441 | id == 441
441 | category_id == 25
441 | category_order == 22
441 | category_name == Blood Sugar
441 | category_color == #C47AC0
441 | slug == jazf1-blood-sugar
441 | title == How Does This Zinc Finger Gene Affect Blood Sugar? (JAZF1)
441 | meta_description == Variants of JAZF1 are associated with blood sugar control problems. Click here for some diet and gene-based tips!
441 | summary == <p style="text-align:justify"><strong>JAZF1 plays a number of roles, including reducing inflammation and increasing glucose transporter expression. Some variants that produce less JAZF1 may have problems with blood sugar. Read on to learn more!</strong></p>
441 | overall_score_text == Your Blood Sugar Score (based on JAZF1)
441 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/JAZF1-Blood-Sugar-Diabetes.jpg
441 | author_id == 15
441 | author_name == John Williams
441 | author_title == B.Sc
441 | author_order == 3987
441 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/sinan_pic.png
441 | author_intro == <p>John received his BSc from the University of Toronto.&nbsp;John has spent the last several years teaching high school science and math to English-language learners, which has forced him to learn how to simplify difficult concepts as much as possible. He has also worked in two different research labs and has experience as a student intern working and studying under doctors in hospitals and clinics to help diagnose and treat patients, interpret lab results and fill out mountains of paperwork.</p>
441 | reviewer == None
441 | medical_reviewer_id == 11
441 | medical_reviewer_name == Puya Yazdi
441 | medical_reviewer_title == MD
441 | publish_date == 2020
441 | publish_date == 10
441 | publish_date == 28
441 | avg_rating == 5.0
441 | tags_id == 127
441 | tags_name == Diabetes Type 2
441 | tags_id == 829
441 | tags_name == Glucose
441 | tags_id == 886
441 | tags_name == GLUT
441 | tags_id == 116
441 | tags_name == Insulin Resistance
441 | tags_id == 414
441 | tags_name == Zinc Fingers
441 | permissions_favorite == False
441 | permissions_rate == False
441 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">JAZF1</span></em><span style="font-weight: 400;"> encodes a protein that reduces inflammation and increases the number of glucose transporter proteins on your cells. Variants of </span><em><span style="font-weight: 400;">JAZF1</span></em><span style="font-weight: 400;"> may play a role in blood sugar by producing less </span><em><span style="font-weight: 400;">JAZF1</span></em><span style="font-weight: 400;"> protein, leading to fewer transporters available to bring glucose from the blood into your cells. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by increasing the number of GLUT proteins, thereby reducing blood sugar.</span></span></p> <h2 style="text-align: justify;"><strong><em>JAZF1</em> and Blood Sugar</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">JAZF1 stands for 'Juxtaposed with another zinc finger gene 1', a protein that controls blood sugar through a number of pathways [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30838734/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">First, JAZF1 activates visfatin, a protein that increases insulin sensitivity. JAZF1 also reduces inflammation. This is important because, in obese individuals, inflammation is associated with insulin resistance, where your cells don't respond properly to insulin [</span><a href="https://www.metabolismjournal.com/article/S0026-0495(14)00146-2/abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30838734/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Finally, during insulin resistance, the number of glucose transporter proteins, called GLUTs, </span><span style="font-weight: 400;">decreases. This prevents glucose from leaving your blood, thereby keeping your blood sugar high. JAZF1 has been associated with increased levels of several of these glucose transporter proteins, including GLUT1, GLUT2 and GLUT4 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28636761/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30838734/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your <em>JAZF1</em> Results for Blood Sugar</strong></h2> <p style="text-align: justify;"><strong>*7794677892820949*</strong></p> <p style="text-align: justify;"><strong>Primary SNP: </strong><strong><em>JAZF1</em></strong> <a href="https://selfdecode.com/snp/rs1635852/"><strong>rs1635852</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with increased risk of Type 2 Diabetes</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = not associated with Type 2 Diabetes risk</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">&lsquo;T&rsquo; variants have an increased risk of Type 2 Diabetes and produce less </span><em><span style="font-weight: 400;">JAZF1</span></em><span style="font-weight: 400;"> messenger RNA, which leads to reduced </span><em><span style="font-weight: 400;">JAZF1</span></em><span style="font-weight: 400;"> activity [</span><a href="https://www.nature.com/articles/ng.2897"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23328127/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><strong>Other Important SNPs: </strong><strong><em>JAZF1 </em></strong><a href="https://selfdecode.com/snp/rs849142/"><strong>rs849142</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with increased risk of Type 2 Diabetes</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = no association with Type 2 Diabetes risk</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">The &lsquo;T&rsquo; variant is more common and is found in 76% of the population.</span></p> <p style="text-align: justify;"><strong>*5968800483408088*</strong></p> <h2 style="text-align: justify;"><strong>Recommendations for Improving Blood Sugar</strong></h2> <p style="text-align: justify;"><strong>*3909226541716031*</strong></p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Physical Exercise</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Insulin resistance is associated with decreased glucose transporter (GLUT) expression and JAZF1 can counteract this decrease. For JAZF1 variants that don't express enough glucose transporters, </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">physical exercise</span></a><span style="font-weight: 400;"> has been found to increase levels of both GLUT2 and GLUT4 in addition to helping with weight loss and overall levels of inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30838734/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10683091/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28636761/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18029442/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">For maximum benefit, you should perform physical exercise on a regular basis.&nbsp;</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Physical exercise can help reduce your blood sugar.</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Reduce Refined Carbohydrates</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">High concentrations of </span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">glucose</span></a><span style="font-weight: 400;"> have been found to reduce JAZF1 expression in cells of the liver and pancreas [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23442068/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">As a result, there are fewer glucose transporters available to remove glucose from the blood and your blood sugar therefore remains high [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28636761/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Besides reducing intake of sweet food, other sources of refined carbohydrates that need to be reduced include pasta, rice and white bread. These foods all have a high glycemic index, meaning they raise your blood sugar a lot and can lead to Type 2 Diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627334/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cutting down on refined carbohydrates, such as sugar, pasta, rice and white bread, is associated with lower blood sugar.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Vitamin D</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">Vitamin D</span></a><span style="font-weight: 400;"> both increases levels of GLUT4 transporters and decreases inflammation in fat cells. </span><span style="font-weight: 400;">GLUT4 is the main glucose transporter found in muscle and fat cells and increasing its activity </span><span style="font-weight: 400;">will cause glucose to be removed from the blood. This can help compensate for the decreased GLUT activity in certain </span><em><span style="font-weight: 400;">JAZF1</span></em><span style="font-weight: 400;"> variants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516775/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462924/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Vitamin D has been associated with improved insulin resistance in general and decrease diabetes risk [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23350644/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30583032/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Supplementing with Vitamin D may help with blood sugar control and insulin resistance.</span></p>
441 | content_snp_table_7794677892820949_key == 7794677892820949
441 | content_snp_table_7794677892820949_blur == True
441 | content_snp_table_7794677892820949_hidden == False
441 | content_learn_more_5968800483408088_key == 5968800483408088
441 | content_learn_more_5968800483408088_blur == True
441 | content_learn_more_5968800483408088_hidden == False
441 | content_learn_more_5968800483408088_text == Based on the variants we looked at, your JAZF1 gene makes you somewhat more likely to develop blood sugar control problems. However, this doesn't necessarily reflect your overall risk; it’s just one gene related to it. Exercise, reducing refined carbohydrates, and Vitamin D may help. Keep scrolling to find out more.
441 | content_recommendation_3909226541716031_key == 3909226541716031
441 | content_recommendation_3909226541716031_blur == True
441 | content_recommendation_3909226541716031_hidden == False
rsIDs = rs1635852,rs849142
rsStatus = rs1635852,JAZF1,chr7,28149792,T,A,C,,33,0,Normal
rsStatus = rs849142,JAZF1,chr7,28146272,T,A,C,,30,0,Normal
