450 | id == 450
450 | category_id == 26
450 | category_order == 23
450 | category_name == Allergies
450 | category_color == #C47AC0
450 | slug == IL1RL1-allergies
450 | title == An Immune System Receptor & Its Influence on Allergies (IL1RL1)
450 | meta_description == IL1RL1 is involved in type 2 immune responses. Variants of IL1RL1 has been associated with allergies. Read more here.
450 | summary == <p style="text-align:justify"><strong><em>IL1RL1</em> codes for a receptor that is involved in mediating type 2 immune response (Th2) activity. Read more to learn about the link between variants of <em>IL1RL1</em> and allergies.&nbsp;</strong><br />  &nbsp;</p>
450 | overall_score_text == Your Allergy Score (based on IL1RL1 gene)
450 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/IL1RL1-IL18R1-Allergies.jpg
450 | author_id == 14
450 | author_name == Shany Lahan
450 | author_title == MS (Neuroscience)
450 | author_order == 5
450 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
450 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
450 | reviewer == None
450 | medical_reviewer_id == 11
450 | medical_reviewer_name == Puya Yazdi
450 | medical_reviewer_title == MD
450 | publish_date == 2020
450 | publish_date == 11
450 | publish_date == 2
450 | avg_rating == 5.0
450 | tags_id == 860
450 | tags_name == Allergic Diseases
450 | tags_id == 591
450 | tags_name == IgE Antibodies
450 | tags_id == 367
450 | tags_name == IL-13
450 | tags_id == 898
450 | tags_name == IL1RL1 Gene
450 | tags_id == 894
450 | tags_name == IL-33
450 | tags_id == 864
450 | tags_name == IL-4
450 | tags_id == 891
450 | tags_name == Th2
450 | permissions_favorite == False
450 | permissions_rate == False
450 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">IL1RL1 </span></em><span style="font-weight: 400;">codes for a receptor involved in mediating type 2 immune response (Th2) activity. Variants of </span><em><span style="font-weight: 400;">IL1RL1 </span></em><span style="font-weight: 400;">may play a role in allergies by increasing the production or activity of IL1RL1. Lifestyle modifications may counteract the effects of these variants by decreasing IL1RL1 production or activity.&nbsp;</span></span></p> <h2 style="text-align: justify;"><strong><em>IL1RL1 </em></strong><strong>and Allergies</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/il1rl1/"><em><span style="font-weight: 400;">IL1RL1 </span></em><span style="font-weight: 400;">gene</span></a><span style="font-weight: 400;"> codes for interleukin 1 receptor-like 1 (IL1RL1).&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">IL1RL1 can be activated by </span><a href="https://selfdecode.com/blog/article/il33-th2-allergies-446/"><span style="font-weight: 400;">IL-33</span></a><span style="font-weight: 400;">, an immune system protein (cytokine) that can be released from cells that line the airway upon exposure to an allergen (allergy-inducing substance) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23380221/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">IL1RL1 is primarily found on the surfaces of immune system cells that release </span><a href="https://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">type 2 immune response</span></a><span style="font-weight: 400;"> (Th2) cytokines, such as </span><a href="https://selfdecode.com/blog/article/il4-allergies-426/"><span style="font-weight: 400;">IL-4</span></a><span style="font-weight: 400;">, IL-5, and </span><a href="https://selfdecode.com/blog/article/il13-allergies-435/"><span style="font-weight: 400;">IL-13</span></a><span style="font-weight: 400;">. Therefore, activation of IL1RL1 via IL-33 can raise levels of Th2-related cytokines [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23380221/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24568840/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Many scientists consider elevated Th2 activity to underlie a number of allergic diseases, such as asthma. Indeed, the release of IL-4 and IL-13 from Th2 cells has been shown to enhance the responsiveness of the airway to allergens [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532591/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">IL-4 and IL-13 have also been linked to the elevated release of a type of antibody called IgE. The release of IgE antibodies from white blood cells is an early step in allergic reaction progression [</span><a href="https://www.jacionline.org/article/S0091-6749(97)70293-8/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532591/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">IL1RL1 </span></em><span style="font-weight: 400;">have been associated with allergies. These variants may increase production or activity of IL1RL1, which may lead to excess release of Th2-related cytokines and elevated IgE antibody levels (after binding by IL-33) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922420/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753407/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068780/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>IL1RL1</em></strong><strong> Results for Allergies</strong></h2> <p style="text-align: justify;">*6728356729452829*</p> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Primary SNP</strong></span></p> <p style="text-align: justify;"><strong><em>IL1RL1 </em></strong><a href="https://selfdecode.com/snp/rs950880/"><strong>rs950880</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of allergies</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with allergies</span></li> </ul> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Other Important SNPs</strong></span></p> <p style="text-align: justify;"><strong><em>IL1RL1 </em></strong><a href="https://selfdecode.com/snp/rs3771175/"><strong>rs3771175</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922420/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of allergies, relative to &lsquo;A&rsquo;&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Decreased risk of allergies, relative to &lsquo;T&rsquo;</span></li> </ul> <p style="text-align: justify;"><strong><em>IL1RL1 </em></strong><a href="https://selfdecode.com/snp/rs10865050/"><strong>rs10865050</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of allergies, relative to &lsquo;A&rsquo;&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Decreased risk of allergies, relative to &lsquo;G&rsquo;</span></li> </ul> <p style="text-align: justify;"><strong><em>IL1RL1 </em></strong><a href="https://selfdecode.com/snp/rs10189629/"><strong>rs10189629</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753407/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased risk of allergies, relative to &lsquo;A&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Decreased risk of allergies, relative to &lsquo;C&rsquo;</span></li> </ul> <p style="text-align: justify;"><strong><em>IL1RL1 </em></strong><a href="https://selfdecode.com/snp/rs10208293/"><strong>rs10208293</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(19)30055-4/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of allergies, relative to &lsquo;A&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Decreased risk of allergies, relative to &lsquo;G&rsquo;</span></li> </ul> <p style="text-align: justify;">*3055706615335671*</p> <h2 style="text-align: left;"><strong>Recommendations for Improving Allergies</strong></h2> <p style="text-align: justify;">*9931346088096880*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Sun Exposure (Vitamin D)</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Exposure to </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sunlight</span></a><span style="font-weight: 400;"> is the best way to increase levels of </span><a href="https://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> in the blood. Vitamin D deficiency has been associated with asthma and allergies in children [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675563/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17919705/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Vitamin D supplements taken alongside an antihistamine improved symptoms of hay fever in people with vitamin D deficiency, in comparison to the antihistamine alone. However, this improvement was not significant until 8 weeks of supplementation, suggesting that symptom improvement might not occur until vitamin D has been adequately replenished in the body [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31332549/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Interestingly, vitamin D has been shown to increase the production of a receptor that is closely related to IL1RL1. While this receptor can still bind IL-33, it can&rsquo;t mediate the release of Th2-related cytokines, and thus effectively functions as a decoy. This is because it&rsquo;s found free-floating, rather than connected to immune system cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348345/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Increased production of the IL1RL1 decoy has been suggested to reduce the IL-33-mediated release of Th2-related cytokines, due to reduced binding of IL-33 to IL1RL1 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348345/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Sunlight is the best source of vitamin D. Vitamin D may improve allergies by increasing production of an IL1RL1 decoy, which may reduce binding of IL-33 to IL1RL1 and ultimately decrease IL1RL1 activity.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Avoid Air Pollution</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Research has linked exposure to air pollution with higher odds of allergic conditions, especially asthma and hay fever [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192198/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034084/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803404/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Multiple studies have suggested that air pollution may increase production of IL-33 and IL1RL1, promote IL-33-mediated activation of IL1RL1, and elevate airway responsiveness and inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29331644/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30159930/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Those carrying </span><em><span style="font-weight: 400;">IL1RL1 </span></em><span style="font-weight: 400;">risk variants may choose to spend more time in nature and non-industrialized environments, in order to prevent and relieve symptoms of asthma and other allergic diseases.</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Avoiding air pollution may improve allergies by decreasing production of IL-33 and IL1RL1, reducing activity of IL1RL1, and preventing excessive airway responsiveness and inflammation.</span></p>
450 | content_snp_table_6728356729452829_key == 6728356729452829
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450 | content_snp_table_6728356729452829_hidden == False
450 | content_learn_more_3055706615335671_key == 3055706615335671
450 | content_learn_more_3055706615335671_blur == True
450 | content_learn_more_3055706615335671_hidden == False
450 | content_learn_more_3055706615335671_text == Based on the variants we looked at, your IL1RL1 gene makes you somewhat more likely to develop allergic diseases. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Getting adequate sun exposure and avoiding air pollution may help. Keep scrolling to find out more.
450 | content_recommendation_9931346088096880_key == 9931346088096880
450 | content_recommendation_9931346088096880_blur == True
450 | content_recommendation_9931346088096880_hidden == False
rsIDs = rs10865050,rs10208293,rs3771175,rs950880,rs10189629
rsStatus = rs10865050,IL1RL1,chr2,102324851,G,A,,,30,0,Normal
rsStatus = rs10208293,IL1RL1,chr2,102349850,G,A,,,31,0,Normal
rsStatus = rs3771175,IL1RL1,chr2,102343750,T,A,,,33,0,Normal
rsStatus = rs950880,IL1RL1,chr2,102316102,C,A,G,,7,28,HET
rsStatus = rs10189629,,chr2,102263004,C,A,T,,25,0,Normal
