453 | id == 453
453 | category_id == 26
453 | category_order == 23
453 | category_name == Allergies
453 | category_color == #C47AC0
453 | slug == HLA-allergies
453 | title == Crucial Immunity Genes & Allergic Reactions (HLA)
453 | meta_description == HLA genes play a crucial role in the immune system. Click to learn about their link with allergies.
453 | summary == <p><strong>Did you know that HLA genes are key players in your immunity? Read this post to learn their associations with allergies, and get gene-based tips!</strong></p>
453 | overall_score_text == Your Allergies Score (based on HLA genes)
453 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/HLA-Allergies.jpg
453 | author_id == 9
453 | author_name == Aleksa Ristic
453 | author_title == MS (Pharmacy)
453 | author_order == 45
453 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
453 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
453 | reviewer == None
453 | medical_reviewer_id == 11
453 | medical_reviewer_name == Puya Yazdi
453 | medical_reviewer_title == MD
453 | publish_date == 2020
453 | publish_date == 11
453 | publish_date == 3
453 | avg_rating == 5.0
453 | tags_id == 860
453 | tags_name == Allergic Diseases
453 | tags_id == 422
453 | tags_name == HLA complex
453 | tags_id == 72
453 | tags_name == HLA Genes
453 | tags_id == 95
453 | tags_name == Immune System
453 | tags_id == 24
453 | tags_name == Inflammation
453 | permissions_favorite == False
453 | permissions_rate == False
453 | content_article == <p>&nbsp;</p> <table style="height: 56px; width: 100%; border-collapse: collapse; margin-left: auto; margin-right: auto;" border="1" cellpadding="10"> <tbody> <tr> <td style="width: 100%; text-align: justify;"><strong>Note:</strong> The <em>HLA</em> genes are analyzed in our <strong><a href="https://get.selfdecode.com/gene-reports/inflammation/"><em>Inflammation</em></a><em> and <a href="https://get.selfdecode.com/guthealth/" target="_blank" rel="noopener">Gut Health</a> DNA Wellness Reports</em></strong>, along with many other genes. If you're looking for comprehensive genetic reports on inflammation and gut health, check them out!</td> </tr> </tbody> </table> <p>&nbsp;</p> <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>HLA genes make proteins that stimulate the immune response against foreign substances. Increased HLA activity may contribute to allergic reactions.<br /><br /></strong><strong>Specific gene variants may increase HLA activity. They have been associated with different allergic conditions.<br /><br /></strong><strong>Recommendations given below may relieve allergies by targeting your HLA variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>The HLA System in Allergic Reactions</strong></h2> <p><span style="font-weight: 400;">The human leukocyte antigen (HLA) system comprises human genes that make proteins on </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;">. HLA proteins help flag and remove external threats that may harm the body [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628004/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">HLA proteins target harmful foreign peptides and stimulate the immune response against them. However, in people with allergies, HLA proteins may have increased activity or impaired structure. These changes cause them to target otherwise benign compounds (such as pollen or cat dander) and provoke allergic reactions [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC474884/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">HLA genes play a role in countless other health conditions, including:</span></p> <ul> <li style="font-weight: 400;"><a href="https://selfdecode.com/blog/article/hla-autoimmunity-diabetes-408/"><span style="font-weight: 400;">Diabetes</span></a></li> <li style="font-weight: 400;"><a href="https://selfdecode.com/blog/article/hla-drb1-thyroid-autoimmunity-92/"><span style="font-weight: 400;">Thyroid autoimmunity</span></a></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/"><span style="font-weight: 400;">IBD</span></a><span style="font-weight: 400;">&nbsp;</span></li> <li style="font-weight: 400;"><a href="https://selfdecode.com/blog/article/hla-dqa1-b1-gluten-celiac-disease-169/"><span style="font-weight: 400;">Celiac disease</span></a></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">HLA genes make proteins that stimulate the immune response against foreign substances. Increased HLA activity may cause allergic reactions to otherwise benign compounds.</span></p> <p>&nbsp;</p> <h2><strong>Your HLA Results for Allergies</strong></h2> <p>*1841119750879054*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/gene/hla-dqa1/"><strong>HLA-DQA1</strong></a> <a href="https://selfdecode.com/snp/rs6906021/"><strong>rs6906021</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922420/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with higher odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may increase HLA activity.</span></li> </ul> <p><a href="https://selfdecode.com/gene/hla-c/"><strong>HLA-C</strong></a> <a href="https://selfdecode.com/snp/rs9266772/"><strong>rs9266772</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753407/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with higher odds of allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with allergic diseases</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may increase HLA activity.</span></li> </ul> <p><strong>Other Important SNPs:</strong></p> <p><a href="https://selfdecode.com/gene/hla-dqa1/"><strong>HLA-DQA1</strong></a> <a href="https://selfdecode.com/snp/rs9271588/"><strong>rs9271588</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31301374/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:&nbsp;</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with higher odds of wheat allergy</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with allergic diseases</span></li> </ul> <p><a href="https://selfdecode.com/gene/hla-dqa1/"><strong>HLA-DQA1</strong></a> <a href="https://selfdecode.com/snp/rs2187668/"><strong>rs2187668</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15536412/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher odds of allergy to latex &amp; fruits</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with allergic diseases</span></li> </ul> <p>*9023772269526424*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Allergic Reactions</strong></h2> <p>*7628293294995228*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Sun Exposure</strong></h4> <p><span style="font-weight: 400;">Some research suggests that UV light and </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> help control the immune response by suppressing HLA proteins [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603567/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626364/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047889/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16046118"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Hence, it&rsquo;s no surprise that vitamin D deficiency correlates with asthma and allergies in children [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675563/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17919705/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Moderate </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sun exposure</span></a><span style="font-weight: 400;"> is the best way to get natural UV light and vitamin D [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566188/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20635942"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Moderate sun exposure may help prevent allergies by targeting your HLA variants.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Black Seed</strong></h4> <p><span style="font-weight: 400;">The active ingredient of </span><a href="https://selfhacked.com/blog/black-cumin-seed-nigella-sativa-top-scientific-benefits/"><span style="font-weight: 400;">black seed</span></a><span style="font-weight: 400;">, thymoquinone, may reduce HLA activity in immune cells [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20110691"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In 2 clinical trials of people with different allergic diseases (allergic rhinitis, asthma, and eczema), black seed supplementation improved the symptoms and well-being. Black seed also enhanced the effectiveness of immunotherapy for dust-mite allergy in another study [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20947211/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14669258/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20357504/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Both the oil and extract of black seed may reduce the frequency of asthma attacks, relieve wheezing, and improve lung function when taken for 2-3 months [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17868210/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28093815/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Black seed supplementation may counteract your variants and help relieve allergies.</span></p> <h4><strong>Probiotics</strong></h4> <p><a href="https://selfhacked.com/blog/a1probiotics-good-bacteria/"><span style="font-weight: 400;">Probiotics</span></a><span style="font-weight: 400;"> have well-known beneficial effects on autoimmune and allergic conditions. In one study, a probiotic containing different </span><em><span style="font-weight: 400;">Lactobacillus</span></em><span style="font-weight: 400;"> and </span><em><span style="font-weight: 400;">Bifidobacterium</span></em><span style="font-weight: 400;"> strains reduced HLA activity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213508/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181139/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569369/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406271/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Different probiotic strains may improve the symptoms of:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Allergic rhinitis (</span><a href="http://selfhacked.com/blog/l-acidophilus/"><em><span style="font-weight: 400;">L. acidophilus</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/health-benefits-l-plantarum/"><em><span style="font-weight: 400;">L. plantarum</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-casei/"><em><span style="font-weight: 400;">L. casei</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/b-longum/"><em><span style="font-weight: 400;">B. longum</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/b-animalis/"><em><span style="font-weight: 400;">B. animalis</span></em></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27442711/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16195581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18072744/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18510694/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Pollen and dust mites allergy ( </span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-johnsonii/"><em><span style="font-weight: 400;">L. johnsonii</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/c-butyricum/"><em><span style="font-weight: 400;">C. butyricum</span></em></a><span style="font-weight: 400;">) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27401319/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22513081/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Asthma (</span><a href="https://selfhacked.com/blog/l-salivarius/"><em><span style="font-weight: 400;">L.salivarius</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/b-breve/"><em><span style="font-weight: 400;">Bifidobacterium. breve</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/c-butyricum/"><em><span style="font-weight: 400;">C. butyricum</span></em></a><span style="font-weight: 400;">) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446640/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746628/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Milk and peanut allergies (</span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-delbrueckii/"><em><span style="font-weight: 400;">L. delbrueckii</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-fermentum/"><em><span style="font-weight: 400;">L. fermentum</span></em></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10024217/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15241356/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370499/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23140691/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21385515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Supplementation with <em>Lactobacillus</em> and <em>Bifidobacterium </em>probiotic strains may relieve different types of allergy by targeting your gene variants.</span></p>
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453 | content_learn_more_9023772269526424_text == Based on the variants we looked at, your HLA genes are associated with slightly higher odds of allergies. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Get more sunlight and consider supplementing with black seed and probiotics to relieve allergies. Keep reading to learn more.
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rsIDs = rs2187668,rs9266772,rs6906021,rs9271588
rsStatus = rs2187668,HLA-DQA1,chr6,32638107,C,T,,,0,0,Unknown
rsStatus = rs9266772,,chr6,31384336,T,A,C,,19,0,Normal
rsStatus = rs6906021,HLA-DQB1-AS1,chr6,32658534,T,C,,,23,0,Normal
rsStatus = rs9271588,,chr6,32623176,T,C,,,14,0,Normal
