487 | id == 487
487 | category_id == 28
487 | category_order == 25
487 | category_name == Joint Inflammation
487 | category_color == #C47AC0
487 | slug == ARID5B-rheumatoid-arthritis
487 | title == How a Cell Cycle Gene Impacts Joint Health (ARID5B)
487 | meta_description == The ARID5B gene can stimulate the growth and development of immune cells. Learn about its link with rheumatoid arthritis.
487 | summary == <p><strong>Overactive white blood cells can be your foe when it comes to joint health! Read this post to learn how the <em>ARID5B</em> gene impacts rheumatoid arthritis and what you can do about it.</strong></p>
487 | overall_score_text == Your Rheumatoid Arthritis Score (based on ARID5B gene)
487 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ARID5B-Rheumatoid-arthritis.jpg
487 | author_id == 9
487 | author_name == Aleksa Ristic
487 | author_title == MS (Pharmacy)
487 | author_order == 45
487 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
487 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
487 | reviewer == None
487 | medical_reviewer_id == 11
487 | medical_reviewer_name == Puya Yazdi
487 | medical_reviewer_title == MD
487 | publish_date == 2020
487 | publish_date == 11
487 | publish_date == 18
487 | avg_rating == 5.0
487 | tags_id == 948
487 | tags_name == ARID5B
487 | tags_id == 536
487 | tags_name == Cell Development
487 | tags_id == 949
487 | tags_name == p21
487 | tags_id == 82
487 | tags_name == Rheumatoid Arthritis
487 | tags_id == 947
487 | tags_name == White Blood Cells
487 | permissions_favorite == False
487 | permissions_rate == False
487 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The ARID5B gene can stimulate the growth and development of immune cells that play a role in joint inflammation.<br /><br /></strong><strong>Specific gene variants may increase ARID5B activity and correlate with higher odds of rheumatoid arthritis.<br /><br /></strong><strong>This post reveals potential ways to improve rheumatoid arthritis by targeting ARID5B variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>ARID5B, Cell Cycle &amp; Rheumatoid Arthritis</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/arid5b/"><span style="font-weight: 400;">ARID5B</span></a><span style="font-weight: 400;"> gene controls the growth and development of </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/gene?Db=gene&amp;Cmd=DetailsSearch&amp;Term=84159"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Reduced activity of this gene can prevent white blood cell maturation and play a role in different types of leukemia. On the other hand, excess ARID5B activity may overstimulate white blood cells and contribute to autoimmune conditions [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11959810/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574699/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">More precisely, this gene inhibits p21, a protein that controls the division of inflammatory cells. The lack of p21 in rheumatoid arthritis patients may worsen joint inflammation and destruction [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574699/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779389/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25077978/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The ARID5B gene may play a role in rheumatoid arthritis by allowing the uncontrolled division of inflammatory cells.</span></p> <p>&nbsp;</p> <h2><strong>Your ARID5B Results for Rheumatoid Arthritis</strong></h2> <p>*9902075815551736*</p> <p><strong>Primary SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs71508903/"><strong>rs71508903</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher odds of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele likely increases ARID5B activity and inhibits p21.</span></li> </ul> <p><strong>Other Important SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs10821944/"><strong>rs10821944</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22446963/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with relatively higher odds of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with lower odds of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele likely reduces ARID5B and boosts p21 activity.</span></li> </ul> <p>*5899697718741956*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Rheumatoid Arthritis</strong></h2> <p>*5391848817740161*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Aquatic Exercise</strong></h4> <p><span style="font-weight: 400;">The anti-inflammatory and anti-cancer potential of </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> partly lies in its ability to boost p21 and prevent excess cell division [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17923812/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20216467/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979999/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Aquatic exercise describes any type of physical activity that takes place either partially or fully submerged in water. These activities can allow people to maintain physical fitness and reap the benefits of exercise even if they are not fully mobile out of the water [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931167/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In two clinical trials comparing different types of exercise, aquatic exercise produced the most significant </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> reduction in people with rheumatoid arthritis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8971230/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821024/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Aquatic exercise may improve rheumatoid arthritis by targeting your gene variants.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Thunder God Vine</strong></h4> <p><span style="font-weight: 400;">The active components of </span><a href="https://selfhacked.com/blog/15-promising-thunder-god-vine-benefits/"><span style="font-weight: 400;">thunder god vine</span></a><span style="font-weight: 400;"> (</span><em><span style="font-weight: 400;">Tripterygium wilfordii</span></em><span style="font-weight: 400;">) may prevent uncontrolled cell division by boosting p21 [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25400429/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741730/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In two clinical trials, thunder god vine extract (60-360 mg/day) improved joint inflammation and </span><a href="https://selfhacked.com/blog/23-ways-to-combat-pain-naturally-by-increasing-your-opioids/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> from rheumatoid arthritis. It was more effective than the anti-rheumatic drug sulfasalazine in another study [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2509153"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12124856"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938780/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Its tincture applied to the joints may also improve rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12610802"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Thunder god vine and its active components improved arthritis in multiple animal studies [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9716258"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22884304"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9778100"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16983598"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18952137"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25456434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25529994"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23183089"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Thunder god vine may counteract your ARID5B gene and improve rheumatoid arthritis.</span></p>
487 | content_snp_table_9902075815551736_key == 9902075815551736
487 | content_snp_table_9902075815551736_blur == True
487 | content_snp_table_9902075815551736_hidden == False
487 | content_learn_more_5899697718741956_key == 5899697718741956
487 | content_learn_more_5899697718741956_blur == True
487 | content_learn_more_5899697718741956_hidden == False
487 | content_learn_more_5899697718741956_text == Based on the variants we looked at, your ARID5B gene is associated with typical or slightly higher odds of rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Practice aquatic exercise to improve joint health by targeting your variants. Keep reading to learn more.
487 | content_recommendation_5391848817740161_key == 5391848817740161
487 | content_recommendation_5391848817740161_blur == True
487 | content_recommendation_5391848817740161_hidden == False
rsIDs = rs71508903,rs10821944
rsStatus = rs71508903,ARID5B,chr10,62020112,C,T,,,28,0,Normal
