461 | id == 461
461 | category_id == 27
461 | category_order == 24
461 | category_name == Fatigue
461 | category_color == #C47AC0
461 | slug == DRD3-fatigue
461 | title == A Chemical Messenger With Dual Roles in Fatigue (DRD3)
461 | meta_description == DRD3 helps regulate sleep. A variant of DRD3 is associated with chronic fatigue syndrome. Read more here.
461 | summary == <p style="text-align:justify"><strong>The <em>DRD3 </em>gene codes for a receptor that is involved in regulating sleep. Can a variant of <em>DRD3</em> increase the risk of developing chronic fatigue syndrome? Read more to find out.&nbsp;</strong></p>
461 | overall_score_text == Your Fatigue Score (based on DRD3 gene)
461 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/DRD3-Chronic-fatigue-syndrome.jpg
461 | author_id == 14
461 | author_name == Shany Lahan
461 | author_title == MS (Neuroscience)
461 | author_order == 5
461 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
461 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
461 | reviewer == None
461 | medical_reviewer_id == 11
461 | medical_reviewer_name == Puya Yazdi
461 | medical_reviewer_title == MD
461 | publish_date == 2020
461 | publish_date == 11
461 | publish_date == 5
461 | avg_rating == 5.0
461 | tags_id == 51
461 | tags_name == Dopamine
461 | tags_id == 902
461 | tags_name == Dopamine Receptor
461 | tags_id == 910
461 | tags_name == DRD3 Gene
461 | tags_id == 906
461 | tags_name == Sleep-Wake Cycle
461 | permissions_favorite == False
461 | permissions_rate == False
461 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">DRD3</span></em><span style="font-weight: 400;"> gene codes for dopamine receptor D3, a receptor involved in regulating the sleep-wake cycle. A variant of </span><em><span style="font-weight: 400;">DRD3 </span></em><span style="font-weight: 400;">may play a role in chronic fatigue syndrome by increasing production or sensitivity of dopamine receptor D3. Diet modifications may counteract the effects of this variant by decreasing dopamine receptor D3 production.</span></span></p> <h2 style="text-align: justify;"><strong><em>DRD3 </em></strong><strong>and Fatigue</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/drd3/"><em><span style="font-weight: 400;">DRD3 </span></em><span style="font-weight: 400;">gene</span></a><span style="font-weight: 400;"> encodes dopamine receptor D3, a receptor that is activated by the chemical messenger (neurotransmitter) </span><a href="https://selfhacked.com/blog/dopamine/"><span style="font-weight: 400;">dopamine</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/gene/1814"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Among its many roles, dopamine is involved in regulating the sleep-wake cycle. While activation of certain types of dopamine receptors (such as dopamine receptor D1) has been shown to promote alertness and arousal, preliminary research has reported that dopamine receptor D3 activation may induce sleepiness [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17275369/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18772053/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9619689/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Indeed, mice that lack dopamine receptor D3 have been observed to be hyperactive, suggesting that dopamine receptor D3 is necessary for suppressing active behaviors such as wakefulness [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8700864/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A variant of </span><em><span style="font-weight: 400;">DRD3 </span></em><span style="font-weight: 400;">has been associated with chronic fatigue syndrome, an illness characterized by prolonged low energy. This variant may increase the sensitivity or production of dopamine receptor D3, which may result in excessive fatigue when activated by dopamine [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>DRD3</em></strong><strong> Results for Fatigue</strong></h2> <p style="text-align: justify;">*1782512109447598*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>DRD3 </em></strong><a href="https://selfdecode.com/snp/rs6280/"><strong>rs6280</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with chronic fatigue syndrome</span></li> </ul> <p style="text-align: justify;">*6664572264046474*</p> <h2 style="text-align: left;"><strong>Recommendations for Reducing Fatigue</strong></h2> <p style="text-align: justify;">*9256410855265038*</p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Cutting Down on Refined Carbohydrates</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The digestion of refined carbohydrates causes a rapid spike in blood sugar (</span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">glucose</span></a><span style="font-weight: 400;">) followed by a drastic fall, due to production of the blood sugar-regulating hormone </span><a href="https://selfhacked.com/blog/insulin-101/"><span style="font-weight: 400;">insulin</span></a><span style="font-weight: 400;">. This effect is observed when eating foods such as baked goods, candy, white bread, and white rice.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Several studies have associated frequent consumption of these foods with mental and physical fatigue. However, its effectiveness in chronic fatigue syndrome is currently a matter of debate [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24091353/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23392888/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17176639/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231210/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28616881/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a study of rats, sugar bingeing was observed to increase production of dopamine receptor D3 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15135221/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cutting down on refined carbohydrates, such as baked goods, may reduce fatigue by decreasing production of dopamine receptor D3.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Sufficient Vitamin B9/Folate Intake</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/16-proven-benefits-vitamin-b9-folate-folic-acid/"><span style="font-weight: 400;">Vitamin B9</span></a><span style="font-weight: 400;"> (folate) is a nutrient required to make red blood cells. Its deficiency causes megaloblastic anemia, a condition characterized by fewer and larger blood cells, and whose main symptom is fatigue. A study found that chronic fatigue syndrome can also be linked to low blood vitamin B9 levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12003352/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828842/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.researchgate.net/publication/8518428_New_Insights_into_Erythropoiesis_The_Roles_of_Folate_Vitamin_B12_and_Iron"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8255470/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Folate deficiency is rare but can occur in people that don&rsquo;t eat enough fruits and vegetables. Alcoholics and lactating mothers are also at increased risk of this deficiency [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18709879/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The name &lsquo;folate&rsquo; comes from the Latin word &lsquo;</span><em><span style="font-weight: 400;">folium&rsquo; </span></em><span style="font-weight: 400;">meaning &lsquo;leaf&rsquo;, since it is mainly found in green leafy vegetables such as spinach, broccoli, cabbage, and kale. Other dietary sources of folate include beef liver, legumes, and whole grains [</span><a href="https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Folic acid is the supplement form of folate, and is often prescribed to pregnant women in order to prevent birth (neural tube) defects. Treatment of cells with folic acid was reported to decrease production of dopamine receptor D3 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21867686/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Sufficient folate intake may reduce fatigue by decreasing production of dopamine receptor D3.</span></p>
461 | content_snp_table_1782512109447598_key == 1782512109447598
461 | content_snp_table_1782512109447598_blur == True
461 | content_snp_table_1782512109447598_hidden == False
461 | content_learn_more_6664572264046474_key == 6664572264046474
461 | content_learn_more_6664572264046474_blur == True
461 | content_learn_more_6664572264046474_hidden == False
461 | content_learn_more_6664572264046474_text == Based on the variants we looked at, your DRD3 gene makes you somewhat more likely to develop chronic fatigue syndrome. However, this doesn't necessarily reflect your overall risk of elevated fatigue; it’s just one gene related to it. Cutting down on refined carbohydrates and consuming sufficient folate may help. Keep scrolling to find out more.
461 | content_recommendation_9256410855265038_key == 9256410855265038
461 | content_recommendation_9256410855265038_blur == True
461 | content_recommendation_9256410855265038_hidden == False
rsIDs = rs6280
rsStatus = rs6280,DRD3,chr3,114171968,C,T,,,7,32,HET
