452 | id == 452
452 | category_id == 27
452 | category_order == 24
452 | category_name == Fatigue
452 | category_color == #C47AC0
452 | slug == DRD2-fatigue
452 | title == Can the Happiness Hormone Keep You From Feeling Tired? (DRD2)
452 | meta_description == DRD2 encodes the D2 dopamine receptor, best known for its role in stress and reward. How does it affect feelings of fatigue?
452 | summary == <p><strong><em>DRD2 </em>encodes the D2 dopamine receptor, which is best known for its role in stress and reward. How does it affect feelings of fatigue? Find out here.</strong></p>
452 | overall_score_text == Your Tiredness Score (based on DRD2)
452 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/DRD2-ANKK1-PTSD.jpg
452 | author_id == 1
452 | author_name == Jasmine Foster
452 | author_title == BSc, BEd
452 | author_order == 36
452 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
452 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
452 | reviewer == None
452 | medical_reviewer_id == 11
452 | medical_reviewer_name == Puya Yazdi
452 | medical_reviewer_title == MD
452 | publish_date == 2020
452 | publish_date == 11
452 | publish_date == 3
452 | avg_rating == 4.666666666666667
452 | tags_id == 51
452 | tags_name == Dopamine
452 | tags_id == 902
452 | tags_name == Dopamine Receptor
452 | tags_id == 156
452 | tags_name == DRD2 Gene
452 | tags_id == 901
452 | tags_name == Energy Levels
452 | tags_id == 68
452 | tags_name == Fatigue
452 | tags_id == 244
452 | tags_name == Fish oil
452 | tags_id == 903
452 | tags_name == Melatonin
452 | permissions_favorite == False
452 | permissions_rate == False
452 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">DRD2</span></em><span style="font-weight: 400;"> encodes the D2 dopamine receptor. Variants of </span><em><span style="font-weight: 400;">DRD2</span></em><span style="font-weight: 400;"> may play a role in feelings of fatigue by reducing sensitivity to dopamine in some parts of the brain. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by increasing either the number or sensitivity of D2 receptors.</span></p> <h2><strong><em>DRD2</em></strong><strong> and Fatigue</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/drd2/"><em><span style="font-weight: 400;">DRD2</span></em></a> <span style="font-weight: 400;">gene encodes a </span><a href="https://selfhacked.com/blog/dopamine/"><span style="font-weight: 400;">dopamine</span></a><span style="font-weight: 400;"> receptor. Dopamine, which is important for signalling pleasure and reward, can also reduce the sensation of </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> and reduce </span><a href="https://selfhacked.com/blog/natural-treatments-anxiety/"><span style="font-weight: 400;">anxiety</span></a><span style="font-weight: 400;"> and fear [</span><a href="https://ghr.nlm.nih.gov/gene/DRD2"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18457535/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Because dopamine is highly involved in many processes that are critical for proper cognitive function, SNPs in the </span><em><span style="font-weight: 400;">DRD2 </span></em><span style="font-weight: 400;">gene can significantly impact cognitive ability and mental health [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10611493"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24713612"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839917/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Dopamine and its receptors also play a part in controlling the </span><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;">-wake cycle. Mainly, dopamine can help keep you awake and alert [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17275369"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Low levels of </span><a href="https://selfdecode.com/gene/DRD2/"><span style="font-weight: 400;">DRD2</span></a><span style="font-weight: 400;"> activation reduce wakefulness and increase Slow Wave (deep) and REM sleep. Low DRD2 furthermore causes rats to become slow and lethargic; the more DRD2 receptors the rats expressed, the more likely they were to spontaneously move around their enclosures [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17275369"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Furthermore, compounds that block both D1 and D2 receptors reduce wakefulness and increase deep sleep [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17275369"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Thus, it&rsquo;s unsurprising that at least one variant in the </span><em><span style="font-weight: 400;">DRD2</span></em><span style="font-weight: 400;"> gene has been associated with </span><a href="https://selfhacked.com/blog/people-get-tired-even-enough-sleep/"><span style="font-weight: 400;">feeling tired in the daytime</span></a><span style="font-weight: 400;">&nbsp;[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822465/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17275369"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">DRD2</span></em><span style="font-weight: 400;"> encodes a receptor for dopamine that plays a role in the sleep-wake cycle. One variant in this gene has been associated with reduced wakefulness and increased lethargy.</span></span></p> <h2><strong>Your </strong><strong><em>DRD2</em></strong><strong> Results for Fatigue</strong></h2> <p>*6707902944236288*</p> <p><strong>DRD2 </strong><a href="https://selfdecode.com/snp/rs6277/"><strong>rs6277</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822465/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively increased feelings of tiredness in the daytime</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Possibly protective against feeling tired in the daytime</span></li> </ul> <p>*1868951105004677*</p> <h2><strong>Recommendations for Increasing Wakefulness</strong></h2> <p>*1777412974203880*</p> <h3><strong>Yoga</strong></h3> <p><a href="https://selfhacked.com/blog/health-benefits-yoga/"><span style="font-weight: 400;">Yoga</span></a><span style="font-weight: 400;">&nbsp;may relieve </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> in part by improving dopamine signalling, making them potentially helpful to people with low DRD2 activity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27537781"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939561/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26752098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769029/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a meta-analysis of studies on </span><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">multiple sclerosis</span></a><span style="font-weight: 400;"> symptoms, yoga improved fatigue associated with the disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229199/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Another study found that yoga improved energy levels in 155 patients with unexplained chronic fatigue [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15889950/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Yoga and meditation may improve dopamine signalling and have been found to reduce fatigue associated with multiple sclerosis and </span><span style="font-weight: 400;">chronic fatigue syndrome</span><span style="font-weight: 400;">.</span></span></p> <h3><strong>Rhodiola</strong></h3> <p><strong><span style="font-weight: 400;">According to preliminary research, </span><a href="https://selfhacked.com/blog/rhodiola/"><span style="font-weight: 400;">rhodiola</span></a><span style="font-weight: 400;"> may increase brain dopamine levels [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856322/">R</a>,<a href="https://www.ncbi.nlm.nih.gov/pubmed/15548230"> R</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976749/">R</a>].</span></strong></p> <p><strong><span style="font-weight: 400;">Standardized </span><a href="https://selfhacked.com/blog/rhodiola/"><span style="font-weight: 400;">rhodiola</span></a><span style="font-weight: 400;"> extracts reduced fatigue and cognitive impairment caused by stress and burnout in different studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10839209/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19170145/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11081987/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12725561/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19016404/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10763116/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370380/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20374974/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></strong></p> <h3><strong>Melatonin</strong></h3> <p><span style="font-weight: 400;">Longer-term (at least 2 weeks) supplementation with </span><a href="https://selfhacked.com/blog/melatonin/"><span style="font-weight: 400;">melatonin</span></a><span style="font-weight: 400;"> increased the sensitivity of DRD2 receptors in the brains of rats [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690488/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some studies have found that melatonin supplements improved fatigue severity in patients with chronic fatigue syndrome (CFS) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16420393/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A study of people with insomnia found that melatonin helped regulate the sleep-wake cycle, but did not necessarily improve daytime sleepiness. However, another study of people with jet lag found that melatonin supplementation did help with daytime fatigue. The effectiveness of melatonin may vary widely from person to person, depending on genetics and other factors [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774131/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273450/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Long-term melatonin supplementation may increase the sensitivity of DRD2 receptors and improve fatigue in some people.</span></p>
452 | content_snp_table_6707902944236288_key == 6707902944236288
452 | content_snp_table_6707902944236288_blur == True
452 | content_snp_table_6707902944236288_hidden == False
452 | content_learn_more_1868951105004677_key == 1868951105004677
452 | content_learn_more_1868951105004677_blur == True
452 | content_learn_more_1868951105004677_hidden == False
452 | content_learn_more_1868951105004677_text == Based on the variants we looked at, your DRD2 gene is somewhat associated with feeling tired during the day. However, this doesn't necessarily reflect your overall risk of fatigue; it’s just one gene related to it. Yoga, fish oil, and melatonin may help. Keep scrolling to find out more.
452 | content_recommendation_1777412974203880_key == 1777412974203880
452 | content_recommendation_1777412974203880_blur == True
452 | content_recommendation_1777412974203880_hidden == False
rsIDs = rs6277
rsStatus = rs6277,DRD2,chr11,113412737,G,A,,,21,13,HET
