479 | id == 479
479 | category_id == 28
479 | category_order == 25
479 | category_name == Joint Inflammation
479 | category_color == #C47AC0
479 | slug == NFKBIE-rheumatoid-arthritis
479 | title == The Role of an Inflammatory Protein Blocker in Rheumatoid Arthritis (NFKBIE)
479 | meta_description == NFKBIE may block inflammatory protein activity. Variants of NFKBIE are linked to rheumatoid arthritis. Read more here.
479 | summary == <p style="text-align:justify"><strong>The <em>NFKBIE</em> gene helps block the actions of an inflammatory protein. How might variants of <em>NFKBIE</em> increase the risk of rheumatoid arthritis? Read more to find out.</strong></p>
479 | overall_score_text == Your Rheumatoid Arthritis Score (based on NFKBIE gene)
479 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/NFKBIE-AARS2-TCTE1-SLC35B2-Rheumatoid-arthritis.jpg
479 | author_id == 14
479 | author_name == Shany Lahan
479 | author_title == MS (Neuroscience)
479 | author_order == 5
479 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
479 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
479 | reviewer == None
479 | medical_reviewer_id == 11
479 | medical_reviewer_name == Puya Yazdi
479 | medical_reviewer_title == MD
479 | publish_date == 2020
479 | publish_date == 11
479 | publish_date == 13
479 | avg_rating == 5.0
479 | tags_id == 926
479 | tags_name == Autoantibodies
479 | tags_id == 33
479 | tags_name == Autoimmunity
479 | tags_id == 934
479 | tags_name == IkBe
479 | tags_id == 24
479 | tags_name == Inflammation
479 | tags_id == 933
479 | tags_name == NFKBIE Gene
479 | tags_id == 369
479 | tags_name == NF-κB
479 | permissions_favorite == False
479 | permissions_rate == False
479 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">NFKBIE</span></em><span style="font-weight: 400;"> encodes IkBe, a protein that can physically block the actions of the inflammatory protein NF-kB. Variants of </span><em><span style="font-weight: 400;">NFKBIE </span></em><span style="font-weight: 400;">may play a role in rheumatoid arthritis by decreasing production or activity of IkBe and consequently increasing NF-kB activity. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by increasing IkBe production, while decreasing production or activity of NF-kB.</span></span></p> <h2 style="text-align: justify;"><strong><em>NFKBIE </em></strong><strong>and Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/nfkbie/"><em><span style="font-weight: 400;">NFKBIE</span></em></a> <span style="font-weight: 400;">gene codes for IkBe, a protein that can block the actions of </span><a href="https://selfhacked.com/blog/nuclear-factor-kappa-b/"><span style="font-weight: 400;">NF-kB</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/gene/4794"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">NF-kB may stimulate the production of inflammatory proteins, as well as promote the formation of antibodies that recognize the body&rsquo;s own tissues (autoantibodies). In this manner, NF-kB may play a major role in the development of autoimmune disorders, such as rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882124/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374037/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18613848/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15838509/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">NFKBIE </span></em><span style="font-weight: 400;">have been associated with rheumatoid arthritis. These variants may decrease production or activity of IkBe, leading to NF-kB-mediated production of inflammatory proteins and formation of autoantibodies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22446963/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>NFKBIE </em></strong><strong>Results for Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*6230532540824454*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>NFKBIE </em></strong><a href="https://selfdecode.com/snp/rs2233434/"><strong>rs2233434</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with rheumatoid arthritis</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNP:</strong></p> <p style="text-align: justify;"><strong><em>NFKBIE </em></strong><a href="https://selfdecode.com/snp/rs2233424/"><strong>rs2233424</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/22446963/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with rheumatoid arthritis</span></li> </ul> <p style="text-align: justify;">*6333420616081384*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*4581036698729281*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Sun Exposure</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sun</span></a><span style="font-weight: 400;"> is the best source of </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;">. Vitamin D has been reported to lower NF-kB activity in a number of studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16455676/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30903715/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31299118/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">However, it&rsquo;s important to limit time spent in the sun -- long periods of sun exposure have actually been reported to </span><em><span style="font-weight: 400;">activate </span></em><span style="font-weight: 400;">NF-kB! This effect was attributed to radiation from the sun&rsquo;s UV rays [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16211268/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Many clinical trials have observed that rheumatoid arthritis patients may be deficient in vitamin D, in comparison to their healthy counterparts. In rheumatoid arthritis patients with vitamin D deficiency, vitamin D supplementation lowered disease activity and associated symptoms, such as </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26481198/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22004229/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28582403/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29479872/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30048002/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Note that these results were inconsistent and varied across trials, with some trials demonstrating no changes in disease activity after vitamin D supplementation. Therefore, more studies need to be conducted to support the potential benefits of vitamin D in rheumatoid arthritis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30148432/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26064964/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The sun is the best source of vitamin D. Vitamin D may help manage rheumatoid arthritis by lowering NF-kB activity.</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Mediterranean Diet</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The Mediterranean diet is a popular anti-inflammatory diet that may reduce swelling and pain in arthritic joints [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23975674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">According to one study of 51 patients, those eating a Mediterranean diet had significantly higher vitality scores (a measurement of energy, quality of life, and general function) than those eating a typical western diet [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23975674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The anti-inflammatory effect of the Mediterranean diet may be due to its high content of </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">. In fact, people whose diets include a lot of olive oil are significantly less likely to develop rheumatoid arthritis than those who use other types of cooking oils [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10584053/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1771399/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Olive oil contains the compound pentanal. Pentanal was found to increase production of IkBe in human-derived cells. Similarly, the Mediterranean diet was found to significantly decrease levels of NF-kB and other inflammatory markers in elderly individuals, in a randomized controlled trial [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26079696/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22085595/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet may help manage rheumatoid arthritis by increasing production of IkBe and decreasing production of NF-kB.</span></p> <h3 style="text-align: justify;"><strong>Supplements&nbsp;</strong></h3> <h4 style="text-align: justify;"><strong>Fish Oil (Omega-3)</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">According to numerous studies, omega-3 fatty acids (abundant in </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;">) may be able to suppress NF-kB [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29678169/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25976467/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Multiple trials have attested to the benefits of omega-3 in lowering inflammation and ameliorating rheumatoid arthritis symptoms. In a clinical study of rheumatoid arthritis patients, </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;"> was shown to enhance the effects of fish oil with regards to a number of clinical parameters, such as joint pain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24081439/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12548439/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28346333/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15723739/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Similarly, a meta-analysis of 17 trials found that fish oil may reduce inflammatory joint pain from rheumatoid arthritis and other inflammatory conditions [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17335973"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Fish oil (omega-3) may reduce symptoms of rheumatoid arthritis by suppressing NF-kB.&nbsp;</span></p> <p style="text-align: justify;"><em><span style="font-weight: 400;">For a comprehensive list of ways to inhibit NF-kB, </span></em><a href="https://selfhack.com/blog/nuclear-factor-kappa-b/#NF-B_Inhibitors"><em><span style="font-weight: 400;">click here</span></em></a><em><span style="font-weight: 400;">.</span></em></p>
479 | content_snp_table_6230532540824454_key == 6230532540824454
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479 | content_learn_more_6333420616081384_text == Based on the variants we looked at, your NFKBIE gene makes you somewhat more likely to develop rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. The Mediterranean diet, sun exposure, and fish oil supplements may help. Keep scrolling to find out more.
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rsIDs = rs2233424,rs2233434
rsStatus = rs2233424,NFKBIE,chr6,44266184,C,A,G,T,32,0,Normal
rsStatus = rs2233434,NFKBIE,chr6,44265183,A,G,,,29,0,Normal
