472 | id == 472
472 | category_id == 27
472 | category_order == 24
472 | category_name == Fatigue
472 | category_color == #C47AC0
472 | slug == CRHR1-fatigue
472 | title == Cortisol and the HPA Axis in Chronic Fatigue Syndrome (CRHR1)
472 | meta_description == CRHR1 encodes a receptor that activates the HPA Axis and produces stress hormones. What is its role in chronic fatigue?
472 | summary == <p><strong><em>CRHR1 </em>encodes a receptor that activates the HPA Axis and produces stress hormones. What is its role in chronic fatigue? Learn more here.</strong></p>
472 | overall_score_text == Your Fatigue Score (based on CRHR1)
472 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CRHR1-Chronic-fatigue-syndrome.jpg
472 | author_id == 1
472 | author_name == Jasmine Foster
472 | author_title == BSc, BEd
472 | author_order == 36
472 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
472 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
472 | reviewer == None
472 | medical_reviewer_id == 11
472 | medical_reviewer_name == Puya Yazdi
472 | medical_reviewer_title == MD
472 | publish_date == 2020
472 | publish_date == 11
472 | publish_date == 10
472 | avg_rating == 5.0
472 | tags_id == 904
472 | tags_name == Chronic Fatigue Syndrome
472 | tags_id == 777
472 | tags_name == Corticotropin-Releasing Hormone
472 | tags_id == 416
472 | tags_name == Cortisol
472 | tags_id == 417
472 | tags_name == CRH
472 | tags_id == 418
472 | tags_name == CRHR1 gene
472 | tags_id == 68
472 | tags_name == Fatigue
472 | tags_id == 415
472 | tags_name == HPA axis
472 | permissions_favorite == False
472 | permissions_rate == False
472 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">CRHR1</span></em><span style="font-weight: 400;"> encodes a receptor for corticotropin-releasing hormone (CRH). Variants of </span><em><span style="font-weight: 400;">CRHR1</span></em><span style="font-weight: 400;"> may play a role in chronic fatigue syndrome by altering the activation of the HPA axis. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by normalizing HPA activation and cortisol levels.</span></p> <h2><strong><em>CRHR1</em></strong><strong> and Chronic Fatigue Syndrome&nbsp;</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/crhr1/"><em><span style="font-weight: 400;">CRHR1 </span></em><span style="font-weight: 400;">gene</span></a><span style="font-weight: 400;"> codes for a receptor that binds </span><a href="http://selfhacked.com/blog/why-your-health-problems-worsen-after-stress-the-role-of-crh/"><span style="font-weight: 400;">corticotropin-releasing hormone</span></a><span style="font-weight: 400;"> (</span><a href="http://selfhacked.com/blog/why-your-health-problems-worsen-after-stress-the-role-of-crh/"><span style="font-weight: 400;">CRH</span></a><span style="font-weight: 400;">).&nbsp;</span></p> <p><span style="font-weight: 400;">CRH plays a major role in the </span><a href="http://selfhacked.com/blog/reasons-cortisol-low-high/"><span style="font-weight: 400;">HPA axis</span></a><span style="font-weight: 400;">. It is released from a region of the brain called the </span><a href="https://selfhacked.com/blog/hypothalamus-101/"><span style="font-weight: 400;">hypothalamus</span></a><span style="font-weight: 400;"> and subsequently binds to CRHR1 in the pituitary gland to stimulate the release of </span><a href="https://selfhacked.com/blog/acth/"><span style="font-weight: 400;">ACTH</span></a><span style="font-weight: 400;">. ACTH, in turn, stimulates the release of the stress-related hormone </span><a href="https://selfhacked.com/blog/need-know-cortisol-health-effects/"><span style="font-weight: 400;">cortisol</span></a><span style="font-weight: 400;"> from the adrenal glands [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181830/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Stress activates the HPA axis, eventually resulting in </span><a href="https://selfhacked.com/blog/need-know-cortisol-health-effects/"><span style="font-weight: 400;">cortisol</span></a><span style="font-weight: 400;"> release. Hence, CRH receptors play a significant role in </span><a href="https://selfhacked.com/blog/factors-counteract-stress-response/"><span style="font-weight: 400;">stress response</span></a><span style="font-weight: 400;"> and related disorders [</span><a href="https://www.ncbi.nlm.nih.gov/gene/1394"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31655035/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Multiple studies have found that activity of the HPA axis was significantly lower in people with </span><a href="https://selfhacked.com/blog/chronic-fatigue-syndrome-real-heres-test/"><span style="font-weight: 400;">chronic fatigue syndrome</span></a><span style="font-weight: 400;">. Some research suggests that </span><a href="https://selfhacked.com/blog/my-cutting-edge-protocol-to-cure-fatigue/"><span style="font-weight: 400;">chronic fatigue</span></a><span style="font-weight: 400;"> syndrome alters the normal daily rise and fall of cortisol levels [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK279099/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730359/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Patients with chronic fatigue syndrome tend to have lower baseline levels of cortisol. Further, the relative responsiveness of their HPA axis may be very sensitive to psychological or environmental changes. This means that a person may have a severe HPA response when stressed, but then their HPA axis may become much less sensitive (and stop responding properly) for a period of time afterward, leading to fatigue [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730359/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">CRH receptors lie at the beginning of the whole HPA response. If they do not activate at the rate that they should, they may lead to low HPA activity and fatigue [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181830/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730359/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">CRHR1 </span></em><span style="font-weight: 400;">gene encodes a receptor for corticotropin-releasing hormone (CRH), which activates the HPA axis. People with chronic fatigue syndrome may have a very sensitive HPA response which overactivates in response to stress and then becomes fatigued for a period afterward.</span></span></p> <h2><strong>Your </strong><strong><em>CRHR1</em></strong><strong> Results for Chronic Fatigue Syndrome</strong></h2> <p>*3982158240447409*</p> <p><strong>CRHR1 </strong><a href="https://selfdecode.com/snp/rs242924/"><strong>rs242924</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively higher rates of chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Possibly protective against chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele may make the HPA axis more sensitive to negative feedback, leading to periods of fatigue [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730359/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong>CRHR1 </strong><a href="https://selfdecode.com/snp/rs110402/"><strong>rs110402</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively higher rates of chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Possibly protective against chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may make the HPA axis more sensitive to negative feedback, leading to periods of fatigue [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730359/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong>CRHR1</strong> <a href="https://selfdecode.com/snp/rs1396862/"><strong>rs1396862</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively higher rates of chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may make the HPA axis more sensitive to negative feedback, leading to periods of fatigue [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730359/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong>CRHR1 </strong><a href="https://selfdecode.com/snp/rs173365/"><strong>rs173365</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively higher rates of chronic fatigue syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may make the HPA axis more sensitive to negative feedback, leading to periods of fatigue [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730359/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*3641246216862788*</p> <h2><strong>Recommendations for Increasing Energy Levels</strong></h2> <p>*5002154218169768*</p> <h3><strong>Stress Management</strong></h3> <p><span style="font-weight: 400;">Stress activates the HPA axis in the short term, potentially causing a negative feedback loop and a period of increased fatigue in people predisposed to chronic fatigue syndrome [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730359/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">Stress</span></a><span style="font-weight: 400;"> and fatigue are closely and reciprocally linked, meaning they often co-occur and can influence each other. Stressful life events can cause not only </span><a href="https://selfhacked.com/blog/ptsd-causes-treatments/"><span style="font-weight: 400;">PTSD</span></a><span style="font-weight: 400;">, but also </span><a href="https://selfhacked.com/blog/chronic-fatigue-syndrome-real-heres-test/"><span style="font-weight: 400;">chronic fatigue syndrome</span></a><span style="font-weight: 400;">. Similarly, occupational exposure to traumatic events of others (e.g., by healthcare workers) causes physical and mental fatigue, and may reduce empathy [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26143479/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24630177/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19812026/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894419/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28119163/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Cognitive-behavioral therapy (CBT) for stress management has been reported to reduce fatigue from </span><a href="https://selfhacked.com/blog/my-cutting-edge-protocol-to-cure-fatigue/"><span style="font-weight: 400;">chronic fatigue</span></a><span style="font-weight: 400;"> syndrome, fibromyalgia, and </span><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">multiple sclerosis</span></a><span style="font-weight: 400;"> in several studies. Similarly, its combination with mindfulness </span><a href="https://selfhacked.com/blog/meditation/"><span style="font-weight: 400;">meditation</span></a><span style="font-weight: 400;"> (mindfulness-based stress reduction) may help with fatigue from fibromyalgia and cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028002/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28984402/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27772557/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719827/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31927347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Relaxation therapy with breathing practices and muscle relaxation exercises has also been reported to help with fatigue from conditions such as chronic fatigue syndrome, multiple sclerosis, cancer, heart failure, and stem cell transplantation. However, CBT was more effective in those studies that compared both treatments [</span><a href="https://pubmed.ncbi.nlm.nih.gov/9054791/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11729022/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22967281/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15338385/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12719750/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20492052/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17057393/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17383494/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15656848/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Stress activates the HPA axis, which may cause a negative feedback loop and a period of increased fatigue in people with chronic fatigue syndrome.</span></p> <h3><strong>Coffee</strong></h3> <p><span style="font-weight: 400;">Caffeine is the most popular stimulant and helps reduce feelings of fatigue. It acts in part by activating the HPA axis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2249754/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409189/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A comprehensive clinical review of 21 meta-analyses concluded that </span><a href="https://selfhacked.com/blog/caffeine-benefits/"><span style="font-weight: 400;">caffeine</span></a><span style="font-weight: 400;"> improves </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> performance in a broad range of exercise tasks, in part through its anti-fatigue effects [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30926628/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">When caffeine delays fatigue, the body&rsquo;s muscles can contract more forcefully and allow people to exercise longer. Aerobic exercise such as running, jogging, cardio workout, swimming, and biking can benefit the most from increased training volume [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11583104/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19757860/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Caffeine may also improve alertness while reducing mental fatigue, especially in </span><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;">-deprived people. Several studies report reduced fatigue from mentally-demanding tasks after taking caffeine-containing beverages. However, frequent users seem to develop tolerance to the effects of caffeine [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608989/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK209050/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29247343/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18006208/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26320858/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16272184/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15678363/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Several studies have found that &lsquo;energy drinks&rsquo; combining caffeine and </span><a href="http://selfhacked.com/blog/taurine-benefits/"><span style="font-weight: 400;">taurine</span></a><span style="font-weight: 400;"> can reduce fatigue from prolonged driving [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24913484/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11310933/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24913484/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Note that your mileage may vary when it comes to caffeine and the HPA axis. If your HPA axis has a very sensitive negative feedback mechanism, caffeine may not work for you in the longer term. Other genetic and environmental factors may affect how you respond to caffeine. Be sure to carefully test out coffee&rsquo;s effects, and if you tend to crash a few hours after a cup, it&rsquo;s best to avoid it!</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Caffeine can wake you up by activating the HPA response, which may help if your HPA activity is low; however, take care not to overstimulate the HPA axis and create a negative feedback loop.</span></p> <h3><strong>Ginseng</strong></h3> <p><span style="font-weight: 400;">According to some researchers, ginseng may help normalize the HPA response, blocking overactivation in response to stress and thereby preventing the negative feedback loop from triggering fatigue. Furthermore, ginseng does not appear to reduce HPA activation except after exposure to stress, so it should not further reduce cortisol in people with chronic fatigue [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628357/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16002200/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240259/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/ginseng/"><span style="font-weight: 400;">Ginseng</span></a><span style="font-weight: 400;"> extract treatment decreased fatigue severity in several studies of both healthy volunteers and people diagnosed with chronic fatigue syndrome [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27754709/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102849/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31987248/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379339/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Ginseng has also been reported to reduce fatigue from cancer and multiple sclerosis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25873296/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32172198/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23301896/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Ginseng may help stabilize an abnormal HPA response, blocking both overactivation and underactivation of the HPA axis. Supplemental ginseng has helped people with chronic fatigue syndrome in some studies.</span></p>
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472 | content_learn_more_3641246216862788_text == Based on the variants we looked at, your CRHR1 gene is somewhat associated with chronic fatigue syndrome. However, this doesn't necessarily reflect your overall risk of fatigue; it’s just one gene related to it. Stress management, coffee, and ginseng may help. Keep scrolling to find out more.
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rsIDs = rs242924,rs1396862,rs110402,rs173365
rsStatus = rs242924,CRHR1,chr17,45808001,G,C,T,,12,0,Normal
rsStatus = rs1396862,CRHR1,chr17,45825631,G,A,,,19,0,Normal
rsStatus = rs110402,CRHR1,chr17,45802681,G,A,C,,8,4,HET
rsStatus = rs173365,CRHR1,chr17,45823708,A,C,G,T,12,0,Normal
