438 | id == 438
438 | category_id == 26
438 | category_order == 23
438 | category_name == Allergies
438 | category_color == #C47AC0
438 | slug == MYC-allergies
438 | title == A Global Regulator of Immunity in Allergies (MYC)
438 | meta_description == The MYC gene encodes c-myc, which regulates the immune response & has been linked to allergies. Which variants do you have?
438 | summary == <p><strong>The <em>MYC</em> gene encodes c-myc, which broadly regulates the immune response and has been linked to allergies. Which variants do you have? Find out here.</strong></p>
438 | overall_score_text == Your Allergy Score (based on MYC)
438 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/MYC-Allergies.jpg
438 | author_id == 1
438 | author_name == Jasmine Foster
438 | author_title == BSc, BEd
438 | author_order == 36
438 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
438 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
438 | reviewer == None
438 | medical_reviewer_id == 11
438 | medical_reviewer_name == Puya Yazdi
438 | medical_reviewer_title == MD
438 | publish_date == 2020
438 | publish_date == 10
438 | publish_date == 26
438 | avg_rating == 4.5
438 | tags_id == 860
438 | tags_name == Allergic Diseases
438 | tags_id == 97
438 | tags_name == Allergies
438 | tags_id == 95
438 | tags_name == Immune System
438 | tags_id == 881
438 | tags_name == MYC Gene
438 | tags_id == 442
438 | tags_name == T Cells
438 | tags_id == 232
438 | tags_name == Vitamin D
438 | permissions_favorite == False
438 | permissions_rate == False
438 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">MYC </span></em><span style="font-weight: 400;">encodes c-myc, a protein strongly associated with both immunity and cancer. Variants of </span><em><span style="font-weight: 400;">MYC</span></em><span style="font-weight: 400;"> may play a role in allergies by altering the activity level of </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;">. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by reducing c-myc activity.</span></p> <h2><strong><em>MYC </em></strong><strong>and Allergies</strong></h2> <p><em><span style="font-weight: 400;">MYC </span></em><span style="font-weight: 400;">encodes c-myc, a proto-oncogene; that is, a gene that is often mutated in many types of cancers. </span><em><span style="font-weight: 400;">MYC </span></em><span style="font-weight: 400;">is an extremely important transcriptional regulator which is believed to have an effect on the expression of 15% of all other genes [</span><a href="https://www.ncbi.nlm.nih.gov/gene/4609"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17928593/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to some researchers, c-myc (in its healthy, unmutated form) is a &ldquo;global regulator&rdquo; of the immune response. That means that c-myc has a very broad effect on many, if not all parts of the immune system [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934797/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">C-myc is heavily involved in the activation of T cells and innate lymphoid cells, two types of white blood cells. Innate lymphoid cells are part of the earliest immune response to many triggers, including allergens [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922420/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31833571/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://science.sciencemag.org/content/348/6237/aaa6566"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some researchers have proposed that innate lymphoid cell activity could be targeted and blocked in future allergy treatments. However, no such treatments currently exist [</span><a href="https://science.sciencemag.org/content/348/6237/aaa6566"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Three variants in the </span><em><span style="font-weight: 400;">MYC</span></em><span style="font-weight: 400;"> gene have been associated with allergic diseases, and the same variants have a less pronounced link to </span><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">multiple sclerosis</span></a><span style="font-weight: 400;">. The association with both allergy and multiple sclerosis, an autoimmune disorder, suggests that </span><em><span style="font-weight: 400;">MYC</span></em><span style="font-weight: 400;"> variants can lead to increased pathological inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922420/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">MYC</span></em><span style="font-weight: 400;"> gene encodes c-myc, which broadly regulates the immune response. Variants in this gene may promote allergies by increasing the activity of some types of white blood cells.</span></span></p> <h2><strong>Your </strong><strong><em>MYC</em></strong><strong> Results for Allergies</strong></h2> <p>*9312118765815873*</p> <p><strong>MYC </strong><a href="https://selfdecode.com/snp/rs6990534/"><strong>rs6990534</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922420/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively increased allergic inflammation</span></li> </ul> <p><strong>MYC </strong><a href="https://selfdecode.com/snp/rs4410871/"><strong>rs4410871</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922420/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively increased allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Possibly protective against allergic inflammation</span></li> </ul> <p><strong>MYC </strong><a href="https://selfdecode.com/snp/rs11783015/"><strong>rs11783015</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922420/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively increased allergic inflammation</span></li> </ul> <p>*6441586742403238*</p> <h2><strong>Recommendations for Preventing Allergies</strong></h2> <p>*8989011538019103*</p> <h3><strong>Sunlight &amp; Vitamin D</strong></h3> <p><a href="https://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">Vitamin D</span></a><span style="font-weight: 400;"> appears to reduce c-myc activity. Once activated, the vitamin D receptor </span><a href="https://selfdecode.com/blog/article/vdr-longevity-85"><span style="font-weight: 400;">VDR</span></a><span style="font-weight: 400;"> can bind to a region of DNA that lowers the expression of the </span><em><span style="font-weight: 400;">MYC </span></em><span style="font-weight: 400;">gene. </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">Sunlight</span></a><span style="font-weight: 400;"> and vitamin D have been studied for their potential to suppress some types of cancer for that reason, but this action may also benefit people with allergies [</span><a href="https://www.hindawi.com/journals/apm/2011/281863/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Vitamin D deficiency has been associated with asthma and allergies in children [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675563/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17919705/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In people with allergic rhinitis and </span><a href="https://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> deficiency, supplementation improved the symptoms. This improvement was not significant at 4 weeks, suggesting that symptom improvement might not occur until vitamin D has been adequately replenished [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31332549/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Healthy exposure to </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sunlight</span></a><span style="font-weight: 400;"> is the best way of increasing your blood vitamin D levels. </span><span style="font-weight: 400;">In addition, you can eat food sources of vitamin D (such as fatty fish, liver, egg yolks, and dairy) or take supplements [</span><a href="https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Vitamin D can reduce </span><em><span style="font-weight: 400;">MYC</span></em><span style="font-weight: 400;"> gene expression; meanwhile, vitamin D deficiency is common in people with allergies and asthma.</span></span></p> <h3><strong>Apples</strong></h3> <p><span style="font-weight: 400;">The active polyphenols found in some types of apples have been found to reduce c-myc activity [</span><a href="https://www.nature.com/articles/s41598-019-49631-x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In 2 small clinical trials of people with allergic rhinitis, taking </span><a href="https://selfhacked.com/blog/apple-polyphenols/"><span style="font-weight: 400;">apple polyphenols</span></a><span style="font-weight: 400;"> reduced sneezing attacks, nose discharge, and turbinate swelling, especially in those taking the highest dose. Apple polyphenols may work by reducing </span><a href="http://selfhacked.com/blog/histamine/"><span style="font-weight: 400;">histamine</span></a><span style="font-weight: 400;"> release&nbsp; [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17039666/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15849424/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Participants saw some improvement from as little as 50 mg of polyphenols, which you could reasonably get from eating one apple per day. However, the polyphenols were more effective at significantly higher doses [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789330"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Importantly, people who are allergic to birch pollen may react to apples because these fruits contain proteins similar to those found in birch pollen (this is called cross-reactivity). In a small clinical trial, gradually increasing apple consumption induced birch pollen tolerance. However, the effect disappeared when the participants stopped eating apples [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11167370/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22070352/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Apple polyphenols may reduce c-myc activity and have been found to reduce the symptoms of seasonal allergies.</span></p> <h3><strong>Black Seed</strong></h3> <p><span style="font-weight: 400;">Thymoquinone, an active compound found in </span><a href="http://selfhacked.com/blog/top-28-scientific-benefits-of-the-panacea-black-cumin-seed-nigella-sativa/"><span style="font-weight: 400;">black seed</span></a><span style="font-weight: 400;"> oil, reduced c-myc activity in mice [</span><a href="https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-12-41"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In 2 clinical trials on people with different allergic diseases (allergic rhinitis, asthma, and eczema) oral supplementation with </span><a href="https://selfhacked.com/blog/black-cumin-seed-nigella-sativa-top-scientific-benefits/"><span style="font-weight: 400;">black seed</span></a><span style="font-weight: 400;"> improved the symptoms and subjective well-being. Black seed also enhanced the effectiveness of immunotherapy for dust mite allergy in another study [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20947211/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14669258/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20357504/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Both the oil and extract of black seed reduced the frequency of asthma attacks, relieved wheezing, improved lung function, and reduced the need for inhaled medications when taken for 2-3 months [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17868210/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28093815/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Thymoquinone from black seed reduced c-myc activity in mice. Black seed supplementation has also reduced allergy symptoms and improved immunotherapy effectiveness in clinical studies.</span></p>
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438 | content_learn_more_6441586742403238_text == Based on the variants we looked at, your MYC gene is somewhat associated with allergic inflammation. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Sunlight exposure, apples, and black seed oil may help. Keep scrolling to find out more.
438 | content_recommendation_8989011538019103_key == 8989011538019103
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438 | content_recommendation_8989011538019103_hidden == False
rsIDs = rs4410871,rs11783015,rs6990534
rsStatus = rs4410871,PVT1,chr8,127802783,T,A,C,,23,0,Normal
rsStatus = rs11783015,,chr8,128682763,T,C,,,7,7,HET
rsStatus = rs6990534,PVT1,chr8,127801845,A,G,,,34,0,Normal
