430 | id == 430
430 | category_id == 26
430 | category_order == 23
430 | category_name == Allergies
430 | category_color == #C47AC0
430 | slug == CXCR5-allergies
430 | title == The Relationship Between Immune System Interactions and Allergic Diseases (CXCR5)
430 | meta_description == CXCR5 is involved in the release of antibodies. Variants of CXCR5 have been linked to allergies. Read more here.
430 | summary == <p style="text-align:justify"><strong>The <em>CXCR5</em> gene codes for a protein that is involved in the release of antibodies. Read more to learn how variants of <em>CXCR5</em> might increase the risk of allergies.&nbsp;</strong><br />  &nbsp;</p>
430 | overall_score_text == Your Allergy Score (based on CXCR5 gene)
430 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CXCR5-Allergies.jpg
430 | author_id == 14
430 | author_name == Shany Lahan
430 | author_title == MS (Neuroscience)
430 | author_order == 5
430 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
430 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
430 | reviewer == None
430 | medical_reviewer_id == 11
430 | medical_reviewer_name == Puya Yazdi
430 | medical_reviewer_title == MD
430 | publish_date == 2020
430 | publish_date == 10
430 | publish_date == 21
430 | avg_rating == 5.0
430 | tags_id == 860
430 | tags_name == Allergic Diseases
430 | tags_id == 98
430 | tags_name == Asthma
430 | tags_id == 242
430 | tags_name == B cells
430 | tags_id == 792
430 | tags_name == Chemokine
430 | tags_id == 868
430 | tags_name == CXCL13
430 | tags_id == 867
430 | tags_name == CXCR5 Gene
430 | tags_id == 99
430 | tags_name == Eczema
430 | tags_id == 848
430 | tags_name == Hay Fever
430 | tags_id == 591
430 | tags_name == IgE Antibodies
430 | tags_id == 870
430 | tags_name == Lymph Nodes
430 | tags_id == 869
430 | tags_name == TFH cells
430 | permissions_favorite == False
430 | permissions_rate == False
430 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">CXCR5 is a receptor that enables cells of the immune system to interact and subsequently release antibodies. Variants of </span><em><span style="font-weight: 400;">CXCR5 </span></em><span style="font-weight: 400;">may play a role in allergies by increasing the amount of CXCR5 found on the surfaces of white blood cells. Diet and supplement modifications may counteract the effects of these variants by decreasing production of CXCR5.</span></span></p> <h2 style="text-align: justify;"><strong><em>CXCR5</em></strong><strong> and Allergies</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">A chemokine is a protein that can attract cells of the immune system to certain areas of the body.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">CXCR5 is a receptor that binds chemokine CXCL13. CXCR5 can be found on the surfaces of two types of white blood cells: T</span><sub><span style="font-weight: 400;">FH</span></sub><span style="font-weight: 400;"> cells and B cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26970097/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Through its actions on CXCR5, CXCL13 can attract T</span><sub><span style="font-weight: 400;">FH</span></sub><span style="font-weight: 400;"> cells and B cells to the same sites within lymph nodes. Interactions between T</span><sub><span style="font-weight: 400;">FH</span></sub><span style="font-weight: 400;"> cells and B cells at these sites can stimulate B cells to release a class of antibody called IgE [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26970097/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The release of IgE antibodies from B cells is an early step in the initiation of allergic reactions [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17259966/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Not surprisingly, variants of </span><a href="https://selfdecode.com/gene/cxcr5/"><em><span style="font-weight: 400;">CXCR5</span></em></a><span style="font-weight: 400;"> have been linked to allergic diseases, such as hay fever, asthma, and eczema [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">These variants may increase the amount of CXCR5 found on the surfaces of T</span><sub><span style="font-weight: 400;">FH</span></sub><span style="font-weight: 400;"> and B cells. This would result in a greater amount of T</span><sub><span style="font-weight: 400;">FH</span></sub><span style="font-weight: 400;"> and B cell interactions within lymph nodes, ultimately leading to excess release of IgE antibodies.&nbsp;</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>CXCR5</em></strong><strong> Results for Allergies</strong></h2> <p style="text-align: justify;">*3968904812444407*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>CXCR5 </em></strong><a href="https://selfdecode.com/snp/rs12365699/"><strong>rs12365699</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of allergies, relative to &lsquo;A&rsquo; allele</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Decreased risk of allergies, relative to &lsquo;G&rsquo; allele</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs:</strong></p> <p style="text-align: justify;"><strong><em>CXCR5 </em></strong><a href="https://selfdecode.com/snp/rs11217036/"><strong>rs11217036</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased risk of allergies, relative to &lsquo;T&rsquo; allele</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Decreased risk of allergies, relative to &lsquo;C&rsquo; allele</span></li> </ul> <p style="text-align: justify;">*3338210463214781*</p> <h2 style="text-align: left;"><strong>Recommendations for Improving Allergies</strong></h2> <p style="text-align: justify;">*7228005965215611*</p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Apple</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Polyphenols are anti-inflammatory and antioxidant compounds that naturally occur in vegetables and fruits, such as apples. While </span><a href="https://selfhacked.com/blog/apple-polyphenols/"><span style="font-weight: 400;">apple polyphenols</span></a><span style="font-weight: 400;"> can be found in apple flesh, the greatest amount is found in the peel [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789330"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In 2 small clinical trials focused on people with hay fever, apple polyphenol consumption reduced sneezing attacks, nose discharge, and nasal swelling. The effects were more prominent in those consuming higher doses of apple polyphenols [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17039666/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15849424/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">It&rsquo;s important to note that people who are allergic to birch pollen may also react to apples, because these fruits contain proteins similar to those found in birch pollen (this is called </span><em><span style="font-weight: 400;">cross-reactivity</span></em><span style="font-weight: 400;">). In a small clinical trial, gradually increasing apple consumption induced birch pollen tolerance. However, the effect disappeared when the participants stopped eating apples [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11167370/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22070352/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Apples also contain a compound called butyraldehyde. Butyraldehyde was found to decrease the production of CXCR5 in human cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26079696/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Consumption of apples may improve allergies by decreasing production of CXCR5.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Resveratrol</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/top-15-scientific-health-benefits-of-resveratrol-with-references/"><span style="font-weight: 400;">Resveratrol</span></a><span style="font-weight: 400;"> is an antioxidant found in high amounts in grapes and wine. It is also available in supplement form.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In 2 preliminary trials focused on adults and children with hay fever, resveratrol nose sprays improved associated symptoms, such as runny and stuffy nose, itching, and sneezing. Resveratrol also reduced the amount of antibodies in the blood, immune system cell counts, and levels of inflammatory markers [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24983742/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29539616/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Treatment with resveratrol significantly reduced the production of CXCR5 in mice [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27693537/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Resveratrol may improve allergies by decreasing production of CXCR5.</span></p>
430 | content_snp_table_3968904812444407_key == 3968904812444407
430 | content_snp_table_3968904812444407_blur == True
430 | content_snp_table_3968904812444407_hidden == False
430 | content_learn_more_3338210463214781_key == 3338210463214781
430 | content_learn_more_3338210463214781_blur == True
430 | content_learn_more_3338210463214781_hidden == False
430 | content_learn_more_3338210463214781_text == Based on the variants we looked at, your CXCR5 gene makes you somewhat more likely to develop allergic diseases. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Consuming apples and taking resveratrol supplements may help. Keep scrolling to find out more.
430 | content_recommendation_7228005965215611_key == 7228005965215611
430 | content_recommendation_7228005965215611_blur == True
430 | content_recommendation_7228005965215611_hidden == False
rsIDs = rs12365699,rs11217036
rsStatus = rs12365699,,chr11,118872577,G,A,,,38,0,Normal
rsStatus = rs11217036,,chr11,118805063,C,G,T,,33,0,Normal
