427 | id == 427
427 | category_id == 26
427 | category_order == 23
427 | category_name == Allergies
427 | category_color == #C47AC0
427 | slug == BCL6-IL4-allergies
427 | title == A Gene That Prevents Allergic Reactions (BCL6)
427 | meta_description == The BCL6 gene helps reduce Th2 immunity and IL-4 levels. Click to learn about its link with allergies.
427 | summary == <p style="text-align:justify"><strong>Scientists discovered a new role of the BCL6 gene: it helps prevent allergies! Read this post to check your variants and get gene-based tips to reduce allergic reactions.</strong></p>
427 | overall_score_text == Your Allergies Score (based on BCL6 gene)
427 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/BCL6-Allergies.jpg
427 | author_id == 9
427 | author_name == Aleksa Ristic
427 | author_title == MS (Pharmacy)
427 | author_order == 45
427 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
427 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
427 | reviewer == None
427 | medical_reviewer_id == 11
427 | medical_reviewer_name == Puya Yazdi
427 | medical_reviewer_title == MD
427 | publish_date == 2020
427 | publish_date == 10
427 | publish_date == 21
427 | avg_rating == 4.5
427 | tags_id == 97
427 | tags_name == Allergies
427 | tags_id == 863
427 | tags_name == BCL6 gene
427 | tags_id == 591
427 | tags_name == IgE Antibodies
427 | tags_id == 864
427 | tags_name == IL-4
427 | tags_id == 853
427 | tags_name == Th2 dominance
427 | permissions_favorite == False
427 | permissions_rate == False
427 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The BCL6 gene helps prevent allergic reactions by suppressing Th2 immunity and reducing IL-4 and IgE levels.<br /><br /></strong><strong>Certain gene variants reduce BCL6 activity and correlate with higher odds of allergic diseases.<br /><br /></strong><strong>In this post, we reveal simple and effective ways to relieve allergies by targeting your BCL6 variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>The BCL6 Gene in Th2 Immunity and Allergic Reactions</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/bcl6/"><em><span style="font-weight: 400;">BCL6</span></em></a><span style="font-weight: 400;"> gene controls the activity of different immune cells and proteins involved in allergic reactions. Primarily, BCL6 suppresses </span><a href="http://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">Th2</span></a><span style="font-weight: 400;"> immunity by blocking IL-4 production [</span><a href="https://www.ncbi.nlm.nih.gov/gene/604"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84719/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904433/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Th2 immune response and IL-4 release stimulate B cells to produce IgE antibodies, which play a central role in allergies. BCL6 protects against allergies by preventing this chain reaction [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904433/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The BCL6 gene helps prevent allergic reactions by suppressing Th2 immunity and reducing IL-4 and IgE levels.</span></p> <p>&nbsp;</p> <h2><strong>Your BCL6 Results for Allergies</strong></h2> <p>*8399588376981324*</p> <p><strong>Primary SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs9865818/"><strong>rs9865818</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068780/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922420/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with higher odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - not associated with allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele reduces BCL6 activity</span></li> </ul> <p><strong>Other Important SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs519973/"><strong>rs519973</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele likely reduces BCL6 activity</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs73196739/"><strong>rs73196739</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with lower odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele likely increases BCL6 activity</span></li> </ul> <p><span style="font-weight: 400;">These variants are also near the </span><a href="https://selfdecode.com/gene/lpp/"><span style="font-weight: 400;">LPP</span></a><span style="font-weight: 400;"> gene, but they influence BCL6 activity.&nbsp;</span></p> <p>*5120396380704215*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Relieve Allergies</strong></h2> <p>*7602788557709004*</p> <h3><strong>Diet</strong></h3> <h4><strong>Mediterranean Diet</strong></h4> <p><span style="font-weight: 400;">The Mediterranean diet may reduce IL-4 levels in asthmatic children. This diet is rich in </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">, which may suppress IL-4 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29980401/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18178046/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis associated adherence to the Mediterranean diet with a slightly reduced incidence of asthma and wheezing [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23578354/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet rich in olive oil may prevent allergies, especially asthma, by targeting your BCL6 variants.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Butterbur</strong></h4> <p><a href="https://selfhacked.com/blog/butterbur-benefits/"><span style="font-weight: 400;">Butterbur</span></a><span style="font-weight: 400;"> can inhibit allergen-induced Th2 immunity and IL-4 release, reducing airway inflammation and sensitivity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19827027/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A standardized butterbur extract (ZE 339) was safe and effective at improving allergic rhinitis, both seasonal and chronic, in multiple clinical trials. A different extract (Petaforce) was similarly effective in people with pollen allergy [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15080820/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15611396/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16751170/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64514/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12859442/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Butterbur extract also improved asthma symptoms when added to standard treatment in two clinical trials [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15005644/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14720270/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Butterbur extract may counteract your gene variants and help relieve allergies.</span></p>
427 | content_snp_table_8399588376981324_key == 8399588376981324
427 | content_snp_table_8399588376981324_blur == True
427 | content_snp_table_8399588376981324_hidden == False
427 | content_learn_more_5120396380704215_key == 5120396380704215
427 | content_learn_more_5120396380704215_blur == True
427 | content_learn_more_5120396380704215_hidden == False
427 | content_learn_more_5120396380704215_text == Based on the variants we looked at, your BCL6 gene is associated with slightly higher odds of allergies. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Consider practicing the Mediterranean diet to counteract your variants & prevent allergies. Keep reading to learn more.
427 | content_recommendation_7602788557709004_key == 7602788557709004
427 | content_recommendation_7602788557709004_blur == True
427 | content_recommendation_7602788557709004_hidden == False
rsIDs = rs9865818,rs519973,rs73196739
rsStatus = rs9865818,LPP,chr3,188354725,A,G,,,32,0,Normal
rsStatus = rs519973,,chr3,187915480,G,A,C,,6,29,HET
rsStatus = rs73196739,LPP,chr3,188684683,C,T,,,26,0,Normal
