435 | id == 435
435 | category_id == 26
435 | category_order == 23
435 | category_name == Allergies
435 | category_color == #C47AC0
435 | slug == IL13-allergies
435 | title == The Relationship Between an Immune System Protein & Allergies (IL13)
435 | meta_description == IL-13 is an immune system protein. Variants of IL13 have been associated with allergies. Read more here.
435 | summary == <p style="text-align:justify"><strong>The <em>IL13</em> gene codes for an immune system protein. Can variants of <em>IL13</em> increase your risk of allergies? Read more to find out.</strong><br />  &nbsp;</p>
435 | overall_score_text == Your Allergy Score (based on IL13 gene)
435 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/PTGER4-Allergies.jpg
435 | author_id == 14
435 | author_name == Shany Lahan
435 | author_title == MS (Neuroscience)
435 | author_order == 5
435 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
435 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
435 | reviewer == None
435 | medical_reviewer_id == 11
435 | medical_reviewer_name == Puya Yazdi
435 | medical_reviewer_title == MD
435 | publish_date == 2020
435 | publish_date == 10
435 | publish_date == 24
435 | avg_rating == 5.0
435 | tags_id == 860
435 | tags_name == Allergic Diseases
435 | tags_id == 98
435 | tags_name == Asthma
435 | tags_id == 99
435 | tags_name == Eczema
435 | tags_id == 857
435 | tags_name == Filaggrin
435 | tags_id == 855
435 | tags_name == Food Allergy
435 | tags_id == 848
435 | tags_name == Hay Fever
435 | tags_id == 591
435 | tags_name == IgE Antibodies
435 | tags_id == 367
435 | tags_name == IL-13
435 | tags_id == 366
435 | tags_name == IL13 gene
435 | tags_id == 858
435 | tags_name == Skin
435 | permissions_favorite == False
435 | permissions_rate == False
435 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">IL-13 is an immune system protein that can stimulate the release of antibodies and compromise the skin barrier. Variants of </span><em><span style="font-weight: 400;">IL13 </span></em><span style="font-weight: 400;">may play a role in allergies by increasing production or activity of IL-13. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by decreasing levels of IL-13.</span></span></p> <h2 style="text-align: justify;"><strong><em>IL13</em></strong><strong> and Allergies</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">IL-13 is a protein released by </span><a href="https://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">type 2 immune response</span></a><span style="font-weight: 400;"> (Th2) cells. Interestingly, many scientists consider elevated Th2 activity to underlie a number of allergic diseases.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Indeed, IL-13 is able to stimulate the release of a type of antibody called IgE from immune system cells. The release of IgE antibodies is an early step in the progression of allergic reactions [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">IL-13 can also inhibit the production of a protein called </span><strong>fil</strong><span style="font-weight: 400;">ament </span><strong>aggr</strong><span style="font-weight: 400;">egating prote</span><strong>in</strong><span style="font-weight: 400;"> (filaggrin). Filaggrin helps provide structure to the outermost layer of the skin by binding together a type of fibrous protein called keratin [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31509236/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In this manner, filaggrin is able to maintain a skin barrier that can protect against allergens (allergy-causing substances), bacteria, and viruses [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18620134/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23374260/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><a href="https://selfdecode.com/gene/il13/"><em><span style="font-weight: 400;">IL13</span></em></a> <span style="font-weight: 400;">have been associated with allergic diseases, such as eczema, asthma, hay fever, and food allergies. These variants may increase the production or activity of IL-13, which can result in increased IgE antibody release [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31509236/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Elevated IL-13 may also decrease the production of filaggrin. Lack of filaggrin would compromise the structure of the outermost skin layer, allowing allergens to enter the skin and interact with components of the immune system [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31509236/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>IL13</em></strong><strong> Results for Allergies</strong></h2> <p style="text-align: justify;">*6448940242608037*</p> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Primary SNP</strong></span></p> <p style="text-align: justify;"><strong><em>IL13 </em></strong><a href="https://selfdecode.com/snp/rs1295686/"><strong>rs1295686</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of food allergies, relative to &lsquo;C&rsquo;&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Decreased risk of food allergies, relative to &lsquo;T&rsquo;</span></li> </ul> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Other Important SNPs</strong></span></p> <p style="text-align: justify;"><strong><em>IL13 </em></strong><a href="https://selfdecode.com/snp/rs1295685/"><strong>rs1295685</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of allergies, relative to &lsquo;G&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Decreased risk of allergies, relative to &lsquo;A&rsquo;</span></li> </ul> <p style="text-align: justify;"><strong><em>IL13 </em></strong><a href="https://selfdecode.com/snp/rs848/"><strong>rs848</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of allergies, relative to &lsquo;C&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Decreased risk of allergies, relative to &lsquo;A&rsquo;&nbsp;</span></li> </ul> <p style="text-align: justify;"><strong><em>IL13 </em></strong><a href="https://selfdecode.com/snp/rs20541/"><strong>rs20541</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of allergies, relative to &lsquo;G&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Decreased risk of allergies, relative to &lsquo;A&rsquo;</span></li> </ul> <p style="text-align: justify;">*1136052364191324*</p> <h2 style="text-align: left;"><strong>Recommendations for Improving Allergies</strong></h2> <p style="text-align: justify;">*7426214109461140*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Allergy Immunotherapy</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Allergy immunotherapy consists of administering a weakened allergen (such as pollen, dust mites, or dog dander) to help develop tolerance or desensitization to said allergen. This treatment can be oral (under-the-tongue allergy tablets) or injected (allergy shots) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27401313/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30095391/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26774974/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25732009/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10963287/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/bee-sting-therapy-101/"><span style="font-weight: 400;">Bee sting therapy</span></a><span style="font-weight: 400;"> is recommended as the first-line treatment for the prevention of severe allergic reactions in people allergic to the venom of bees and other insects of the same order (</span><em><span style="font-weight: 400;">Hymenoptera</span></em><span style="font-weight: 400;">). This may be due to the ability of bee sting therapy to decrease Th2 activity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420609/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8564721/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12704369/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Multiple trials attest to the effectiveness and safety of bee sting therapy. Unfortunately, the venom must be repeatedly administered at 3-month intervals to maintain its effects on the immune system [</span><a href="https://pubmed.ncbi.nlm.nih.gov/375434/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/4008075/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420609/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21447964/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17941283/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1545581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10669863/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27012015/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10505462/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a study of children with cow milk allergy, oral immunotherapy was found to desensitize approximately 70% of the allergic children. Desensitization was linked to decreases in IL-13 release, as well as decreases in IgE antibody levels. Moreover, oral immunotherapy eliminated any immune response differences originally observed between children with cow milk allergy and non-allergic children [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27826960/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a randomized controlled trial focused on children with peanut allergy, researchers found similar decreases in IL-13 levels after oral immunotherapy [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30126028/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Allergy immunotherapy may improve allergies by decreasing IL-13 and IgE antibody levels.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Allergen-Elimination Diets</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Although any food can cause allergy, only a few foods account for the vast majority of these allergies. Milk and egg allergies are the most common in children, while peanuts, shellfish, wheat, and nut allergies are common in adults [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK482187/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The only proven therapy for food allergies is the elimination of the allergen. If you're allergic to certain foods, you know the importance of reading food labels and inquiring about what goes into restaurant-prepared meals [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK482187/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Fortunately, tolerance develops to most offending foods over time. Some exceptions include peanuts, nuts, and seafood [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK482187/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414527/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In one study, immune system cells obtained from children whose eczema worsened after consumption of milk and eggs were observed to release significant amounts of Th2 proteins. This suggests that eliminating certain foods from the diet may improve allergies by decreasing the release of Th2 proteins, including IL-13 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8977715/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414527/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Allergen-elimination diets may improve allergies by decreasing the release of IL-13 and other Th2 proteins.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Probiotics</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/a1probiotics-good-bacteria/"><span style="font-weight: 400;">Probiotics</span></a><span style="font-weight: 400;"> are live strains of beneficial bacteria.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Probiotics such as </span><a href="https://selfhacked.com/blog/l-paracasei/"><em><span style="font-weight: 400;">Lactobacillus (L.) paracasei</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-acidophilus/"><em><span style="font-weight: 400;">L. acidophilus</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/health-benefits-l-plantarum/"><em><span style="font-weight: 400;">L. plantarum</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-casei/"><em><span style="font-weight: 400;">L. casei</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-gasseri/"><em><span style="font-weight: 400;">L. gasseri</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/b-longum/"><em><span style="font-weight: 400;">Bifidobacterium (B.) longum</span></em></a><span style="font-weight: 400;">, and </span><a href="http://selfhacked.com/blog/b-animalis/"><em><span style="font-weight: 400;">B. animalis</span></em></a><span style="font-weight: 400;"> improved hay fever in multiple trials. Moreover, </span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-johnsonii/"><em><span style="font-weight: 400;">L. johnsonii</span></em></a><span style="font-weight: 400;">, and </span><a href="https://selfhacked.com/blog/c-butyricum/"><em><span style="font-weight: 400;">Clostridium (C.) butyricum</span></em></a><span style="font-weight: 400;"> enhanced the effectiveness of immune system therapy (immunotherapy) for pollen and dust mite allergies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27442711/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16101937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24569538/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16195581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15653517/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18072744/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18510694/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19734682/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17259812/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23299716/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27401319/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22513081/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In people with asthma, </span><a href="https://selfhacked.com/blog/l-salivarius/"><em><span style="font-weight: 400;">L. salivarius</span></em></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/b-breve/"><em><span style="font-weight: 400;">B. breve</span></em></a><span style="font-weight: 400;"> reduced the production of inflammatory proteins, while </span><em><span style="font-weight: 400;">C. butyricum</span></em><span style="font-weight: 400;"> combined with immunotherapy helped improve asthma symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446640/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746628/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Preliminary research in adults and children with an allergy to cow milk suggests that the potential for </span><em><span style="font-weight: 400;">L. rhamnosus</span></em><span style="font-weight: 400;"> to modulate immune system activity may help prevent allergic reactions. This probiotic also enhanced the effectiveness of immunotherapy for peanut allergy [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10024217/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15241356/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25592987/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Other probiotics may help by fermenting the food proteins that cause allergies. For instance, </span><a href="http://selfhacked.com/blog/l-helveticus/"><em><span style="font-weight: 400;">L. helveticus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-delbrueckii/"><em><span style="font-weight: 400;">L. delbrueckii</span></em></a><span style="font-weight: 400;">, and </span><a href="http://selfhacked.com/blog/l-fermentum/"><em><span style="font-weight: 400;">L. fermentum</span></em></a><span style="font-weight: 400;"> successfully reduced the allergenic potential of cow milk and </span><a href="https://www.selfhacked.com/blog/bee-propolis/"><span style="font-weight: 400;">propolis</span></a><span style="font-weight: 400;"> in several studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20583192/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370499/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23140691/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21385515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In people with eczema, supplementation with different probiotic strains, such as</span><em><span style="font-weight: 400;"> L. rhamnosus</span></em><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/l-reuteri/"><em><span style="font-weight: 400;">L.reuteri</span></em></a><span style="font-weight: 400;">, </span><em><span style="font-weight: 400;">L. plantarum</span></em><span style="font-weight: 400;">, </span><em><span style="font-weight: 400;">L. paracasei</span></em><span style="font-weight: 400;">, </span><em><span style="font-weight: 400;">L. fermentum</span></em><span style="font-weight: 400;">, and </span><em><span style="font-weight: 400;">L. sakei</span></em><span style="font-weight: 400;">, slightly improved skin inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11069570/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12589361/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23050557/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735031/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25600169/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21269308/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25600169/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20408346/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><em><span style="font-weight: 400;">Bifidobacterium </span></em><span style="font-weight: 400;">species, such as </span><em><span style="font-weight: 400;">B. animalis</span></em><span style="font-weight: 400;">, </span><em><span style="font-weight: 400;">B. breve</span></em><span style="font-weight: 400;">, and </span><em><span style="font-weight: 400;">B. longum</span></em><span style="font-weight: 400;">, have been mainly tested in combination with </span><em><span style="font-weight: 400;">Lactobacillus </span></em><span style="font-weight: 400;">strains. These studies produced mixed results, possibly due to differences in the strains used [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11069570/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22092692/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12598719/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22955355/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20184604/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29117309/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Supplementation (in mothers before birth, or in their children after birth) with combinations of some of these </span><em><span style="font-weight: 400;">Lactobacillus </span></em><span style="font-weight: 400;">and </span><em><span style="font-weight: 400;">Bifidobacterium </span></em><span style="font-weight: 400;">strains in families with a history of allergies significantly lowered the incidence of eczema in children [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21787448/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155824/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12589361/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17349686/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22702506/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29415330/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23083673/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23083673/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215350/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30790361/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522068/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30465329/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a randomized controlled trial focused on children with asthma and hay fever, 8-week daily supplementation of </span><em><span style="font-weight: 400;">L. gasseri</span></em><span style="font-weight: 400;"> was found to significantly reduce IL-13 production [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20658483/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Probiotics may improve allergies by reducing IL-13 production. </span></p>
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435 | content_learn_more_1136052364191324_text == Based on the variants we looked at, your IL13 gene makes you somewhat more likely to develop allergies. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Allergen-elimination diets, allergy immunotherapy, and probiotic supplements may help. Keep scrolling to find out more.
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rsIDs = rs1295685,rs848,rs20541,rs1295686
rsStatus = rs1295685,IL13,chr5,132660753,A,G,T,,6,25,HET
rsStatus = rs848,IL13,chr5,132660808,A,C,G,,8,25,HET
rsStatus = rs20541,IL13,chr5,132660272,A,C,G,T,25,0,Normal
rsStatus = rs1295686,IL13,chr5,132660151,T,A,C,,28,0,Normal
