444 | id == 444
444 | category_id == 26
444 | category_order == 23
444 | category_name == Allergies
444 | category_color == #C47AC0
444 | slug == NFATC2-allergies
444 | title == Th2 Dysregulation & Allergies (NFATC2)
444 | meta_description == NFATC2 is involved in immune response regulation. A variant of NFATC2 has been associated with allergies. Read more here.
444 | summary == <p style="text-align:justify"><strong>NFATC2 is a protein involved in type 2 immune response (Th2) regulation. Read more to learn about the association between an <em>NFATC2</em> variant and allergies.</strong><br />  &nbsp;</p>
444 | overall_score_text == Your Allergy Score (based on NFATC2 gene)
444 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/NFATC2-Allergies.jpg
444 | author_id == 14
444 | author_name == Shany Lahan
444 | author_title == MS (Neuroscience)
444 | author_order == 5
444 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
444 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
444 | reviewer == None
444 | medical_reviewer_id == 11
444 | medical_reviewer_name == Puya Yazdi
444 | medical_reviewer_title == MD
444 | publish_date == 2020
444 | publish_date == 10
444 | publish_date == 29
444 | avg_rating == 4.5
444 | tags_id == 878
444 | tags_name == Airway
444 | tags_id == 860
444 | tags_name == Allergic Diseases
444 | tags_id == 98
444 | tags_name == Asthma
444 | tags_id == 591
444 | tags_name == IgE Antibodies
444 | tags_id == 367
444 | tags_name == IL-13
444 | tags_id == 864
444 | tags_name == IL-4
444 | tags_id == 890
444 | tags_name == NFATC2 Gene
444 | tags_id == 891
444 | tags_name == Th2
444 | permissions_favorite == False
444 | permissions_rate == False
444 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">NFATC2 is a protein that can regulate the production of type 2 immune response (Th2) proteins. A variant of </span><em><span style="font-weight: 400;">NFATC2 </span></em><span style="font-weight: 400;">may play a role in allergic diseases by altering production of NFATC2 and increasing levels of Th2 proteins. Lifestyle and supplement modifications may counteract the effects of this variant by decreasing Th2 protein levels.</span></span></p> <h2 style="text-align: justify;"><strong><em>NFATC2</em></strong><strong> and Allergies</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">NFATC2 is a protein involved in regulating the production of other proteins, including </span><a href="https://selfdecode.com/blog/article/il4-allergies-426/"><span style="font-weight: 400;">IL-4</span></a><span style="font-weight: 400;"> and </span><a href="https://selfdecode.com/blog/article/il13-allergies-435/"><span style="font-weight: 400;">IL-13</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11163226/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9846484/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">IL-4 and IL-13 are released by </span><a href="https://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">type 2 immune response</span></a><span style="font-weight: 400;"> (Th2) cells. Many scientists consider elevated Th2 activity to underlie a number of allergic diseases [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Indeed, the production of IL-4 and IL-13 has been shown to enhance the responsiveness of the airway to allergens (allergy-inducing substances). These immune system proteins have also been linked to elevated release of a type of antibody called IgE -- an early step in allergic reaction progression [</span><a href="https://www.jacionline.org/article/S0091-6749(97)70293-8/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532591/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9846484/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Interestingly, both increased and decreased production of NFATC2 has been linked to dysregulated Th2 activity and consequent susceptibility to allergic diseases, such as asthma. It&rsquo;s therefore likely that NFATC2 needs to be produced in optimal amounts in order to properly regulate immune responses [</span><a href="https://pubmed.ncbi.nlm.nih.gov/33079489/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19414766/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><a href="https://selfdecode.com/gene/nfatc2/"><em><span style="font-weight: 400;">NFATC2</span></em></a> <span style="font-weight: 400;">have been associated with allergic diseases. These variants may increase or decrease NFATC2 production, which may result in dysregulated Th2 activity, enhanced airway responsiveness to allergens, and increased production of IgE antibodies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753407/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22317750/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>NFATC2</em></strong><strong> Results for Allergies</strong></h2> <p style="text-align: justify;">*4568472929224243*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>NFATC2 </em></strong><a href="https://selfdecode.com/snp/rs6021270/"><strong>rs6021270</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of allergies, relative to &lsquo;C&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Decreased risk of allergies, relative to &lsquo;T&rsquo;</span></li> </ul> <p style="text-align: justify;">*2839784976297481*</p> <h2 style="text-align: left;"><strong>Recommendations for Improving Allergies</strong></h2> <p style="text-align: justify;">*4386292297096066*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Allergy Immunotherapy</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Allergy immunotherapy consists of administering a weakened allergen (such as pollen, dust mites, or dog dander) to help develop tolerance or desensitization to said allergen. This treatment can be oral (under-the-tongue allergy tablets) or injected (allergy shots) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27401313/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30095391/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26774974/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25732009/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10963287/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/bee-sting-therapy-101/"><span style="font-weight: 400;">Bee sting therapy</span></a><span style="font-weight: 400;"> is recommended as the first-line treatment for the prevention of severe allergic reactions in people allergic to the venom of bees and other insects of the same order (</span><em><span style="font-weight: 400;">Hymenoptera</span></em><span style="font-weight: 400;">). This may be due to the ability of bee sting therapy to lower Th2 activity, including lowering IL-4 production [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420609/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8564721/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12704369/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Multiple trials attest to the effectiveness and safety of bee sting therapy. Unfortunately, the venom must be repeatedly administered at 3-month intervals to maintain its effects on the immune system [</span><a href="https://pubmed.ncbi.nlm.nih.gov/375434/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/4008075/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420609/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21447964/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17941283/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1545581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10669863/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27012015/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10505462/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a study of children with cow milk allergy, oral immunotherapy was found to desensitize approximately 70% of the allergic children. Desensitization was linked to decreases in IL-13 release, as well as decreases in IgE antibody levels. Moreover, oral immunotherapy eliminated any immune response differences originally observed between children with cow milk allergy and non-allergic children [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27826960/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Allergy immunotherapy may improve allergies by lowering Th2 activity via decreased IL-4 and IL-13 production, and by lowering IgE antibody levels.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Mediterranean Diet</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">A meta-analysis linked adherence to the Mediterranean diet with a slightly reduced incidence of wheezing and asthma [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23578354/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In one study, Mediterranean diet adherence was found to lower levels of allergy-associated immune system proteins, such as IL-4, in children with asthma [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29980401/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The Mediterranean diet states that </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;"> should be the main source of added fat in the diet. In a cell-based study, olive oil was reported to decrease production of IL-4 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18178046/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Adherence to the Mediterranean diet may improve allergies by lowering production of the Th2-related protein IL-4.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Probiotics</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/a1probiotics-good-bacteria/"><span style="font-weight: 400;">Probiotics</span></a><span style="font-weight: 400;"> are live strains of beneficial bacteria that may improve allergies by reducing Th2 activity, including the production of IL-4 and IL-13 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30426014/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Indeed, probiotics such as </span><a href="https://selfhacked.com/blog/l-paracasei/"><em><span style="font-weight: 400;">Lactobacillus (L.) paracasei</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-acidophilus/"><em><span style="font-weight: 400;">L. acidophilus</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/health-benefits-l-plantarum/"><em><span style="font-weight: 400;">L. plantarum</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-casei/"><em><span style="font-weight: 400;">L. casei</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-gasseri/"><em><span style="font-weight: 400;">L. gasseri</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/b-longum/"><em><span style="font-weight: 400;">Bifidobacterium (B.) longum</span></em></a><span style="font-weight: 400;">, and </span><a href="http://selfhacked.com/blog/b-animalis/"><em><span style="font-weight: 400;">B. animalis</span></em></a><span style="font-weight: 400;"> were found to improve hay fever in multiple trials. Moreover, </span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-johnsonii/"><em><span style="font-weight: 400;">L. johnsonii</span></em></a><span style="font-weight: 400;">, and </span><a href="https://selfhacked.com/blog/c-butyricum/"><em><span style="font-weight: 400;">Clostridium (C.) butyricum</span></em></a><span style="font-weight: 400;"> enhanced the effectiveness of immunotherapy for pollen and dust mite allergies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27442711/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16101937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24569538/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16195581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15653517/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18072744/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18510694/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19734682/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17259812/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23299716/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27401319/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22513081/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a randomized controlled trial focused on children with asthma and hay fever, 8-week daily supplementation of </span><em><span style="font-weight: 400;">L. gasseri</span></em><span style="font-weight: 400;"> significantly lowered levels of IL-13 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20658483/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In people with asthma, </span><a href="https://selfhacked.com/blog/l-salivarius/"><em><span style="font-weight: 400;">L. salivarius</span></em></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/b-breve/"><em><span style="font-weight: 400;">B. breve</span></em></a><span style="font-weight: 400;"> reduced the production of inflammatory proteins, while </span><em><span style="font-weight: 400;">C. butyricum</span></em><span style="font-weight: 400;"> combined with immunotherapy helped improve asthma symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446640/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746628/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Preliminary research in adults and children with an allergy to cow milk suggests that the potential for </span><em><span style="font-weight: 400;">L. rhamnosus</span></em><span style="font-weight: 400;"> to modulate immune system activity may help prevent allergic reactions. This probiotic also enhanced the effectiveness of immunotherapy for peanut allergy [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10024217/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15241356/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25592987/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Other probiotics may help by fermenting the food proteins that cause allergies. For instance, </span><a href="http://selfhacked.com/blog/l-helveticus/"><em><span style="font-weight: 400;">L. helveticus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-delbrueckii/"><em><span style="font-weight: 400;">L. delbrueckii</span></em></a><span style="font-weight: 400;">, and </span><a href="http://selfhacked.com/blog/l-fermentum/"><em><span style="font-weight: 400;">L. fermentum</span></em></a><span style="font-weight: 400;"> successfully reduced the allergenic potential of cow milk and </span><a href="https://www.selfhacked.com/blog/bee-propolis/"><span style="font-weight: 400;">propolis</span></a><span style="font-weight: 400;"> in several studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20583192/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370499/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23140691/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21385515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Probiotics may improve allergies by reducing Th2 activity, including the production of IL-4 and IL-13.&nbsp;</span></p>
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444 | content_learn_more_2839784976297481_text == Based on the variants we looked at, your NFATC2 gene makes you somewhat more likely to develop allergic diseases. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Allergy immunotherapy, the Mediterranean diet, and probiotic supplements may help. Keep scrolling to find out more.
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rsIDs = rs6021270
rsStatus = rs6021270,NFATC2,chr20,51524725,T,C,,,30,0,Normal
