483 | id == 483
483 | category_id == 28
483 | category_order == 25
483 | category_name == Joint Inflammation
483 | category_color == #C47AC0
483 | slug == AFF3-TNF-rheumatoid-arthritis
483 | title == Genetics of Inflammation in Rheumatoid Arthritis (AFF3)
483 | meta_description == The AFF3 gene can increase inflammation and TNF-alpha levels. Click to learn about its link with rheumatoid arthritis.
483 | summary == <p>Did you know that genes may influence joint inflammation? This post reveals the link between AFF3 and rheumatoid arthritis, along with gene-based tips to improve joint health!</p>
483 | overall_score_text == Your Rheumatoid Arthritis Score (based on AFF3 gene)
483 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/AFF3-Rheumatoid-arthritis.jpg
483 | author_id == 9
483 | author_name == Aleksa Ristic
483 | author_title == MS (Pharmacy)
483 | author_order == 45
483 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
483 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
483 | reviewer == None
483 | medical_reviewer_id == 11
483 | medical_reviewer_name == Puya Yazdi
483 | medical_reviewer_title == MD
483 | publish_date == 2020
483 | publish_date == 11
483 | publish_date == 17
483 | avg_rating == 5.0
483 | tags_id == 942
483 | tags_name == AFF3 gene
483 | tags_id == 33
483 | tags_name == Autoimmunity
483 | tags_id == 24
483 | tags_name == Inflammation
483 | tags_id == 74
483 | tags_name == Joint Disorders
483 | tags_id == 82
483 | tags_name == Rheumatoid Arthritis
483 | tags_id == 235
483 | tags_name == TNF-alpha
483 | permissions_favorite == False
483 | permissions_rate == False
483 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The AFF3 gene stimulates white blood cells to increase inflammation and TNF-alpha levels, paving the way to rheumatoid arthritis.<br /><br /></strong><strong>Specific gene variants may increase AFF3 activity and correlate with higher odds of rheumatoid arthritis.<br /><br /></strong><strong>Read this post to learn the potential ways to improve joint health by targeting AFF3 variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>AFF3, Inflammation &amp; Rheumatoid Arthritis</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/aff3/"><em><span style="font-weight: 400;">AFF3</span></em></a><span style="font-weight: 400;"> gene controls the activity of immune cells involved in </span><a href="https://selfhacked.com/blog/natural-ways-lower-inflammation/"><span style="font-weight: 400;">inflammation</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/gene?Db=gene&amp;Cmd=DetailsSearch&amp;Term=3899"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Autoimmune inflammation is a culprit behind </span><a href="https://selfhacked.com/blog/rheumatoid-factor/"><span style="font-weight: 400;">rheumatoid arthritis</span></a><span style="font-weight: 400;">, TNF-alpha being the key inflammatory marker. Many treatment options for rheumatoid arthritis aim at blocking </span><a href="https://selfhack.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">TNF-alpha</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410649/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Scientists are still studying the exact role of AFF3 variants in rheumatoid arthritis. According to one paper, they may stimulate the inflammatory response of white blood cells, resulting in higher levels of TNF-alpha and other inflammatory proteins [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930850/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8555498/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Variants in the AFF3 gene may stimulate white blood cells to increase inflammation and TNF-alpha levels, paving the way to rheumatoid arthritis.</span></p> <p>&nbsp;</p> <h2><strong>Your AFF3 Results for Rheumatoid Arthritis</strong></h2> <p>*3348401815469335*&nbsp;</p> <p><strong>Primary SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs9653442/"><strong>rs9653442</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with lower odds of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher odds of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele likely reduces AFF3 activity, leading to lower inflammation and TNF-alpha levels</span></li> </ul> <p><strong>Other Important SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs6712515/"><strong>rs6712515</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/23143596"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with lower odds of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with relatively higher odds of rheumatoid arthritis</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs10209110/"><strong>rs10209110</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/23143596"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with lower odds of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher odds of rheumatoid arthritis</span></li> </ul> <p>*1836090287410454*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Joint Health</strong></h2> <p>*6628456139256242*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Aquatic Exercise</strong></h4> <p><span style="font-weight: 400;">According to animal research, moderate </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> helps prevent arthritis by boosting anti-inflammatory proteins and suppressing TNF-alpha [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28216540/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22554223/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It&rsquo;s important to note that long-term moderate exercise generally reduces inflammation and TNF-alpha, while acute vigorous exercise can have an opposite effect [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15772055/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Aquatic exercise describes any type of physical activity that takes place either partially or fully submerged in water. These activities can allow people to maintain physical fitness and reap the benefits of exercise even if they are not fully mobile out of the water [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931167/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In two clinical trials comparing different types of exercise, aquatic exercise produced the most significant </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> reduction in people with rheumatoid arthritis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8971230/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821024/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Aquatic exercise may improve rheumatoid arthritis by targeting your gene variants.</span></p> <h4><strong>Massage</strong></h4> <p><span style="font-weight: 400;">In one clinical study, </span><a href="https://selfhacked.com/blog/massage-health-benefits/"><span style="font-weight: 400;">massage</span></a><span style="font-weight: 400;"> promoted tissue repair by reducing TNF-alpha and other inflammatory markers [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22301554/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to one clinical review, massage therapy may reduce </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> and increase function in joints affected by rheumatoid arthritis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28177937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">As part of a broader physical therapy regimen, practitioners use massage to improve flexibility and function in arthritic joints [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1395797/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Massage may improve joint health by targeting your gene variant.</span></p> <h3><strong>Diet</strong></h3> <h4><strong>Increased Omega-3 Intake</strong></h4> <p><span style="font-weight: 400;">Omega-3 fatty acids have well-known anti-inflammatory effects, and their increased intake may reduce TNF-alpha levels. In one study, dietary omega-3s reduced the impact of different inflammatory genes, including TNF [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914936/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708344/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Research suggests that increased dietary intake of </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">omega-3</span></a><span style="font-weight: 400;"> fatty acids may protect against rheumatoid arthritis. In a meta-analysis of 20 clinical trials, higher omega-3 consumption improved rheumatoid arthritis symptoms and lab markers [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634864/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28965775/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Good dietary omega-3 sources include [</span><a href="https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Fish and seafood</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/flaxseed-oil-benefits/"><span style="font-weight: 400;">Flaxseed</span></a></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Chia seeds</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Walnuts</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/hemp-seeds/"><span style="font-weight: 400;">Hemp seeds</span></a></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Increase your intake of omega-3 fatty acids to lessen the impact of your variants on joint health.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong><em>Lactobacillus Casei</em></strong></h4> <p><span style="font-weight: 400;">In two clinical trials, supplementation with a </span><a href="http://selfhacked.com/blog/l-casei/"><em><span style="font-weight: 400;">Lactobacillus casei</span></em></a> <span style="font-weight: 400;">probiotic strain for eight weeks improved rheumatoid arthritis by reducing inflammation and TNF-alpha levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24355439/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24673738/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This strain also improved rheumatoid arthritis in animal studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21810608/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20838859/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18804867/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p>
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483 | content_learn_more_1836090287410454_text == Based on the variants we looked at, your AFF3 gene is associated with typical or slightly higher odds of rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Practice aquatic exercise and increase your omega-3 intake to improve joint health by targeting your variants. Keep reading to learn more.
483 | content_recommendation_6628456139256242_key == 6628456139256242
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rsIDs = rs10209110,rs6712515,rs9653442
rsStatus = rs10209110,AFF3,chr2,100056230,C,T,,,21,11,HET
rsStatus = rs6712515,,chr2,100190052,T,A,C,G,35,0,Normal
rsStatus = rs9653442,LINC01104,chr2,100208905,C,T,,,21,8,HET
