43 | id == 43
43 | category_id == 11
43 | category_order == 8
43 | category_name == Metabolic Health
43 | category_color == #C47AC0
43 | slug == diabetes-FOXO1
43 | title == Are You At Risk for Insulin Resistance and Diabetic Complications? (FOXO1)
43 | meta_description == High FOXO1 activity may put you at risk of insulin resistance and diabetes. Should you be worried? Learn what to do here.
43 | summary == <p><strong>High FOXO1 activity may put you at risk of insulin resistance and diabetes. You can keep this gene within its optimal range by activating AMPK, the &ldquo;master switch&rdquo; of metabolism that keeps FOXO1 from getting too high or too low. Should you make this a priority? Find out here.</strong></p>
43 | overall_score_text == Glucose Metabolism Score (Based on FOXO1 Gene)
43 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/FOXO1--Glucose-metabolism_JPG.jpg
43 | author_id == 1
43 | author_name == Jasmine Foster
43 | author_title == BSc, BEd
43 | author_order == 36
43 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
43 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
43 | reviewer_id == 2
43 | reviewer_name == Joe Cohen
43 | reviewer_title == BS
43 | medical_reviewer_id == 11
43 | medical_reviewer_name == Puya Yazdi
43 | medical_reviewer_title == MD
43 | publish_date == 2019
43 | publish_date == 9
43 | publish_date == 12
43 | avg_rating == 5.0
43 | tags_id == 126
43 | tags_name == AMPK
43 | tags_id == 81
43 | tags_name == Diabetes Type 1
43 | tags_id == 127
43 | tags_name == Diabetes Type 2
43 | tags_id == 125
43 | tags_name == FOXO1 Gene
43 | tags_id == 139
43 | tags_name == Insulin
43 | tags_id == 116
43 | tags_name == Insulin Resistance
43 | tags_id == 141
43 | tags_name == Metabolic Health
43 | tags_id == 140
43 | tags_name == Metabolism
43 | permissions_favorite == False
43 | permissions_rate == False
43 | content_article == <h2><span style="font-weight: 400;">Forkhead Box O1</span></h2> <p><span style="font-weight: 400;">FOXO1 is a strange, doubled-edged little protein. It is a transcription factor, meaning that it binds to DNA and regulates the activity of other genes. More specifically, it regulates insulin production, DNA repair, cell suicide (apoptosis) and parts of the human body&rsquo;s antioxidant response [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24452601"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">High FOXO1 activity can be good or bad, depending on the circumstance. On the bright side, this protein [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24452601"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783344/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Protects many cells from </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidative stress</span></a></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Suppresses the growth and metastasis of cancer cells</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Promotes DNA repair</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Improves wound healing</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Stimulates cellular recycling (</span><a href="https://selfhacked.com/blog/autophagy-benefits-and-how-to-harness/"><span style="font-weight: 400;">autophagy</span></a><span style="font-weight: 400;">) to destroy and replace damaged proteins</span></li> </ul> <p><span style="font-weight: 400;">On the other hand, FOXO1 enhances the inflammatory response and reduces </span><a href="https://selfhacked.com/blog/insulin-101/"><span style="font-weight: 400;">insulin</span></a><span style="font-weight: 400;"> sensitivity. In fact, FOXO1 tends to be highly expressed in atherosclerotic plaques (fatty buildup in blood vessels), and mice with overactive FOXO1 tend to develop diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24452601"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411770/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://cardiab.biomedcentral.com/articles/10.1186/s12933-016-0361-1"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285669/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">With such a broad and complex role, it&rsquo;s not surprising that FOXO1 mutations may significantly change a person&rsquo;s health outcomes and even lifespan.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">FOXO1 protects cells from oxidative stress and promotes DNA repair, making it an important cancer suppressor gene. It also stimulates autophagy and improves wound healing, but too much FOXO1 activity may increase risk of diabetes and atherosclerosis.</span></p> <h2><span style="font-weight: 400;">FOXO1 and Diabetes: a Complicated Relationship</span></h2> <p><span style="font-weight: 400;">FOXO1 and diabetes have what you might call a complicated relationship. According to some studies, low FOXO1 activity prevents the body from making enough insulin, thereby creating a diabetes-like state. According to others, low FOXO1 could improve diabetes symptoms like impaired healing [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29724916"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30279162"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">So, what&rsquo;s the truth? What&rsquo;s going on here?</span></p> <h3><span style="font-weight: 400;">Type 1 Diabetes and Impaired Healing</span></h3> <p><span style="font-weight: 400;">In people with type 1 diabetes, wound and fracture healing is often extremely slow; according to rodent studies, FOXO1 may be partially responsible. In mice, blocking or deleting FOXO1 restored the animals&rsquo; ability to heal broken bones [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155046/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://diabetes.diabetesjournals.org/content/67/12/2682.long"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Thus, high FOXO1 activity may prevent wounds from healing in people with type 1 diabetes, and suppressing FOXO1 may help.</span></p> <h3><span style="font-weight: 400;">Insulin Resistance and Type 2 Diabetes</span></h3> <p><span style="font-weight: 400;">At least three SNPs in FOXO1 have been associated with type 2 diabetes risk in humans: rs10507486, rs7986407, and rs4581585 [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19346957"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219992/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In all cases, the risk allele appears to increase the activity of FOXO1 in the pancreas; according to a series of mouse studies, over-active FOXO1 prevents the pancreas from producing enough insulin and responding appropriately to changes in blood </span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">glucose</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23959366"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032249"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">At least two of these variations could interact significantly with obesity; that is, obesity intensifies the risk associated with the bad alleles at these SNPs [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219992/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">On the other hand, in some cell studies, low FOXO1 in fat tissue could also trigger </span><a href="https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin resistance</span></a><span style="font-weight: 400;">. More research will be needed to untangle the complex relationship between this gene and diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29724916"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">In both type 1 and type 2 diabetes, high FOXO1 activity is associated with complications like poor wound healing and damage to the pancreas.</span></p> <h2><span style="font-weight: 400;">Should You Increase or Decrease FOXO1?</span></h2> <p><span style="font-weight: 400;">As we&rsquo;ve discussed, over-active FOXO1 can damage the pancreas and trigger type 2 diabetes in mice, while under-active FOXO1 causes a diabetes-like state to develop in human fat cells. FOXO1 as expressed in healthy people is beneficial to wound healing; in people with diabetes, it is destructive and may increase lesions, ulcers, and inflammatory complications [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Given this apparent contradiction, what can we do to make sure FOXO1 is working well? We&rsquo;ve got some good news: there&rsquo;s a pathway in your body that can keep FOXO1 activity from getting too high </span><em><span style="font-weight: 400;">or </span></em><span style="font-weight: 400;">too low.</span></p> <h3><span style="font-weight: 400;">AMPK: The Key to Balancing FOXO1</span></h3> <p><a href="http://selfhacked.com/blog/natural-ampk-activators/"><span style="font-weight: 400;">AMPK</span></a><span style="font-weight: 400;"> is the master energy regulator in your body. It detects available energy in the form of ATP in your cells, and modifies both metabolism and appetite appropriately. When cellular energy is low, AMPK activates and promotes energy production from storage (for example, by burning fat) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980534/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287273/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">AMPK can both increase and decrease FOXO1 activity, depending on which is appropriate. It has been shown to induce FOXO1 in healthy animals and to suppress it in animals with diabetes. Furthermore, AMPK increases insulin sensitivity; thus, high AMPK activity may be the key to balancing and optimizing FOXO1 to prevent insulin resistance [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25065674"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29093682"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">AMPK, the master energy regulator, can turn FOXO1 activity either up or down. AMPK is likely the key to keeping FOXO1 within its optimal range.</span></p> <h2><span style="font-weight: 400;">Your FOXO1 Results for Glucose Metabolism</span></h2> <p>*7721717693165819*</p> <p><strong>FOXO1 rs10507486</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased FOXO1 activity, increased risk of insulin resistance</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Decreased FOXO1 activity, decreased risk of insulin resistance</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">70.9% of all people worldwide have the &lsquo;GG&rsquo; genotype (highest risk)</span></li> </ul> <p><strong>FOXO1 rs7986407</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased FOXO1 activity, increased risk of insulin resistance</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Decreased FOXO1 activity, decreased risk of insulin resistance</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">28.5% of all people worldwide have &lsquo;GG&rsquo; genotype (highest risk)</span></li> </ul> <p><strong>FOXO1 rs4581585</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased FOXO1 activity, increased risk of insulin resistance</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Decreased FOXO1 activity, decreased risk of insulin resistance</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">24.2% of all people worldwide have the &lsquo;CC&rsquo; genotype (highest risk)</span></li> </ul> <p><span style="font-weight: 400;">Relatively speaking, rs10507486 has less of an impact than either of the other two variants listed here. People with the &lsquo;GG&rsquo; genotype at rs10507486 are only about 27% more likely than those with the &lsquo;</span><a href="https://www.selfhacked.com/blog/arachidonic-acid/"><span style="font-weight: 400;">AA</span></a><span style="font-weight: 400;">&rsquo; genotype to develop insulin resistance. The effect is significant, but small [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19346957"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">By contrast, rs7986407 and rs4581585 are much more strongly linked to insulin resistance, each capable of more than doubling your risk. Unfortunately, the research linking these SNPs to diabetes risk is quite recent, only published in 2017. These variants are therefore less likely to be included on a commercial DNA file [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219992/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p>*9210286459386603*</p> <h2><span style="font-weight: 400;">Recommendations to Prevent Insulin Resistance</span></h2> <p><span style="font-weight: 400;">Remember that the key to balancing FOXO1 is AMPK, but even if you don&rsquo;t have risk alleles, you can probably benefit from activating AMPK. Besides regulating glucose tolerance, AMPK promotes healthy aging, decreases inflammation, and prevents cardiovascular disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287273/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973318/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27815596"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Insulin resistance is a serious health issue. Before adopting any of the recommendations below, talk to your doctor about your genetic data. Together, you'll find the right strategies for you.</span></p> <p><span style="font-weight: 400;">*3840918772161516*</span></p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <p><span style="font-weight: 400;">When you </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;">, you use up a lot of cellular energy in the form of ATP. This loss of energy triggers AMPK, which in turn can keep FOXO1 in balance [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980534/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25065674"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29093682"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Likewise, </span><a href="http://selfhacked.com/blog/intermittent-fasting/"><span style="font-weight: 400;">intermittent fasting</span></a><span style="font-weight: 400;"> and calorie restriction reduce available energy and activate AMPK [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973318/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Diet</span></h3> <p><a href="http://selfhacked.com/blog/natural-ampk-activators/"><span style="font-weight: 400;">Substances that increase AMPK</span></a><span style="font-weight: 400;"> may be the best options for balancing FOXO1 and keeping its activity within the beneficial range. AMPK has been shown to induce FOXO1 in healthy animals and to suppress it in animals with diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25065674"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29093682"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Many plant polyphenols activate AMPK; eating foods that contain them may help you balance FOXO1 and maintain healthy insulin sensitivity, including:</span></p> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/top-15-scientific-health-benefits-of-resveratrol-with-references/"><span style="font-weight: 400;">Resveratrol</span></a><span style="font-weight: 400;"> (red grapes, peanuts, Japanese knotweed) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://www.selfhacked.com/blog/quercetin-22-scientifically-proven-benefits-quercetin/"><span style="font-weight: 400;">Quercetin</span></a><span style="font-weight: 400;"> (leafy greens, broccoli, red onions, tea&hellip;) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://www.selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">EGCG</span></a><span style="font-weight: 400;"> (</span><a href="http://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">green tea</span></a><span style="font-weight: 400;">) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/top-11-science-based-health-benefits-apigenin/"><span style="font-weight: 400;">Apigenin</span></a><span style="font-weight: 400;"> (parsley, onions, oranges, tea&hellip;) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21538580"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><a href="http://selfhacked.com/blog/top-18-science-based-health-effects-carnitine/"><span style="font-weight: 400;">Carnitine</span></a><span style="font-weight: 400;">, a compound found in meat and dairy, also activates AMPK and prevents insulin resistance. Fresh beef is by far the best dietary source of carnitine [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19121314"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ods.od.nih.gov/factsheets/Carnitine-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <p><a href="https://selfhacked.com/blog/berberine-19-health-benefits-of-berberine-with-references/"><span style="font-weight: 400;">Berberine</span></a><span style="font-weight: 400;"> is the best-known supplement for diabetes, insulin sensitivity and AMPK activation. In obese animal models, berberine improves insulin sensitivity and reduces body weight; in cell studies, berberine directly activates AMPK. Berberine can interact with some medications, so make sure to do your research and talk to your doctor before supplementing [</span><a href="https://diabetes.diabetesjournals.org/content/55/8/2256"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898966/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In cell studies, resveratrol has been shown to increase FOXO1 and the antioxidant enzyme </span><a href="http://selfhacked.com/blog/the-brain-fog-gene-rs4880-or-sod2/"><span style="font-weight: 400;">MnSOD</span></a><span style="font-weight: 400;"> through </span><a href="http://selfhacked.com/blog/natural-ampk-activators/"><span style="font-weight: 400;">AMPK activation</span></a><span style="font-weight: 400;">. AMPK and resveratrol have both been found to increase insulin sensitivity and reduce one&rsquo;s risk of diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25065674"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27812983"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820197/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973318/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28843911"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Salidroside (the active compound in </span><a href="https://selfhacked.com/blog/rhodiola/"><em><span style="font-weight: 400;">Rhodiola rosea</span></em></a><span style="font-weight: 400;">) also activates AMPK and down-regulates FOXO1 in diabetic mice. Thus, </span><a href="http://selfhacked.com/blog/rhodiola/"><span style="font-weight: 400;">rhodiola</span></a><span style="font-weight: 400;"> may be an especially good option for people with diabetes or prediabetic insulin resistance [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29093682"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Other strong AMPK activators include bioavailable </span><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">curcumin</span></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">EGCG</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">For a complete list of natural AMPK activators, </span><a href="https://selfhacked.com/blog/natural-ampk-activators/"><span style="font-weight: 400;">check out this post</span></a><span style="font-weight: 400;">.</span></p> <h3><span style="font-weight: 400;">Drugs</span></h3> <p><span style="font-weight: 400;">Unsurprisingly, </span><a href="https://selfhacked.com/blog/uses-benefits-metformin/"><span style="font-weight: 400;">metformin</span></a><span style="font-weight: 400;">, one of the most commonly prescribed diabetes drugs, activates AMPK and prevents insulin resistance. We don&rsquo;t recommend taking metformin without a doctor&rsquo;s prescription; however, if you develop prediabetes and you have FOXO1 risk alleles, you may want to talk to your doctor about metformin [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973318/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://diabetes.diabetesjournals.org/content/51/8/2420"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Most lifestyle, diet, and supplement choices that strongly activate AMPK will be good choices to balance FOXO1 and increase insulin sensitivity. The best include exercise, fasting, resveratrol, rhodiola, and metformin.</span></p>
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43 | content_learn_more_7721717693165819_text == Based on the variants we looked at, your FOXO1 gene makes you somewhat more susceptible to insulin resistance and complications from type 2 diabetes. However, this doesn’t reflect your overall risk of diabetes—just one gene related to it. You’ll need to activate AMPK to keep FOXO1 balanced. Keep scrolling to find out how.
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rsIDs = rs7986407,rs4581585,rs4880,rs10507486
rsStatus = rs7986407,FOXO1,chr13,40605661,A,G,,,25,0,Normal
rsStatus = rs4581585,FOXO1,chr13,40629768,C,G,T,,45,0,Normal
rsStatus = rs4880,SOD2,chr6,159692840,A,G,,,17,16,HET
rsStatus = rs10507486,FOXO1,chr13,40612364,G,A,,,30,0,Normal
