434 | id == 434
434 | category_id == 26
434 | category_order == 23
434 | category_name == Allergies
434 | category_color == #C47AC0
434 | slug == ORMDL3-allergies
434 | title == Airway Alterations & Allergies (ORMDL3)
434 | meta_description == ORMDL3 may induce airway changes. A variant of ORMDL3 has been associated with allergic diseases. Read more here.
434 | summary == <p style="text-align:justify"><strong>The <em>ORMDL3</em> gene may induce structural and functional airway changes that have been associated with asthma and other allergic diseases. Read more to learn how a variant of this gene may promote allergies.&nbsp;</strong><br />  &nbsp;</p>
434 | overall_score_text == Your Allergy Score (based on ORMDL3 gene)
434 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ORMDL3-Allergies.jpg
434 | author_id == 14
434 | author_name == Shany Lahan
434 | author_title == MS (Neuroscience)
434 | author_order == 5
434 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
434 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
434 | reviewer == None
434 | medical_reviewer_id == 11
434 | medical_reviewer_name == Puya Yazdi
434 | medical_reviewer_title == MD
434 | publish_date == 2020
434 | publish_date == 10
434 | publish_date == 23
434 | avg_rating == 5.0
434 | tags_id == 878
434 | tags_name == Airway
434 | tags_id == 860
434 | tags_name == Allergic Diseases
434 | tags_id == 98
434 | tags_name == Asthma
434 | tags_id == 591
434 | tags_name == IgE Antibodies
434 | tags_id == 877
434 | tags_name == Mucus
434 | tags_id == 875
434 | tags_name == ORMDL3 Gene
434 | tags_id == 876
434 | tags_name == Sphingolipid
434 | permissions_favorite == False
434 | permissions_rate == False
434 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">ORMDL3</span></em><span style="font-weight: 400;"> codes for ORMDL sphingolipid biosynthesis regulator 3, a protein that can induce structural and functional changes to the airway. A variant of </span><em><span style="font-weight: 400;">ORMDL3 </span></em><span style="font-weight: 400;">may play a role in asthma and other allergic diseases by increasing production of ORMDL sphingolipid biosynthesis regulator 3. Lifestyle modifications may counteract the effects of this variant by modulating the production of sphingolipids or ORMDL sphingolipid biosynthesis regulator 3.</span></span></p> <h2 style="text-align: justify;"><strong><em>ORMDL3</em></strong><strong> and Allergies</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/ormdl3/"><em><span style="font-weight: 400;">ORMDL3 gene</span></em></a><span style="font-weight: 400;"> codes for ORMDL sphingolipid biosynthesis regulator 3. This protein is predominantly found in cells that line the airway [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23011799/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In accordance with its name, ORMDL sphingolipid biosynthesis regulator 3 has been shown to block the actions of an enzyme required for sphingolipid production [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30193828/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28030368/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Sphingolipids are compounds that help to form the outer layers of cell surfaces, thus providing structural support to cells. The outer cell layer also acts as a barrier to prevent substances from passing into or out of these cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28030368/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">ORMDL sphingolipid biosynthesis regulator 3 can also mediate the activation of a protein, as well as activation of immune system components, that have been linked to structural and functional airway changes [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24623133/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23011799/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">These changes include: increasing the amount of airway muscle, inducing thickening and scarring below airway muscle, and augmenting the production of mucus that lines the airway. Collectively, structural and functional airway changes may elevate airway reactivity to allergens (allergy-causing substances) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24623133/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The actions of ORMDL sphingolipid biosynthesis regulator 3 have been shown to stimulate the release of a type of antibody called IgE. The release of IgE antibodies is an early step in the progression of an allergic reaction [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24623133/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A variant of </span><em><span style="font-weight: 400;">ORMDL3 </span></em><span style="font-weight: 400;">has been associated with asthma and other allergic diseases. This variant may increase production of ORMDL sphingolipid biosynthesis regulator 3, which may make the airway more susceptible to allergens by inducing changes to the cells, muscles, and mucus that line the airway [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981544/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>ORMDL3</em></strong><strong> Results for Allergies</strong></h2> <p style="text-align: justify;">*7776784235192999*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>ORMDL3 </em></strong><a href="https://selfdecode.com/snp/rs9303280/"><strong>rs9303280</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased risk of allergies</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with allergies</span></li> </ul> <p style="text-align: justify;">*2569498275315185*</p> <h2 style="text-align: left;"><strong>Recommendations for Improving Allergies</strong></h2> <p style="text-align: justify;">*7018567608512498*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Sun Exposure (Vitamin D)</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Exposure to </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sunlight</span></a><span style="font-weight: 400;"> is the best way to increase levels of </span><a href="https://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> in the blood. Vitamin D deficiency has been associated with asthma and allergies in children [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675563/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17919705/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Vitamin D supplements taken alongside an antihistamine improved symptoms of hay fever in people with vitamin D deficiency, in comparison to the antihistamine alone. However, this improvement was not significant until 8 weeks of supplementation, suggesting that symptom improvement might not occur until vitamin D has been adequately replenished in the body [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31332549/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Vitamin D supplementation in pregnant women was suggested to decrease the risk of asthma in their children, by increasing sphingolipid production. However, this effect may be limited to certain </span><em><span style="font-weight: 400;">ORMDL3 </span></em><span style="font-weight: 400;">variants [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31439681/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The sun is the best source of vitamin D. Vitamin D may improve allergies by increasing production of sphingolipids.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Avoid Air Pollution</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Research has linked exposure to air pollution with higher odds of allergic conditions, especially asthma and hay fever [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192198/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034084/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803404/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Air pollution, including second-hand smoke, was found to increase production of ORMDL sphingolipid biosynthesis regulator 3 and further increase the risk of asthma in individuals carrying certain risk variants of </span><em><span style="font-weight: 400;">ORMDL3 </span></em><span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/28740106/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18923164/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464127/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Those carrying </span><em><span style="font-weight: 400;">ORMDL3 </span></em><span style="font-weight: 400;">risk variants may choose to spend more time in nature and non-industrialized environments, in order to prevent and relieve allergies.</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Avoiding air pollution may improve allergies by preventing the excess production of ORMDL sphingolipid biosynthesis regulator 3.</span></p>
434 | content_snp_table_7776784235192999_key == 7776784235192999
434 | content_snp_table_7776784235192999_blur == True
434 | content_snp_table_7776784235192999_hidden == False
434 | content_learn_more_2569498275315185_key == 2569498275315185
434 | content_learn_more_2569498275315185_blur == True
434 | content_learn_more_2569498275315185_hidden == False
434 | content_learn_more_2569498275315185_text == Based on the variants we looked at, your ORMDL3 gene makes you somewhat more likely to develop asthma and other allergic diseases. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Avoiding air pollution and increasing sun exposure may help. Keep scrolling to find out more.
434 | content_recommendation_7018567608512498_key == 7018567608512498
434 | content_recommendation_7018567608512498_blur == True
434 | content_recommendation_7018567608512498_hidden == False
rsIDs = rs9303280
rsStatus = rs9303280,GSDMB,chr17,39917778,T,A,C,,32,0,Normal
