429 | id == 429
429 | category_id == 26
429 | category_order == 23
429 | category_name == Allergies
429 | category_color == #C47AC0
429 | slug == STAT6-allergies
429 | title == What Happens When Antiparasitic Immunity Goes Wrong? (STAT6)
429 | meta_description == STAT6 stimulates the immune response to parasitic infection, but it may cause allergies if left unregulated. Are you vulnerable?
429 | summary == <p><strong><em>STAT6 </em>stimulates the immune response to parasitic infection, but it may cause allergies if left unregulated. Are you genetically vulnerable? Find out here.</strong></p>
429 | overall_score_text == Your Allergy Score (based on STAT6)
429 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/STAT6-Allergies.jpg
429 | author_id == 1
429 | author_name == Jasmine Foster
429 | author_title == BSc, BEd
429 | author_order == 36
429 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
429 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
429 | reviewer == None
429 | medical_reviewer_id == 11
429 | medical_reviewer_name == Puya Yazdi
429 | medical_reviewer_title == MD
429 | publish_date == 2020
429 | publish_date == 10
429 | publish_date == 21
429 | avg_rating == 5.0
429 | tags_id == 860
429 | tags_name == Allergic Diseases
429 | tags_id == 97
429 | tags_name == Allergies
429 | tags_id == 848
429 | tags_name == Hay Fever
429 | tags_id == 591
429 | tags_name == IgE Antibodies
429 | tags_id == 367
429 | tags_name == IL-13
429 | tags_id == 782
429 | tags_name == IL4
429 | tags_id == 95
429 | tags_name == Immune System
429 | tags_id == 24
429 | tags_name == Inflammation
429 | tags_id == 866
429 | tags_name == STAT6 Gene
429 | permissions_favorite == False
429 | permissions_rate == False
429 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">STAT6 </span></em><span style="font-weight: 400;">encodes signal transducer and activator of transcription 6. Variants of </span><em><span style="font-weight: 400;">STAT6</span></em><span style="font-weight: 400;"> may play a role in allergies by increasing IgE production and promoting allergic sensitization. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by preventing STAT6 activation.</span></p> <h2><strong><em>STAT6</em></strong><strong> and Allergies</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/stat6/" target="_blank" rel="noopener"><em><span style="font-weight: 400;">STAT6 </span></em></a><span style="font-weight: 400;">gene codes for one member of a family of proteins called signal transducer and activator of transcription, or just &ldquo;STAT&rdquo; for short. STAT proteins are activated by other proteins (such as </span><a href="https://www.selfdecode.com/gene/jak2/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">JAK</span></a><span style="font-weight: 400;">), which causes them to bind to DNA to turn certain genes &ldquo;on&rdquo; or &ldquo;off&rdquo; [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524500/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">STAT6 is activated by the </span><a href="https://selfdecode.com/blog/article/il4-allergies-426/"><span style="font-weight: 400;">IL-4</span></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/interleukin-1/"><span style="font-weight: 400;">IL-1</span></a><a href="http://www.selfdecode.com/gene/IL13/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">3</span></a><span style="font-weight: 400;"> cytokines and goes on to stimulate an immune response. Under normal, healthy circumstances, STAT6 helps the immune system fight off parasitic infection. However, when it is activated in the absence of infection, STAT6 may trigger allergic disorders like asthma, food allergies, and atopic dermatitis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107597/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">STAT6 can easily cause allergies because it increases the production of IgE, a type of antibody that typically attacks parasites but can also become reactive to otherwise harmless allergens like pollen and peanuts [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19665768/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Unsurprisingly, at least five variants in the </span><em><span style="font-weight: 400;">STAT6</span></em><span style="font-weight: 400;"> gene have been associated with allergic disease. These variants probably lead to increased STAT6 activity, possibly triggering the uncontrolled immune response of an allergic reaction [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068780/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922420/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The production of IgE against harmless allergens is called allergic sensitization. Some </span><em><span style="font-weight: 400;">STAT6</span></em><span style="font-weight: 400;"> variants have specifically been linked to increased rates of allergic sensitization, meaning that people with these variants are more likely to suffer from allergies of all kinds [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23817571/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">STAT6</span></em><span style="font-weight: 400;"> encodes a gene that increases IgE antibody production when stimulated by IL-4 and IL-13. Higher STAT6 activity may increase susceptibility to allergies.</span></span></p> <h2><strong>Your </strong><strong><em>STAT6</em></strong><strong> Results for Allergies</strong></h2> <p>*7084919220800319*</p> <p><strong>STAT6 </strong><a href="https://selfdecode.com/snp/rs324011/"><strong>rs324011</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with allergic disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with allergic disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele increases STAT6 activity, which may lead to increased IgE production and allergic sensitization [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19665768/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong>STAT6 </strong><a href="https://selfdecode.com/snp/rs1059513/"><strong>rs1059513</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with allergic disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with allergic disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele may lead to increased IgE production and higher rates of allergic sensitization [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23817571/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong>STAT6 </strong><a href="https://selfdecode.com/snp/rs3024971/"><strong>rs3024971</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with allergic disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Possibly protective again allergic disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele may decrease IgE production [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19665768/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong>STAT6 </strong><a href="https://selfdecode.com/snp/rs3001426/"><strong>rs3001426</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with allergic disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with allergic disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may increase IgE production [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19665768/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong>STAT6 </strong><a href="https://selfdecode.com/snp/rs167769/"><strong>rs167769</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with allergic disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with allergic disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele significantly increases STAT6 activity, which may lead to increased IgE production and allergic sensitization [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205328/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*4836344276645916*</p> <h2><strong>Recommendations for Preventing Allergies</strong></h2> <p>*3381321339843817*</p> <h3><strong>Acupuncture</strong></h3> <p><span style="font-weight: 400;">In a mouse study, </span><a href="https://selfhacked.com/blog/acupuncture-benefits-mechanisms-risks/"><span style="font-weight: 400;">acupuncture</span></a><span style="font-weight: 400;"> reduced STAT6 activity and reduced inflammation in allergic rhinitis, or hay fever [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22020787/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Several clinical trials suggest that acupuncture may be a safe and valid way to improve the symptoms of allergic rhinitis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17874980/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15154290/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15291903/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25590322/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Acupuncture may improve the symptoms of allergic rhinitis by blocking STAT6.</span></p> <h3><strong>Vitamin E</strong></h3> <p><span style="font-weight: 400;">In human cells, </span><a href="https://selfhacked.com/blog/vitamin-e-can-help-fertility-pregnancy/"><span style="font-weight: 400;">vitamin E</span></a><span style="font-weight: 400;"> blocks IL-13 signalling. Since IL-13 stimulates STAT6, this may be a good way to prevent STAT6 activation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201713/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Several studies have associated high intake of vitamin E with a reduced incidence of asthma, while a diet poor in this vitamin increases the risk. Similarly, some people with asthma have lower levels of this vitamin in the blood and lungs [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7735592/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16763215/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1745426/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10731863/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10465176/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Food sources of vitamin E include wheat germ, nuts, sunflower and sesame seeds, and their respective plant oils [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956867/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Vitamin E may block STAT6 by preventing its activation through IL-13. Dietary intake of vitamin E is also closely linked to rates of allergic disease.</span></p> <h3><strong>Pycnogenol</strong></h3> <p><a href="https://selfhacked.com/blog/pycnogenol-pine-bark-extract-health-benefits/"><span style="font-weight: 400;">Pycnogenol</span></a><span style="font-weight: 400;">, a blend of active compounds from pine bark, improved airway function in mice by blocking the JAK/STAT6 pathway [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27643741/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Pycnogenol improved eye and nose symptoms in people with allergy to birch pollen, especially when taken 7-8 weeks before allergy season [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20549654/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27501213/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Pycnogenol also reduced blood inflammatory markers (</span><a href="https://selfhacked.com/blog/leukotrienes/"><span style="font-weight: 400;">leukotrienes</span></a><span style="font-weight: 400;">) and the use of inhalers in adults and children with asthma [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12639402/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15641632/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22108478/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Pycnogenol may prevent or improve allergic disorders by blocking STAT6.</span></p>
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429 | content_learn_more_4836344276645916_text == Based on the variants we looked at, your STAT6 gene is somewhat associated with allergic disorders. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Acupuncture, vitamin E, and pycnogenol may help. Keep scrolling to find out more.
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rsIDs = rs3001426,rs167769,rs1059513,rs324011,rs3024971
rsStatus = rs3001426,,chr12,57115272,T,C,,,10,31,HET
rsStatus = rs167769,STAT6,chr12,57109992,C,T,,,4,36,HET
rsStatus = rs1059513,NAB2,chr12,57095926,T,C,,,33,0,Normal
rsStatus = rs324011,STAT6,chr12,57108399,C,A,T,,38,0,Normal
rsStatus = rs3024971,STAT6,chr12,57099944,T,G,,,37,0,Normal
