442 | id == 442
442 | category_id == 26
442 | category_order == 23
442 | category_name == Allergies
442 | category_color == #C47AC0
442 | slug == SERPINB7-Th2-allergies
442 | title == Can This Gene Worsen Allergic Reactions? (SERPINB7)
442 | meta_description == The SERPINB7 gene stimulates Th2 immunity. Click to learn about its link with allergies and get tailored tips.
442 | summary == <p style="text-align:justify"><strong>One variant in the SERPINB7 gene may contribute to allergic reactions by stimulating Th2 immunity. Are you among 4% of the world population carrying this variant? Read this post to find out and get gene-based tips!</strong></p>
442 | overall_score_text == Your Allergies Score (based on SERPINB7 gene)
442 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/SERPINB7-Allergies.jpg
442 | author_id == 9
442 | author_name == Aleksa Ristic
442 | author_title == MS (Pharmacy)
442 | author_order == 45
442 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
442 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
442 | reviewer == None
442 | medical_reviewer_id == 11
442 | medical_reviewer_name == Puya Yazdi
442 | medical_reviewer_title == MD
442 | publish_date == 2020
442 | publish_date == 10
442 | publish_date == 28
442 | avg_rating == 5.0
442 | tags_id == 98
442 | tags_name == Asthma
442 | tags_id == 855
442 | tags_name == Food Allergy
442 | tags_id == 864
442 | tags_name == IL-4
442 | tags_id == 887
442 | tags_name == SERPINB7
442 | tags_id == 853
442 | tags_name == Th2 dominance
442 | permissions_favorite == False
442 | permissions_rate == False
442 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The </strong><strong><em>SERPINB7</em></strong><strong> gene enables the production of IL-4 and IL-13, two inflammatory proteins involved in Th2 immunity and allergic reactions.<br /><br /></strong><strong>One gene variant may increase SERPINB7 activity and correlate with higher odds of food allergies and asthma.<br /><br /></strong><strong>This post reveals simple ways to potentially prevent allergies by targeting the SERPINB7 gene.</strong></span></p> <p>&nbsp;</p> <h2><strong>The SERPINB7 Gene in Allergic Reactions</strong></h2> <p><span style="font-weight: 400;">Among its diverse roles, the </span><a href="https://selfdecode.com/gene/SERPINB7/"><em><span style="font-weight: 400;">SERPINB7</span></em></a><span style="font-weight: 400;"> gene controls the activity of cells and proteins involved in inflammatory and allergic reactions. More precisely, it can increase the levels of IL-4 and IL-13, two inflammatory proteins that stimulate Th2 immunity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23325331/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648765/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21215659/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Given that allergies tend to be </span><a href="http://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">Th2</span></a><a href="https://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">-dominant</span></a><span style="font-weight: 400;"> states, it&rsquo;s no wonder that </span><em><span style="font-weight: 400;">SERPINB7</span></em><span style="font-weight: 400;"> gene variants correlate with their development. This gene is particularly active in the upper digestive tract and has a robust association with food allergies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15962113/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15962113/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21215659/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21215659/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The SERPINB7 gene controls the production of IL-4 and IL-13, two inflammatory proteins involved in Th2 immunity and allergic reactions.</span></p> <p>&nbsp;</p> <h2><strong>Your SERPINB7 Results for Allergies</strong></h2> <p>*1857198929345513*</p> <p><strong>Primary SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs12964116/"><strong>rs12964116</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648765/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(19)30055-4/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21215659/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with higher odds of food allergies and asthma</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - not associated with allergies</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele likely stimulates Th2 cell development, contributing to allergic inflammation</span></li> </ul> <p>*6510806820569885*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Prevent Allergies</strong></h2> <p>*1668066179138105*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Avoid Air Pollution</strong></h4> <p><span style="font-weight: 400;">Particulate matter and other air pollutants from urban environments may contribute to allergic reactions by stimulating Th2 cells and increasing IL-4 and IL-13 production in the airways [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906287/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650824/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Research has associated exposure to air pollution with higher odds of allergic conditions, especially asthma and allergic rhinitis. Thus, spending more time in nature and non-industrialized environments may help prevent allergies. [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192198/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034084/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803404/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Avoid air pollution and spend more time in nature to lessen your variant&rsquo;s impact on allergies.</span></p> <h3><strong>Diet</strong></h3> <h4><strong>Mediterranean Diet</strong></h4> <p><span style="font-weight: 400;">The Mediterranean diet may reduce IL-4 levels in asthmatic children. This diet is rich in </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">, which may also suppress IL-4 and thus lower Th2 activity&nbsp; [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29980401/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18178046/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis associated adherence to the Mediterranean diet with a slightly reduced incidence of asthma and wheezing [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23578354/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet rich in olive oil may prevent allergies, especially asthma, by targeting your SERPINB7 variant.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Butterbur</strong></h4> <p><a href="https://selfhacked.com/blog/butterbur-benefits/"><span style="font-weight: 400;">Butterbur</span></a><span style="font-weight: 400;"> can inhibit allergen-induced Th2 immunity and IL-4 release, reducing airway inflammation and sensitivity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19827027/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A standardized butterbur extract (ZE 339) was safe and effective at improving allergic rhinitis, both seasonal and chronic, in multiple clinical trials. A different extract (Petaforce) was similarly effective in people with pollen allergy [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15080820/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15611396/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16751170/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64514/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12859442/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Butterbur extract also improved asthma symptoms when added to standard treatment in two clinical trials [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15005644/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14720270/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Butterbur extract may counteract your gene variant and help relieve allergies.</span></p>
442 | content_snp_table_1857198929345513_key == 1857198929345513
442 | content_snp_table_1857198929345513_blur == True
442 | content_snp_table_1857198929345513_hidden == False
442 | content_learn_more_6510806820569885_key == 6510806820569885
442 | content_learn_more_6510806820569885_blur == True
442 | content_learn_more_6510806820569885_hidden == False
442 | content_learn_more_6510806820569885_text == Based on the variants we looked at, your SERPINB7 gene is associated with slightly higher odds of allergies. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Avoid air pollution, practice the Mediterranean diet, and follow other gene-based tips to relieve allergies. Keep reading to learn more.
442 | content_recommendation_1668066179138105_key == 1668066179138105
442 | content_recommendation_1668066179138105_blur == True
442 | content_recommendation_1668066179138105_hidden == False
rsIDs = rs12964116
rsStatus = rs12964116,SERPINB7,chr18,63775385,A,G,,,39,0,Normal
