462 | id == 462
462 | category_id == 27
462 | category_order == 24
462 | category_name == Fatigue
462 | category_color == #C47AC0
462 | slug == BDNF-fatigue-fibromyalgia
462 | title == Surprising Link Between Glutamate & Fatigue (BDNF)
462 | meta_description == BDNF may over-stimulate nerves by activating glutamate receptors. Click to learn about its link with fatigue.
462 | summary == <p style="text-align:justify"><strong>BDNF is crucial for brain development, but does it have a dark side? Read this post to learn about the link between <em>BDNF</em> gene variants, glutamate, and fatigue!</strong></p>
462 | overall_score_text == Your Fatigue Score (based on BDNF gene)
462 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/BDNF-Fatigue-Fibromyalgia.jpg
462 | author_id == 9
462 | author_name == Aleksa Ristic
462 | author_title == MS (Pharmacy)
462 | author_order == 45
462 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
462 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
462 | reviewer == None
462 | medical_reviewer_id == 11
462 | medical_reviewer_name == Puya Yazdi
462 | medical_reviewer_title == MD
462 | publish_date == 2020
462 | publish_date == 11
462 | publish_date == 5
462 | avg_rating == 5.0
462 | tags_id == 159
462 | tags_name == BDNF
462 | tags_id == 460
462 | tags_name == Brain Development
462 | tags_id == 68
462 | tags_name == Fatigue
462 | tags_id == 7
462 | tags_name == Fibromyalgia
462 | tags_id == 659
462 | tags_name == Glutamate
462 | permissions_favorite == False
462 | permissions_rate == False
462 | content_article == <p>&nbsp;</p> <table style="height: 56px; width: 100%; border-collapse: collapse; margin-left: auto; margin-right: auto;" border="1" cellpadding="10"> <tbody> <tr> <td style="width: 100%; text-align: justify;"><strong>Note:</strong> The <em>BDNF</em> gene is analyzed in our <strong><a href="https://get.selfdecode.com/mind-protocol-nm/">Cognitive function</a><em> and <a href="https://get.selfdecode.com/headaches-migraines/" target="_blank" rel="noopener">Headache</a> DNA Wellness Reports</em></strong>, along with many other genes. If you're looking for a comprehensive gene analysis on these topics, check out these reports!</td> </tr> </tbody> </table> <p>&nbsp;</p> <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>BDNF can stimulate glutamate receptors and thus play a role in conditions accompanied by chronic fatigue.<br /><br /></strong><strong>Specific BDNF gene variants have been associated with fatigue and low energy, mostly due to fibromyalgia.<br /><br /></strong><strong>This post reveals potential ways to reduce fatigue by targeting your gene variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>BDNF, Glutamate &amp; Fatigue</strong></h2> <p><a href="https://selfhacked.com/blog/a-comprehensive-list-of-natural-ways-to-increase-bdnf/"><span style="font-weight: 400;">BDNF</span></a><span style="font-weight: 400;"> is essential for </span><a href="https://selfhacked.com/blog/can-regrow-brain/"><span style="font-weight: 400;">brain growth</span></a><span style="font-weight: 400;"> and development, but it may also play a role in conditions with chronic fatigue and pain, such as fibromyalgia. BDNF can stimulate </span><a href="https://selfhacked.com/blog/glutamate/"><span style="font-weight: 400;">glutamate</span></a><span style="font-weight: 400;"> receptors; their excess activity may damage brain cells and make them more sensitive to </span><span style="font-weight: 400;">stress</span><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15519688/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17045972/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Scientists have suggested the role of glutamate in mental fatigue, fibromyalgia, and other conditions accompanied by low energy. Variants in the </span><a href="https://selfhacked.com/blog/bdnf-genes-correct/"><em><span style="font-weight: 400;">BDNF</span></em><span style="font-weight: 400;"> gene</span></a><span style="font-weight: 400;"> correlate with such conditions, likely due to their effects on glutamate receptors [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC533886/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671489/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22466550/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235218/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your BDNF Results for Fatigue</strong></h2> <p>*5631368460579724*&nbsp;</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs11030104/"><strong>rs11030104</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235218/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with relatively higher odds of fatigue due to fibromyalgia</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with lower odds of fatigue due to fibromyalgia</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may be associated with higher BDNF levels and glutamate receptor activity.</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs6265/"><strong>rs6265</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:&nbsp;</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively lower energy levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher energy levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may be associated with higher BDNF levels and glutamate receptor activity.</span></li> </ul> <p><strong>Other Important SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs12273539/"><strong>rs12273539</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235218/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher odds of fatigue due to fibromyalgia</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with fatigue</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele may be associated with higher BDNF levels and glutamate receptor activity.</span></li> </ul> <p>*5947598561353447*&nbsp;</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Fatigue</strong></h2> <p>*3567640374255787*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Reduce Stress</strong></h4> <p><span style="font-weight: 400;">According to research, glutamate receptors mediate the harmful effects of stress on brain function and mental health [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10073474/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19857581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21383235/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">Stress</span></a><span style="font-weight: 400;"> and fatigue are closely related and may contribute to each other. Chronic stress exposure and stressful life events may increase physical and mental fatigue and even cause </span><a href="https://selfhacked.com/blog/chronic-fatigue-syndrome-real-heres-test/"><span style="font-weight: 400;">chronic fatigue syndrome</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26143479/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24630177/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19812026/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894419/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28119163/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Cognitive-behavioral therapy for stress management may reduce fatigue from chronic fatigue syndrome, fibromyalgia, and </span><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">multiple sclerosis</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028002/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28984402/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27772557/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719827/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31927347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Relaxation therapy with breathing and muscle relaxation exercises may also reduce fatigue from different chronic conditions [</span><a href="https://pubmed.ncbi.nlm.nih.gov/9054791/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11729022/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22967281/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15338385/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12719750/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Avoid stress and practice relaxation techniques to reduce the impact of your gene variants on fatigue.</span></p> <h3><strong>Diet</strong></h3> <h4><strong>Limit Sugar Intake</strong></h4> <p><span style="font-weight: 400;">Excess sugar consumption and blood levels may increase glutamate receptor activity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356012/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27975343/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Foods high in sugar and refined carbs&mdash;such as sugar-sweetened drinks, baked goods, candy, white bread&mdash;cause a spike in blood </span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">glucose</span></a><span style="font-weight: 400;"> and energy levels, followed by a drastic fall. Studies have associated their frequent consumption with mental and physical fatigue [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24091353/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23392888/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17176639/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231210/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Foods high in sugar and refined carbs may worsen the effects of your variants on fatigue.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Coenzyme Q10</strong></h4> <p><a href="https://selfhacked.com/blog/coenzyme-q10-ubiquinol/"><span style="font-weight: 400;">Coenzyme Q10</span></a><span style="font-weight: 400;"> (CoQ10) may protect the brain cells, partly by inhibiting glutamate receptors [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24458150/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301180/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12774309/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In two clinical trials on healthy people, CoQ10 supplementation reduced fatigue and improved performance during </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18272335/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19644406/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Daily supplementation with coenzyme Q10 may also improve fatigue from different chronic conditions, especially fibromyalgia [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2797412/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837523/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23458405/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22342824/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25603363/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346380/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26212172/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Coenzyme Q10 supplementation may help reduce fatigue by targeting your BDNF variants.</span></p>
462 | content_snp_table_5631368460579724_key == 5631368460579724
462 | content_snp_table_5631368460579724_blur == True
462 | content_snp_table_5631368460579724_hidden == False
462 | content_learn_more_5947598561353447_key == 5947598561353447
462 | content_learn_more_5947598561353447_blur == True
462 | content_learn_more_5947598561353447_hidden == False
462 | content_learn_more_5947598561353447_text == Based on the variants we looked at, your BDNF gene is slightly associated with fatigue. However, this doesn't necessarily reflect your overall risk of fatigue; it’s just one gene related to it. Try to avoid stress, reduce sugar intake, and consider supplementing with coenzyme Q10 to combat fatigue. Keep reading to learn more.
462 | content_recommendation_3567640374255787_key == 3567640374255787
462 | content_recommendation_3567640374255787_blur == True
462 | content_recommendation_3567640374255787_hidden == False
rsIDs = rs12273539,rs11030104,rs6265
rsStatus = rs12273539,BDNF,chr11,27661764,C,T,,,23,0,Normal
rsStatus = rs11030104,BDNF,chr11,27662970,A,G,,,15,12,HET
rsStatus = rs6265,BDNF,chr11,27658369,C,T,,,38,0,Normal
