451 | id == 451
451 | category_id == 26
451 | category_order == 23
451 | category_name == Allergies
451 | category_color == #C47AC0
451 | slug == IL7R-allergies
451 | title == The Development of White Blood Cells in Allergies (IL7R)
451 | meta_description == IL7R encodes a receptor for IL-7, an inflammatory cytokine that helps develop white blood cells. What is its role in allergies?
451 | summary == <p><strong><em>IL7R </em>encodes a receptor for IL-7, an inflammatory cytokine that helps develop white blood cells. What is its role in allergies? Find out here.</strong></p>
451 | overall_score_text == Your Allergy Score (based on IL7R)
451 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/IL7R-Allergies.jpg
451 | author_id == 1
451 | author_name == Jasmine Foster
451 | author_title == BSc, BEd
451 | author_order == 36
451 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
451 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
451 | reviewer == None
451 | medical_reviewer_id == 11
451 | medical_reviewer_name == Puya Yazdi
451 | medical_reviewer_title == MD
451 | publish_date == 2020
451 | publish_date == 11
451 | publish_date == 2
451 | avg_rating == 5.0
451 | tags_id == 860
451 | tags_name == Allergic Diseases
451 | tags_id == 97
451 | tags_name == Allergies
451 | tags_id == 98
451 | tags_name == Asthma
451 | tags_id == 242
451 | tags_name == B cells
451 | tags_id == 99
451 | tags_name == Eczema
451 | tags_id == 848
451 | tags_name == Hay Fever
451 | tags_id == 899
451 | tags_name == IL-7
451 | tags_id == 900
451 | tags_name == IL7R Gene
451 | tags_id == 24
451 | tags_name == Inflammation
451 | tags_id == 442
451 | tags_name == T Cells
451 | permissions_favorite == False
451 | permissions_rate == False
451 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">IL7R </span></em><span style="font-weight: 400;">encodes a receptor for the IL-7 cytokine. Variants of </span><em><span style="font-weight: 400;">IL7R </span></em><span style="font-weight: 400;">may play a role in allergies by developing and activating white blood cells. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by reducing IL-7 signalling and blocking the JAK/STAT pathway.</span></p> <h2><strong><em>IL7R</em></strong><strong> and Allergies</strong></h2> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">IL7R</span></em><span style="font-weight: 400;"> gene encodes a receptor for interleukin-7 (IL-7), an inflammatory cytokine [</span><a href="https://www.ncbi.nlm.nih.gov/gene/3574"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">IL-7 is mainly produced by cells in the intestinal lining and mucous membranes (such as those in the mouth, respiratory passages, and reproductive tract). It is important for the development and survival of </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/gene/3574"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">IL-7 is essential for the immune system to fight off infection, but it may also contribute to an unhealthy inflammatory response. HIV patients tend to have higher than normal IL-7 levels, and high IL-7 is associated with severe disease in COVID-19 infection [</span><a href="https://www.ncbi.nlm.nih.gov/gene/3574"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826542/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358500/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">On the other hand, clinical studies have found that giving IL-7 intravenously may improve disease outcomes in HIV and some forms of cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358500/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463645/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">IL-7 and its receptor are not especially well studied in the context of allergy and asthma, but some research suggests that people with asthma may have a greater number of IL7R receptors in their white blood cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851244/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The IL7R receptor sends signals through the </span><a href="https://www.selfdecode.com/gene/jak2/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">JAK</span></a><span style="font-weight: 400;">/STAT inflammatory pathway, and blocking JAK/STAT reversed the effects of IL-7 in a cell study. Thus, people who tend to have excessively high IL-7 may benefit more than most from blocking the JAK/STAT pathway [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729333/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">IL-7 promotes the development of white blood cells through its receptor, IL7R. High levels of IL7R may increase inflammation in allergies and asthma, and this inflammation may be reversed by blocking the JAK/STAT pathway.</span></p> <h2><strong>Your </strong><strong><em>IL7R</em></strong><strong> Results for Allergies</strong></h2> <p>*6330137525625954*</p> <p><strong>IL7R </strong><a href="https://selfdecode.com/snp/rs7717955/"><strong>rs7717955</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively higher allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Possibly protective against allergic inflammation</span></li> </ul> <p><strong>IL7R </strong><a href="https://selfdecode.com/snp/rs11742240/"><strong>rs11742240</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451732/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively higher allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Possibly protective against allergic inflammation</span></li> </ul> <p><strong>IL7R </strong><a href="https://selfdecode.com/snp/rs11742270/"><strong>rs11742270</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively higher allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Possibly protective against allergic inflammation</span></li> </ul> <p><strong>IL7R </strong><a href="https://selfdecode.com/snp/rs4594881/"><strong>rs4594881</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31619474/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively higher allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Possibly protective against allergic inflammation</span></li> </ul> <p><strong>IL7R </strong><a href="https://selfdecode.com/snp/rs987106/"><strong>rs987106</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively higher allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Possibly protective against allergic inflammation</span></li> </ul> <p><strong>IL7R </strong><a href="https://selfdecode.com/snp/rs6881706/"><strong>rs6881706</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively higher allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Possibly protective against allergic inflammation</span></li> </ul> <p><strong>IL7R </strong><a href="https://selfdecode.com/snp/rs10214273/"><strong>rs10214273</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively higher allergic inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Possibly protective against allergic inflammation</span></li> </ul> <p>*9490841507056873*</p> <h2><strong>Recommendations for Improving Allergies</strong></h2> <p>*8071152898247551*</p> <h3><strong>Sunlight &amp; Vitamin D</strong></h3> <p><span style="font-weight: 400;">Some variants of the </span><em><span style="font-weight: 400;">IL7R </span></em><span style="font-weight: 400;">gene have been associated with </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> deficiency in humans. Furthermore, vitamin D may stimulate the development of </span><a href="http://selfhacked.com/blog/treg/"><span style="font-weight: 400;">Tregs</span></a><span style="font-weight: 400;">, which may counteract the effects of IL7R receptor binding [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175123/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063672"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759203/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Vitamin D has also been found to reduce JAK/STAT signalling in cell studies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499847/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16547967/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.biorxiv.org/content/10.1101/2020.02.18.946335v1"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Vitamin D deficiency has been associated with asthma and allergies in children [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675563/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17919705/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In people with allergic rhinitis and vitamin D deficiency, supplementation improved the symptoms. This improvement was not significant at 4 weeks, suggesting that symptom improvement might not occur until vitamin D has been adequately replenished [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31332549/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Healthy exposure to </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sunlight</span></a><span style="font-weight: 400;"> is the best way of increasing your blood vitamin D levels. In addition, you can eat food sources of vitamin D (such as fatty fish, liver, egg yolks, and dairy) or take supplements [</span><a href="https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">People with some </span><em><span style="font-weight: 400;">IL7R</span></em><span style="font-weight: 400;"> variants may be prone to vitamin D deficiency, which in turn is common in people with allergies. You can get vitamin D from sunlight or from supplements.</span></span></p> <h3><strong>Mediterranean Diet</strong></h3> <p><span style="font-weight: 400;">The Mediterranean diet may reduce both IL-7 and IL7R levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443792/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452202/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis associated adherence to a Mediterranean diet with a slightly reduced incidence of asthma and wheezing [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23578354/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet may reduce IL-7 signalling and has been associated with reduced asthma symptom severity.</span></p> <h3><strong>Quercetin</strong></h3> <p><a href="https://selfhacked.com/blog/quercetin-23-scientifically-proven-benefits-quercetin/"><span style="font-weight: 400;">Quercetin</span></a><span style="font-weight: 400;"> is a plant flavonoid and antioxidant recognized as one of the best natural </span><a href="https://selfhacked.com/blog/natural-antihistamines/"><span style="font-weight: 400;">antihistamines</span></a><span style="font-weight: 400;">. It has been found to block a cellular pathway that activates the IL7R receptor [</span><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199332"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one human trial, quercetin even outperformed Cromolyn, a mast cell-stabilizing drug, in reducing </span><a href="http://selfhacked.com/blog/histamine/"><span style="font-weight: 400;">histamine</span></a><span style="font-weight: 400;"> release and improving dermatitis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314669/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18958421/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Preliminary clinical research shows that a formulation with quercetin added to conventional therapy reduced the symptoms of asthma and rhinitis, and the need for medication [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31578841/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Quercetin is available as a supplement but is also common in fruits and vegetables. Food sources of this flavonoid include vegetables such as </span><a href="https://www.selfhacked.com/blog/capers/"><span style="font-weight: 400;">capers</span></a><span style="font-weight: 400;">, onions, eggplant, celery, and asparagus, fruits such as berries, apples, and oranges, nuts, and tea (both </span><a href="https://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">green</span></a><span style="font-weight: 400;"> and black) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808895/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Quercetin may block the activation of IL7R. It has also shown promise against allergies, mainly for its potential to block histamine release.</span></p>
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451 | content_learn_more_9490841507056873_text == Based on the variants we looked at, your IL7R gene is somewhat associated with allergic inflammation. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Vitamin D, Quercetin, and a Mediterranean diet may help. Keep scrolling to find out more.
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rsIDs = rs11742240,rs6881706,rs4594881,rs7717955,rs11742270,rs10214273,rs987106
rsStatus = rs11742240,,chr5,35881274,G,A,T,,38,0,Normal
rsStatus = rs6881706,IL7R,chr5,35879054,G,C,T,,29,0,Normal
rsStatus = rs4594881,LOC105374724,chr5,35846713,G,T,,,21,9,HET
rsStatus = rs7717955,IL7R,chr5,35862739,C,T,,,11,10,HET
rsStatus = rs11742270,,chr5,35881341,G,A,,,21,18,HET
rsStatus = rs10214273,,chr5,35883884,T,A,G,,34,0,Normal
rsStatus = rs987106,IL7R,chr5,35875491,A,T,,,18,18,HET
