46 | id == 46
46 | category_id == 10
46 | category_order == 7
46 | category_name == Detox
46 | category_color == #C47AC0
46 | slug == detox-ugt1a1
46 | title == Are Plastics More Dangerous For You?  (UGT1A1)
46 | meta_description == Your UGT1A1 gene determines how well you can detox from drugs and plastics. Find out if your genes are protecting you.
46 | summary == <p><strong>The UGT1A1 gene helps you detox from drugs, plastic chemicals, and even your body&rsquo;s own waste products. However, variations in this gene can impair your detox ability, potentially leading to a number of health problems. Find out what your genetic variants for this gene mean here.&nbsp;</strong></p>
46 | overall_score_text == Detox Score (based on UGT1A1)
46 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/Have-Problems-Detoxing-The-Role-of-UGT1A1.jpg
46 | author_id == 8
46 | author_name == Mathew Eng
46 | author_title == PharmD
46 | author_order == 40
46 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Mathew.jpg
46 | author_intro == <p><strong>Mathew received his PharmD from the University of Hawaii and an undergraduate degree in Biology from the University of Washington.</strong></p>    <p>Mathew is a licensed pharmacist with clinical experience in oncology, infectious disease, and diabetes management. He has a passion for personalized patient care and believes that education is essential to living a healthy life. His goal is to motivate individuals to find ways to manage their chronic conditions.</p>
46 | reviewer_id == 1
46 | reviewer_name == Jasmine Foster
46 | reviewer_title == BSc, BEd
46 | medical_reviewer_id == 11
46 | medical_reviewer_name == Puya Yazdi
46 | medical_reviewer_title == MD
46 | publish_date == 2019
46 | publish_date == 9
46 | publish_date == 19
46 | avg_rating == 5.0
46 | tags_id == 148
46 | tags_name == Bilirubin
46 | tags_id == 147
46 | tags_name == BPA
46 | tags_id == 119
46 | tags_name == Detox
46 | tags_id == 150
46 | tags_name == Glucuronidation
46 | tags_id == 149
46 | tags_name == Jaundice
46 | tags_id == 122
46 | tags_name == Toxins
46 | tags_id == 146
46 | tags_name == UGT1A1 Gene
46 | permissions_favorite == False
46 | permissions_rate == False
46 | content_article == <h2><span style="font-weight: 400;">What Is </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;">?</span></h2> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> gene encodes an enzyme called UGT (short for UDP-glucuronosyltransferase). This enzyme is responsible for performing a chemical reaction called </span><a href="https://selfhacked.com/blog/glucuronidation-detox-estrogen-hormone-balance-prevent-cancer-red-meat/"><strong>glucuronidation</strong></a><span style="font-weight: 400;">, which is an important step in the body&rsquo;s </span><a href="https://selfhacked.com/blog/the-science-of-detoxification/"><span style="font-weight: 400;">detox process</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338934/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Genetic variations in </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> can impair your body&rsquo;s ability to clear out harmful substances, which may lead to liver disorders, a dangerous buildup of drug compounds, and even cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338934/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22448797"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> gene is responsible for encoding an enzyme called UGT, which plays an important role in the body&rsquo;s detox process.</span></span></p> <h3><span style="font-weight: 400;">How Does UGT Help You Detox?</span></h3> <p><span style="font-weight: 400;">The UGT enzyme performs a reaction called glucuronidation, which involves adding a compound called glucuronic acid to different substances in the body. This addition helps neutralize harmful toxins and prepares them for excretion out of the body [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26828111"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some important targets of UGT include:</span></p> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/the-health-effects-of-pthalates-and-bpa/"><span style="font-weight: 400;">BPA plastics</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531270/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/bilirubin-benefit-how-to-optimize/"><span style="font-weight: 400;">Bilirubin</span></a><span style="font-weight: 400;">, a waste product from the breakdown of </span><a href="https://selfhacked.com/blog/increase-decrease-red-blood-cells/"><span style="font-weight: 400;">red blood cells</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22448797"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Steroid hormones [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10419020"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Medications: up to 15% of all FDA-approved drugs according to some estimates [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27324196/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The UGT enzyme neutralizes harmful compounds, like BPA plastics, bilirubin, and drugs, so they can be excreted out of the body.</span></p> <h2><span style="font-weight: 400;">How Does </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> Cause Detox Problems?</span></h2> <p><span style="font-weight: 400;">Certain genetic variations in </span><em><span style="font-weight: 400;">UGT1A1 </span></em><span style="font-weight: 400;">reduce the enzymatic activity of UGT, which impairs the body&rsquo;s ability to detox and results in a buildup of toxic substances in the body. The normal version of </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> (the one with normal detox activity) is called </span><em><span style="font-weight: 400;">UGT1A1*1</span></em><span style="font-weight: 400;">, or the &ldquo;wild&rdquo; type allele [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK294473/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">One of the most important and well-studied genetic variants is </span><strong><em>UGT1A1*28</em></strong><span style="font-weight: 400;">. This variant causes an &ldquo;insertion&rdquo; mutation, which means it adds an extra &lsquo;TA&rsquo; into the gene where there should be none. According to some reports, </span><strong><em>UGT1A1*28</em></strong><strong> causes a 70% reduction in enzyme activity</strong><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461737/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Other variants include </span><strong><em>UGT1A1*6</em></strong><span style="font-weight: 400;"> and </span><strong><em>UGT1A1*27</em></strong><span style="font-weight: 400;">, which also lower enzyme activity, leading to a reduced ability to detox. All of these variations in </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> can lead to toxicity disorders, which we&rsquo;ll detail in the following sections [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461737/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Genetic variations of </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;">, which include </span><em><span style="font-weight: 400;">UGT1A1*28</span></em><span style="font-weight: 400;">, </span><em><span style="font-weight: 400;">UGT1A1*6</span></em><span style="font-weight: 400;">, </span><em><span style="font-weight: 400;">UGT1A1*27</span></em><span style="font-weight: 400;">, lower the activity of the UGT enzyme, which leads to a buildup of toxic substances in the body.</span></span></p> <h3><span style="font-weight: 400;">BPA Plastic Toxicity</span></h3> <p><a href="https://selfhacked.com/blog/the-health-effects-of-pthalates-and-bpa/"><span style="font-weight: 400;">BPA</span></a><span style="font-weight: 400;">, short for bisphenol-A, is a chemical compound found in many types of plastic. A buildup of BPA in the body is linked to several disorders, including cancer, heart disease, and thyroid dysfunction. Removal of BPA is primarily the responsibility of UGT; genetic variations in </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> can lower the body&rsquo;s ability to detox BPA-based plastics [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531270/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A small study of 15 people found that </span><strong>those with </strong><strong><em>UGT1A1*28</em></strong><strong> remove BPAs in the breast tissue 10 times more slowly compared to those without the allele</strong><span style="font-weight: 400;">. This finding has important clinical implications: BPA exposure has been connected to breast cancer in several studies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531270/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Genetic variations like </span><em><span style="font-weight: 400;">UGT1A1*28</span></em><span style="font-weight: 400;"> can impair the body&rsquo;s ability to remove BPA, which some researchers believe can lead to an increased risk of breast cancer.</span></span></p> <h3><span style="font-weight: 400;">Drug Toxicity</span></h3> <p><span style="font-weight: 400;">According to some estimates, the UGT enzyme is responsible for metabolizing and clearing 15% of all FDA-approved drugs. Certain genetic variations of </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> can impair the body&rsquo;s ability to remove these drugs, which can worsen side effects and cause toxicities [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27324196/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15304429"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The most researched drug interaction with </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> is irinotecan, a drug used to treat colon and lung cancer. Studies show that people with </span><em><span style="font-weight: 400;">UGT1A1*28</span></em><span style="font-weight: 400;"> who take this drug are much more likely to experience neutropenia, a dangerous reduction in </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cell</span></a><span style="font-weight: 400;"> count. The FDA recommends that people with </span><em><span style="font-weight: 400;">UGT1A1*28</span></em><span style="font-weight: 400;"> should start at a lower dose to reduce toxicity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338934/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK294473/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Other drugs with serious interactions with </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> variants include [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525209/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Raloxifene, used to treat osteoporosis and prevent breast cancer</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Raltegravir, used to treat HIV</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Indinavir, used to treat HIV</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Atazanavir, used to treat HIV</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Sorafenib, used to treat various cancers</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">People with the </span><em><span style="font-weight: 400;">UGT1A1*28</span></em><span style="font-weight: 400;"> variant may experience more side effects with certain drugs and may need a lower starting dose.</span></span></p> <h3><span style="font-weight: 400;">Bilirubin Toxicity</span></h3> <p><a href="https://selfhacked.com/blog/bilirubin-benefit-how-to-optimize/"><span style="font-weight: 400;">Bilirubin</span></a><span style="font-weight: 400;"> is a waste product that your body naturally produces during the breakdown of old red blood cells. The UGT in your liver will then process bilirubin so that it can be excreted either through urine or feces [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18433389"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Genetic variations of </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> can reduce or completely eliminate the body&rsquo;s ability to remove bilirubin, causing a dangerous buildup. This can lead to disorders like Gilbert&rsquo;s syndrome or Crigler&ndash;Najjar syndrome, which can cause yellowing of the skin, </span><a href="https://selfhacked.com/blog/people-get-tired-even-enough-sleep/"><span style="font-weight: 400;">fatigue</span></a><span style="font-weight: 400;">, loss of appetite, and even more serious symptoms in children [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22160004"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20955959"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Those with genetic variations in </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> may have difficulty detoxing bilirubin, which may lead to disorders like Gilbert&rsquo;s syndrome or Crigler&ndash;Najjar syndrome.</span></span></p> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> Results for Toxicity</span></h2> <p>*2153076366995798*</p> <p><strong>Primary SNP:&nbsp;</strong></p> <p><strong><em>UGT1A1*28 </em></strong><span style="font-weight: 400;">is one of the primary genetic variants responsible for reduced detox ability. This variant adds a &lsquo;TA&rsquo; allele where they should be none. These SNPs normally have no allele; gene reports will sometimes use &lsquo;D&rsquo; (short for deletion) to represent the absence of an allele.</span></p> <p><span style="font-weight: 400;">The &lsquo;TA&rsquo; addition increases your risk for toxicity, which is sometimes represented as &lsquo;I&rsquo; (short for insertion).</span></p> <p><strong>UGT1A1 rs34983651</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;D&rsquo; (short for deletion, represents an absence of the extra &lsquo;TA&rsquo;) = Normal detox function</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;I&rsquo; or &lsquo;TA&rsquo; insertion = Increases your risk for toxicity</span></li> <li style="font-weight: 400;"><em><span style="font-weight: 400;">UGT1A1*28</span></em><span style="font-weight: 400;"> occurs in 26-31% of Caucasians, but only 9-16% of Asian populations</span></li> </ul> <p><strong>Other Important SNPs:</strong></p> <p><strong>UGT1A1 rs4148323</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Normal detox function</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increases your risk for toxicity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 6% of people have the risky 'AA' genotype</span></li> </ul> <p><strong>UGT1A1 rs6742078</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Normal detox function</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increases your risk for toxicity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 56% of people have the risky 'TT' genotype</span></li> </ul> <p>*5909085688597353*</p> <h2><span style="font-weight: 400;">Ways To Improve Detox Health Regardless of </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> Genotype</span></h2> <p>BPA and other toxins can cause serious health problems. Before trying the recommendations below on your own, discuss your concerns with your doctor. Together, you can find the best strategies for you.</p> <p>*7840775305866283*</p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <p><span style="font-weight: 400;">Reduce the use of plastics, such as plastic water bottles, cups, etc...</span></p> <h3><span style="font-weight: 400;">Diet</span></h3> <p><span style="font-weight: 400;">Research has found that </span><strong>cruciferous vegetables</strong><span style="font-weight: 400;"> can increase </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> activity by 16-21% in people with </span><em><span style="font-weight: 400;">UGT1A1*28 </span></em><span style="font-weight: 400;">compared to diets without these vegetables. Even those with a normal genotype can benefit; cruciferous vegetables increased activity by 7% in people with </span><em><span style="font-weight: 400;">UGT1A1*1</span></em><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666928/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some examples of cruciferous vegetables include [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666928/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Broccoli</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Cauliflower</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Cabbage</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Radish</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Kale</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Bok choy</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Brussel sprouts</span></li> </ul> <p><span style="font-weight: 400;">Other foods that have been shown to increase </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;"> activity in human and animal studies include:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Citrus fruits (only in women with the </span><em><span style="font-weight: 400;">UGT1A1*28 </span></em><span style="font-weight: 400;">variant) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19141701"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">Green tea</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/7821873"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9605416"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://www.selfhacked.com/blog/dandelion/"><span style="font-weight: 400;">Dandelion</span></a><span style="font-weight: 400;"> tea [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11697539"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Rooibos tea [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14690405"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/coffee-may-cause-inflammation/"><span style="font-weight: 400;">Coffee</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20600030"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://www.selfhacked.com/blog/quercetin-22-scientifically-proven-benefits-quercetin/"><span style="font-weight: 400;">Quercetin</span></a><span style="font-weight: 400;"> (found in many fruits and veggies, </span><a href="https://www.selfhacked.com/blog/capers/"><span style="font-weight: 400;">capers</span></a><span style="font-weight: 400;">, onions, berries, and tea) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12869420"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">Also be careful about excessive consumption of seafood, which contains microplastics.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Cruciferous vegetables, like broccoli, cauliflower, and Brussels sprouts, can significantly increase the activity of </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;">, potentially boosting your body&rsquo;s ability to detox.</span></span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <p><span style="font-weight: 400;">Activated charcoal is a supplement that can bind to plastics and can help with detoxification of the compounds normally handled by UGT1A1.</span></p> <p><span style="font-weight: 400;">Certain supplements may also increase the activity of </span><em><span style="font-weight: 400;">UGT1A1</span></em><span style="font-weight: 400;">, including:</span></p> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12869420"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/astaxanthin/"><span style="font-weight: 400;">Astaxanthin</span></a><span style="font-weight: 400;"> and canthaxanthin (carotenoids) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8851821"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Ellagic acid (also found in walnuts, pecans, berries, grapes, and </span><a href="https://selfhacked.com/blog/pomegranate/"><span style="font-weight: 400;">pomegranate</span></a><span style="font-weight: 400;">) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12869420"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Fumaric acid [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12869420"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">However, these supplements have only been studied in animals, their effect on human <em>UGT1A1</em> is not entirely clear.</span></p>
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46 | content_learn_more_2153076366995798_text == Based on the variants we looked at, your UGT1A1 gene somewhat reduces your ability to detox. A diet rich in cruciferous vegetables, like broccoli and cauliflower, can help. Keep scrolling to find out more.
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