428 | id == 428
428 | category_id == 26
428 | category_order == 23
428 | category_name == Allergies
428 | category_color == #C47AC0
428 | slug == OVOL1-allergies
428 | title == A Genetic Link Between the Skin Barrier & Allergic Diseases (OVOL1)
428 | meta_description == OVOL1 is involved in skin barrier formation. Variants of OVOL1 have been associated with allergies. Read more here.
428 | summary == <p style="text-align:justify"><strong>The <em>OVOL1</em> gene is involved in the formation of the outermost skin layer. How might variants of <em>OVOL1</em> affect allergy progression? Read more to find out.</strong></p>
428 | overall_score_text == Your Allergy Score (based on OVOL1 gene)
428 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/OVOL1-Allergies.jpg
428 | author_id == 14
428 | author_name == Shany Lahan
428 | author_title == MS (Neuroscience)
428 | author_order == 5
428 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
428 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
428 | reviewer == None
428 | medical_reviewer_id == 11
428 | medical_reviewer_name == Puya Yazdi
428 | medical_reviewer_title == MD
428 | publish_date == 2020
428 | publish_date == 10
428 | publish_date == 21
428 | avg_rating == 5.0
428 | tags_id == 860
428 | tags_name == Allergic Diseases
428 | tags_id == 99
428 | tags_name == Eczema
428 | tags_id == 857
428 | tags_name == Filaggrin
428 | tags_id == 848
428 | tags_name == Hay Fever
428 | tags_id == 859
428 | tags_name == Keratin
428 | tags_id == 865
428 | tags_name == OVOL1 Gene
428 | tags_id == 858
428 | tags_name == Skin
428 | permissions_favorite == False
428 | permissions_rate == False
428 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">OVOL1 </span></em><span style="font-weight: 400;">codes for ovo-like transcriptional repressor 1, a protein that regulates the production of a protein called filaggrin. Filaggrin is involved in the formation of the outermost skin layer. Variants of </span><em><span style="font-weight: 400;">OVOL1 </span></em><span style="font-weight: 400;">may play a role in allergies by influencing the production of filaggrin. Supplement modifications may counteract the effects of these variants by increasing production of filaggrin.&nbsp;</span></span></p> <h2 style="text-align: justify;"><strong><em>OVOL1</em></strong><strong> and Allergies</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/ovol1/"><em><span style="font-weight: 400;">OVOL1 </span></em><span style="font-weight: 400;">gene</span></a><span style="font-weight: 400;"> codes for ovo-like transcriptional repressor 1. Ovo-like transcriptional repressor 1 is able to increase the production of a protein called </span><strong>fil</strong><span style="font-weight: 400;">ament </span><strong>aggr</strong><span style="font-weight: 400;">egating prote</span><strong>in</strong><span style="font-weight: 400;"> (filaggrin) [</span><a href="https://www.ncbi.nlm.nih.gov/gene?Db=gene&amp;Cmd=DetailsSearch&amp;Term=5017"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31509236/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Filaggrin helps provide structure to the outermost layer of the skin by binding together a type of fibrous protein called keratin [</span><a href="https://www.ncbi.nlm.nih.gov/gene/2312"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In this manner, filaggrin is able to maintain a skin barrier that can protect against allergens (allergy-causing substances), bacteria, and viruses [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18620134/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23374260/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Filaggrin breakdown products have also been shown to act as natural moisturizing factors, helping the skin to remain hydrated [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23374260/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Not surprisingly, individuals with low amounts of filaggrin often have dry and flaky skin. This may be partly due to their inability to form a tough skin barrier, and partly due to the inability of their skin to retain moisture [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8844122/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">OVOL1 </span></em><span style="font-weight: 400;">have been associated with allergic diseases, such as eczema, asthma, and hay fever. These variants may decrease the production of ovo-like transcriptional repressor 1, which in turn would decrease production of filaggrin [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31509236/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Lack of filaggrin would compromise the structure of the outermost skin layer, allowing allergens to enter the skin and interact with components of the immune system. This would ultimately give rise to allergic reactions [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8844122/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>OVOL1</em></strong><strong> Results for Allergies</strong></h2> <p style="text-align: justify;">*3735765963811439*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>OVOL1 </em></strong><a href="https://selfdecode.com/snp/rs479844/"><strong>rs479844</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of allergies</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with allergies</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs:</strong></p> <p style="text-align: justify;"><strong><em>OVOL1 </em></strong><a href="https://selfdecode.com/snp/rs10791824/"><strong>rs10791824</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of allergies</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with allergies</span></li> </ul> <p style="text-align: justify;">*1855475181985033*</p> <h2 style="text-align: left;"><strong>Recommendations for Improving Allergies</strong></h2> <p style="text-align: justify;">*5206233035883459*</p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Probiotics</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/a1probiotics-good-bacteria/"><span style="font-weight: 400;">Probiotics</span></a><span style="font-weight: 400;"> are live strains of beneficial bacteria.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Probiotics such as </span><a href="https://selfhacked.com/blog/l-paracasei/"><em><span style="font-weight: 400;">Lactobacillus (L.) paracasei</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-acidophilus/"><em><span style="font-weight: 400;">L. acidophilus</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/health-benefits-l-plantarum/"><em><span style="font-weight: 400;">L. plantarum</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-casei/"><em><span style="font-weight: 400;">L. casei</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-gasseri/"><em><span style="font-weight: 400;">L. gasseri</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/b-longum/"><em><span style="font-weight: 400;">Bifidobacterium (B.) longum</span></em></a><span style="font-weight: 400;">, and </span><a href="http://selfhacked.com/blog/b-animalis/"><em><span style="font-weight: 400;">B. animalis</span></em></a><span style="font-weight: 400;"> improved hay fever in multiple trials. Moreover, </span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-johnsonii/"><em><span style="font-weight: 400;">L. johnsonii</span></em></a><span style="font-weight: 400;">, and </span><a href="https://selfhacked.com/blog/c-butyricum/"><em><span style="font-weight: 400;">Clostridium (C.) butyricum</span></em></a><span style="font-weight: 400;"> enhanced the effectiveness of immune system therapy (immunotherapy) for pollen and dust mite allergies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27442711/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16101937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24569538/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16195581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15653517/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18072744/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18510694/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19734682/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17259812/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23299716/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27401319/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22513081/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In people with asthma, </span><a href="https://selfhacked.com/blog/l-salivarius/"><em><span style="font-weight: 400;">L. salivarius</span></em></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/b-breve/"><em><span style="font-weight: 400;">B. breve</span></em></a><span style="font-weight: 400;"> reduced the production of inflammatory proteins, while </span><em><span style="font-weight: 400;">C. butyricum</span></em><span style="font-weight: 400;"> combined with immunotherapy helped improve asthma symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446640/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746628/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Preliminary research in adults and children with an allergy to cow milk suggests that the potential for </span><em><span style="font-weight: 400;">L. rhamnosus</span></em><span style="font-weight: 400;"> to modulate immune system activity may help prevent allergic reactions. This probiotic also enhanced the effectiveness of immunotherapy for peanut allergy [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10024217/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15241356/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25592987/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Other probiotics may help by fermenting the food proteins that cause allergies. For instance, </span><a href="http://selfhacked.com/blog/l-helveticus/"><em><span style="font-weight: 400;">L. helveticus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-delbrueckii/"><em><span style="font-weight: 400;">L. delbrueckii</span></em></a><span style="font-weight: 400;">, and </span><a href="http://selfhacked.com/blog/l-fermentum/"><em><span style="font-weight: 400;">L. fermentum</span></em></a><span style="font-weight: 400;"> successfully reduced the allergenic potential of cow milk and </span><a href="https://www.selfhacked.com/blog/bee-propolis/"><span style="font-weight: 400;">propolis</span></a><span style="font-weight: 400;"> in several studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20583192/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370499/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23140691/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21385515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In people with eczema, supplementation with different probiotic strains, such as</span><em><span style="font-weight: 400;"> L. rhamnosus</span></em><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/l-reuteri/"><em><span style="font-weight: 400;">L.reuteri</span></em></a><span style="font-weight: 400;">, </span><em><span style="font-weight: 400;">L. plantarum</span></em><span style="font-weight: 400;">, </span><em><span style="font-weight: 400;">L. paracasei</span></em><span style="font-weight: 400;">, </span><em><span style="font-weight: 400;">L. fermentum</span></em><span style="font-weight: 400;">, and </span><em><span style="font-weight: 400;">L. sakei</span></em><span style="font-weight: 400;">, slightly improved skin inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11069570/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12589361/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23050557/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735031/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25600169/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21269308/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25600169/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20408346/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><em><span style="font-weight: 400;">Bifidobacterium </span></em><span style="font-weight: 400;">species, such as </span><em><span style="font-weight: 400;">B. animalis</span></em><span style="font-weight: 400;">, </span><em><span style="font-weight: 400;">B. breve</span></em><span style="font-weight: 400;">, and </span><em><span style="font-weight: 400;">B. longum</span></em><span style="font-weight: 400;">, have been mainly tested in combination with </span><em><span style="font-weight: 400;">Lactobacillus </span></em><span style="font-weight: 400;">strains. These studies produced mixed results, possibly due to differences in the strains used [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11069570/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22092692/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12598719/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22955355/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20184604/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29117309/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Supplementation (in mothers before birth, or in their children after birth) with combinations of some of these </span><em><span style="font-weight: 400;">Lactobacillus </span></em><span style="font-weight: 400;">and </span><em><span style="font-weight: 400;">Bifidobacterium </span></em><span style="font-weight: 400;">strains in families with a history of allergies significantly lowered the incidence of eczema in children [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21787448/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155824/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12589361/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17349686/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22702506/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29415330/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23083673/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23083673/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215350/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30790361/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522068/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30465329/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Treatment of a reconstructed human skin cell model with </span><em><span style="font-weight: 400;">L. rhamnosus</span></em><span style="font-weight: 400;"> significantly increased the production of filaggrin. Similarly, </span><em><span style="font-weight: 400;">L. plantarum</span></em><span style="font-weight: 400;"> supplements were found to increase filaggrin production in rat and mouse models of eczema [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31480681/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31546298/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Probiotic supplements may improve allergic diseases by increasing production of filaggrin.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Borage Oil</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/borage/"><span style="font-weight: 400;">Borage oil</span></a><span style="font-weight: 400;"> contains high levels of omega-6 fatty acids (such as </span><a href="https://selfhacked.com/blog/gamma-linolenic-acid/"><span style="font-weight: 400;">gamma linolenic acid</span></a><span style="font-weight: 400;">) that are vital to the proper structure and function of the skin barrier [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/1760354"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In children with eczema, wearing undershirts coated with borage oil for 2 weeks improved skin redness. They also experienced relief from itch [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18078406"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Oral borage oil supplements increased skin hydration and reduced skin roughness and scaling in a study of healthy women with sensitive and dry skin. However, most studies of borage oil supplements found no improvements in eczema [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18761778"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10233322"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9244815/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12663296/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC292992/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10233322/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15099370/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Filaggrin was observed to increase in amount in guinea pigs fed borage oil [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30340812/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Borage oil applied to the skin may improve eczema by increasing production of filaggrin.</span></p> <h4 style="text-align: justify;"><strong>Coconut Oil</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Virgin </span><a href="https://selfhacked.com/blog/coconut-oil-benefits-of-coconut-oil/"><span style="font-weight: 400;">coconut oil</span></a><span style="font-weight: 400;">, applied daily for eight weeks, was an effective treatment for mild to moderate eczema in a clinical trial [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24320105/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Coconut oil has also been reported to moisturize the skin and prevent infections, which may further help improve eczema [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15724344/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19134433/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Virgin coconut oil increased the amount of filaggrin and decreased the amount of inflammatory proteins found in human cells. From these observations, the authors of the study suggested that virgin coconut oil may enhance the integrity of the skin barrier [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30671361/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Coconut oil applied to the skin may improve eczema by increasing production of filaggrin.</span></p>
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428 | content_learn_more_1855475181985033_text == Based on the variants we looked at, your OVOL1 gene makes you somewhat more likely to develop allergic diseases. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Probiotics, borage oil, and coconut oil may help. Keep scrolling to find out more.
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rsIDs = rs10791824,rs479844
rsStatus = rs10791824,OVOL1,chr11,65791795,A,C,G,T,35,0,Normal
rsStatus = rs479844,,chr11,65784486,A,C,G,,30,1,HET
