 623
422 | tags_name == Histamine
422 | tags_id == 442
422 | tags_name == T Cells
422 | tags_id == 853
422 | tags_name == Th2 dominance
422 | tags_id == 854
422 | tags_name == TSLP Gene
422 | permissions_favorite == False
422 | permissions_rate == False
422 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">TSLP</span></em><span style="font-weight: 400;"> encodes thymic stromal lymphopoietin, an inflammatory cytokine. Variants of </span><em><span style="font-weight: 400;">TSLP</span></em><span style="font-weight: 400;"> may play a role in allergies by activating IgE-producing B cells, histamine-producing mast cells, and eosinophils. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by decreasing either TSLP or its downstream effects.</span></p> <h2><strong><em>TSLP</em></strong><strong> and Allergies</strong></h2> <p><a href="https://selfdecode.com/gene/tslp/" target="_blank" rel="noopener"><em><span style="font-weight: 400;">TSLP </span></em></a><span style="font-weight: 400;">encodes thymic stromal lymphopoietin, a cytokine that activates Th2 type T cells. These T cells, in turn, activate other white blood cells including B cells (which produce IgE), mast cells (which produce histamine), and eosinophils [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462264/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Th2 cells are said to mediate the activation and maintenance of the &ldquo;humoral&rdquo; or antibody-mediated, immune response. People with a more dominant Th2 response (as opposed to Th1, the other major type of immune response) may produce more antibodies. Allergies might be more likely to occur in Th2-dominant people, according to limited data [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://archive.foundationalmedicinereview.com/publications/8/3/223.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The Th2 response has been linked to a wide variety of allergic-type conditions, including [</span><a href="http://archive.foundationalmedicinereview.com/publications/8/3/223.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://en.wikipedia.org/wiki/T_helper_cell#Th1.2FTh2_Model_for_helper_T_cells"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">IgE-related allergies</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Seasonal allergies</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Airway constriction</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Asthma</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Nasal drip</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Mucus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Eczema (Dermatitis)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Hay fever (Allergic rhinitis)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Excess </span><a href="https://selfhacked.com/blog/deal-histamine/"><span style="font-weight: 400;">histamine</span></a><span style="font-weight: 400;"> (also called histamine intolerance)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Hives (urticaria)</span></li> </ul> <p><span style="font-weight: 400;">Increased </span><em><span style="font-weight: 400;">TSLP</span></em><span style="font-weight: 400;"> expression may lead to increased activation of Th2 immune mechanisms, including IgE production and histamine release. Genetic studies have found that certain </span><em><span style="font-weight: 400;">TSLP</span></em><span style="font-weight: 400;"> variants are associated with allergic diseases like hay fever, asthma, and eczema [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462264/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332833/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">TSLP encodes thymic stromal lymphopoietin, a cytokine that activates Th2 type T cells. In excess, the Th2 response can cause allergic diseases like hay fever, asthma, and eczema.</span></p> <h2><strong>Your </strong><strong><em>TSLP</em></strong><strong> Results for Allergies</strong></h2> <p>*9158163272913047*</p> <p><strong><em>TSLP</em></strong> <a href="https://selfdecode.com/snp/rs1837253/"><strong>rs1837253</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Possibly protective against allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele may reduce the activation of B cells, mast cells, and eosinophils [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462264/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong><em>TSLP </em></strong><a href="https://selfdecode.com/snp/rs1438673/"><strong>rs1438673</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may increase the activation of B cells, mast cells, and eosinophils [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462264/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong><em>TSLP</em></strong> <a href="https://selfdecode.com/snp/rs6594499/"><strong>rs6594499</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Possibly protective against allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may reduce the activation of B cells, mast cells, and eosinophils [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462264/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong><em>TSLP</em></strong> <a href="https://selfdecode.com/snp/rs10455025/"><strong>rs10455025</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may increase the activation of B cells, mast cells, and eosinophils [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462264/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*6703229732360885*</p> <h2><strong>Recommendations for Preventing Allergies</strong></h2> <p>*4101374632957302*</p> <h3><strong>Allergy Immunotherapy</strong></h3> <p><span style="font-weight: 400;">Allergy immunotherapy consists of administering a dilution of the allergen (such as pollen, dust mites, or dog dander) to help develop tolerance. This treatment can be injected (allergy shots) or oral (under-the-tongue allergy tablets) and is indicated for allergic rhinitis, asthma, and conjunctivitis, but not for food allergies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27401313/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30095391/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26774974/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25732009/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10963287/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some research suggests that allergy immunotherapy may work, in part, by targeting the TSLP signalling cascade [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27012942/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22948028/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/bee-sting-therapy-101/"><span style="font-weight: 400;">Bee sting therapy</span></a><span style="font-weight: 400;"> is recommended as the first-line treatment to prevent severe allergic reactions in people allergic to the venom of bees and other insects of the same order (Hymenoptera), owing to its ability to induce an immune shift from </span><a href="https://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">Th2</span></a><span style="font-weight: 400;"> to </span><a href="http://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420609/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8564721/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12704369/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Multiple trials attest to the effectiveness and safety of this therapy. Unfortunately, the allergen must be repeatedly administered at 3-month intervals to maintain its effects on the immune system [</span><a href="https://pubmed.ncbi.nlm.nih.gov/375434/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/4008075/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420609/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21447964/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17941283/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1545581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10669863/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27012015/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10505462/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">We recommend against trying to administer allergy immunotherapy alone. Talk to your doctor to see if this is a good option for you.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Allergy immunotherapy gradually imparts tolerance to an allergen by repeated exposure. This type of therapy may work by reducing TSLP.</span></p> <h3><strong>Vitamin E</strong></h3> <p><span style="font-weight: 400;">In mice, vitamin E ingestion directly reduced TSLP levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266234/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980725/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Several studies have associated high intake of </span><a href="https://selfhacked.com/blog/vitamin-e-can-help-fertility-pregnancy/"><span style="font-weight: 400;">vitamin E</span></a><span style="font-weight: 400;"> with a reduced incidence of asthma, while a diet poor in this vitamin increases the risk. Similarly, some people with asthma have lower levels of this vitamin in the blood and lungs [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7735592/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16763215/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1745426/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10731863/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10465176/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Food sources of vitamin E include wheat germ, nuts, sunflower and sesame seeds, and their respective plant oils. Vitamin E is also available as a supplement [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956867/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Vitamin E reduces TSLP in animals. Increased dietary vitamin E is associated with reduced levels of allergic diseases like asthma.</span></p> <h3><strong>Black Seed Oil</strong></h3> <p><span style="font-weight: 400;">While its effects on TSLP directly are unknown, black seed oil (also known as black cumin oil) improves all of the major downstream effects of TSLP. In various studies, black seed oil has reduced the overall Th2 response, prevented mast cell activation, and reduced IgE production [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19059494/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194640/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387213/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In 2 clinical trials on people with different allergic diseases (allergic rhinitis, asthma, and eczema) oral supplementation with </span><a href="https://selfhacked.com/blog/black-cumin-seed-nigella-sativa-top-scientific-benefits/"><span style="font-weight: 400;">black seed</span></a><span style="font-weight: 400;"> improved the symptoms and subjective well-being. Black seed also enhanced the effectiveness of immunotherapy for dust mite allergy in another study [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20947211/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14669258/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20357504/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Both the oil and extract of black seed reduced the frequency of asthma attacks, relieved wheezing, improved lung function, and reduced the need for inhaled medications when taken for 2-3 months [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17868210/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28093815/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Black seed oil counteracts the downstream effects of high TSLP, decreasing the number of B cells, mast cells, and eosinophils. This supplement has also been found to improve the effectiveness of immunotherapy and decrease the frequency of asthma attacks.</span></p>
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422 | content_learn_more_6703229732360885_text == Based on the variants we looked at, your TSLP gene is somewhat associated with allergic inflammation. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Allergy immunotherapy, vitamin E, and black seed oil may help. Keep scrolling to find out more.
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rsIDs = rs6594499,rs10455025,rs1837253,rs1438673
rsStatus = rs6594499,,chr5,111134439,C,A,,,14,29,HET
rsStatus = rs10455025,TSLP,chr5,111069301,A,C,G,T,32,0,Normal
rsStatus = rs1837253,,chr5,111066174,T,C,,,22,3,HET
rsStatus = rs1438673,,chr5,111131801,C,T,,,13,16,HET
