446 | id == 446
446 | category_id == 26
446 | category_order == 23
446 | category_name == Allergies
446 | category_color == #C47AC0
446 | slug == IL33-Th2-allergies
446 | title == How This Inflammatory Gene Impacts Allergies (IL33)
446 | meta_description == The IL33 gene plays a key role in Th2 immunity & inflammation. Click to learn about its link with allergies.
446 | summary == <p style="text-align:justify"><strong>Did you know that inflammatory genes can change your predisposition to allergies? Read this post to learn about the role of IL33 in allergic reactions and get gene-based tips!</strong></p>
446 | overall_score_text == Your Allergies Score (Based on IL33 Gene)
446 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/IL33-Allergies.jpg
446 | author_id == 9
446 | author_name == Aleksa Ristic
446 | author_title == MS (Pharmacy)
446 | author_order == 45
446 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
446 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
446 | reviewer == None
446 | medical_reviewer_id == 11
446 | medical_reviewer_name == Puya Yazdi
446 | medical_reviewer_title == MD
446 | publish_date == 2020
446 | publish_date == 10
446 | publish_date == 30
446 | avg_rating == 5.0
446 | tags_id == 97
446 | tags_name == Allergies
446 | tags_id == 894
446 | tags_name == IL-33
446 | tags_id == 893
446 | tags_name == IL33 gene
446 | tags_id == 24
446 | tags_name == Inflammation
446 | tags_id == 853
446 | tags_name == Th2 dominance
446 | permissions_favorite == False
446 | permissions_rate == False
446 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The IL33 gene helps make interleukin-33, an inflammatory protein that promotes allergic inflammation.<br /><br /></strong><strong>Specific gene variants may increase IL33 activity and correlate with higher odds of allergic conditions.<br /><br /></strong><strong>This post reveals potential ways to reduce allergic reactions by targeting IL33 variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>The IL33 Gene, Th2 Immunity &amp; Allergies</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/il33/"><em><span style="font-weight: 400;">IL33</span></em></a><span style="font-weight: 400;"> gene helps make interleukin-33, a protein that activates different immune cells and promotes inflammation. IL-33 stimulates <a href="https://selfhacked.com/blog/supplements-people-th2-dominant/" target="_blank" rel="noopener">Th2 immunity</a>, which is usually overactive in people with allergies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16286016/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409346/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Scientists have established the role of IL-33 in various allergic conditions, and they&rsquo;ve been researching potential drugs that inhibit this inflammatory protein [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099536/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131616/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068600/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your IL33 Results for Allergies</strong></h2> <p>*8173557775490912*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs928413/"><strong>rs928413</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(19)30055-4/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with relatively higher odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with lower odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele is likely associated with lower IL-33 levels</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs76962799/"><strong>rs76962799</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele is likely associated with higher IL-33 levels</span></li> </ul> <p><span style="font-weight: 400;"><a href="https://selfdecode.com/snp/rs1342326/"><strong>rs1342326</strong></a> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753407/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with higher odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - not associated with allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele is likely associated with higher IL-33 levels</span></li> </ul> <p>*4675101368027374*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Allergic Reactions</strong></h2> <p>*3976150342455986*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Allergy Immunotherapy</strong></h4> <p><span style="font-weight: 400;">Allergy immunotherapy consists of administering a dilution of the allergen (such as pollen, dust mites, or dog dander) to help develop tolerance. Doctors use this treatment for allergic rhinitis, asthma, conjunctivitis, peanut allergy, and more [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27401313/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30095391/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26774974/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25732009/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10963287/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223701/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In different clinical trials, immunotherapy for allergic rhinitis reduced IL-33 levels in the blood and airways [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26281057/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29790007/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882380/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Allergy immunotherapy may relieve different types of allergy by targeting your IL33 variants.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Quercetin</strong></h4> <p><a href="https://selfhacked.com/blog/quercetin-23-scientifically-proven-benefits-quercetin/"><span style="font-weight: 400;">Quercetin</span></a><span style="font-weight: 400;"> is a plant antioxidant recognized as one of the best natural antihistamines. It may reduce airway inflammation by inhibiting IL-33 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314669/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227109/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one clinical trial, quercetin outperformed Cromolyn, a mast cell-stabilizing drug, in dermatitis treatment [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314669/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to preliminary research, a formulation with quercetin added to conventional therapy may improve asthma and allergic rhinitis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31578841/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Quercetin may counteract your gene variants and help improve allergies.</span></p>
446 | content_snp_table_8173557775490912_key == 8173557775490912
446 | content_snp_table_8173557775490912_blur == True
446 | content_snp_table_8173557775490912_hidden == False
446 | content_learn_more_4675101368027374_key == 4675101368027374
446 | content_learn_more_4675101368027374_blur == True
446 | content_learn_more_4675101368027374_hidden == False
446 | content_learn_more_4675101368027374_text == Based on the variants we looked at, your IL33 gene is associated with slightly higher odds of allergies. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Consider supplementing with quercetin to relieve allergies by targeting your variants. Keep reading to learn more.
446 | content_recommendation_3976150342455986_key == 3976150342455986
446 | content_recommendation_3976150342455986_blur == True
446 | content_recommendation_3976150342455986_hidden == False
rsIDs = rs76962799,rs928413,rs1342326
rsStatus = rs76962799,,chr9,6187132,C,A,,,31,0,Normal
rsStatus = rs928413,IL33,chr9,6213387,G,A,C,T,8,23,HET
rsStatus = rs1342326,,chr9,6190076,A,C,,,30,0,Normal
