490 | id == 490
490 | category_id == 28
490 | category_order == 25
490 | category_name == Joint Inflammation
490 | category_color == #C47AC0
490 | slug == CCL21-rheumatoid-arthritis
490 | title == Can Variants in This Gene Contribute to Rheumatoid Arthritis? (CCL21)
490 | meta_description == The CCL21 gene helps make a protein that contributes to joint inflammation. Learn about its link with rheumatoid arthritis.
490 | summary == <p style="text-align:justify"><strong>Did you know that joint inflammation has a strong genetic background? Read this post to learn the link between <em>CCL21</em> and rheumatoid arthritis, and get gene-based tips!</strong></p>
490 | overall_score_text == Your Rheumatoid Arthritis Score (based on CCL21 gene)
490 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CCL21-Rheumatoid-arthritis.jpg
490 | author_id == 9
490 | author_name == Aleksa Ristic
490 | author_title == MS (Pharmacy)
490 | author_order == 45
490 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
490 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
490 | reviewer == None
490 | medical_reviewer_id == 11
490 | medical_reviewer_name == Puya Yazdi
490 | medical_reviewer_title == MD
490 | publish_date == 2020
490 | publish_date == 11
490 | publish_date == 19
490 | avg_rating == 5.0
490 | tags_id == 953
490 | tags_name == CCL21
490 | tags_id == 24
490 | tags_name == Inflammation
490 | tags_id == 82
490 | tags_name == Rheumatoid Arthritis
490 | tags_id == 946
490 | tags_name == Rheumatoid Factor
490 | tags_id == 243
490 | tags_name == Smoking
490 | permissions_favorite == False
490 | permissions_rate == False
490 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The CCL21 gene helps make a protein that contributes to joint inflammation.<br /><br /></strong><strong>Certain gene variants may increase CCL21 activity and correlate with higher odds of rheumatoid arthritis.<br /><br /></strong><strong>This post reveals lifestyle changes and supplements that may improve rheumatoid arthritis by targeting CCL21 variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>The Role of CCL21 in Rheumatoid Arthritis</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/ccl21/"><em><span style="font-weight: 400;">CCL21</span></em></a><span style="font-weight: 400;"> gene codes for a protein that can stimulate inflammation and the growth of blood vessels in rheumatoid arthritis-affected tissue. More precisely, CCL21 binds CCR7 and triggers the production of different inflammatory proteins and growth factors (such as IL-6, IL-23, and VEGF) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15832291/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079365/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32499193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This cascade of inflammation and blood vessel growth results in joint pain, swelling, and stiffness&mdash;the hallmarks of rheumatoid arthritis. People with rheumatoid arthritis have significantly higher CCL21 levels in their joints [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31342120/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409328/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079365/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your CCL21 Results for Rheumatoid Arthritis</strong></h2> <p>*6634324370699596*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs11574914/"><strong>rs11574914</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele likely increases CCL21 levels.</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs2812378/"><strong>rs2812378</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605761/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with relatively higher odds of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with lower odds of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele likely reduces CCL21 levels.</span></li> </ul> <p>*5705157143075354*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Rheumatoid Arthritis</strong></h2> <p>*9822929981143744*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Avoid Cigarette Smoke</strong></h4> <p><span style="font-weight: 400;">In one study, animals exposed to cigarette smoke had significantly higher CCL21 blood levels. Smoking can increase a range of CCL21-activated inflammatory proteins and thus worsen the impact of your variants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196219/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160597/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Smoking is one of the strongest environmental risk factors for developing rheumatoid arthritis. In one study, 88% of smokers tested positive for </span><a href="https://selfhacked.com/blog/rheumatoid-factor/"><span style="font-weight: 400;">rheumatoid factor</span></a><span style="font-weight: 400;"> in 10 years [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898190/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11085797"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9833699"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Other studies have reported up to 4 times higher odds of having elevated rheumatoid factor in smokers [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1004225/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16403829"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9306868"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10743800"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11085797"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Avoid cigarette smoke to lessen the impact of your gene variants on joint health.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Fish Oil</strong></h4> <p><span style="font-weight: 400;">In one clinical trial, supplementation with omega-3 fatty acids from </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;"> reduced CCL21 levels [</span><a href="https://www.mdpi.com/2072-6643/12/9/2614"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Fish oil may improve different inflammatory and autoimmune conditions, including rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12480795"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11802309"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a meta-analysis of 17 trials, supplemental fish oil reduced joint </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> from rheumatoid arthritis and other inflammatory conditions [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17335973"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Fish oil may improve rheumatoid arthritis by targeting your CCL21 variants.</span></p> <h4><strong>Curcumin</strong></h4> <p><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;">, the active ingredient in turmeric, may inhibit a range of CCL21-associated inflammatory proteins. In test tubes, curcumin directly reduced CCL21 activity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25613752/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319308/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <p><span style="font-weight: 400;">Curcumin reduced the symptoms of rheumatoid arthritis in multiple studies. At high doses, it improved pain, morning stiffness, joint inflammation, and mobility [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7390600/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28850308/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22407780/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, curcumin does not appear to be effective at lower doses. In the available studies, patients only benefited when consuming at least 500 mg per day [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31482684/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">High-dose curcumin supplements may counteract your gene variants and improve rheumatoid arthritis.</span></p>
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490 | content_learn_more_5705157143075354_hidden == False
490 | content_learn_more_5705157143075354_text == Based on the variants we looked at, your CCL21 gene is associated with typical or slightly higher odds of rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Avoid cigarette smoke and consider taking certain supplements to improve joint health by targeting your variants. Keep reading to learn more.
490 | content_recommendation_9822929981143744_key == 9822929981143744
490 | content_recommendation_9822929981143744_blur == True
490 | content_recommendation_9822929981143744_hidden == False
rsIDs = rs2812378,rs11574914
rsStatus = rs2812378,CCL21,chr9,34710263,G,A,C,,21,14,HET
rsStatus = rs11574914,CCL21,chr9,34710341,G,A,,,20,8,HET
