466 | id == 466
466 | category_id == 27
466 | category_order == 24
466 | category_name == Fatigue
466 | category_color == #C47AC0
466 | slug == TNF-inflammation-fatigue
466 | title == Genetics of Inflammation in Chronic Fatigue (TNF)
466 | meta_description == The TNF gene encodes TNF-alpha, a crucial inflammatory protein. Click to learn about its link with fatigue.
466 | summary == <p style="text-align:justify"><strong>The root cause of fatigue may lie in inflammatory genes! Read this post to learn the link between <em>TNF</em> and fatigue, and get gene-based tips.</strong></p>
466 | overall_score_text == Your Fatigue Score (based on TNF gene)
466 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TNF-Fatigue.jpg
466 | author_id == 9
466 | author_name == Aleksa Ristic
466 | author_title == MS (Pharmacy)
466 | author_order == 45
466 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
466 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
466 | reviewer == None
466 | medical_reviewer_id == 11
466 | medical_reviewer_name == Puya Yazdi
466 | medical_reviewer_title == MD
466 | publish_date == 2020
466 | publish_date == 11
466 | publish_date == 7
466 | avg_rating == 5.0
466 | tags_id == 904
466 | tags_name == Chronic Fatigue Syndrome
466 | tags_id == 68
466 | tags_name == Fatigue
466 | tags_id == 24
466 | tags_name == Inflammation
466 | tags_id == 235
466 | tags_name == TNF-alpha
466 | tags_id == 234
466 | tags_name == TNF gene
466 | permissions_favorite == False
466 | permissions_rate == False
466 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The TNF gene helps make TNF-alpha, a crucial inflammatory protein involved in chronic fatigue.<br /><br /></strong><strong>One gene variant may increase TNF-alpha levels and correlate with fatigue &amp; malaise.<br /><br /></strong><strong>Read this post to discover potential ways to reduce fatigue by targeting the TNF gene.</strong></span></p> <p>&nbsp;</p> <h2><strong>TNF-Alpha, Inflammation &amp; Fatigue</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/blog/article/tnf-longevity-86"><em><span style="font-weight: 400;">TNF</span></em></a><span style="font-weight: 400;"> gene codes for </span><a href="http://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">TNF-alpha</span></a><span style="font-weight: 400;">, a crucial inflammatory protein. Studies suggest an important role of inflammation in </span><a href="https://selfhacked.com/blog/chronic-fatigue-syndrome-real-heres-test/"><span style="font-weight: 400;">chronic fatigue syndrome</span></a><span style="font-weight: 400;"> and other conditions with low energy levels [</span><a href="https://www.ncbi.nlm.nih.gov/gene/7124"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247454/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932180/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">TNF-alpha is the best-studied inflammation marker in chronic fatigue syndrome, and it&rsquo;s usually elevated in people with this condition [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599310/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your </strong><strong><em>TNF</em></strong><strong> Results for Fatigue</strong></h2> <p>*2555878632470671*</p> <p><strong>Primary SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs1800629/"><strong>rs1800629</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.leelabsg.org/resources"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with fatigue and malaise</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with fatigue or malaise</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may increase TNF-alpha levels</span></li> </ul> <p>*7187712658628453*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Increase Energy Levels</strong></h2> <p>*7805840820539789*</p> <h3><strong>Lifestyle</strong></h3> <p><span style="font-weight: 400;">In one clinical trial, low </span><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;"> quality was associated with increased TNF-alpha levels and chronic fatigue severity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28038892/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The lack of proper sleep is associated with fatigue, among many other health issues. People who perform shift or night work are at increased risk of sleep disturbances and fatigue [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11439783/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434546/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25940538/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17505227/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Sleep issues are frequent in people with chronic fatigue syndrome, cancer, </span><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">multiple sclerosis</span></a><span style="font-weight: 400;"> (MS), </span><a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/"><span style="font-weight: 400;">IBD</span></a><span style="font-weight: 400;">, and allergic rhinitis. They can in turn worsen fatigue, so it&rsquo;s crucial to work on improving sleep quality [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23046847/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17573454/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24360534/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32002666/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17165263/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Improving your sleep quality may reduce fatigue by targeting your gene variant.</span></p> <h3><strong>Diet</strong></h3> <p><strong><span style="font-weight: 400;">In sensitive people, potential food irritants&mdash;such as gluten, lactose, </span><a href="https://selfhacked.com/blog/fodmap-food-list/"><span style="font-weight: 400;">FODMAPs</span></a><span style="font-weight: 400;">, and</span><a href="https://selfhacked.com/blog/lectins-beneficial-harmful/"> <span style="font-weight: 400;">lectins</span></a><span style="font-weight: 400;">&mdash;may trigger inflammation and increase TNF-alpha [<a href="https://pubmed.ncbi.nlm.nih.gov/2044082/">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749529/">R</a>].</span></strong></p> <p><strong><span style="font-weight: 400;">Mental and physical fatigue, especially after meals, are common symptoms of hidden </span><a href="https://get.selfdecode.com/foodsensitivity-wr/"><span style="font-weight: 400;">food sensitivities</span></a><span style="font-weight: 400;">. If you suspect that might be your case, an </span><a href="https://selfhack.com/blog/elimination-diet-safest-foods-people-sensitive-everything/"><span style="font-weight: 400;">elimination diet</span></a><span style="font-weight: 400;"> may help your identify and remove hidden food irritants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835556/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586565/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/25089542/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706251/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></strong></p> <h3><strong>Supplements</strong></h3> <p><span style="font-weight: 400;">According to a review of 13 clinical studies, </span><a href="https://selfhacked.com/blog/carnitine-top-18-science-based-health-effects-carnitine/"><span style="font-weight: 400;">L-</span></a><a href="http://selfhacked.com/blog/top-18-science-based-health-effects-carnitine/"><span style="font-weight: 400;">carnitine</span></a><span style="font-weight: 400;"> may significantly reduce TNF-alpha and other markers of inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30915521/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In people with chronic fatigue syndrome, supplementation with L-carnitine for two weeks reduced the symptoms with no side effects. In studies on elderly patients, it reduced mental fatigue by 40% and enhanced cognition [</span><a href="https://pubmed.ncbi.nlm.nih.gov/9018019/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17658628/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12875611/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18065594/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117993/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">L-carnitine may also reduce fatigue from fibromyalgia and </span><a href="https://selfhacked.com/blog/low-thyroid-hormones-low-t3-syndrome/"><span style="font-weight: 400;">hypothyroidism</span></a><span style="font-weight: 400;">, while its effectiveness for cancer- and MS-related fatigue is limited [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17543140/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27432821/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21310833/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11325685/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10718283/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28870581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707696/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">L-carnitine supplementation may counteract your TNF variant and reduce fatigue of different origins.</span></p>
466 | content_snp_table_2555878632470671_key == 2555878632470671
466 | content_snp_table_2555878632470671_blur == True
466 | content_snp_table_2555878632470671_hidden == False
466 | content_learn_more_7187712658628453_key == 7187712658628453
466 | content_learn_more_7187712658628453_blur == True
466 | content_learn_more_7187712658628453_hidden == False
466 | content_learn_more_7187712658628453_text == Based on the variant we looked at, your TNF gene is slightly associated with fatigue. However, this doesn't necessarily reflect your overall risk of fatigue; it’s just one gene related to it. Try to improve your sleep quality and consider supplementing with L-carnitine to combat fatigue. Keep reading to learn more.
466 | content_recommendation_7805840820539789_key == 7805840820539789
466 | content_recommendation_7805840820539789_blur == True
466 | content_recommendation_7805840820539789_hidden == False
rsIDs = rs1800629
rsStatus = rs1800629,TNF,chr6,31575254,G,A,,,9,0,Normal
