45 | id == 45
45 | category_id == 9
45 | category_order == 6
45 | category_name == Longevity
45 | category_color == #C47AC0
45 | slug == longevity-SIRT1
45 | title == Can You Hack This Gene to Live Longer? (SIRT1)
45 | meta_description == Low SIRT1 activity could increase your risk of age-related diseases. Find out which variants you have and learn to hack them.
45 | summary == <p><strong>SIRT1 is the first of the sirtuins, proteins that decrease inflammation, oxidative stress, and DNA damage. If you have low SIRT1 activity, you may be more susceptible to age-related diseases; find out which variants you have and how to hack them here.</strong></p>
45 | overall_score_text == Longevity Score (Based on SIRT1 Gene)
45 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/Can-You-Hack-This-Gene-to-Live-Longer-SIRT1_JPG.jpg
45 | author_id == 1
45 | author_name == Jasmine Foster
45 | author_title == BSc, BEd
45 | author_order == 36
45 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
45 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
45 | reviewer_id == 2
45 | reviewer_name == Joe Cohen
45 | reviewer_title == BS
45 | medical_reviewer_id == 11
45 | medical_reviewer_name == Puya Yazdi
45 | medical_reviewer_title == MD
45 | publish_date == 2019
45 | publish_date == 9
45 | publish_date == 13
45 | avg_rating == 5.0
45 | tags_id == 126
45 | tags_name == AMPK
45 | tags_id == 45
45 | tags_name == cAMP
45 | tags_id == 101
45 | tags_name == Longevity
45 | tags_id == 144
45 | tags_name == NAD+
45 | tags_id == 39
45 | tags_name == Oxidative Stress
45 | tags_id == 143
45 | tags_name == SIRT1 Gene
45 | tags_id == 145
45 | tags_name == Sirtuins
45 | permissions_favorite == False
45 | permissions_rate == False
45 | content_article == <h2><span style="font-weight: 400;">What are the Sirtuins?</span></h2> <p><span style="font-weight: 400;">The </span><a href="http://selfhacked.com/blog/nad-and-sirt1-their-role-in-chronic-health-issues/"><span style="font-weight: 400;">sirtuins</span></a><span style="font-weight: 400;"> are a group of enzymes heavily implicated in aging, cell death, inflammation, mental and physical </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> resistance, and energy metabolism. They regulate and &ldquo;turn off&rdquo; other genes, especially those involved in the process of aging [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18419308"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887872/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831942/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745579/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">When your cells experience stress, acetyl groups are added to proteins as a response to changes induced by inflammation and oxidation. Sirtuins (like SIRT1) remove these acetyl groups to keep the protein in service longer than usual [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745579/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674397/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Many age-related and degenerative diseases are characterized by low sirtuin activity, including [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269041/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674397/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Cancer</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Alzheimer&rsquo;s disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Parkinson&rsquo;s disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Huntington&rsquo;s disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Amyotrophic lateral sclerosis (ALS)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Kennedy&rsquo;s disease</span></li> </ul> <p><span style="font-weight: 400;">Sirtuin activity is also unusually low in chronic inflammation. Some researchers believe that activating the sirtuins&mdash;and especially SIRT1&mdash;may help manage obesity, atherosclerosis, diabetes, and other inflammatory diseases [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745579/#sec3title"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Given all of this, it&rsquo;s not surprising that SIRT1 has been touted as a longevity gene.</span></p> <h2><span style="font-weight: 400;">SIRT1 and Lifespan</span></h2> <p><span style="font-weight: 400;">Research on SIRT1 originates in yeast, of all things: the first sirtuin ever identified was a gene called sir2, which is required for yeast to grow and divide. From sir2, researchers discovered the animal and mammalian sirtuins, SIRT1 through SIRT7 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC479720/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514220/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Today, SIRT1 is among the best-known of the longevity genes, which also include </span><a href="../article/longevity-foxo3-32"><span style="font-weight: 400;">FOXO3</span></a><span style="font-weight: 400;">, </span><a href="../../gene/foxo1/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">FOXO1</span></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/about-pon1-and-natural-ways-to-increase-it/"><span style="font-weight: 400;">PON1</span></a><span style="font-weight: 400;">, and others.</span></p> <h3><span style="font-weight: 400;">SIRT1 Knockouts and Duplications</span></h3> <p><span style="font-weight: 400;">One of the best ways to study the function of a particular gene is to see what happens when it&rsquo;s not working and when it&rsquo;s working too much. Mice and rats can be genetically modified to delete (knock out) or duplicate one gene at a time for this purpose [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514220/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">When SIRT1 is knocked out of mice, many die before they are born, and only 20% reach maturity. Those who make it are small, infertile, and prone to diseases of the eye, brain, and heart [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514220/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">When SIRT1 is doubled in mice, they experience less DNA damage and other markers of aging. Excess SIRT1 activity also protected heart tissue from damage after a heart attack [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514220/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Together, these mouse studies demonstrate not only that SIRT1 is necessary for a healthy life, but that more SIRT1 is better for healthy aging.</span></p> <h3><span style="font-weight: 400;">SIRT1 and Human Longevity</span></h3> <p><span style="font-weight: 400;">A handful of studies have shown that people with certain SIRT1 variants are more likely to live very long lives. One of the variations with the strongest effect so far is rs12778366: even one copy of the &lsquo;C&rsquo; allele may reduce all-cause mortality risk by as much as 30% [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591365/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Another SNP with a large potential impact on lifespan is rs7895833: the &lsquo;G&rsquo; allele here is almost twice as common in older people as it is in the average adult [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365019/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Animals and humans with increased SIRT1 activity tend to have fewer age-related diseases, possibly because SIRT1 prevents DNA damage.</span></p> <h2><span style="font-weight: 400;">How Might SIRT1 Make You Live Longer?</span></h2> <p><span style="font-weight: 400;">SIRT1 is active in every tissue in your body, working tirelessly to maintain cell function and prevent disease [</span><a href="https://www.ncbi.nlm.nih.gov/gene/23411"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269041/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674397/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">*8026384884635394*</span></p> <h3><span style="font-weight: 400;">NAD+</span><span style="font-weight: 400;">, SIRT1, and DNA Damage</span></h3> <p><span style="font-weight: 400;">The exact mechanism by which SIRT1 affects aging is still under intense investigation. However, we do know a few things [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514220/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365019/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">SIRT1 activity (especially in the liver and cardiovascular system) decreases as we age</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/nad-important-increase/"><span style="font-weight: 400;">NAD</span></a><span style="font-weight: 400;">+, which is required for SIRT1 function, decreases as we age</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Decreases in NAD+ and SIRT1 coincide with DNA damage and age-related diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">When SIRT1 activity is low, the activity of genes associated with aging increases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">SIRT1 activity is closely linked with antioxidant status in the elderly</span></li> </ul> <p><span style="font-weight: 400;">Together, this paints a picture wherein high SIRT1 activity could prevent age-related DNA damage and disease.</span></p> <h3><span style="font-weight: 400;">Interactions with FOXO1, FOXO3, and PON1</span></h3> <p><span style="font-weight: 400;">SIRT1 appears to have an effect on lifespan on its own, but it works best in concert with other longevity genes.</span></p> <p><span style="font-weight: 400;">SIRT1 and FOXO1, for example, are both required to activate the antioxidant enzyme </span><a href="http://selfhacked.com/blog/the-brain-fog-gene-rs4880-or-sod2/"><span style="font-weight: 400;">MnSOD</span></a><span style="font-weight: 400;">. On the other hand, FOXO1 can bind to and turn off SIRT1, which is one of the reasons </span><a href="../article/longevity-foxo1-39"><span style="font-weight: 400;">why FOXO1 should be kept in balance by </span></a><a href="http://selfhacked.com/blog/natural-ampk-activators/"><span style="font-weight: 400;">AMPK</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514220/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">SIRT1 also directly activates </span><a href="../article/longevity-foxo3-32"><span style="font-weight: 400;">FOXO3</span></a><span style="font-weight: 400;">, perhaps the best-studied human longevity gene. FOXO3 suppresses tumors, promotes </span><a href="http://selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin sensitivity</span></a><span style="font-weight: 400;">, repairs DNA, and improves immune function [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514220/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">SIRT1&rsquo;s relationship with PON1 is more complex. Some researchers believe that SIRT1 and PON1 have similar or overlapping functions, and that the activity of one can compensate for the activity of the other. Since both SIRT1 and PON1 are highly beneficial, there&rsquo;s no harm in trying to increase both [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365019/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">SIRT1 works together with other longevity genes like FOXO1, FOXO3, and PON1 to repair DNA, flush toxins, and prevent oxidative stress.</span></p> <h2><span style="font-weight: 400;">Your SIRT1 Results for Longevity</span></h2> <p>*8026384884635394*</p> <p><strong>Important SNPs:</strong></p> <p><strong>SIRT1 rs12778366</strong> [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591365/" target="_blank" rel="noopener">R</a>]</p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased SIRT1 activity, reduced risk of diabetes, longer lifespan</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Reduced SIRT1 activity, increased risk of diabetes, average lifespan</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Only about 1% of people worldwide have the most beneficial &lsquo;CC&rsquo; genotype!</span></li> </ul> <p><strong>SIRT1 rs7895833</strong> [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365019/" target="_blank" rel="noopener">R</a>]</p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = More common in long-lived populations, may increase lifespan</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Less common in long-lived populations</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 18% of people worldwide have the most beneficial &lsquo;GG&rsquo; genotype</span></li> </ul> <p><strong>SIRT1 rs3758391</strong> [<a href="https://academic.oup.com/biomedgerontology/article/62/9/960/525936" target="_blank" rel="noopener">R</a>]</p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Lower cardiovascular mortality risk, less cognitive decline during aging, may increase lifespan</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Normal cognitive decline during aging, normal aging</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 29% of people worldwide have the most beneficial &lsquo;TT&rsquo; genotype</span></li> </ul> <p><strong>SIRT1 rs7896005</strong> [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272146/" target="_blank" rel="noopener">R</a>]</p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = More common in long-lived populations, may increase lifespan</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Less common in long-lived populations</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 51% of people worldwide have the most beneficial &lsquo;GG&rsquo; genotype</span></li> </ul> <h2><span style="font-weight: 400;">Frequency in Population</span></h2> <p><span style="font-weight: 400;">At rs12778366, the SIRT1 variant with the best-established impact on lifespan, only about 20% of the world&rsquo;s population has at least one copy of the beneficial &lsquo;C&rsquo; allele. Furthermore, only 1% of the world&rsquo;s population has the &lsquo;CC&rsquo; genotype.</span></p> <p><span style="font-weight: 400;">At the other relevant SNPs, the most beneficial genotypes are considerably more common. However, if your genotype file only has rs12778366 and you see a red face in the table below, don't worry! That just means you have room to improve your SIRT1 function.</span></p> <p>*9548109357498618*</p> <h2><span style="font-weight: 400;">Recommendations to Increase Lifespan</span></h2> <p><span style="font-weight: 400;">Fortunately, there are many, </span><em><span style="font-weight: 400;">many</span></em><span style="font-weight: 400;"> ways to activate SIRT1, so if you have risk alleles, you have a lot of strategies to choose from. Just about anything that increases cyclic AMP (cAMP) will also activate SIRT1, while many other hacks target SIRT1 directly [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331675/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The only caveats to keep in mind in your quest for longevity is that SIRT1 may promote </span><a href="http://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1</span></a><a href="http://selfhacked.com/blog/th17/"><span style="font-weight: 400;">7</span></a><span style="font-weight: 400;"> cells and worsen some autoimmune disorders like </span><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">multiple sclerosis</span></a><span style="font-weight: 400;">. If you have MS, be cautious using supplements that activate SIRT1, and make sure to research each one before trying it [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419343/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">With that in mind, it's important to discuss your genetic data and plans to activate SIRT1 with your doctor. Together, you can determine which strategies are right for you.</span></p> <p><span style="font-weight: 400;">*9204226178287343*</span></p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <p><span style="font-weight: 400;">Regular </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> is among the best ways to activate SIRT1 and feel younger for longer. In both rats and humans, exercise directly increases SIRT1 in the liver, muscles, and heart&mdash;and both young and elderly people can benefit [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514220/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="http://selfhacked.com/blog/12-reasons-embrace-cold/"><span style="font-weight: 400;">Cold</span></a><span style="font-weight: 400;"> exposure can activate SIRT1 by increasing cAMP, while </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sun</span></a><span style="font-weight: 400;"> exposure can activate SIRT1 by increasing nitric oxide [</span><a href="https://www.sciencedirect.com/science/article/pii/S1097276511009440"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042195/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593895/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Diet</span></h3> <p><span style="font-weight: 400;">The </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">omega-3</span></a><span style="font-weight: 400;"> fatty acid DHA is one of the best dietary activators of SIRT1. DHA is abundant in oily fish like salmon and anchovies, so include these in your diet if you can [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465287/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/"><span style="font-weight: 400;">Zinc</span></a><span style="font-weight: 400;"> is required for SIRT1 to function correctly, so it&rsquo;s important to avoid zinc deficiency. Oysters are by far the best source of zinc, but there&rsquo;s plenty in beef, pork, and dark chicken meat (like thigh) as well. If you are a </span><a href="https://selfhacked.com/blog/16-nutrients-vegans-arent-getting/"><span style="font-weight: 400;">vegan</span></a><span style="font-weight: 400;"> or vegetarian, you may find it more difficult to prevent zinc deficiency, and you may want to consider supplementing [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19923004"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <p><span style="font-weight: 400;">Many supplements are known to activate SIRT1. For a complete list, </span><a href="https://selfhacked.com/blog/nad-and-sirt1-their-role-in-chronic-health-issues/#How_to_Activate_SIRT1"><span style="font-weight: 400;">check out this post</span></a><span style="font-weight: 400;">. We&rsquo;ll try to include the most important and best studied here.</span></p> <p><a href="https://selfhacked.com/blog/nicotinamide-riboside/"><span style="font-weight: 400;">Nicotinamide riboside</span></a><span style="font-weight: 400;"> is a precursor to NAD+, which is required for SIRT1 to function. NAD+ availability tends to decrease over the human lifespan, so this may be an especially good supplement for middle-aged and older people [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22682224"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514220/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/pterostilbene/"><span style="font-weight: 400;">Pterostilbene</span></a><span style="font-weight: 400;"> is an antioxidant found in </span><a href="https://selfhacked.com/blog/blueberries-health-benefits/"><span style="font-weight: 400;">blueberries</span></a><span style="font-weight: 400;">. It is closely related to </span><a href="https://selfhacked.com/blog/top-15-scientific-health-benefits-of-resveratrol-with-references/"><span style="font-weight: 400;">resveratrol</span></a><span style="font-weight: 400;">, but may be more bioavailable and more effective. It activates SIRT1 on its own, but it seems to work especially well in combination with nicotinamide riboside [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26921129"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102308/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">If you don&rsquo;t eat a lot of oily fish, </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;"> supplements can help you get enough </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">DHA</span></a><span style="font-weight: 400;"> to keep SIRT1 running smoothly [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465287/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Finally, </span><a href="http://selfhacked.com/blog/19-health-benefits-of-berberine-with-references/"><span style="font-weight: 400;">berberine</span></a><span style="font-weight: 400;"> increases SIRT1 by activating AMPK, the master energy regulator. AMPK also activates FOXO1, FOXO3, and other longevity genes, making berberine a good choice if you have risk alleles in multiple genes [</span><a href="https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0450-z"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814416/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, you'd probably only want to take berberine if your blood glucose or HbA1C is higher, as it's a potent glucose lowering supplement.&nbsp;</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Many lifestyle, diet, and supplement choices activate SIRT1 either directly or by increasing cAMP or AMPK. The best include nicotinamide riboside (in combination with pterostilbene), exercise, and DHA.</span></p>
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45 | content_learn_more_8026384884635394_text == Based on the variants we looked at, your SIRT1 gene makes you somewhat more susceptible to DNA damage and age-related disease. You’ll need to increase SIRT1 expression, either directly or through AMPK or cAMP. Keep scrolling to find out how.
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rsIDs = rs4880,rs3758391,rs12778366,rs7896005,rs7895833
rsStatus = rs4880,SOD2,chr6,159692840,A,G,,,17,16,HET
rsStatus = rs3758391,SIRT1,chr10,67883584,T,A,C,G,22,1,HET
rsStatus = rs12778366,SIRT1,chr10,67883321,T,C,G,,12,13,HET
rsStatus = rs7896005,SIRT1,chr10,67891367,A,G,T,,27,0,Normal
rsStatus = rs7895833,,chr10,67863299,G,A,C,,20,9,HET
