436 | id == 436
436 | category_id == 26
436 | category_order == 23
436 | category_name == Allergies
436 | category_color == #C47AC0
436 | slug == RUNX3-Th2-allergies
436 | title == Can You Target This Immune-Balancing Gene to Relieve Allergies? (RUNX3)
436 | meta_description == The RUNX3 gene controls the activity of immune cells and proteins. Click to learn about its link with allergies.
436 | summary == <p style="text-align:justify"><strong>By balancing your immune response, the RUNX3 gene can help prevent allergic reactions. Read this post to learn the details and get gene-based recommendations for allergies!&nbsp;</strong></p>
436 | overall_score_text == Your Allergies Score (based on RUNX3 gene)
436 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/RUNX3-Allergies.jpg
436 | author_id == 9
436 | author_name == Aleksa Ristic
436 | author_title == MS (Pharmacy)
436 | author_order == 45
436 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
436 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
436 | reviewer == None
436 | medical_reviewer_id == 11
436 | medical_reviewer_name == Puya Yazdi
436 | medical_reviewer_title == MD
436 | publish_date == 2020
436 | publish_date == 10
436 | publish_date == 24
436 | avg_rating == 5.0
436 | tags_id == 97
436 | tags_name == Allergies
436 | tags_id == 864
436 | tags_name == IL-4
436 | tags_id == 95
436 | tags_name == Immune System
436 | tags_id == 343
436 | tags_name == Interferons
436 | tags_id == 879
436 | tags_name == RUNX3 gene
436 | tags_id == 853
436 | tags_name == Th2 dominance
436 | permissions_favorite == False
436 | permissions_rate == False
436 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The RUNX3 gene helps prevent allergic reactions by shifting the immune response from Th2 towards Th1 dominance.<br /><br /></strong><strong>Specific gene variants reduce RUNX3 activity and correlate with allergic diseases.<br /><br /></strong><strong>This post reveals practical ways to prevent &amp; reduce allergies by targeting the RUNX3 gene.</strong></span></p> <p>&nbsp;</p> <h2><strong>The Role of RUNX3 in Allergies</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/runx3/"><span style="font-weight: 400;">RUNX3</span></a><span style="font-weight: 400;"> gene controls the activity of different immune cells and proteins. It suppresses Th2 cells by blocking interleukin-4 (IL-4) and stimulates </span><a href="http://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1</span></a><span style="font-weight: 400;"> cells by boosting </span><a href="https://www.selfhacked.com/blog/interferon-gamma-how-to-increase-decrease-high-low-levels/"><span style="font-weight: 400;">interferon-gamma</span></a><span style="font-weight: 400;"> (IFN-gamma) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652680/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17195845/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820333/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Typically, allergies are </span><a href="http://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">Th2</span></a><a href="https://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">-dominant</span></a><span style="font-weight: 400;"> states, so RUNX3 helps prevent allergic reactions by shifting the immune response towards Th1 dominance. Mice lacking the RUNX3 gene produce more mucus in the airways and develop lung inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15962113/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15962113/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC380997/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The RUNX3 gene helps prevent allergic reactions by shifting the immune response from Th2 towards Th1 dominance.</span></p> <p>&nbsp;</p> <h2><strong>Your RUNX3 Results for Allergies</strong></h2> <p>*9675255014999486*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs760805/"><strong>rs760805</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - not associated with allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele likely reduces RUNX3 activity and favors Th2 immunity</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs7517302/"><strong>rs7517302</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele likely reduces RUNX3 activity and favors Th2 immunity</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs742230/"><strong>rs742230</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele likely reduces RUNX3 activity and favors Th2 immunity</span></li> </ul> <p><span style="font-weight: 400;">These three variants are almost always inherited together, meaning they act as a single genetic factor.</span></p> <p>*4872292817874306*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Allergies</strong></h2> <p>*9593451677602397*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Acupuncture</strong></h4> <p><span style="font-weight: 400;">Several clinical trials suggest that </span><a href="https://selfhacked.com/blog/acupuncture-benefits-mechanisms-risks/"><span style="font-weight: 400;">acupuncture</span></a><span style="font-weight: 400;"> may be a safe and effective way to improve allergic rhinitis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17874980/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15154290/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15291903/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25590322/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Acupuncture appears to help with allergic diseases by boosting IFN-gamma and reducing IL-4, making it a potentially right choice for people with RUNX3 variants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479426/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://link.springer.com/article/10.1007/s11726-010-0085-9"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Acupuncture may relieve allergic reactions by targeting your RUNX3 variants.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Probiotics</strong></h4> <p><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">Probiotic</span></a><span style="font-weight: 400;"> supplementation may counteract your variants by blocking IL-4 and increasing IFN-gamma levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16393321/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888046/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.hindawi.com/journals/bmri/2018/8063647/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <ol> <li><a href="http://selfhacked.com/blog/l-acidophilus/"><em><span style="font-weight: 400;"> acidophilus</span></em></a><span style="font-weight: 400;"> may even directly boost RUNX3 activity, but scientists observed this in test tubes only [</span><a href="https://annalsmicrobiology.biomedcentral.com/articles/10.1007/s13213-019-01451-0"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ol> <p><span style="font-weight: 400;">Different probiotic strains may improve the symptoms of:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Allergic rhinitis (</span><a href="http://selfhacked.com/blog/l-acidophilus/"><em><span style="font-weight: 400;">L. acidophilus</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/health-benefits-l-plantarum/"><em><span style="font-weight: 400;">L. plantarum</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-casei/"><em><span style="font-weight: 400;">L. casei</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/b-longum/"><em><span style="font-weight: 400;">B. longum</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/b-animalis/"><em><span style="font-weight: 400;">B. animalis</span></em></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27442711/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16195581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18072744/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18510694/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Pollen and dust mites allergy ( </span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-johnsonii/"><em><span style="font-weight: 400;">L. johnsonii</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/c-butyricum/"><em><span style="font-weight: 400;">C. butyricum</span></em></a><span style="font-weight: 400;">) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27401319/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22513081/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Asthma (</span><a href="https://selfhacked.com/blog/l-salivarius/"><em><span style="font-weight: 400;">L.salivarius</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/b-breve/"><em><span style="font-weight: 400;">B. breve</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/c-butyricum/"><em><span style="font-weight: 400;">C. butyricum</span></em></a><span style="font-weight: 400;">) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446640/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746628/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Milk and peanut allergies (</span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-delbrueckii/"><em><span style="font-weight: 400;">L. delbrueckii</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-fermentum/"><em><span style="font-weight: 400;">L. fermentum</span></em></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10024217/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15241356/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370499/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23140691/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21385515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Probiotic supplementation may counteract your gene variants and help with different types of allergy.</span></p>
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436 | content_learn_more_4872292817874306_text == Based on the variants we looked at, your RUNX3 gene is associated with slightly higher odds of allergies. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Consider supplementing with specific probiotic strains to relieve allergies by targeting your variants. Keep reading to learn more.
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rsIDs = rs742230,rs760805,rs7517302
rsStatus = rs742230,RUNX3,chr1,24924933,G,A,,,16,14,HET
rsStatus = rs760805,RUNX3,chr1,24925432,A,T,,,15,15,HET
rsStatus = rs7517302,RUNX3,chr1,24927826,C,A,G,T,31,0,Normal
