443 | id == 443
443 | category_id == 26
443 | category_order == 23
443 | category_name == Allergies
443 | category_color == #C47AC0
443 | slug == ID2-allergies
443 | title == Can This Gene Prevent IgE From Triggering Allergies? (ID2)
443 | meta_description == The ID2 gene prevents B cells from triggering dangerous allergic reactions. Do you have the potentially detrimental alleles?
443 | summary == <p><strong>The <em>ID2 </em>gene prevents B cells from triggering dangerous allergic reactions. Do you have the potentially detrimental alleles? Find out here.</strong></p>
443 | overall_score_text == Your Allergy Score (based on ID2)
443 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ID2-Allergies.jpg
443 | author_id == 1
443 | author_name == Jasmine Foster
443 | author_title == BSc, BEd
443 | author_order == 36
443 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
443 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
443 | reviewer == None
443 | medical_reviewer_id == 11
443 | medical_reviewer_name == Puya Yazdi
443 | medical_reviewer_title == MD
443 | publish_date == 2020
443 | publish_date == 10
443 | publish_date == 28
443 | avg_rating == 4.5
443 | tags_id == 860
443 | tags_name == Allergic Diseases
443 | tags_id == 97
443 | tags_name == Allergies
443 | tags_id == 98
443 | tags_name == Asthma
443 | tags_id == 242
443 | tags_name == B cells
443 | tags_id == 99
443 | tags_name == Eczema
443 | tags_id == 848
443 | tags_name == Hay Fever
443 | tags_id == 888
443 | tags_name == ID2 Gene
443 | tags_id == 591
443 | tags_name == IgE Antibodies
443 | tags_id == 889
443 | tags_name == IL-21
443 | permissions_favorite == False
443 | permissions_rate == False
443 | content_article == <h2><strong>Summary</strong></h2> <p><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">ID2</span></em><span style="font-weight: 400;"> may play a role in allergies by allowing B cells to produce too much IgE antibody. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by increasing ID2 and blocking the class switching of B cells.</span></p> <h2><strong><em>ID2</em></strong><strong> and Allergies</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/id2/" target="_blank" rel="noopener"><em><span style="font-weight: 400;">ID2</span></em></a><span style="font-weight: 400;"> gene encodes a protein called inhibitor of DNA binding 2, which helps regulate the expression of other genes involved in cell development [</span><a href="https://www.ncbi.nlm.nih.gov/gene/3398"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The ID2 protein appears to have a central role in how immune cells differentiate from their early forms into more active cells. More specifically, ID2 coordinates the production of specialized T cells and prevents B cells from triggering dangerous inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12483209/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27213691/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In animals without ID2, B cells undergo &ldquo;class switching&rdquo; and start producing dangerous amounts of <a href="https://selfhacked.com/blog/immunoglobulin-e-ige-antibody-test/" target="_blank" rel="noopener">IgE</a>, an antibody that triggers allergic reactions. Thus, any variant that produces a less functional version of the ID2 protein or that decreases </span><em><span style="font-weight: 400;">ID2</span></em><span style="font-weight: 400;"> expression may lead to increased IgE production and a predisposition to allergic reactions [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12483209/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Said another way, ID2 promotes the </span><a href="http://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1</span></a><span style="font-weight: 400;"> response and moves the immune system away from the allergy-associated </span><a href="https://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">Th2</span></a><span style="font-weight: 400;"> response [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27213691/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">ID2</span></em><span style="font-weight: 400;"> encodes a protein that pushes the immune system toward the Th1 response and away from Th2. Variants that reduce ID2 activity may increase the production of IgE antibodies, leading to allergic inflammation.</span></span></p> <h2><strong>Your </strong><strong><em>ID2</em></strong><strong> Results for Allergies</strong></h2> <p>*9893022639938036*</p> <p><strong>ID2 </strong><a href="https://selfdecode.com/snp/rs10174949/"><strong>rs10174949</strong></a> [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a>]:</p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively increased allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Possibly protective against allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may increase ID2 activity, leading to reduced IgE production and possible protection against allergic inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12483209/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong>ID2 </strong><a href="https://selfdecode.com/snp/rs891058/"><strong>rs891058</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively increased allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may decrease ID2 activity, leading to increased IgE production and a possible increase in allergic inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12483209/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*5532789393821085*</p> <h2><strong>Recommendations for Preventing Allergies</strong></h2> <p>*9334536903880966*</p> <h3><strong>Ultraviolet Light Therapy</strong></h3> <p><span style="font-weight: 400;">Exposure to ultraviolet light increased ID2 activity in human cells in a laboratory setting [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16007217/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis of 13 studies concluded that light therapy (with </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">UV</span></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/blue-light-therapy-benefits/"><span style="font-weight: 400;">blue</span></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/red-light-therapy-benefits/"><span style="font-weight: 400;">red</span></a><span style="font-weight: 400;">, and </span><a href="http://selfhacked.com/blog/infrared-radiation-benefits/"><span style="font-weight: 400;">infrared radiation</span></a><span style="font-weight: 400;">) applied through the nose relieved allergic rhinitis symptoms and improved quality of life. However, the authors warned about the heterogeneity and low quality of the studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26163248/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">UV light increased ID2 activity in cells and improved allergic rhinitis symptoms in some studies.</span></p> <h3><strong>Forskolin</strong></h3> <p><span style="font-weight: 400;">Forskolin, an active compound produced by the coleus plant, increased </span><em><span style="font-weight: 400;">ID2</span></em><span style="font-weight: 400;"> gene expression in cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/14761970/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Oral </span><a href="https://selfhacked.com/blog/health-benefits-of-forskolin/"><span style="font-weight: 400;">forskolin</span></a><span style="font-weight: 400;"> was more effective than one asthma drug (sodium cromoglycate) and as effective as another (beclomethasone) at preventing asthma attacks in two clinical trials [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16749416/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20515580/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Injected colforsin daropate, a water-soluble forskolin derivative, prevented the tightening of the airways, suggesting its potential to prevent asthma attacks faster than oral forskolin [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11940752/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Forskolin increased </span><em><span style="font-weight: 400;">ID2</span></em><span style="font-weight: 400;"> gene expression in cells and was similarly effective compared to asthma medication in two clinical trials.</span></span></p> <h3><strong>Probiotics</strong></h3> <p><span style="font-weight: 400;">People with certain </span><em><span style="font-weight: 400;">ID2</span></em><span style="font-weight: 400;"> variants may have more difficulty regulating their gut microbiota than the average person. Broadly speaking, low ID2 activity has been linked to reduced defenses against gut infections, suggesting that the gut microbiota isn&rsquo;t healthy. Researchers attribute this difference in part to ID2 and its ability to regulate gut microbes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725053/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A healthier and more balanced gut flora may be supplemented with probiotics. </span><em><span style="font-weight: 400;">Lactobacillus</span></em><span style="font-weight: 400;"> species including </span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-acidophilus/"><em><span style="font-weight: 400;">L. acidophilus</span></em></a><em><span style="font-weight: 400;">, </span></em><a href="https://selfhacked.com/blog/health-benefits-l-plantarum/"><em><span style="font-weight: 400;">L. plantarum</span></em></a><span style="font-weight: 400;">, and </span><a href="https://selfhacked.com/blog/l-reuteri/"><em><span style="font-weight: 400;">L. reuteri</span></em></a><span style="font-weight: 400;"> have been reported to improve the immune response</span> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006993/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656559/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/a1probiotics-good-bacteria/"><span style="font-weight: 400;">Probiotics</span></a><span style="font-weight: 400;"> such as </span><a href="https://selfhacked.com/blog/l-paracasei/"><em><span style="font-weight: 400;">Lactobacillus paracasei</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-acidophilus/"><em><span style="font-weight: 400;">L. acidophilus</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/health-benefits-l-plantarum/"><em><span style="font-weight: 400;">L. plantarum</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-casei/"><em><span style="font-weight: 400;">L. casei</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-gasseri/"><em><span style="font-weight: 400;">L. gasseri</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/b-longum/"><em><span style="font-weight: 400;">Bifidobacterium longum</span></em></a><span style="font-weight: 400;">, and </span><a href="http://selfhacked.com/blog/b-animalis/"><em><span style="font-weight: 400;">B. animalis</span></em></a><span style="font-weight: 400;"> improved allergic rhinitis in multiple trials. Moreover, </span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-johnsonii/"><em><span style="font-weight: 400;">L. johnsonii</span></em></a><span style="font-weight: 400;">, and </span><a href="https://selfhacked.com/blog/c-butyricum/"><em><span style="font-weight: 400;">Clostridium butyricum</span></em></a><span style="font-weight: 400;"> enhanced the effectiveness of immunotherapy for allergy to pollen and dust mites [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27442711/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16101937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24569538/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16195581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15653517/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18072744/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18510694/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19734682/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17259812/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23299716/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27401319/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22513081/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In people with asthma, </span><a href="https://selfhacked.com/blog/l-salivarius/"><em><span style="font-weight: 400;">L.salivarius</span></em></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/b-breve/"><em><span style="font-weight: 400;">B. breve</span></em></a><span style="font-weight: 400;"> reduced the production of inflammatory cytokines while </span><a href="https://selfhacked.com/blog/c-butyricum/"><em><span style="font-weight: 400;">Clostridium butyricum</span></em></a><span style="font-weight: 400;"> helped improve the symptoms when combined with immunotherapy [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446640/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746628/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Preliminary research in adults and children with allergy to cow milk suggests that the immunomodulatory activity of </span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;"> may help prevent allergic responses. This </span><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">probiotic</span></a><span style="font-weight: 400;"> also enhanced the effectiveness of immunotherapy for peanut allergy [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10024217/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15241356/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25592987/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Other </span><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">probiotics</span></a><span style="font-weight: 400;"> may help by fermenting the food proteins that cause allergies. For instance, </span><a href="http://selfhacked.com/blog/l-helveticus/"><em><span style="font-weight: 400;">L. helveticus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-delbrueckii/"><em><span style="font-weight: 400;">L. delbrueckii</span></em></a><span style="font-weight: 400;">, and </span><a href="http://selfhacked.com/blog/l-fermentum/"><em><span style="font-weight: 400;">L. fermentum</span></em></a><span style="font-weight: 400;"> successfully reduced the allergenic potential of cow milk and </span><a href="https://www.selfhacked.com/blog/bee-propolis/"><span style="font-weight: 400;">propolis</span></a><span style="font-weight: 400;"> in several studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20583192/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370499/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23140691/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21385515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Certain types of </span><em><span style="font-weight: 400;">Lactobacillus</span></em><span style="font-weight: 400;"> probiotics may help improve the composition of the gut flora, leading to better immune health and reduced allergic symptoms.</span></span></p>
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443 | content_learn_more_5532789393821085_text == Based on the variants we looked at, your ID2 gene is somewhat associated with allergic inflammation. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Ultraviolet light, forskolin, and some probiotics may help. Keep scrolling to find out more.
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rsIDs = rs10174949,rs891058
rsStatus = rs10174949,LINC00299,chr2,8302118,G,A,T,,7,25,HET
rsStatus = rs891058,LINC00299,chr2,8302417,G,A,,,13,26,HET
