449 | id == 449
449 | category_id == 26
449 | category_order == 23
449 | category_name == Allergies
449 | category_color == #C47AC0
449 | slug == RORC-allergies
449 | title == A Connection Between Sleep Cycles and Allergies (RORC)
449 | meta_description == The RORC gene regulates the circadian rhythm and the development of Th17 cells. What is its role in allergies?
449 | summary == <p><strong>The <em>RORC </em>gene regulates the circadian rhythm and the development of Th17 cells. What is its role in allergies? Read on to learn more.</strong></p>
449 | overall_score_text == Your Allergy Score (based on RORC)
449 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/RORC-Allergies.jpg
449 | author_id == 1
449 | author_name == Jasmine Foster
449 | author_title == BSc, BEd
449 | author_order == 36
449 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
449 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
449 | reviewer == None
449 | medical_reviewer_id == 11
449 | medical_reviewer_name == Puya Yazdi
449 | medical_reviewer_title == MD
449 | publish_date == 2020
449 | publish_date == 10
449 | publish_date == 30
449 | avg_rating == 5.0
449 | tags_id == 860
449 | tags_name == Allergic Diseases
449 | tags_id == 97
449 | tags_name == Allergies
449 | tags_id == 98
449 | tags_name == Asthma
449 | tags_id == 486
449 | tags_name == Circadian rhythm
449 | tags_id == 99
449 | tags_name == Eczema
449 | tags_id == 848
449 | tags_name == Hay Fever
449 | tags_id == 897
449 | tags_name == RORC Gene
449 | tags_id == 485
449 | tags_name == Sleep
449 | tags_id == 440
449 | tags_name == Th17 Cells
449 | permissions_favorite == False
449 | permissions_rate == False
449 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">RORC </span></em><span style="font-weight: 400;">encodes retinoic acid related orphan receptor gamma, or ROR-gamma. Variants of </span><em><span style="font-weight: 400;">RORC</span></em><span style="font-weight: 400;"> may play a role in allergies by boosting Th17 cell production. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by directly blocking ROR-gamma or the Th17 response.</span></p> <h2><strong><em>RORC</em></strong><strong> and Allergies</strong></h2> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">RORC</span></em><span style="font-weight: 400;"> gene encodes </span><a href="http://selfhacked.com/blog/importance-real-vitamin-retinol/"><span style="font-weight: 400;">retinoic acid</span></a><span style="font-weight: 400;"> related orphan receptor gamma (ROR-gamma). This protein is mainly expressed in certain types of </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;"> and plays a role in regulating </span><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/gene/6097"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750502/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">ROR-gamma is required for T cells to develop into T helper 17 (Th17) cells, which produce </span><a href="http://selfhacked.com/blog/th17/"><span style="font-weight: 400;">IL-17</span></a><span style="font-weight: 400;">, </span><a href="http://www.selfdecode.com/gene/il2/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">IL-2</span></a><span style="font-weight: 400;">1, and IL-22 cytokines. Th17 cells play an important role in protecting the body from infection; however, poorly regulated Th17 has been associated with inflammatory diseases like rheumatoid arthritis and allergic asthma [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858703/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750502/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670432/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In rheumatoid arthritis, ROR-gamma may even be a target for future treatments [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474185/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Because of its essential role in Th17 cell development, researchers have considered ROR-gamma as a target for asthma therapies as well. Some </span><a href="http://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">Th2</span></a><span style="font-weight: 400;"> cells carry ROR-gamma proteins and stimulate the development of Th17 cells, and people with asthma have significantly more of these Th2 cells than the healthy average. It&rsquo;s possible that blocking ROR-gamma could prevent Th17-triggered inflammation in these cases [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115366/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Connecting Allergies &amp; Sleep</span></h3> <p><span style="font-weight: 400;">Researchers are currently investigating a connection between sleep rhythms and allergies. Since ROR-gamma is involved in both, it represents a potential mechanism by which sleep may affect allergic inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304491/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750502/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The circadian rhythm, which is the daily cycle of waking and sleeping, strongly affects the development of Th17 cells, but not Th2 cells. This relationship appears to mirror ROR-gamma, which stimulates Th17 cell production, but not Th2 directly [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165400/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304491/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Th17 and Th2 cells regulate each other&rsquo;s activity and keep each other in balance; dysregulation of this relationship may lead to allergic asthma. The dynamic between sleep cycles, Th17, and Th2 is highly complex, and researchers are still exploring exactly how it works. Nevertheless, ROR-gamma is likely to play a part [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855890/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">RORC</span></em><span style="font-weight: 400;"> encodes ROR-gamma, a protein that regulates both sleep and the production of Th17 cells. It has been implicated in allergic diseases like asthma.</span></span></p> <h2><strong>Your </strong><strong><em>RORC</em></strong><strong> Results for Allergies</strong></h2> <p>*4004844315915665*</p> <p><strong>RORC </strong><a href="http://selfdecode.com/snp/rs4845604"><strong>rs4845604</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively increased allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Possibly protective against allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may decrease ROR-gamma activity, leading to reduced Th17 production [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115366/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*4337641155814107*</p> <h2><strong>Recommendations for Preventing Allergies</strong></h2> <p>*4526756172508401*</p> <h3><strong>Regular Sleep Schedule</strong></h3> <p><span style="font-weight: 400;">ROR-gamma and the circadian rhythm are closely intertwined, and keeping to a regular sleep schedule may help regulate ROR-gamma [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304491/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750502/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Sleep impairments and disorders are significantly more common in people with allergic disorders than in people without. Allergic symptoms like airway inflammation can make it significantly more difficult to get a good night&rsquo;s sleep; in turn, disturbed sleep can increase inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576835/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666828/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It can be very difficult to get out of the cycle of poor sleep causing inflammation and inflammation contributing to poor sleep. </span><a href="https://get.selfdecode.com/gene-reports/sleep/"><span style="font-weight: 400;">This DNA wellness report</span></a><span style="font-weight: 400;"> can help you find personalized recommendations for improving your sleep cycle. For more general sleep tips, try </span><a href="https://selfhack.com/blog/methods-to-fall-asleep-insomniac/"><span style="font-weight: 400;">this SelfHacked post</span></a><span style="font-weight: 400;">.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Because ROR-gamma and the circadian rhythm are so closely linked, it&rsquo;s especially important to regulate your sleep cycle if you have detrimental </span><em><span style="font-weight: 400;">RORC</span></em><span style="font-weight: 400;"> variants.</span></span></p> <h3><strong>Probiotic Yogurt</strong></h3> <p><span style="font-weight: 400;">In a clinical study of 75 overweight people, eating yogurt (containing </span><a href="https://selfhacked.com/blog/a1probiotics-good-bacteria/"><span style="font-weight: 400;">probiotic</span></a> <em><span style="font-weight: 400;">Lactobacillus</span></em><span style="font-weight: 400;"> strains) every day for eight weeks decreased ROR-gamma activity, among other inflammatory markers [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25079040/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Many </span><em><span style="font-weight: 400;">Lactobacillus</span></em><span style="font-weight: 400;"> probiotics have produced beneficial results in allergy studies. Probiotics such as </span><a href="https://selfhacked.com/blog/l-paracasei/"><em><span style="font-weight: 400;">L. paracasei</span></em></a><em><span style="font-weight: 400;">, </span></em><a href="http://selfhacked.com/blog/l-acidophilus/"><em><span style="font-weight: 400;">L. acidophilus</span></em></a><em><span style="font-weight: 400;">, </span></em><a href="https://selfhacked.com/blog/health-benefits-l-plantarum/"><em><span style="font-weight: 400;">L. plantarum</span></em></a><em><span style="font-weight: 400;">, </span></em><a href="http://selfhacked.com/blog/l-casei/"><em><span style="font-weight: 400;">L. casei</span></em></a><em><span style="font-weight: 400;">, </span></em><span style="font-weight: 400;">and </span><a href="http://selfhacked.com/blog/l-gasseri/"><em><span style="font-weight: 400;">L. gasseri</span></em></a><span style="font-weight: 400;"> improved allergic rhinitis in multiple trials. Moreover, </span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a> <span style="font-weight: 400;">and </span><a href="http://selfhacked.com/blog/l-johnsonii/"><em><span style="font-weight: 400;">L. johnsonii</span></em></a><span style="font-weight: 400;"> enhanced the effectiveness of immunotherapy for allergy to pollen and dust mites [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27442711/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16101937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24569538/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16195581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15653517/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18072744/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18510694/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19734682/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17259812/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23299716/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27401319/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22513081/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In people with asthma,</span> <a href="https://selfhacked.com/blog/l-salivarius/"><em><span style="font-weight: 400;">L. salivarius</span></em></a><span style="font-weight: 400;"> reduced the production of inflammatory cytokines [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446640/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746628/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Preliminary research in adults and children with allergy to cow milk suggests that the immunomodulatory activity of </span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;"> may help prevent allergic responses. This </span><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">probiotic</span></a><span style="font-weight: 400;"> also enhanced the effectiveness of immunotherapy for peanut allergy [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10024217/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15241356/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25592987/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Other </span><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">probiotics</span></a><span style="font-weight: 400;"> may help by fermenting the food proteins that cause allergies. For instance, </span><a href="http://selfhacked.com/blog/l-helveticus/"><em><span style="font-weight: 400;">L. helveticus</span></em></a><em><span style="font-weight: 400;">, </span></em><a href="http://selfhacked.com/blog/l-delbrueckii/"><em><span style="font-weight: 400;">L. delbrueckii</span></em></a><em><span style="font-weight: 400;">, and </span></em><a href="http://selfhacked.com/blog/l-fermentum/"><em><span style="font-weight: 400;">L. fermentum</span></em></a> <span style="font-weight: 400;">successfully reduced the allergenic potential of cow milk and </span><a href="https://www.selfhacked.com/blog/bee-propolis/"><span style="font-weight: 400;">propolis</span></a><span style="font-weight: 400;"> in several studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20583192/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370499/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23140691/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21385515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Probiotic yogurt containing </span><em><span style="font-weight: 400;">Lactobacillus</span></em><span style="font-weight: 400;"> strains decreased ROR-gamma activity. </span><em><span style="font-weight: 400;">Lactobacillus</span></em><span style="font-weight: 400;"> probiotics have also been found to improve allergic inflammation.</span></span></p> <h3><strong>Astragalus</strong></h3> <p><a href="https://selfhacked.com/blog/astragalus/"><span style="font-weight: 400;">Astragalus</span></a><span style="font-weight: 400;"> is an herb most commonly used in traditional Chinese medicine (TCM). A study on the mechanisms of certain TCM remedies found that astragalus supplementation reduced ROR-gamma activity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32345031/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Astragalus improved allergic rhinitis symptoms and quality of life in a small trial of people with seasonal allergy to weed pollen [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19504468/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It also played a role in preventing the recurrence of asthma in children. A combination of astragalus and standard treatment showed even better effects [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21910341/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Astragalus, a common component of traditional Chinese medicine, reduced ROR-gamma activity in one trial and improved allergic symptoms in two others.</span></p>
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449 | content_learn_more_4337641155814107_text == Based on the variants we looked at, your RORC gene is somewhat associated with allergic inflammation. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. A regular sleep schedule, probiotic yogurt, and astragalus may help. Keep scrolling to find out more.
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rsIDs = rs4845604
rsStatus = rs4845604,RORC,chr1,151829204,G,A,C,T,23,0,Normal
