471 | id == 471
471 | category_id == 26
471 | category_order == 23
471 | category_name == Allergies
471 | category_color == #C47AC0
471 | slug == IL2RA-Tregs-allergies
471 | title == Can This Gene Reduce Allergic Inflammation? (IL2RA)
471 | meta_description == The IL2RA gene helps make a receptor for interleukin-2 (IL-2), which reduces inflammation. Learn how it affects allergies.
471 | summary == <p style="text-align:justify"><strong>Did you know that genes may protect you against allergic inflammation? Read this post to learn about the link between <em>IL2RA</em> and allergies &mdash; gene-based tips included!</strong></p>
471 | overall_score_text == Your Allergies Score (based on IL2RA gene)
471 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ILR2A-Allergies.jpg
471 | author_id == 9
471 | author_name == Aleksa Ristic
471 | author_title == MS (Pharmacy)
471 | author_order == 45
471 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
471 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
471 | reviewer == None
471 | medical_reviewer_id == 11
471 | medical_reviewer_name == Puya Yazdi
471 | medical_reviewer_title == MD
471 | publish_date == 2020
471 | publish_date == 11
471 | publish_date == 10
471 | avg_rating == 5.0
471 | tags_id == 97
471 | tags_name == Allergies
471 | tags_id == 393
471 | tags_name == IL-2
471 | tags_id == 95
471 | tags_name == Immune System
471 | tags_id == 24
471 | tags_name == Inflammation
471 | tags_id == 104
471 | tags_name == Tregs
471 | permissions_favorite == False
471 | permissions_rate == False
471 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The </strong><strong><em>IL2RA</em></strong><strong> gene helps make a receptor for interleukin-2 (IL-2), a protein that reduces allergic inflammation.<br /><br /></strong><strong>One </strong><strong><em>IL2RA</em></strong><strong> variant may reduce IL-2 activity and correlate with higher odds of allergic conditions.<br /><br /></strong><strong>Read this post to learn the ways to potentially relieve allergies by targeting the </strong><strong><em>IL2RA</em></strong><strong> gene.</strong></span></p> <p>&nbsp;</p> <h2><strong>The Role of IL2RA in Allergic Reactions</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/il2ra/"><em><span style="font-weight: 400;">IL2RA</span></em></a><span style="font-weight: 400;"> gene helps make a receptor for interleukin-2 (IL-2), a crucial protein involved in the immune response. By boosting regulatory T cells or </span><a href="https://selfhack.com/blog/treg/"><span style="font-weight: 400;">Tregs</span></a><span style="font-weight: 400;">, IL-2 helps reduce allergic inflammation present in [</span><a href="https://www.ncbi.nlm.nih.gov/gene/3559"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706157/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432919/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27259854/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Respiratory allergies</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Dermatitis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Food allergies</span></li> </ul> <p><span style="font-weight: 400;">Researchers are studying the therapeutic potential of IL-2 in different allergic conditions [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27259854/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your IL2RA Results for Allergies</strong></h2> <p>*2154308738271164*</p> <p><strong>Primary SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs61839660/"><strong>rs61839660</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher odds of allergic conditions</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with allergic conditions</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele likely reduces IL-2 activity</span></li> </ul> <p>*4307605091006776*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Relieve Allergies</strong></h2> <p>*6815366650408863*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Sun Exposure</strong></h4> <p><a href="https://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">Vitamin D</span></a><span style="font-weight: 400;"> stimulates IL-2, and they work together to increase the activity of Tregs and suppress inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810518/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12051670/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Vitamin D deficiency has been associated with asthma and allergies in children [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675563/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17919705/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Healthy exposure to </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sunlight</span></a><span style="font-weight: 400;"> is the best way to increase your vitamin D levels. You can also eat food sources of this vitamin (such as fatty fish, liver, egg yolks, and dairy) or take supplements [</span><a href="https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">By boosting vitamin D, healthy sun exposure may counteract your gene variant and prevent allergies.</span></p> <h3><strong>Diet</strong></h3> <h4><strong>Vitamin E</strong></h4> <p><span style="font-weight: 400;">Increased </span><a href="https://selfhacked.com/blog/vitamin-e-can-help-fertility-pregnancy/"><span style="font-weight: 400;">vitamin E</span></a><span style="font-weight: 400;"> intake may stimulate IL-2 production [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266234/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2327029/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Several studies have associated a higher intake of vitamin E with a reduced incidence of asthma. Similarly, some people with asthma have lower levels of this vitamin in the blood and lungs [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7735592/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16763215/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1745426/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10731863/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10465176/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Excellent vitamin E sources include wheat germ, nuts, sunflower, sesame seeds, and oils derived from these foods [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956867/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Increased vitamin E intake may help prevent allergies by targeting your IL2RA variant.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>CLA</strong></h4> <p><span style="font-weight: 400;">Conjugated linoleic acids or </span><a href="https://selfhacked.com/blog/conjugated-linoleic-acid/"><span style="font-weight: 400;">CLA</span></a><span style="font-weight: 400;"> increased IL-2 production in test tubes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107217/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14687725/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Supplementation with CLA starting 8 weeks before the pollen season reduced sneezing and improved well-being in people with allergy to birch pollen [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18167173/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">CLA also reduced airway inflammation and sensitivity in people with allergic asthma [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20642580/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739392/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">CLA supplementation may counteract your variant and reduce the symptoms of allergies.</span></p>
471 | content_snp_table_2154308738271164_key == 2154308738271164
471 | content_snp_table_2154308738271164_blur == True
471 | content_snp_table_2154308738271164_hidden == False
471 | content_learn_more_4307605091006776_key == 4307605091006776
471 | content_learn_more_4307605091006776_blur == True
471 | content_learn_more_4307605091006776_hidden == False
471 | content_learn_more_4307605091006776_text == Based on the variant we looked at, your IL2RA gene is associated with slightly higher odds of allergies. However, this doesn't necessarily reflect your overall risk of allergies; it’s just one gene related to it. Get more sunlight, increase your vitamin E intake, and consider supplementing with CLA to relieve allergies. Keep reading to learn more.
471 | content_recommendation_6815366650408863_key == 6815366650408863
471 | content_recommendation_6815366650408863_blur == True
471 | content_recommendation_6815366650408863_hidden == False
rsIDs = rs61839660
rsStatus = rs61839660,IL2RA,chr10,6052734,C,T,,,29,0,Normal
