425 | id == 425
425 | category_id == 26
425 | category_order == 23
425 | category_name == Allergies
425 | category_color == #C47AC0
425 | slug == TLR10-immunity-allergies
425 | title == Can Antimicrobial Immunity Prevent Allergies? (TLR10)
425 | meta_description == The TLR10 gene enables antimicrobial immunity. Click to learn about its link with allergies.
425 | summary == <p style="text-align:justify"><strong>Can microbial exposure protect you from allergies? It depends on your genes! Read this post to discover the role of TLR10 in allergies and get gene-based recommendations (+bonus parent tips at the bottom).</strong></p>
425 | overall_score_text == Your Allergies Score (based on TLR10 gene)
425 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TLR1---TLR6---TLR10-Allergies.jpg
425 | author_id == 9
425 | author_name == Aleksa Ristic
425 | author_title == MS (Pharmacy)
425 | author_order == 45
425 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
425 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
425 | reviewer == None
425 | medical_reviewer_id == 11
425 | medical_reviewer_name == Puya Yazdi
425 | medical_reviewer_title == MD
425 | publish_date == 2020
425 | publish_date == 10
425 | publish_date == 21
425 | avg_rating == 5.0
425 | tags_id == 97
425 | tags_name == Allergies
425 | tags_id == 862
425 | tags_name == Hygiene hypothesis
425 | tags_id == 95
425 | tags_name == Immune System
425 | tags_id == 853
425 | tags_name == Th2 dominance
425 | tags_id == 861
425 | tags_name == TLR10 gene
425 | tags_id == 386
425 | tags_name == Toll-Like Receptors
425 | permissions_favorite == False
425 | permissions_rate == False
425 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The TLR10 gene helps make a crucial immune system receptor. TLR activation by microbes stimulates Th1 immunity and helps prevent allergies.<br /><br /></strong><strong>Specific gene variants reduce TLR10 activity and correlate with higher odds of allergic diseases.<br /><br /></strong><strong>This post reveals simple ways to reduce allergies by targeting TLR10 variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>TLRs and Th1 Immunity in Allergy Prevention</strong></h2> <p><a href="https://selfdecode.com/gene/tlr10/"><span style="font-weight: 400;">TLR10</span></a><span style="font-weight: 400;"> belongs to a group of genes encoding vital immune system receptors (toll-like receptors or TLRs). They recognize parts of different microbes, supporting their removal [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753407/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174766/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">TLR receptor activation by pathogens stimulates different inflammatory cytokines that promote </span><a href="http://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1</span></a><span style="font-weight: 400;"> and suppress Th2 immunity. Allergies are </span><a href="https://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">Th2-dominant</span></a><span style="font-weight: 400;"> states, so adequate TLR activity is crucial for their prevention, especially during the immune system development [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650946/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8096238/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15962113/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The above pathways are central to the &ldquo;hygiene hypothesis,&rdquo; suggesting that the lack of microbial exposure in early childhood may contribute to allergic diseases [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202673/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918254/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The TLR10 gene helps make a crucial immune system receptor. TLR activation by microbes stimulates Th1 immunity and helps prevent allergies.</span></p> <p>&nbsp;</p> <h2><strong>Your TLR10 Results for Allergies</strong></h2> <p>*9609872202163412*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs5743618/"><strong>rs5743618</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(19)30055-4/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with lower odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher odds of allergic diseases</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs17616434/"><strong>rs17616434</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068780/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922420/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with lower odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with relatively higher odds of allergic diseases</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs2101521/"><strong>rs2101521</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753407/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with lower odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with relatively higher odds of allergic diseases</span></li> </ul> <p><span style="font-weight: 400;">These variants are often inherited together, especially in European descendants. They belong to a group of TLR genes including </span><a href="https://selfdecode.com/gene/tlr1/"><span style="font-weight: 400;">TLR1</span></a><span style="font-weight: 400;">, </span><a href="https://selfdecode.com/gene/tlr6/"><span style="font-weight: 400;">TLR6</span></a><span style="font-weight: 400;">, and </span><a href="https://selfdecode.com/gene/tlr10/"><span style="font-weight: 400;">TLR10</span></a><span style="font-weight: 400;">.</span></p> <p><span style="font-weight: 400;">Protective alleles increase TLR activity and stimulate antimicrobial responses, shifting the immune system from Th2 towards Th1 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18547625/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p>*1219007368486551*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Allergic Reactions</strong></h2> <p>*4252496506052499*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Allergy Immunotherapy</strong></h4> <p><span style="font-weight: 400;">Allergy immunotherapy consists of administering a dilution of the allergen (such as pollen, dust mites, or dog dander) to help develop tolerance. Doctors use this treatment for allergic rhinitis, asthma, and conjunctivitis but not for food allergies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27401313/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30095391/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26774974/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25732009/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10963287/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/bee-sting-therapy-101/"><span style="font-weight: 400;">Bee sting therapy</span></a><span style="font-weight: 400;"> is recommended as the first-line treatment to prevent severe allergic reactions in people allergic to the venom of bees and other insects of the same order (</span><em><span style="font-weight: 400;">Hymenoptera</span></em><span style="font-weight: 400;">) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420609/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8564721/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12704369/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Immunotherapy does the same thing as TLR activation: it induces a shift from </span><a href="https://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">Th2</span></a><span style="font-weight: 400;"> to </span><a href="http://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1</span></a><span style="font-weight: 400;"> immunity. New forms of immunotherapy directly targeting TLRs have yielded promising results, and more research is underway [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16393325/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808817/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26418475/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Immunotherapy may reduce allergic reactions by targeting your TLR10 variants.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Probiotics</strong></h4> <p><span style="font-weight: 400;">Different </span><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">probiotic</span></a><span style="font-weight: 400;"> strains, such as </span><a href="http://selfhacked.com/blog/l-acidophilus/"><em><span style="font-weight: 400;">L. acidophilus</span></em></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/l-paracasei/"><em><span style="font-weight: 400;">L. paracasei</span></em></a><span style="font-weight: 400;">, can enhance antimicrobial immunity through TLR activation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26418475/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419202/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353866/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Probiotic supplementation may improve the symptoms of:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Allergic rhinitis (</span><a href="http://selfhacked.com/blog/l-acidophilus/"><em><span style="font-weight: 400;">L. acidophilus</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/l-paracasei/"><em><span style="font-weight: 400;">L. paracasei</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/health-benefits-l-plantarum/"><em><span style="font-weight: 400;">L. plantarum</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-casei/"><em><span style="font-weight: 400;">L. casei</span></em></a><span style="font-weight: 400;">) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16195581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16101937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24569538/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18510694/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Pollen and dust mites allergy ( </span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-johnsonii/"><em><span style="font-weight: 400;">L. johnsonii</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/c-butyricum/"><em><span style="font-weight: 400;">C. butyricum</span></em></a><span style="font-weight: 400;">) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27401319/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22513081/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Asthma (</span><a href="https://selfhacked.com/blog/l-salivarius/"><em><span style="font-weight: 400;">L.salivarius</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/b-breve/"><em><span style="font-weight: 400;">B. breve</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/c-butyricum/"><em><span style="font-weight: 400;">C. butyricum</span></em></a><span style="font-weight: 400;">) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446640/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746628/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Milk and peanut allergies (</span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-delbrueckii/"><em><span style="font-weight: 400;">L. delbrueckii</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-fermentum/"><em><span style="font-weight: 400;">L. fermentum</span></em></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10024217/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15241356/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370499/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23140691/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21385515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Eczema (</span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/l-reuteri/"><em><span style="font-weight: 400;">L.reuteri</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/health-benefits-l-plantarum/"><em><span style="font-weight: 400;">L. plantarum</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-paracasei/"><em><span style="font-weight: 400;">L. paracasei</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-fermentum/"><em><span style="font-weight: 400;">L. fermentum</span></em></a><span style="font-weight: 400;">) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11069570/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12589361/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23050557/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735031/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Probiotic supplementation may boost TLR activity and help with different types of allergy.</span></p> <p><strong><em>*BONUS PARENT TIPS:</em></strong> <span style="font-weight: 400;">Early childhood is a crucial period to &ldquo;train&rdquo; the immune system and achieve the right Th1/Th2 balance and TLR activity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650946/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">If you have children, make sure they spend some time in nature and allow them to get dirty&mdash;it may help prevent allergies! Children exposed to rural farming environments have lower odds of allergic diseases [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580568/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27377679/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069066/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Breastfeeding is another way to stimulate immunity and TLR function in infants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650946/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p>
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425 | content_learn_more_1219007368486551_text == Based on the variants we looked at, your TLR10 gene is associated with average or slightly higher odds of allergies. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Consider supplementing with specific probiotic strains to counteract your variants & relieve allergies. Keep reading to learn more.
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rsIDs = rs17616434,rs2101521,rs5743618
rsStatus = rs17616434,,chr4,38811255,T,C,,,23,10,HET
rsStatus = rs2101521,,chr4,38809930,G,A,T,,15,7,HET
rsStatus = rs5743618,TLR1,chr4,38797027,C,A,G,,25,9,HET
