445 | id == 445
445 | category_id == 26
445 | category_order == 23
445 | category_name == Allergies
445 | category_color == #C47AC0
445 | slug == SH2B3-allergies
445 | title == Can This Autoimmunity Gene Cause Asthma? (SH2B3)
445 | meta_description == SH2B3 encodes an adapter protein that regulates the function of T cells. How can this gene affect asthma and allergies?
445 | summary == <p><strong><em>SH2B3 </em>encodes an adapter protein that regulates the function of T cells. How can this gene affect asthma and allergies? Find out here.</strong></p>
445 | overall_score_text == Your Asthma Score (based on SH2B3)
445 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/SH2B3-Allergies-Asthma.jpg
445 | author_id == 1
445 | author_name == Jasmine Foster
445 | author_title == BSc, BEd
445 | author_order == 36
445 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
445 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
445 | reviewer == None
445 | medical_reviewer_id == 11
445 | medical_reviewer_name == Puya Yazdi
445 | medical_reviewer_title == MD
445 | publish_date == 2020
445 | publish_date == 10
445 | publish_date == 29
445 | avg_rating == 5.0
445 | tags_id == 860
445 | tags_name == Allergic Diseases
445 | tags_id == 97
445 | tags_name == Allergies
445 | tags_id == 98
445 | tags_name == Asthma
445 | tags_id == 892
445 | tags_name == Eosinophils
445 | tags_id == 350
445 | tags_name == Respiratory Health
445 | tags_id == 211
445 | tags_name == SH2B3 Gene
445 | tags_id == 442
445 | tags_name == T Cells
445 | tags_id == 435
445 | tags_name == Th1 Cells
445 | tags_id == 891
445 | tags_name == Th2
445 | permissions_favorite == False
445 | permissions_rate == False
445 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">SH2B3</span></em><span style="font-weight: 400;"> encodes an adapter protein that regulates the function of T cells. Variants of </span><em><span style="font-weight: 400;">SH2B3</span></em><span style="font-weight: 400;"> may play a role in allergies by altering the Th1/Th2 balance and increasing eosinophil counts. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by reducing eosinophil counts and decreasing the Th2 immune response.</span></p> <h2><strong><em>SH2B3</em></strong><strong> and Asthma</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/sh2b3/"><em><span style="font-weight: 400;">SH2B3</span></em></a> <span style="font-weight: 400;">gene codes for SH2B adapter protein 3. This protein helps regulate an array of essential pathways, including [</span><a href="https://ghr.nlm.nih.gov/gene/SH2B3"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Inflammation and the immune response</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Blood cell formation (hematopoiesis)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Cell growth and migration</span></li> </ul> <p><span style="font-weight: 400;">Due to its wide range of functions, SH2B3 has considerable significance for human health. Studies have linked its variants with different autoimmune conditions, heart disease, blood disorders, and more [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21723852"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ahajournals.org/lookup/doi/10.1161/HYPERTENSIONAHA.115.04887"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">SH2B3 primarily regulates the function of T cells and has been associated with relative numbers of eosinophils (a type of </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cell</span></a><span style="font-weight: 400;">). It may suppress </span><a href="http://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1</span></a><span style="font-weight: 400;"> cell response and prevent autoimmunity by inhibiting the formation of auto-antibodies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298800/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151648/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26535636"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some evidence suggests this gene may also be involved in fine-tuning the inflammatory response. For example, a rare human case of a genetic </span><em><span style="font-weight: 400;">SH2B3 </span></em><span style="font-weight: 400;">loss resulted in severe autoimmune disease, along with other developmental issues. In mice without this protein, scientists have observed over-production of inflammatory cytokines [</span><a href="https://www.jimmunol.org/content/193/4/1728.long"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790510/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ahajournals.org/lookup/doi/10.1161/HYPERTENSIONAHA.115.04887"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, when the Th1 response is suppressed, the </span><a href="http://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">Th2</span></a><span style="font-weight: 400;"> response may increase to compensate. The Th2 response is responsible for allergic inflammation, so this change may increase susceptibility to allergies. This is an example of why it&rsquo;s so important to keep </span><a href="https://selfhacked.com/blog/supplements-foods-exercise-right-type-th1-vs-th2-dominance/"><span style="font-weight: 400;">Th1 and Th2</span></a><span style="font-weight: 400;"> in balance [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25024389/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://archive.foundationalmedicinereview.com/publications/8/3/223.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">SH2B3</span></em><span style="font-weight: 400;"> gene appears to affect the Th1/Th2 immune system balance, and variants that tip the scale toward Th2 may increase susceptibility to allergic inflammation.</span></span></p> <h2><strong>Your </strong><strong><em>SH2B3</em></strong><strong> Results for Asthma</strong></h2> <p>*4605007397631468*</p> <p><a href="https://selfdecode.com/gene/sh2b3/"><strong>SH2B3</strong></a> <a href="https://selfdecode.com/snp/rs10774625/"><strong>rs10774625</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively increased incidence of asthma</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Possibly protective against asthma</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may tip the immune response toward Th2, leading to increased susceptibility to allergic inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25024389/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://archive.foundationalmedicinereview.com/publications/8/3/223.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/sh2b3/"><strong>SH2B3</strong></a> <a href="https://selfdecode.com/snp/rs653178/"><strong>rs653178</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively increased incidence of asthma</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Possibly protective against asthma</span></li> <li><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may tip the immune response toward Th2, leading to increased susceptibility to allergic inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25024389/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://archive.foundationalmedicinereview.com/publications/8/3/223.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*3635208225679356*</p> <h2><strong>Recommendations for Improving Asthma</strong></h2> <p>*3440999126604054*</p> <p><strong>Note</strong><span style="font-weight: 400;">: Very few studies have made any associations between lifestyle, diet, and supplement changes and the </span><em><span style="font-weight: 400;">SH2B3</span></em><span style="font-weight: 400;"> gene directly. This section will therefore focus on the downstream effects of this gene on Th2 immunity and eosinophils, a type of white blood cell heavily involved in the Th2 response [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298800/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151648/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26535636"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Acupuncture</strong></h3> <p><span style="font-weight: 400;">In one clinical study of asthma patients, acupuncture improved symptoms and reduced eosinophil numbers in the blood [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11152056/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In mice, acupuncture similarly reduced blood eosinophil counts, suggesting a reduced Th2 response [</span><a href="https://www.hindawi.com/journals/ecam/2015/340126/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Several clinical trials suggest that </span><a href="https://selfhacked.com/blog/acupuncture-benefits-mechanisms-risks/"><span style="font-weight: 400;">acupuncture</span></a><span style="font-weight: 400;"> may be a safe and valid way to improve the symptoms of allergic rhinitis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17874980/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15154290/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15291903/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25590322/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Acupuncture may improve allergies by reducing eosinophil counts in the blood.</span></p> <h3><strong>Sunlight &amp; Vitamin D</strong></h3> <p><a href="https://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">Vitamin D</span></a><span style="font-weight: 400;"> deficiency has been closely associated with higher blood eosinophil counts in otherwise healthy human subjects [</span><a href="https://www.sciencedirect.com/science/article/pii/S1658387617300936"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Vitamin D deficiency has also been associated with asthma and allergies in children [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675563/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17919705/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In people with allergic rhinitis and vitamin D deficiency, supplementation improved the symptoms. This improvement was not significant at 4 weeks, suggesting that symptom improvement might not occur until vitamin D has been adequately replenished [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31332549/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Healthy exposure to </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sunlight</span></a><span style="font-weight: 400;"> is the best way of increasing your blood vitamin D levels. In addition, you can eat food sources of vitamin D (such as fatty fish, liver, egg yolks, and dairy) or take supplements [</span><a href="https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Vitamin D deficiency has been associated with higher eosinophil counts, allergies, and asthma, so it&rsquo;s important to get enough sunlight exposure or to supplement.</span></p> <h3><strong>Butterbur</strong></h3> <p><span style="font-weight: 400;">Petatewalide B, an active compound from the </span><a href="https://selfhacked.com/blog/butterbur-benefits/"><span style="font-weight: 400;">butterbur</span></a><span style="font-weight: 400;"> plant, has been found to produce anti-allergic effects by reducing eosinophil counts [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK537160/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A standardized butterbur extract (ZE 339) was safe and effective at reducing allergic symptoms in multiple trials of people with both seasonal and permanent allergic rhinitis. A different extract (Petaforce) was similarly effective in people with allergy to pollen [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15080820/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15611396/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16751170/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16114089/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12188041/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64514/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12859442/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <p><span style="font-weight: 400;">Butterbur extract also improved the symptoms of asthma when added to conventional medication in 2 clinical trials [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15005644/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14720270/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, butterbur itself may cause allergic symptoms such as rhinitis, conjunctivitis, and eczema in people allergic to Compositae or Asteraceae plants (such as ragweed, daisies, and chrysanthemums) as it belongs to this plant family.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Active compounds from the butterbur plant may reduce eosinophil counts and improve allergic symptoms, as long as you&rsquo;re not allergic to the plant itself.</span></p>
445 | content_snp_table_4605007397631468_key == 4605007397631468
445 | content_snp_table_4605007397631468_blur == True
445 | content_snp_table_4605007397631468_hidden == False
445 | content_learn_more_3635208225679356_key == 3635208225679356
445 | content_learn_more_3635208225679356_blur == True
445 | content_learn_more_3635208225679356_hidden == False
445 | content_learn_more_3635208225679356_text == Based on the variants we looked at, your SH2B3 gene is somewhat associated with allergies. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Acupuncture, sunlight exposure, vitamin D, and butterbur may help. Keep scrolling to find out more.
445 | content_recommendation_3440999126604054_key == 3440999126604054
445 | content_recommendation_3440999126604054_blur == True
445 | content_recommendation_3440999126604054_hidden == False
rsIDs = rs653178,rs10774625
rsStatus = rs653178,ATXN2,chr12,111569952,C,G,T,,41,0,Normal
rsStatus = rs10774625,ATXN2,chr12,111472415,A,C,G,T,24,0,Normal
