459 | id == 459
459 | category_id == 27
459 | category_order == 24
459 | category_name == Fatigue
459 | category_color == #C47AC0
459 | slug == ADRA1A-fatigue
459 | title == The Fight or Flight Response in Chronic Fatigue Syndrome (ADRA1A)
459 | meta_description == ADRA1A encodes a receptor for epinephrine and contributes to the fight or flight response. What is its role in fatigue?
459 | summary == <p><strong><em>ADRA1A </em>encodes a receptor for epinephrine and contributes to the fight or flight response. What is its role in chronic fatigue? Read on to find out.</strong></p>
459 | overall_score_text == Your Fatigue Score (based on ADRA1A)
459 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ADRA1A-Tiredness-CFS.jpg
459 | author_id == 1
459 | author_name == Jasmine Foster
459 | author_title == BSc, BEd
459 | author_order == 36
459 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
459 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
459 | reviewer == None
459 | medical_reviewer_id == 11
459 | medical_reviewer_name == Puya Yazdi
459 | medical_reviewer_title == MD
459 | publish_date == 2020
459 | publish_date == 11
459 | publish_date == 5
459 | avg_rating == 5.0
459 | tags_id == 670
459 | tags_name == ADRA1A Gene
459 | tags_id == 671
459 | tags_name == Adrenergic System
459 | tags_id == 904
459 | tags_name == Chronic Fatigue Syndrome
459 | tags_id == 53
459 | tags_name == Epinephrine
459 | tags_id == 68
459 | tags_name == Fatigue
459 | tags_id == 52
459 | tags_name == Norepinephrine
459 | permissions_favorite == False
459 | permissions_rate == False
459 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">ADRA1A </span></em><span style="font-weight: 400;">encodes a receptor for epinephrine. Variants of </span><em><span style="font-weight: 400;">ADRA1A</span></em><span style="font-weight: 400;"> may play a role in fatigue by decreasing epinephrine signalling. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by restoring epinephrine to normal levels.</span></p> <h2><strong><em>ADRA1A </em></strong><strong>and Fatigue</strong></h2> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">ADRA1A </span></em><span style="font-weight: 400;">gene encodes the alpha-1A adrenergic receptor. This is a receptor for epinephrine (also called adrenaline), one of the major signals responsible for the fight or flight response [</span><a href="https://onlinelibrary.wiley.com/doi/full/10.1002/art.24655"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056281/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The effects of epinephrine include increased </span><a href="https://www.selfhacked.com/blog/resting-heart-rate/"><span style="font-weight: 400;">heart rate</span></a><span style="font-weight: 400;">, breathing rate, and blood flow to the muscles, to name a few. For this reason, it is also used as a medication for several conditions, such as cardiac arrest, serious allergic reactions, and asthma [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1959222/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27982306"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28193791"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25969360"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The adrenal glands make most of the epinephrine in the body, but small amounts are also produced in other tissues, like some neurons and the kidneys [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8995750"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with </span><a href="https://selfhacked.com/blog/chronic-fatigue-syndrome-real-heres-test/"><span style="font-weight: 400;">chronic fatigue syndrome</span></a><span style="font-weight: 400;"> are suspected to have significantly reduced epinephrine signalling. This lack of epinephrine may worsen symptoms, such as fatigue, difficulty thinking, and muscle pain [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23062157"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23770415"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A large association study identified an association between two </span><em><span style="font-weight: 400;">ADRA1A</span></em><span style="font-weight: 400;"> gene variants and </span><a href="https://selfhacked.com/blog/my-cutting-edge-protocol-to-cure-fatigue/"><span style="font-weight: 400;">chronic fatigue</span></a><span style="font-weight: 400;">. The authors of another more focused study suggested that certain </span><em><span style="font-weight: 400;">ADRA1A</span></em><span style="font-weight: 400;"> variants may change the way that epinephrine and its receptor bind together, making it more difficult for the body to receive epinephrine signals [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105265/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">ADRA1A</span></em><span style="font-weight: 400;"> encodes a receptor for epinephrine, a &ldquo;fight or flight&rdquo; signalling hormone. Variants in </span><em><span style="font-weight: 400;">ADRA1A</span></em><span style="font-weight: 400;"> may cause fatigue by reducing the availability of receptors or by making it more difficult for epinephrine to bind to its receptor.</span></span></p> <h2><strong>Your </strong><strong><em>ADRA1A</em></strong><strong> Results for Fatigue</strong></h2> <p>*5847794583706685*</p> <p><strong>ADRA1A </strong><a href="https://selfdecode.com/snp/rs1048101/"><strong>rs1048101</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with increased rates of chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may make it more difficult for epinephrine to bind to its receptor [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105265/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong>ADRA1A </strong><a href="https://selfdecode.com/snp/rs1383914/"><strong>rs1383914</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with feelings of fatigue during the day</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with slightly increased feelings of fatigue during the day</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele may make it more difficult for epinephrine to bind to its receptor [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105265/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*4478873712328131*</p> <h2><strong>Recommendations for Improving Fatigue</strong></h2> <p>*2648074145214676*</p> <h3><strong>Exercise</strong></h3> <p><span style="font-weight: 400;">During </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;">, epinephrine levels can increase by 1.5 to over 20 times [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18416594"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]!</span></p> <p><span style="font-weight: 400;">Some studies show that men experience a greater spike in epinephrine during exercise than women. Age is also a factor; older people release less epinephrine in response to exercise [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18416594"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A sedentary lifestyle is a common cause of persistent fatigue. Several studies have reported that practicing more </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> may reduce fatigue in healthy people. Paradoxically, being &lsquo;too tired&rsquo; was the most common excuse for not exercising in a study on middle-aged and elderly people [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23783259/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18277063/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816334/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24154584/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with chronic fatigue syndrome are at especially high risk of not meeting physical activity requirements. In people with this condition, engaging in regular physical exercise may help reduce fatigue &mdash; even more than in healthy controls according to one meta-analysis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21166613/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419524/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026555/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Multiple studies have reported that exercise may help with fatigue from other conditions such as </span><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">multiple sclerosis</span></a><span style="font-weight: 400;">, cancer, rheumatoid arthritis, COPD, lupus, ALS, fibromyalgia, muscle disease, and heart failure [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068865/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931245/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168432/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937526/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28477898/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32452880/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911859/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20091552/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16713337/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, over-exercising can lead to fatigue and several health issues. Experts recommend moderate exercise such as brisk walking, swimming, or cycling.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Exercise dramatically increases epinephrine for a short period of time. Regular moderate exercise is also strongly recommended to increase energy levels for people with chronic fatigue syndrome.</span></p> <h3><strong>Coffee</strong></h3> <p><a href="https://selfhacked.com/blog/caffeine-benefits/"><span style="font-weight: 400;">Caffeine</span></a><span style="font-weight: 400;"> stimulates the adrenergic system and causes epinephrine levels to rise. One study found that coffee elevates epinephrine levels in the urine by 32% [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12140349"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A comprehensive clinical review of 21 meta-analyses concluded that </span><a href="https://selfhacked.com/blog/caffeine-benefits/"><span style="font-weight: 400;">caffeine</span></a><span style="font-weight: 400;"> improves </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> performance in a broad range of exercise tasks, in part through its anti-fatigue effects [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30926628/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">When caffeine delays fatigue, the body&rsquo;s muscles can contract more forcefully and allow people to exercise longer. Aerobic exercise such as running, jogging, cardio workout, swimming, and biking can benefit the most from increased training volume [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11583104/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19757860/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Caffeine may also improve alertness while reducing mental fatigue, especially in </span><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;">-deprived people. Several studies report reduced fatigue from mentally-demanding tasks after taking caffeine-containing beverages. However, frequent users seem to develop tolerance to the effects of caffeine [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608989/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK209050/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29247343/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18006208/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26320858/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16272184/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15678363/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Several studies have found that &lsquo;energy drinks&rsquo; combining caffeine and </span><a href="http://selfhacked.com/blog/taurine-benefits/"><span style="font-weight: 400;">taurine</span></a><span style="font-weight: 400;"> can reduce fatigue from prolonged driving [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24913484/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11310933/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24913484/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Caffeine increases epinephrine levels and can reduce mental fatigue. However, it&rsquo;s important not to overdo it, as frequent use may lead to tolerance and reduced effectiveness.</span></p>
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459 | content_learn_more_4478873712328131_text == Based on the variants we looked at, your ADRA1A gene is somewhat associated with chronic fatigue syndrome and feeling tired during the day. However, this doesn't necessarily reflect your overall risk of fatigue; it’s just one gene related to it. Exercise and coffee may help. Keep scrolling to find out more.
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rsIDs = rs1048101,rs1383914
rsStatus = rs1048101,ADRA1A,chr8,26770511,A,C,G,T,43,0,Normal
rsStatus = rs1383914,ADRA1A,chr8,26865532,T,C,,,16,16,HET
