473 | id == 473
473 | category_id == 27
473 | category_order == 24
473 | category_name == Fatigue
473 | category_color == #C47AC0
473 | slug == IL17F-fatigue
473 | title == The Role of an Inflammatory Protein in Fatigue (IL17F)
473 | meta_description == IL17F may promote inflammation. A variant of IL17F has been associated with fatigue. Read more here.
473 | summary == <p style="text-align:justify"><strong>The <em>IL17F</em> gene codes for an inflammatory protein. Read more to find out how a variant of <em>IL17F</em> may be linked to chronic fatigue syndrome, and how you may be able to mitigate the negative effects of this variant.</strong></p>
473 | overall_score_text == Your Fatigue Score (based on IL17F gene)
473 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/IL17F-Chronic-fatigue-syndrome.jpg
473 | author_id == 14
473 | author_name == Shany Lahan
473 | author_title == MS (Neuroscience)
473 | author_order == 5
473 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
473 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
473 | reviewer == None
473 | medical_reviewer_id == 11
473 | medical_reviewer_name == Puya Yazdi
473 | medical_reviewer_title == MD
473 | publish_date == 2020
473 | publish_date == 11
473 | publish_date == 11
473 | avg_rating == 4.5
473 | tags_id == 924
473 | tags_name == Blood-Brain Barrier
473 | tags_id == 923
473 | tags_name == IL-17F
473 | tags_id == 922
473 | tags_name == IL17F Gene
473 | tags_id == 24
473 | tags_name == Inflammation
473 | tags_id == 744
473 | tags_name == Neuroinflammation
473 | tags_id == 440
473 | tags_name == Th17 Cells
473 | permissions_favorite == False
473 | permissions_rate == False
473 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">IL-17F is an inflammatory protein released by cells of the immune system. A variant of </span><em><span style="font-weight: 400;">IL17F </span></em><span style="font-weight: 400;">may play a role in chronic fatigue syndrome by increasing production of IL-17F. Lifestyle and supplement modifications may counteract the effects of this variant by decreasing IL-17F production.</span></span></p> <h2 style="text-align: justify;"><strong><em>IL17F</em></strong><strong> and Fatigue</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/il17f/"><em><span style="font-weight: 400;">IL17F</span></em></a> <span style="font-weight: 400;">gene codes for interleukin 17F (IL-17F), an inflammatory protein (cytokine) that is released by T helper 17 (</span><a href="https://selfhacked.com/blog/th17/"><span style="font-weight: 400;">Th17</span></a><span style="font-weight: 400;">) immune system cells.&nbsp;&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">IL-17F plays an essential role in the fight against microscopic organisms; however, when released in excess, IL-17F has the potential to induce widespread, uncontrolled inflammation. Inflammation is linked to many unwanted conditions, including <a href="https://selfhack.com/blog/chronic-fatigue-syndrome-real-heres-test/" target="_blank" rel="noopener">chronic fatigue syndrome</a> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932180/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19361847/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593220/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Interestingly, IL-17F may also have the ability to compromise the integrity of the blood-brain barrier. This would allow Th17 cells to migrate more freely across the compromised barrier, and release inflammatory Th17-related cytokines in the brain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11461179/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">As such, it&rsquo;s no surprise that a variant of </span><em><span style="font-weight: 400;">IL17F </span></em><span style="font-weight: 400;">has been associated with chronic fatigue syndrome. This variant may increase production of IL-17F, which may lead to blood-brain barrier disruptions and brain inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18774769/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>IL17F</em></strong><strong> Results for Fatigue</strong></h2> <p style="text-align: justify;">*6897263804981706*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>IL17F </em></strong><a href="https://selfdecode.com/snp/rs763780/"><strong>rs763780</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18774769/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of chronic fatigue syndrome, relative to &lsquo;C&rsquo;&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Decreased risk of chronic fatigue syndrome, relative to &lsquo;T&rsquo;</span></li> </ul> <p style="text-align: justify;">*9424160806261281*</p> <h2 style="text-align: left;"><strong>Recommendations for Reducing Fatigue</strong></h2> <p style="text-align: justify;">*3245004470093831*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Sun Exposure</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Many studies have associated </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> deficiency with fatigue and muscle weakness, although not all people with this deficiency experience these symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442332/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19835345"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17634462/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22020957/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Correcting vitamin D deficiency with supplements improved fatigue in both healthy people and those with various diseases [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207540/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25210673/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182952/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158648/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513642/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A healthy exposure to </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sunlight</span></a><span style="font-weight: 400;">, which provides 50-90% of our vitamin D requirements, is the best way of replenishing this vitamin. In addition, you can eat food sources of this vitamin (such as fatty fish, liver, egg yolks, and dairy) or take supplements [</span><a href="https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">UV rays and vitamin D sourced from the sun may reduce the activity of Th17 cells and in turn, lower levels of IL-17F [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554687/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998156/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The sun provides exposure to UV rays and is the best source of vitamin D. Sun exposure may lower fatigue by reducing Th17 cell activity and decreasing production of IL-17F.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Coenzyme Q10</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">In individuals with <a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/" target="_blank" rel="noopener">multiple sclerosis</a>, 3-month supplementation with </span><a href="https://selfhacked.com/blog/coenzyme-q10-ubiquinol/"><span style="font-weight: 400;">coenzyme Q10</span></a><span style="font-weight: 400;"> was reported to significantly decrease levels of IL-17F, as well as lower levels of other inflammatory markers [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381428/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In 2 clinical trials focused on healthy individuals, oral administration of coenzyme Q10 reduced fatigue and improved performance during physical exercise [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18272335/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19644406/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Daily supplementation with coenzyme Q10 has also been reported to improve fatigue and other symptoms in people suffering from fibromyalgia, </span><span style="font-weight: 400;">multiple sclerosis</span><span style="font-weight: 400;">, muscle wasting, and bipolar disorder [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2797412/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837523/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23458405/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22342824/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25603363/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24621064/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/7599221/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414830/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30106880/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">An oral supplement combining coenzyme Q10 and NADH reduced fatigue and improved exercise performance in people with chronic fatigue syndrome [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346380/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26212172/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Coenzyme Q10 may reduce fatigue by decreasing levels of IL-17F.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Ginseng</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Asian </span><a href="https://selfhacked.com/blog/ginseng/"><span style="font-weight: 400;">ginseng</span></a><span style="font-weight: 400;"> (Panax ginseng) may inhibit the development of Th17 cells, suggesting that it may reduce IL-17F levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132415/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Ginseng extract decreased fatigue severity in several studies of both healthy volunteers and people diagnosed with chronic fatigue syndrome [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27754709/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102849/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31987248/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379339/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Ginseng has also been reported to reduce fatigue from cancer and multiple sclerosis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25873296/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32172198/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23301896/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Ginseng may reduce fatigue by inhibiting Th17 cell development and thus, lowering levels of IL-17F.</span></p>
473 | content_snp_table_6897263804981706_key == 6897263804981706
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rsIDs = rs763780
rsStatus = rs763780,IL17F,chr6,52236941,T,C,,,30,0,Normal
