475 | id == 475
475 | category_id == 28
475 | category_order == 25
475 | category_name == Joint Inflammation
475 | category_color == #C47AC0
475 | slug == CXCR5-rheumatoid-arthritis
475 | title == The Relationship Between Immune System Interactions & Rheumatoid Arthritis (CXCR5)
475 | meta_description == CXCR5 is involved in the release of antibodies. A variant of CXCR5 has been linked to rheumatoid arthritis. Read more here.
475 | summary == <p style="text-align:justify"><strong>The <em>CXCR5 </em>gene codes for a protein that is involved in the release of antibodies. Read more to learn how a variant of <em>CXCR5 </em>might increase the risk of rheumatoid arthritis.&nbsp;</strong></p>
475 | overall_score_text == Your Rheumatoid Arthritis Score (based on CXCR5 gene)
475 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CXCR5-TREH-DDX6-Rheumatoid-arthritis.jpg
475 | author_id == 14
475 | author_name == Shany Lahan
475 | author_title == MS (Neuroscience)
475 | author_order == 5
475 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
475 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
475 | reviewer == None
475 | medical_reviewer_id == 11
475 | medical_reviewer_name == Puya Yazdi
475 | medical_reviewer_title == MD
475 | publish_date == 2020
475 | publish_date == 11
475 | publish_date == 12
475 | avg_rating == 5.0
475 | tags_id == 926
475 | tags_name == Autoantibodies
475 | tags_id == 33
475 | tags_name == Autoimmunity
475 | tags_id == 242
475 | tags_name == B cells
475 | tags_id == 792
475 | tags_name == Chemokine
475 | tags_id == 868
475 | tags_name == CXCL13
475 | tags_id == 867
475 | tags_name == CXCR5 Gene
475 | tags_id == 870
475 | tags_name == Lymph Nodes
475 | tags_id == 869
475 | tags_name == TFH cells
475 | permissions_favorite == False
475 | permissions_rate == False
475 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">CXCR5 is a receptor that enables cells of the immune system to interact and subsequently release antibodies. A variant of </span><em><span style="font-weight: 400;">CXCR5 </span></em><span style="font-weight: 400;">may play a role in rheumatoid arthritis by increasing the amount of CXCR5 found on the surfaces of white blood cells. Lifestyle, diet, and supplement modifications may counteract the effects of this variant by decreasing production or activity of CXCR5.</span></span></p> <h2 style="text-align: justify;"><strong><em>CXCR5 </em></strong><strong>and Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">A chemokine is a protein that can attract cells of the immune system to certain areas of the body.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">CXCR5 is a receptor that binds chemokine CXCL13. CXCR5 can be found on the surfaces of two types of white blood cells: T</span><sub><span style="font-weight: 400;">FH</span></sub><span style="font-weight: 400;"> cells and B cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26970097/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Through its actions on CXCR5, CXCL13 can attract T</span><sub><span style="font-weight: 400;">FH</span></sub><span style="font-weight: 400;"> cells and B cells to the same sites within lymph nodes. Interactions between T</span><sub><span style="font-weight: 400;">FH</span></sub><span style="font-weight: 400;"> cells and B cells at these sites can stimulate B cells to generate antibodies -- including those that recognize the body&rsquo;s own tissues (autoantibodies) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26970097/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">CXCR5 may be necessary for the development of rheumatoid arthritis. In rheumatoid arthritis, autoantibodies that are specific for joints help target components of the immune system to these regions. This can result in inflammation and joint thickening, leading to symptoms such as pain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567121/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A variant of </span><em><span style="font-weight: 400;">CXCR5 </span></em><span style="font-weight: 400;">has been associated with rheumatoid arthritis. This variant may increase the amount of CXCR5 found on the surfaces of T</span><sub><span style="font-weight: 400;">FH</span></sub><span style="font-weight: 400;"> and B cells. Elevated CXCR5 may result in a greater amount of T</span><sub><span style="font-weight: 400;">FH</span></sub><span style="font-weight: 400;"> and B cell interactions within lymph nodes, ultimately leading to excess production of autoantibodies specific for joints [</span><a href="https://europepmc.org/article/med/20453842"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>CXCR5</em></strong><strong> Results for Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*1372883600438326*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>CXCR5 </em></strong><a href="https://selfdecode.com/snp/rs10892279/"><strong>rs10892279</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/article/med/20453842"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with rheumatoid arthritis</span></li> </ul> <p style="text-align: justify;">*2221527929625926*</p> <h2 style="text-align: left;"><strong>Recommendations for Improving Symptoms of Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*6631577147305359*</p> <h3><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Avoid Smoking Cigarettes</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">In lung cancer cells derived from humans, greater CXCL13 production was linked to cigarette smoke. This suggests that cigarette smoke may increase the activity of CXCR5 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26565418/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Smoking cigarettes is a known risk factor for the development of rheumatoid arthritis; approximately 25% of the risk can be attributed to cigarettes alone [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29716677/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30173215/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10323446/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175164/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">While the risk of developing rheumatoid arthritis may return to normal once an individual has quit smoking, it seems that it can take up to 20 years for this to occur. Therefore, individuals carrying risk variants of </span><em><span style="font-weight: 400;">CXCR5 </span></em><span style="font-weight: 400;">may benefit from avoiding cigarettes altogether, or quitting as soon as possible [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175164/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Avoiding cigarette smoke may help manage symptoms of rheumatoid arthritis by preventing an increase in CXCL13 production and CXCR5 activity.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Mediterranean Diet</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Adhering to the Mediterranean diet was reported to reduce inflammation and improve vitality in a small clinical trial of rheumatoid arthritis patients. Another study found that Mediterranean diet adherence may lower the risk of rheumatoid arthritis -- but only in men [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12594104/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30092814/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The Mediterranean diet recommends 1-2 servings of fatty fish (rich in </span><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">omega-3</span></a><span style="font-weight: 400;"> fatty acids) per week, and suggests that </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;"> should be one&rsquo;s main source of fat.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Multiple trials have attested to the benefits of omega-3-rich fish oil in lowering inflammation and ameliorating rheumatoid arthritis symptoms. In a clinical study of rheumatoid arthritis patients, olive oil was shown to enhance the effects of fish oil with regards to a number of clinical parameters, such as joint pain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24081439/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12548439/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28346333/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15723739/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Olive oil contains a compound called pentanal. Pentanal was found to decrease the production of CXCR5 in human-derived cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26079696/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Mediterranean diet adherence may help manage symptoms of rheumatoid arthritis by decreasing production of CXCR5.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Resveratrol</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/top-15-scientific-health-benefits-of-resveratrol-with-references/"><span style="font-weight: 400;">Resveratrol</span></a><span style="font-weight: 400;"> is an antioxidant and anti-inflammatory substance found in high amounts in grapes and wine. It is also available in supplement form.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Many studies have suggested that the anti-inflammatory effects of resveratrol may be beneficial in managing the symptoms of rheumatoid arthritis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30511573/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31883358/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30496633/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a randomized controlled trial of rheumatoid arthritis patients, 3-month daily supplementation with resveratrol was reported to decrease swelling and tenderness of joints, as well as decrease levels of rheumatoid arthritis markers [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29611086/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Treatment with resveratrol significantly reduced the production of CXCR5 in mice [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27693537/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Resveratrol may help manage symptoms of rheumatoid arthritis by decreasing production of CXCR5.</span></p>
475 | content_snp_table_1372883600438326_key == 1372883600438326
475 | content_snp_table_1372883600438326_blur == True
475 | content_snp_table_1372883600438326_hidden == False
475 | content_learn_more_2221527929625926_key == 2221527929625926
475 | content_learn_more_2221527929625926_blur == True
475 | content_learn_more_2221527929625926_hidden == False
475 | content_learn_more_2221527929625926_text == Based on the variants we looked at, your CXCR5 gene makes you somewhat more likely to develop rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Refraining from smoking cigarettes, adhering to the Mediterranean diet, and taking resveratrol supplements may help. Keep scrolling to find out more.
475 | content_recommendation_6631577147305359_key == 6631577147305359
475 | content_recommendation_6631577147305359_blur == True
475 | content_recommendation_6631577147305359_hidden == False
rsIDs = rs10892279
rsStatus = rs10892279,,chr11,118741072,G,A,T,,28,0,Normal
