431 | id == 431
431 | category_id == 26
431 | category_order == 23
431 | category_name == Allergies
431 | category_color == #C47AC0
431 | slug == CCR7-inflammation-allergies
431 | title == Genetics of Inflammation in Allergies (CCR7)
431 | meta_description == The CCR7 gene stimulates the immune cells involved in inflammation. Click to learn about its link with allergies.
431 | summary == <p style="text-align:justify"><strong>Can your genes contribute to allergies by promoting inflammation? Read this post to learn how the CCR7 gene impacts allergic reactions and what you can do about it!</strong></p>
431 | overall_score_text == Your Allergies Score (based on CCR7 gene)
431 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CCR7-Allergies.jpg
431 | author_id == 9
431 | author_name == Aleksa Ristic
431 | author_title == MS (Pharmacy)
431 | author_order == 45
431 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
431 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
431 | reviewer == None
431 | medical_reviewer_id == 11
431 | medical_reviewer_name == Puya Yazdi
431 | medical_reviewer_title == MD
431 | publish_date == 2020
431 | publish_date == 10
431 | publish_date == 22
431 | avg_rating == 5.0
431 | tags_id == 170
431 | tags_name == Air Pollution
431 | tags_id == 97
431 | tags_name == Allergies
431 | tags_id == 871
431 | tags_name == CCR7 gene
431 | tags_id == 95
431 | tags_name == Immune System
431 | tags_id == 853
431 | tags_name == Th2 dominance
431 | permissions_favorite == False
431 | permissions_rate == False
431 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The CCR7 gene stimulates the immune cells involved in allergic reactions.<br /><br /></strong><strong>Specific gene variants increase CCR7 activity and correlate with higher odds of allergies.<br /><br /></strong><strong>Read this post to discover effective ways to prevent allergies by targeting CCR7 variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>The CCR7 Gene in Allergic Reactions</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/ccr7/"><span style="font-weight: 400;">CCR7</span></a><span style="font-weight: 400;"> gene helps make a protein that stimulates the immune cells involved in inflammation and allergies. Higher CCR7 activity may increase </span><a href="http://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">Th2</span></a><span style="font-weight: 400;"> cytokines (IL-4, IL-12) and IgE antibodies, worsening allergic reactions [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797982/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691338/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Scientists are developing potential allergy drugs that suppress CCR7 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your CCR7 Results for Allergies</strong></h2> <p>*5670087696571890*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs7221109/"><strong>rs7221109</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with higher odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele increases CCR7 activity</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs112401631/"><strong>rs112401631</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele increases CCR7 activity</span></li> </ul> <p>*2226349953518640*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Allergic Reactions</strong></h2> <p>*4833050577225579*&nbsp;</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Avoid Air Pollution</strong></h4> <p><span style="font-weight: 400;">Particulate matter and other air pollutants from urban environments can worsen allergic reactions by increasing CCR7 activity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838419/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831906/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Research has associated exposure to air pollution with higher odds of allergic conditions, especially asthma and allergic rhinitis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192198/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034084/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803404/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Try spending more time in nature and non-industrialized environments to prevent allergies.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Avoid air pollution and spend more time in nature to lessen the impact of your CCR7 gene on allergies.</span></p> <h4><strong>Get More Sunlight</strong></h4> <p><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">Vitamin D</span></a><span style="font-weight: 400;"> deficiency is associated with inflammation, partly due to excess CCR7 activity in immune cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23239393/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175496/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586578/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">At the same time, vitamin D deficiency correlates with higher odds of asthma and allergies in children [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675563/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17919705/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Healthy exposure to </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sunlight</span></a><span style="font-weight: 400;"> is the best way to boost your vitamin D levels. You can also get it from food sources (such as fatty fish, liver, egg yolks, and dairy) or supplements [</span><a href="https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Sunlight exposure will boost your vitamin D levels and help prevent allergies by targeting your CCR7 variants.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Vitamin D</strong></h4> <p><span style="font-weight: 400;">If you&rsquo;re unable to maintain optimal vitamin D levels with sun exposure, consider taking a supplement. In people with allergic rhinitis and vitamin D deficiency, supplementation improved the symptoms [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31332549/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p>
431 | content_snp_table_5670087696571890_key == 5670087696571890
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431 | content_snp_table_5670087696571890_hidden == False
431 | content_learn_more_2226349953518640_key == 2226349953518640
431 | content_learn_more_2226349953518640_blur == True
431 | content_learn_more_2226349953518640_hidden == False
431 | content_learn_more_2226349953518640_text == Based on the variants we looked at, your CCR7 gene is associated with slightly higher odds of allergies. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Avoid air pollution and get more sunlight to counteract your variants & prevent allergies. Keep reading to learn more.
431 | content_recommendation_4833050577225579_key == 4833050577225579
431 | content_recommendation_4833050577225579_blur == True
431 | content_recommendation_4833050577225579_hidden == False
rsIDs = rs112401631,rs7221109
rsStatus = rs112401631,,chr17,40608272,T,A,,,41,0,Normal
rsStatus = rs7221109,,chr17,40614034,T,A,C,,42,0,Normal
