448 | id == 448
448 | category_id == 26
448 | category_order == 23
448 | category_name == Allergies
448 | category_color == #C47AC0
448 | slug == GATA3-allergies
448 | title == A Genetic Link Between Immune System Protein Production & Allergies (GATA3)
448 | meta_description == GATA3 is necessary for immune system protein release. Variants of GATA3 have been associated with allergies. Read more here.
448 | summary == <p style="text-align:justify"><strong>GATA3 is a protein necessary for the production of type 2 immune response (Th2) proteins. Read more to find out how variants of <em>GATA3</em> might affect allergies.</strong><br />  &nbsp;</p>
448 | overall_score_text == Your Allergy Score (based on GATA3 gene)
448 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/GATA3-Allergies.jpg
448 | author_id == 14
448 | author_name == Shany Lahan
448 | author_title == MS (Neuroscience)
448 | author_order == 5
448 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
448 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
448 | reviewer == None
448 | medical_reviewer_id == 11
448 | medical_reviewer_name == Puya Yazdi
448 | medical_reviewer_title == MD
448 | publish_date == 2020
448 | publish_date == 10
448 | publish_date == 30
448 | avg_rating == 5.0
448 | tags_id == 896
448 | tags_name == GATA3 Gene
448 | tags_id == 591
448 | tags_name == IgE Antibodies
448 | tags_id == 367
448 | tags_name == IL-13
448 | tags_id == 864
448 | tags_name == IL-4
448 | tags_id == 891
448 | tags_name == Th2
448 | permissions_favorite == False
448 | permissions_rate == False
448 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">GATA3 is a protein essential for the release of proteins from type 2 immune response (Th2) cells. Variants of </span><em><span style="font-weight: 400;">GATA3 </span></em><span style="font-weight: 400;">may play a role in allergies by increasing Th2 protein levels, via increased production or activity of GATA3. Supplement modifications may counteract the effects of these variants by decreasing GATA3 production.</span></span></p> <h2 style="text-align: justify;"><strong><em>GATA3 </em></strong><strong>and Allergies</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">GATA3 is a protein necessary for the production of the immune system proteins (cytokines) </span><a href="https://selfdecode.com/blog/article/il4-allergies-426/"><span style="font-weight: 400;">IL-4</span></a><span style="font-weight: 400;">, IL-5, and </span><a href="https://selfdecode.com/blog/article/il13-allergies-435/"><span style="font-weight: 400;">IL-13</span></a><span style="font-weight: 400;">. These cytokines are released by cells belonging to the </span><a href="https://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">type 2 immune response</span></a><span style="font-weight: 400;"> (Th2) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/9160750/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Many scientists consider elevated Th2 activity to underlie a number of allergic diseases. Indeed, the release of IL-4 and IL-13 from Th2 cells has been shown to enhance the responsiveness of the airway to allergens (allergy-inducing substances) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532591/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">IL-4 and IL-13 have also been linked to the elevated release of a type of antibody called IgE. The release of IgE antibodies from white blood cells is an early step in allergic reaction progression [</span><a href="https://www.jacionline.org/article/S0091-6749(97)70293-8/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532591/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><a href="https://selfdecode.com/gene/gata3/"><em><span style="font-weight: 400;">GATA3</span></em></a><span style="font-weight: 400;"> have been associated with allergic diseases. These variants may increase production or activity of GATA3, which may lead to elevated production of Th2-related cytokines, enhanced airway responsiveness to allergens, and excess release of IgE antibodies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753407/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31619474/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>GATA3</em></strong><strong> Results for Allergies</strong></h2> <p style="text-align: justify;">*9045554244997307*</p> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Primary SNP</strong></span></p> <p style="text-align: justify;"><strong><em>GATA3 </em></strong><a href="https://selfdecode.com/snp/rs962993/"><strong>rs962993</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased risk of allergies, relative to &lsquo;T&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Decreased risk of allergies, relative to &lsquo;C&rsquo;</span></li> </ul> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Other Important SNPs</strong></span></p> <p style="text-align: justify;"><strong><em>GATA3 </em></strong><a href="https://selfdecode.com/snp/rs12785018/"><strong>rs12785018</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of allergies&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with allergies</span></li> </ul> <p style="text-align: justify;"><strong><em>GATA3 </em></strong><a href="https://selfdecode.com/snp/rs10795656/"><strong>rs10795656</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of allergies</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with allergies</span></li> </ul> <p style="text-align: justify;"><strong><em>GATA3 </em></strong><a href="https://selfdecode.com/snp/rs12413578/"><strong>rs12413578</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased risk of allergies, relative to &lsquo;T&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Decreased risk of allergies, relative to &lsquo;C&rsquo;</span></li> </ul> <p style="text-align: justify;"><strong><em>GATA3 </em></strong><a href="https://selfdecode.com/snp/rs72782676/"><strong>rs72782676</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of allergies&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with allergies</span></li> </ul> <p style="text-align: justify;"><strong><em>GATA3 </em></strong><a href="https://selfdecode.com/snp/rs11255753/"><strong>rs11255753</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of allergies</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with allergies</span></li> </ul> <p style="text-align: justify;"><strong><em>GATA3 </em></strong><a href="https://selfdecode.com/snp/rs7894791/"><strong>rs7894791</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased risk of allergies, relative to &lsquo;A&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Decreased risk of allergies, relative to &lsquo;C&rsquo;</span></li> </ul> <p style="text-align: justify;">*4249885109562152*</p> <h2 style="text-align: left;"><strong>Recommendations for Improving Allergies</strong></h2> <p style="text-align: justify;">*5566559786583374*</p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Resveratrol</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/top-15-scientific-health-benefits-of-resveratrol-with-references/"><span style="font-weight: 400;">Resveratrol</span></a><span style="font-weight: 400;"> is an antioxidant that occurs naturally in grapes and wine, and is also available in supplement form.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In 2 preliminary trials focused on adults and children with hay fever, resveratrol nose sprays improved symptoms such as runny and stuffy nose, itching, and sneezing. Resveratrol also reduced blood levels of antibodies, immune system cells, and allergy-associated cytokines, such as IL-4 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24983742/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29539616/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In one study, resveratrol was reported to prevent mice from developing food allergies. Reduced production of GATA3, IL-4, IL-13, and IgE were among the observations suggested to underlie this result [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22962611/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Supplementation with resveratrol may improve allergies by decreasing production of GATA3, IL-4, IL-13, and IgE.</span></p> <h4 style="text-align: justify;"><strong>Perilla</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/perilla-oil/"><em><span style="font-weight: 400;">Perilla frutescens</span></em></a><span style="font-weight: 400;"> (shiso) is a popular herb in Asia, where it is used as a garnish for food and as a treatment for allergies.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a clinical trial, supplementation with perilla extract (enriched for rosmarinic acid) improved symptoms such as itchy and watery eyes, and itchy nose. Supplementation of this extract also reduced the number of white blood cells found in the airways of people with seasonal allergies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/14988517/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a small clinical trial, people with asthma who consumed perilla oil were reported to have improved lung function and decreased levels of inflammatory compounds [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10732825/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Mice induced to have symptoms of hay fever were reported to have decreased hay fever-related symptoms after treatment with luteolin, an active compound of perilla. This effect may have been due to decreases in GATA3, as well as reductions in the number of IL-4-releasing cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32256362/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Supplementation with perilla may improve allergies by reducing production of GATA3, as well as the number of IL-4-releasing cells.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Astragalus</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/astragalus/"><span style="font-weight: 400;">Astragalus</span></a><span style="font-weight: 400;"> is a large genus of plants that are part of the legume family.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Astragalus was found to improve hay fever symptoms and quality of life in a small randomized controlled trial of people with seasonal allergy to weed pollen [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19504468/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Astragalus also played a role in preventing the recurrence of asthma in children. A combination of astragalus and a standard asthma treatment was even more effective at preventing asthma [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21910341/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Various species of astragalus or their active ingredients were reported to decrease production of GATA3 and Th2 cytokines in multiple studies of mice with asthma [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25264079/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28586019/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25171656/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Astragalus supplementation may improve allergies by reducing production of GATA3 and Th2 cytokines.</span></p>
448 | content_snp_table_9045554244997307_key == 9045554244997307
448 | content_snp_table_9045554244997307_blur == True
448 | content_snp_table_9045554244997307_hidden == False
448 | content_learn_more_4249885109562152_key == 4249885109562152
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448 | content_learn_more_4249885109562152_text == Based on the variants we looked at, your GATA3 gene makes you somewhat more likely to develop allergic diseases. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Supplementation with resveratrol, perilla, or astragalus may help. Keep scrolling to find out more.
448 | content_recommendation_5566559786583374_key == 5566559786583374
448 | content_recommendation_5566559786583374_blur == True
448 | content_recommendation_5566559786583374_hidden == False
rsIDs = rs72782676,rs12785018,rs7894791,rs962993,rs10795656,rs11255753,rs12413578
rsStatus = rs12785018,,chr10,8473385,C,G,T,,33,0,Normal
rsStatus = rs7894791,,chr10,8549406,C,A,,,13,12,HET
rsStatus = rs962993,,chr10,9011169,C,T,,,27,0,Normal
rsStatus = rs10795656,,chr10,8553876,G,A,T,,27,0,Normal
rsStatus = rs11255753,,chr10,8563590,G,C,T,,27,0,Normal
rsStatus = rs12413578,,chr10,9007290,C,G,T,,24,0,Normal
