463 | id == 463
463 | category_id == 27
463 | category_order == 24
463 | category_name == Fatigue
463 | category_color == #C47AC0
463 | slug == CFB-fatigue
463 | title == The Complement Cascade in Chronic Fatigue Syndrome (CFB)
463 | meta_description == CFB encodes a part of the complement cascade, which has been linked to chronic fatigue. Do you have risk alleles? Find out here.
463 | summary == <p><strong><em>CFB </em>encodes a part of the complement cascade, which increases inflammation and has been linked to chronic fatigue. Do you have a risk allele? Find out here.</strong></p>
463 | overall_score_text == Your Fatigue Score (based on CFB)
463 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CFB-Chronic-fatigue-syndrome.jpg
463 | author_id == 1
463 | author_name == Jasmine Foster
463 | author_title == BSc, BEd
463 | author_order == 36
463 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
463 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
463 | reviewer == None
463 | medical_reviewer_id == 11
463 | medical_reviewer_name == Puya Yazdi
463 | medical_reviewer_title == MD
463 | publish_date == 2020
463 | publish_date == 11
463 | publish_date == 6
463 | avg_rating == 5.0
463 | tags_id == 911
463 | tags_name == CFB Gene
463 | tags_id == 904
463 | tags_name == Chronic Fatigue Syndrome
463 | tags_id == 198
463 | tags_name == Complement System
463 | tags_id == 68
463 | tags_name == Fatigue
463 | tags_id == 24
463 | tags_name == Inflammation
463 | tags_id == 906
463 | tags_name == Sleep-Wake Cycle
463 | tags_id == 50
463 | tags_name == Stress
463 | permissions_favorite == False
463 | permissions_rate == False
463 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">CFB </span></em><span style="font-weight: 400;">encodes complement factor B. Variants of </span><em><span style="font-weight: 400;">CFB</span></em><span style="font-weight: 400;"> may play a role in chronic fatigue syndrome by increasing inflammation. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by blocking the complement cascade and preventing inflammatory signalling.</span></p> <h2><strong><em>CFB</em></strong><strong> and Chronic Fatigue Syndrome</strong></h2> <p><em><span style="font-weight: 400;">CFB</span></em><span style="font-weight: 400;"> encodes complement factor B, a member of the complement system that helps antibodies and </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;"> bind to, attack, and kill invading bacteria. CFB activates the complement cascade, leading to increased activation of the immune system [</span><a href="https://www.ncbi.nlm.nih.gov/gene/629"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.sciencedirect.com/science/article/pii/S0198885915001809?via%3Dihub"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Variation in the </span><em><span style="font-weight: 400;">CFB </span></em><span style="font-weight: 400;">gene has been associated with </span><a href="https://selfhacked.com/blog/chronic-fatigue-syndrome-real-heres-test/"><span style="font-weight: 400;">chronic fatigue syndrome</span></a><span style="font-weight: 400;">. According to one study, the risk alleles for </span><a href="https://selfhacked.com/blog/my-cutting-edge-protocol-to-cure-fatigue/"><span style="font-weight: 400;">chronic fatigue</span></a><span style="font-weight: 400;"> appear to increase complement cascade activation [</span><a href="https://www.sciencedirect.com/science/article/pii/S0198885915001809?via%3Dihub"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Because CFB activates the immune system, </span><em><span style="font-weight: 400;">CFB</span></em><span style="font-weight: 400;"> variants probably promote chronic fatigue through inflammation [</span><a href="https://www.sciencedirect.com/science/article/pii/S0198885915001809?via%3Dihub"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Chronic inflammation, meanwhile, has been strongly linked to fatigue disorders. When low grade inflammation persists for a long period of time, cellular energy reserves may become depleted. When cells don&rsquo;t have energy reserves to draw on, we may become fatigued as a result [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247454/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932180/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Anti-inflammatory lifestyle and diet changes have therefore been promoted as management strategies for fatigue disorders like chronic fatigue syndrome [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835556/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with detrimental </span><em><span style="font-weight: 400;">CFB</span></em><span style="font-weight: 400;"> variants may benefit from anti-inflammatory strategies that target the complement system.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">CFB </span></em><span style="font-weight: 400;">gene encodes a part of the complement system, which helps antibodies and white blood cells kill bacteria. Variants of this gene that increase inflammation have been linked to chronic fatigue syndrome.</span></span></p> <h2><strong>Your </strong><strong><em>CFB</em></strong><strong> Results for Chronic Fatigue Syndrome</strong></h2> <p>*6701208067624558*</p> <p><strong>CFB </strong><a href="https://selfdecode.com/snp/rs4151667/"><strong>rs4151667</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/26116897/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with increased rates of chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may increase complement activation and inflammation, thereby leading to fatigue [</span><a href="https://www.sciencedirect.com/science/article/pii/S0198885915001809?via%3Dihub"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*4362470925695965*</p> <h2><strong>Recommendations for Increasing Energy Levels</strong></h2> <p>*1799344288556721*</p> <h3><strong>Stress Management</strong></h3> <p><span style="font-weight: 400;">Psychological </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> may activate the complement cascade, so people with detrimental </span><em><span style="font-weight: 400;">CFB</span></em><span style="font-weight: 400;"> variants may benefit more than most from stress-busting activities [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18480187/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">Stress</span></a><span style="font-weight: 400;"> and fatigue are closely and reciprocally linked, meaning they often co-occur and can influence each other. Stressful life events can cause not only </span><a href="https://selfhacked.com/blog/ptsd-causes-treatments/"><span style="font-weight: 400;">PTSD</span></a><span style="font-weight: 400;">, but also </span><a href="https://selfhacked.com/blog/chronic-fatigue-syndrome-real-heres-test/"><span style="font-weight: 400;">chronic fatigue syndrome</span></a><span style="font-weight: 400;">. Similarly, occupational exposure to traumatic events of others (e.g., by healthcare workers) causes physical and mental fatigue, and may reduce empathy [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26143479/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24630177/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19812026/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894419/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28119163/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Cognitive-behavioral therapy (CBT) for stress management has been reported to reduce fatigue from </span><a href="https://selfhacked.com/blog/my-cutting-edge-protocol-to-cure-fatigue/"><span style="font-weight: 400;">chronic fatigue</span></a><span style="font-weight: 400;"> syndrome, fibromyalgia, and </span><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">multiple sclerosis</span></a><span style="font-weight: 400;"> in several studies. Similarly, its combination with mindfulness </span><a href="https://selfhacked.com/blog/meditation/"><span style="font-weight: 400;">meditation</span></a><span style="font-weight: 400;"> (mindfulness-based stress reduction) may help with fatigue from fibromyalgia and cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028002/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28984402/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27772557/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719827/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31927347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Relaxation therapy with breathing practices and muscle relaxation exercises has also been reported to help with fatigue from conditions such as chronic fatigue syndrome, multiple sclerosis, cancer, heart failure, and stem cell transplantation. However, CBT was more effective in those studies that compared both treatments [</span><a href="https://pubmed.ncbi.nlm.nih.gov/9054791/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11729022/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22967281/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15338385/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12719750/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20492052/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17057393/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17383494/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15656848/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Psychological stress may increase activation of the complement cascade, leading to inflammation and fatigue. Stress has also been strongly linked to fatigue disorders.</span></p> <h3><strong>Regular Sleep Schedule</strong></h3> <p><span style="font-weight: 400;">The complement cascade has a </span><a href="http://selfhacked.com/blog/what-it-means-to-keep-to-a-circadian-rhythm/"><span style="font-weight: 400;">circadian rhythm</span></a><span style="font-weight: 400;">; that is, it is more active during some parts of the day than others. To avoid disrupting this rhythm and activating complement at the wrong times, it&rsquo;s important to go to bed and wake up around the same time each day [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456827/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">Sleep</span></a><span style="font-weight: 400;"> is essential for optimal health. Failing to get enough quality sleep is associated with fatigue among many other health issues. People who perform shift or night work (such as healthcare professionals) are at increased risk of sleep disturbances and fatigue [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11439783/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434546/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25940538/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17505227/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Sleep disturbances are frequent in people with chronic fatigue syndrome, cancer, multiple sclerosis, </span><a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/"><span style="font-weight: 400;">IBD</span></a><span style="font-weight: 400;">, and allergic rhinitis, and can further worsen fatigue associated with these conditions [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23046847/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17573454/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24360534/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32002666/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17165263/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some clinical research suggests that therapy for sleep disturbances may improve fatigue from some of these conditions (such as cancer and multiple sclerosis). In turn, CBT for chronic fatigue syndrome has been inconsistently suggested to improve sleep quality [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138396/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22914848/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27524207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Complement activation follows a daily circadian rhythm. Going to sleep and waking up at the same time each day may help prevent excess inflammation and fatigue.</span></p> <h3><strong>Address Food Sensitivities</strong></h3> <p><span style="font-weight: 400;">If you are experiencing inflammation-related fatigue, especially right after meals, you may have a hidden food sensitivity. Food sensitivities are generally caused by compounds from food crossing the intestinal barrier into the bloodstream, and the immune system reacting to these compounds with inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835556/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Mental and physical fatigue are common symptoms of sensitivity to food components such as gluten, lactose, FODMAPS, and </span><a href="https://selfhacked.com/blog/lectins-beneficial-harmful/"><span style="font-weight: 400;">lectins</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586565/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25089542/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706251/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30309810/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">If you suspect that your low energy levels may be due to intolerance to certain foods, consider working with an allergist or dietitian to test for food sensitivities. They will prescribe an elimination diet to help identify the cause of intolerance, followed by avoidance of the problematic food.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">People with food sensitivities may have increased complement and inflammation after eating certain foods. Removing these triggers may help improve fatigue.</span></p>
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463 | content_learn_more_4362470925695965_text == Based on the variants we looked at, your CFB gene is somewhat associated with chronic fatigue syndrome. However, this doesn't necessarily reflect your overall risk of fatigue disorders; it’s just one gene related to it. Stress management, a regular sleep schedule, and diet changes that address food sensitivities may help. Keep scrolling to find out more.
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rsIDs = rs4151667
rsStatus = rs4151667,CFB,chr6,31946247,T,A,,,5,0,Normal
