447 | id == 447
447 | category_id == 26
447 | category_order == 23
447 | category_name == Allergies
447 | category_color == #C47AC0
447 | slug == ICE2-allergies
447 | title == A Mysterious Gene That May Be Connected to Asthma (ICE2)
447 | meta_description == ICE2 encodes a regulatory protein with a very poorly-studied mechanism. How might it be connected to allergic asthma?
447 | summary == <p><strong><em>ICE2 </em>encodes a regulatory protein with a very poorly-studied mechanism. How might it be connected to allergic asthma? Read on to learn more.</strong></p>
447 | overall_score_text == Your Allergy Score (based on ICE2)
447 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ICE2-Allergies-Asthma.jpg
447 | author_id == 1
447 | author_name == Jasmine Foster
447 | author_title == BSc, BEd
447 | author_order == 36
447 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
447 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
447 | reviewer == None
447 | medical_reviewer_id == 11
447 | medical_reviewer_name == Puya Yazdi
447 | medical_reviewer_title == MD
447 | publish_date == 2020
447 | publish_date == 10
447 | publish_date == 30
447 | avg_rating == 5.0
447 | tags_id == 860
447 | tags_name == Allergic Diseases
447 | tags_id == 97
447 | tags_name == Allergies
447 | tags_id == 98
447 | tags_name == Asthma
447 | tags_id == 895
447 | tags_name == ICE2 Gene
447 | tags_id == 442
447 | tags_name == T Cells
447 | tags_id == 435
447 | tags_name == Th1 Cells
447 | tags_id == 891
447 | tags_name == Th2
447 | permissions_favorite == False
447 | permissions_rate == False
447 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">ICE2</span></em><span style="font-weight: 400;"> encodes interactor of little elongation complex ELL subunit 2. Variants of </span><em><span style="font-weight: 400;">ICE2</span></em><span style="font-weight: 400;"> may play a role in asthma by affecting the transformation of blood cells. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by preventing the overproduction of Th2 cells and cytokines.</span></p> <h2><strong><em>ICE2</em></strong><strong> and Asthma</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/ice2/" target="_blank" rel="noopener"><em><span style="font-weight: 400;">ICE2 </span></em></a><span style="font-weight: 400;">gene encodes a protein called interactor of little elongation complex ELL subunit 2, which regulates how messages are sent within the nucleus of the cell [</span><a href="https://www.ncbi.nlm.nih.gov/gene/79664"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubchem.ncbi.nlm.nih.gov/gene/ICE2/human"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Genome-wide association studies have found two variants in the </span><em><span style="font-weight: 400;">ICE2</span></em><span style="font-weight: 400;"> gene that were associated with asthma. However, research into the mechanism of this connection is very scarce [</span><a href="https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(19)30055-4/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451732/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">ICE2 helps move proteins and messenger molecules into a part of the cell where they can combine into larger complexes and thereafter perform whatever function they perform. This gene and protein are present in animals, plants, yeasts, and other organisms, suggesting an essential role and ancient origin [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376971/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25641738/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In yeast, ICE2 stabilizes </span><a href="https://selfhacked.com/blog/cyp-enzymes-interact-supplements-related-genes/"><span style="font-weight: 400;">CYP enzymes</span></a><span style="font-weight: 400;">, which break down drugs and other active compounds, but it is unclear whether this function is conserved in animals. In mammals such as dogs, the </span><em><span style="font-weight: 400;">ICE2</span></em><span style="font-weight: 400;"> gene has been studied in the context of blood cell plasticity; that is, the ability of blood cells to change their structure and function depending on what kind of immune response is needed [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25641738/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This possible connection to the immune system via blood cells may be the most promising lead for explaining ICE2&rsquo;s association with asthma. However, more details are currently lacking [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">ICE2</span></em><span style="font-weight: 400;"> gene encodes a protein that may affect how </span><span style="font-weight: 400;">white blood cells</span><span style="font-weight: 400;"> transform according to what kind of immune response is needed, but its mechanism is poorly studied.</span></span></p> <h2><strong>Your </strong><strong><em>ICE2</em></strong><strong> Results for Asthma</strong></h2> <p>*8025465294816629*</p> <p><a href="https://selfdecode.com/gene/ice2/" target="_blank" rel="noopener"><strong>ICE2 </strong></a><a href="https://selfdecode.com/snp/rs11071559/"><strong>rs11071559</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively higher rates of allergic asthma</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Possibly protective against allergic asthma</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele may affect the transformation of white blood cells and influence the immune response [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/ice2/" target="_blank" rel="noopener"><strong>ICE2 </strong></a><a href="https://selfdecode.com/snp/rs10519067/"><strong>rs10519067</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively higher rates of allergic asthma&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Possibly protective against allergic asthma</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may affect the transformation of white blood cells and influence the immune response [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*8091675497882904*</p> <h2><strong>Recommendations for Improving Asthma</strong></h2> <p>*8566610876198495*</p> <p><strong>Note</strong><span style="font-weight: 400;">: Because of how little we know about ICE2&rsquo;s mechanism, it is difficult to target recommendations directly to the gene. This section will therefore focus on recommendations that reduce the number of T cells that promote the Th2 response, since ICE2 has been implicated in the transformation of blood cells.</span></p> <h3><strong>Light Therapies</strong></h3> <p><span style="font-weight: 400;">In animals with allergic asthma, low-level laser therapy (</span><a href="http://selfhacked.com/blog/my-review-of-lllt/"><span style="font-weight: 400;">LLLT</span></a><span style="font-weight: 400;">, a type of specialized light therapy) reduced Th2 inflammation in the airway [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24486607/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis of 13 studies concluded that light therapy (with </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">UV</span></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/blue-light-therapy-benefits/"><span style="font-weight: 400;">blue</span></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/red-light-therapy-benefits/"><span style="font-weight: 400;">red</span></a><span style="font-weight: 400;">, and </span><a href="http://selfhacked.com/blog/infrared-radiation-benefits/"><span style="font-weight: 400;">infrared radiation</span></a><span style="font-weight: 400;">) applied through the nose can relieve allergic rhinitis symptoms and improve quality of life. However, the authors warned about the heterogeneity and low quality of the studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26163248/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Some wavelengths of light may reduce airway inflammation by reducing Th2 inflammation.</span></p> <h3><strong>Vitamin E</strong></h3> <p><span style="font-weight: 400;">Vitamin E is believed to play a central role in regulating the balance between Th1 and Th2 cell formation. If ICE2 is important for </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cell</span></a><span style="font-weight: 400;"> transformation as some researchers suggest, then vitamin E could be part of the same regulatory systems [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266234/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2327029/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Several studies have associated high intake of </span><a href="https://selfhacked.com/blog/vitamin-e-can-help-fertility-pregnancy/"><span style="font-weight: 400;">vitamin E</span></a><span style="font-weight: 400;"> with a reduced incidence of asthma, while a diet poor in this vitamin increases the risk. Similarly, some people with asthma have lower levels of this vitamin in the blood and lungs [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7735592/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16763215/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1745426/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10731863/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10465176/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Food sources of vitamin E include wheat germ, nuts, sunflower and sesame seeds, and their respective plant oils [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956867/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Vitamin E may be a part of the same regulatory mechanisms that determine how white blood cells develop into Th1 or Th2 cells. High vitamin E intake is also associated with low incidence of asthma.</span></p> <h3><strong>Quercetin</strong></h3> <p><span style="font-weight: 400;">Quercetin, a common polyphenol found in many fruits and vegetables, reduced the number of Th2 cells and the production of Th2 inflammatory signals in a cell study [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459988/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/quercetin-23-scientifically-proven-benefits-quercetin/"><span style="font-weight: 400;">Quercetin</span></a><span style="font-weight: 400;"> is recognized as one of the best natural antihistamines. In one human trial, quercetin even outperformed Cromolyn, a mast cell-stabilizing drug; quercetin was more effective for prevention, while Cromolyn worked more quickly once the </span><a href="http://selfhacked.com/blog/histamine/"><span style="font-weight: 400;">histamine</span></a><span style="font-weight: 400;"> reaction had already started [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314669/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18958421/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Preliminary clinical research shows that a formulation with quercetin added to conventional therapy reduced the symptoms of asthma and rhinitis, and the need for medication [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31578841/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Food sources of this flavonoid include vegetables such as </span><a href="https://www.selfhacked.com/blog/capers/"><span style="font-weight: 400;">capers</span></a><span style="font-weight: 400;">, onions, eggplant, celery, and asparagus, fruits such as berries, apples, and oranges, nuts, and tea (both </span><a href="https://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">green</span></a><span style="font-weight: 400;"> and black) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808895/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Quercetin is a common dietary polyphenol that may reduce Th2 cell count and prevent allergic inflammation.</span></p>
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447 | content_learn_more_8091675497882904_text == Based on the variants we looked at, your ICE2 gene is somewhat associated with allergic asthma. However, this doesn't necessarily reflect your overall risk of asthma; it’s just one gene related to it. Light therapy, vitamin E, and quercetin may help. Keep scrolling to find out more.
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rsIDs = rs11071559,rs10519067
rsStatus = rs10519067,RORA,chr15,60776148,G,A,,,41,0,Normal
