465 | id == 465
465 | category_id == 27
465 | category_order == 24
465 | category_name == Fatigue
465 | category_color == #C47AC0
465 | slug == NR3C1-fatigue
465 | title == The Involvement of a Stress Hormone in Fatigue (NR3C1)
465 | meta_description == NR3C1 helps regulate stress-related proteins. Variants of NR3C1 have been associated with fatigue. Read more here.
465 | summary == <p style="text-align:justify"><strong>The <em>NR3C1 </em>gene codes for a receptor that helps regulate the production of stress-related proteins. Read more to find out how variants of <em>NR3C1</em> might elevate levels of fatigue.</strong></p>
465 | overall_score_text == Your Fatigue Score (based on NR3C1 gene)
465 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/NR3C1-Chronic-fatigue-syndrome.jpg
465 | author_id == 14
465 | author_name == Shany Lahan
465 | author_title == MS (Neuroscience)
465 | author_order == 5
465 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
465 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
465 | reviewer == None
465 | medical_reviewer_id == 11
465 | medical_reviewer_name == Puya Yazdi
465 | medical_reviewer_title == MD
465 | publish_date == 2020
465 | publish_date == 11
465 | publish_date == 6
465 | avg_rating == 5.0
465 | tags_id == 416
465 | tags_name == Cortisol
465 | tags_id == 913
465 | tags_name == Glucocorticoid Receptor
465 | tags_id == 415
465 | tags_name == HPA axis
465 | tags_id == 24
465 | tags_name == Inflammation
465 | tags_id == 912
465 | tags_name == NR3C1 Gene
465 | permissions_favorite == False
465 | permissions_rate == False
465 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">NR3C1 </span></em><span style="font-weight: 400;">gene encodes the glucocorticoid receptor. The glucocorticoid receptor helps regulate the production of stress-related, inflammatory proteins, which may promote fatigue. Variants of </span><em><span style="font-weight: 400;">NR3C1 </span></em><span style="font-weight: 400;">may play a role in chronic fatigue syndrome by decreasing activity or sensitivity of the glucocorticoid receptor. Lifestyle and supplement modifications may counteract the effects of these variants by increasing glucocorticoid receptor activity.</span></span></p> <h2 style="text-align: justify;"><strong><em>NR3C1</em></strong><strong> and Fatigue</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/nr3c1/"><em><span style="font-weight: 400;">NR3C1</span></em></a><span style="font-weight: 400;"> gene codes for the </span><a href="https://selfhacked.com/blog/glucocorticoid-receptor/"><span style="font-weight: 400;">glucocorticoid receptor</span></a><span style="font-weight: 400;">. Upon activation by glucocorticoids (such as the primary stress hormone </span><a href="https://selfhacked.com/blog/need-know-cortisol-health-effects/"><span style="font-weight: 400;">cortisol</span></a><span style="font-weight: 400;">), the glucocorticoid receptor is able to regulate the production of stress-related, inflammatory proteins [</span><a href="https://www.ncbi.nlm.nih.gov/gene/2908"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The glucocorticoid receptor is also an integral component of the </span><a href="https://selfhacked.com/blog/reasons-cortisol-low-high/"><span style="font-weight: 400;">HPA axis</span></a><span style="font-weight: 400;">, where it functions to inhibit HPA axis activity and suppress the release of cortisol when levels are elevated [</span><a href="https://www.ncbi.nlm.nih.gov/gene/2908"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Excess cortisol release may lead to continuous stimulation of the glucocorticoid receptor, which may ultimately lower sensitivity of the receptor to glucocorticoids. This is called </span><em><span style="font-weight: 400;">glucocorticoid resistance</span></em><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263906/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Glucocorticoid resistance has been shown to result in HPA axis dysregulation, excess cortisol release, and inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933142/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Inflammation has the potential to induce a variety of unwanted effects, including fatigue. Interestingly, elevated fatigue has been linked to both high and low levels of cortisol, suggesting that optimal cortisol levels and glucocorticoid receptor activity may be required to control energy [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8239231"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593220/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932180/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16610949/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/j.1601-183X.2006.00244.x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">NR3C1 </span></em><span style="font-weight: 400;">have been associated with chronic fatigue syndrome, an illness characterized by prolonged low energy. These variants may lower sensitivity or activity of the glucocorticoid receptor, thus resulting in dysregulated HPA axis activity, excess cortisol release, and inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765429/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16610949/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/j.1601-183X.2006.00244.x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015684/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;&nbsp;</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>NR3C1 </em></strong><strong>Results for Fatigue</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">*3837388358590345*</span></p> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Primary SNP</strong></span></p> <p style="text-align: justify;"><strong><em>NR3C1 </em></strong><a href="https://selfdecode.com/snp/rs852977/"><strong>rs852977</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765429/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16610949/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/j.1601-183X.2006.00244.x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with chronic fatigue syndrome</span></li> </ul> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Other Important SNPs</strong></span></p> <p style="text-align: justify;"><strong><em>NR3C1 </em></strong><a href="https://selfdecode.com/snp/rs1866388/"><strong>rs1866388</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765429/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16610949/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/j.1601-183X.2006.00244.x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with chronic fatigue syndrome</span></li> </ul> <p style="text-align: justify;"><strong><em>NR3C1 </em></strong><a href="https://selfdecode.com/snp/rs6188/"><strong>rs6188</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765429/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16610949/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/j.1601-183X.2006.00244.x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased risk of chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with chronic fatigue syndrome</span></li> </ul> <p style="text-align: justify;"><strong><em>NR3C1 </em></strong><a href="https://selfdecode.com/snp/rs2918419/"><strong>rs2918419</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765429/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16610949/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/j.1601-183X.2006.00244.x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of chronic fatigue syndrome&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with chronic fatigue syndrome</span></li> </ul> <p style="text-align: justify;"><strong><em>NR3C1 </em></strong><a href="https://selfdecode.com/snp/rs6196/"><strong>rs6196</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765429/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16610949/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/j.1601-183X.2006.00244.x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with chronic fatigue syndrome</span></li> </ul> <p style="text-align: justify;">*6543032508590407*</p> <h2 style="text-align: left;"><strong>Recommendations for Reducing Fatigue</strong></h2> <p style="text-align: justify;">*7253590682743654*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Stress Reduction</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Chronic stress is a major cause of excess cortisol release and glucocorticoid receptor dysfunction. In two studies consisting of over 350 healthy volunteers, prolonged stress was reported to inhibit glucocorticoid receptor activity and promote inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341031/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">As alluded to above,</span> <a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> and fatigue are closely and reciprocally linked, meaning that they often co-occur and can influence each other. Stressful life events can cause not only </span><a href="https://selfhacked.com/blog/ptsd-causes-treatments/"><span style="font-weight: 400;">PTSD</span></a><span style="font-weight: 400;">, but also </span><a href="https://selfhacked.com/blog/chronic-fatigue-syndrome-real-heres-test/"><span style="font-weight: 400;">chronic fatigue syndrome</span></a><span style="font-weight: 400;">. Similarly, occupational exposure to traumatic events of others (e.g., by healthcare workers) causes physical and mental fatigue, and may reduce empathy [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26143479/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24630177/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19812026/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894419/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28119163/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Cognitive-behavioral therapy (CBT) for stress management has been reported to reduce fatigue from chronic fatigue syndrome, fibromyalgia, and </span><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">multiple sclerosis</span></a><span style="font-weight: 400;"> in several studies. Similarly, its combination with mindfulness </span><a href="https://selfhacked.com/blog/meditation/"><span style="font-weight: 400;">meditation</span></a><span style="font-weight: 400;"> (mindfulness-based stress reduction) may help with fatigue from fibromyalgia and cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028002/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28984402/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27772557/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719827/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31927347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Relaxation therapy with breathing practices and muscle relaxation exercises has also been reported to help with fatigue from conditions such as chronic fatigue syndrome, multiple sclerosis, cancer, heart failure, and stem cell transplantation. However, CBT was more effective in studies that compared the two therapies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/9054791/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11729022/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22967281/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15338385/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12719750/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20492052/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17057393/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17383494/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15656848/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Stress reduction by means of cognitive-behavioral therapy or meditation (for example) may reduce fatigue by stimulating glucocorticoid receptor activity and preventing inflammation.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Yoga</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/health-benefits-yoga/"><span style="font-weight: 400;">Yoga</span></a><span style="font-weight: 400;"> interventions reduced fatigue in a few clinical trials on healthy adolescents, adults, and seniors [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21647811/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24906581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16454146/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27502801/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">This practice has been most widely investigated regarding fatigue from multiple sclerosis and breast cancer. The most recent meta-analyses concluded that yoga may be effective as an add-on to conventional therapies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32379628/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31127466/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Yoga has also been reported to help with fatigue from chronic fatigue syndrome, fibromyalgia, Parkinson&rsquo;s disease, </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;">, low-back </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;">, IBS, COPD, end-stage kidney disease, HIV, and arthritis in a few preliminary trials [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15889950/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20946990/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30901529/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15055096/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22812905/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25025601/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27830924/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17709061/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31103108/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28008603/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23548052/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a randomized controlled trial of breast cancer survivors with fatigue, a 12-week yoga intervention was reported to increase activity of the glucocorticoid receptor, while decreasing production of inflammatory proteins [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24703167/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Yoga may reduce fatigue by stimulating activity of the glucocorticoid receptor and decreasing inflammatory protein production.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>L-Carnitine</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Multiple studies have reported that the nutrient </span><a href="https://selfhacked.com/blog/carnitine-top-18-science-based-health-effects-carnitine/"><span style="font-weight: 400;">L-carnitine</span></a><span style="font-weight: 400;"> has the ability to mimic glucocorticoids and activate the glucocorticoid receptor, thus resulting in decreased production of inflammatory proteins [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12824292/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15591012/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15265779/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In people with chronic fatigue syndrome, supplementation with L-carnitine for 2 weeks improved related symptoms and was well tolerated. Its derived compounds acetyl-L-carnitine and propionyl-L-carnitine were also effective for mental and general fatigue, respectively [</span><a href="https://pubmed.ncbi.nlm.nih.gov/9018019/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15039515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In elderly subjects, both L-carnitine and acetyl-L-carnitine reduced physical and mental fatigue (by approximately 40%), increased muscle mass, and improved cognitive function [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17658628/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12875611/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18065594/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117993/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A few trials found L-carnitine effective at improving fatigue from conditions such as fibromyalgia, hypothyroidism, and hepatic encephalopathy, dialysis-associated anemia, and medication for kidney cancer and hepatitis C [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17543140/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27432821/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21310833/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11325685/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10718283/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30374764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12707492/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Although L-carnitine has been widely investigated for fatigue from multiple sclerosis and cancer with mixed results, two meta-analyses concluded that it has little or no effectiveness in both cases [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28870581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707696/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">L-carnitine may reduce fatigue by mimicking glucocorticoids, stimulating glucocorticoid receptor activity, and decreasing production of inflammatory proteins.</span></p>
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465 | content_learn_more_6543032508590407_text == Based on the variants we looked at, your NR3C1 gene makes you somewhat more likely to develop chronic fatigue syndrome. However, this doesn't necessarily reflect your overall risk of elevated fatigue; it’s just one gene related to it. Stress reduction, yoga, and L-carnitine supplements may help. Keep scrolling to find out more.
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rsIDs = rs2918419,rs6196,rs852977,rs6188,rs1866388
rsStatus = rs2918419,NR3C1,chr5,143342788,T,C,G,,33,0,Normal
rsStatus = rs6196,NR3C1,chr5,143281925,A,G,,,19,0,Normal
rsStatus = rs852977,NR3C1,chr5,143307929,A,G,,,10,12,HET
rsStatus = rs6188,NR3C1,chr5,143300779,C,A,,,21,13,HET
rsStatus = rs1866388,NR3C1,chr5,143380220,A,G,T,,17,8,HET
