491 | id == 491
491 | category_id == 28
491 | category_order == 25
491 | category_name == Joint Inflammation
491 | category_color == #C47AC0
491 | slug == ETS1-rheumatoid-arthritis
491 | title == Regulating B Cell Activity to Prevent Rheumatoid Arthritis (ETS1)
491 | meta_description == The ETS1 gene regulates B cell activity & the production of autoantibodies. What role does it play in rheumatoid arthritis?
491 | summary == <p><strong>The <em>ETS1 </em>gene regulates the activity of B cells and the production of autoantibodies. What role does it play in rheumatoid arthritis? Find out here.</strong></p>
491 | overall_score_text == Your Arthritis Score (based on ETS1)
491 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ETS1-FLI1-SENCR-Rheumatoid-arthritis.jpg
491 | author_id == 1
491 | author_name == Jasmine Foster
491 | author_title == BSc, BEd
491 | author_order == 36
491 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
491 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
491 | reviewer == None
491 | medical_reviewer_id == 11
491 | medical_reviewer_name == Puya Yazdi
491 | medical_reviewer_title == MD
491 | publish_date == 2020
491 | publish_date == 11
491 | publish_date == 19
491 | avg_rating == 5.0
491 | tags_id == 926
491 | tags_name == Autoantibodies
491 | tags_id == 33
491 | tags_name == Autoimmunity
491 | tags_id == 242
491 | tags_name == B cells
491 | tags_id == 439
491 | tags_name == ETS1 Gene
491 | tags_id == 95
491 | tags_name == Immune System
491 | tags_id == 82
491 | tags_name == Rheumatoid Arthritis
491 | permissions_favorite == False
491 | permissions_rate == False
491 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">ETS1</span></em><span style="font-weight: 400;"> encodes ETS proto-oncogene 1 transcription factor. Variants of </span><em><span style="font-weight: 400;">ETS1</span></em><span style="font-weight: 400;"> may play a role in rheumatoid arthritis by increasing B cell activity and the production of autoantibodies. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by reducing B cell activity and decreasing autoantibody production.</span></p> <h2><strong><em>ETS1</em></strong><strong> and Rheumatoid Arthritis</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/ets1/" target="_blank" rel="noopener"><em><span style="font-weight: 400;">ETS1 </span></em></a><span style="font-weight: 400;">gene encodes a protein called ETS proto-oncogene 1 transcription factor. This gene is involved in the development of stem cells, and it has been implicated in multiple types of cancer [</span><a href="https://www.ncbi.nlm.nih.gov/gene/2113"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10451486/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><em><span style="font-weight: 400;">ETS1 </span></em><span style="font-weight: 400;">is mainly expressed in the bone marrow and thymus, as well as in immune cells produced by these tissues such as T cells, B cells, NK cells, and NKT cells. </span><em><span style="font-weight: 400;">ETS1 </span></em><span style="font-weight: 400;">promotes the development, activity, and survival of the following cell types [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2448555/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC369111/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636162/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/7566176"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Th1 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213045/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Th2 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809820/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">CD8+ [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806616/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Tregs [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947068/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">NK [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389314/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9806641"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">NKT [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10706669"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">In contrast, it prevents the development of Th17 and B cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118518/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082765/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911503/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Researchers&rsquo; understanding of ETS1 as a potential driver of autoimmunity is fairly recent. However, it has already been linked to systemic lupus erythematosus (SLE) and rheumatoid arthritis [</span><a href="https://www.immunohorizons.org/content/3/7/331"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, R].</span></p> <p><span style="font-weight: 400;">New research suggests that ETS1 is required to prevent autoimmunity in animals and humans. According to one study, mice without ETS1 have significantly higher than normal B and T cell activity. These same mice also produce autoantibodies (antibodies that attack their own tissues) at much higher rates, leading to autoimmune disease [</span><a href="https://www.immunohorizons.org/content/3/7/331"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Other research has found that ETS1 expression is actually higher than normal in rheumatoid arthritis, however [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11229456/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11976735/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Researchers believe that inflammatory cytokines </span><a href="https://selfdecode.com/blog/article/tnf-longevity-86"><span style="font-weight: 400;">TNF</span></a><a href="http://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">-alpha</span></a><span style="font-weight: 400;"> and IL-1 directly cause ETS1 to increase. Thus, high expression of ETS1 in rheumatoid arthritis may be a symptom rather than a cause of destructive inflammation&mdash;that is, ETS1 itself doesn&rsquo;t destroy joint tissues; it is upregulated by the system that does [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11229456/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">ETS1 is believed to regulate B and T cell activity and regulate the production of autoantibodies. Variants in the </span><em><span style="font-weight: 400;">ETS1</span></em><span style="font-weight: 400;"> gene have been implicated in autoimmune diseases like rheumatoid arthritis.</span></span></p> <h2><strong>Your </strong><strong><em>ETS1</em></strong><strong> Results for Rheumatoid Arthritis</strong></h2> <p>*6244412121515363*</p> <p><a href="https://selfdecode.com/gene/ets1/"><strong>ETS1</strong></a> <a href="https://selfdecode.com/snp/rs73013527/"><strong>rs73013527</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively higher rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Possibly protective against rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele may alter the expression of ETS1 on B and/or T cells, leading to decreased autoantibody production [</span><a href="https://www.immunohorizons.org/content/3/7/331"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11229456/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/ets1/"><strong>ETS1</strong></a> <a href="https://selfdecode.com/snp/rs4936059/"><strong>rs4936059</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively higher rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele may alter the expression of ETS1 on B and/or T cells, leading to increased autoantibody production [</span><a href="https://www.immunohorizons.org/content/3/7/331"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11229456/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*6914035578616324*</p> <h2><strong>Recommendations for Reducing Arthritic Inflammation</strong></h2> <p>*8891704371756419*</p> <p><strong>Note</strong><span style="font-weight: 400;">: There&rsquo;s a lot we don&rsquo;t currently understand about ETS1, including whether or not it&rsquo;s good to have high or low levels. As such, the recommendations in this section focus on the downstream effects of detrimental ETS1 variants, such as high B cell activity and production of autoantibodies.</span></p> <h3><strong>Black Seed Oil</strong></h3> <p><span style="font-weight: 400;">Preliminary research in animals and cells suggests that </span><a href="http://selfhacked.com/blog/top-28-scientific-benefits-of-the-panacea-black-cumin-seed-nigella-sativa/"><span style="font-weight: 400;">black seed</span></a><span style="font-weight: 400;"> and its active compound thymoquinone may reduce </span><a href="https://selfhacked.com/blog/supplements-foods-exercise-right-type-th1-vs-th2-dominance/"><span style="font-weight: 400;">Th1 dominance</span></a><span style="font-weight: 400;"> and IFN-&gamma; release, both of which are associated with ETS1 activity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20600757"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26117430"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213045/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Thymoquinone reduced symptoms of rheumatoid arthritis in a study of 40 female patients, at a dose of 500 mg of the oil twice per day. Women who took black seed oil experienced reduced overall symptoms, joint stiffness, and swelling [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22162258"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In rats with arthritis, the active ingredient, thymoquinone lowered numerous pro-inflammatory cytokines (including </span><a href="http://selfhacked.com/blog/interleukin-6/"><span style="font-weight: 400;">IL-6</span></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/interleukin-1/"><span style="font-weight: 400;">IL-1&beta;</span></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">TNF alpha</span></a><span style="font-weight: 400;">, all </span><a href="http://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1</span></a><span style="font-weight: 400;"> cytokines) while increasing anti-inflammatory ones (</span><a href="http://selfhacked.com/blog/il-10/"><span style="font-weight: 400;">IL-10</span></a><span style="font-weight: 400;">) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22450443"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Black seed&rsquo;s active compound thymoquinone may improve rheumatoid arthritis by decreasing inflammation associated with ETS1 activity.</span></p> <h3><strong>Fish Oil</strong></h3> <p><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">DHA</span></a><span style="font-weight: 400;">, an omega-3 fatty acid found primarily in fish oil, suppressed the production of autoantibodies in mice. Experimental animals supplemented with DHA produced much lower levels of autoantibodies and developed autoimmune diseases (like rheumatoid arthritis) at much lower rates [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6574718/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Supplementation with </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;"> may lower the activity of chronic inflammatory and autoimmune diseases, including rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12480795"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11802309"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis of 17 trials found that supplemental fish oil reduced inflammatory joint </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> from rheumatoid arthritis and other inflammatory conditions [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17335973"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one study of 250 patients, fish oil was as effective as ibuprofen in reducing pain caused by arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16531187"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Resolvins found in </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">EPA</span></a><span style="font-weight: 400;"> and DHA appear to prevent certain inflammatory cytokines such as </span><a href="https://selfdecode.com/blog/article/tnf-thyroid-health-89"><span style="font-weight: 400;">TNF</span></a><a href="http://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">-&alpha;</span></a><span style="font-weight: 400;"> from inducing pain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20383154/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">DHA from fish oil reduced autoantibody production in mice. It has also produced positive results in clinical studies of rheumatoid arthritis patients.</span></p> <h3><strong>Thunder God Vine</strong></h3> <p><span style="font-weight: 400;">Celastrol, an active compound found in </span><a href="https://selfhacked.com/blog/15-promising-thunder-god-vine-benefits/"><span style="font-weight: 400;">thunder god vine</span></a><span style="font-weight: 400;"> (</span><em><span style="font-weight: 400;">Tripterygium wilfordii</span></em><span style="font-weight: 400;">), may reduce the production and excretion of autoantibodies. Thunder god vine is a traditional remedy for rheumatoid arthritis in traditional Chinese medicine [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471334/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In 2 clinical trials, </span><a href="https://selfhacked.com/blog/15-promising-thunder-god-vine-benefits/"><span style="font-weight: 400;">thunder god vine</span></a><span style="font-weight: 400;"> extract (60-360 mg/day) improved joint inflammation and </span><a href="https://selfhacked.com/blog/23-ways-to-combat-pain-naturally-by-increasing-your-opioids/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> from rheumatoid arthritis. It was more effective than the anti-rheumatic drug sulfasalazine in another trial on 62 people [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2509153"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12124856"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938780/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Similarly, its tincture applied on the skin improved rheumatoid arthritis in a trial on 61 people [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12610802"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Thunder god vine and its active components also improved arthritis in multiple animal studies [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9716258"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22884304"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9778100"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16983598"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16399624"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18782267"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17097618"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17354165"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18952137"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25456434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25529994"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23183089"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Celastrol, an active compound from thunder god vine, may help improve rheumatoid arthritis by reducing the production of autoantibodies.</span></p> <h3><strong>Mangiferin</strong></h3> <p><span style="font-weight: 400;">Mangiferin, an active compound found primarily in mangoes, reduced autoantibody production and B cell activity in mice [</span><a href="https://www.karger.com/Article/Fulltext/494654"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Mangiferin has shown promise in cell studies for reducing the type of inflammation that causes rheumatoid arthritis. According to one study, mangiferin may prevent the destruction of joint tissues by promoting cell death in certain destructive </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">immune cells</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25204703/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.frontiersin.org/articles/10.3389/fnut.2017.00052/full"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a small randomized controlled trial, a standard rheumatoid arthritis medication combined with mango stem bark extract reduced disease activity and symptoms after a year of supplementation. However, the effects on disease activity were similar to that of the medication alone [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24344049/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It may not be feasible to get the mangiferin needed by eating mangoes. However, mango leaf extract is available as a supplement.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Mangiferin, which is found in mangoes, may improve rheumatoid arthritis by reducing autoantibody production and B cell activity.</span></p>
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491 | content_learn_more_6914035578616324_text == Based on the variants we looked at, your ETS1 gene is somewhat associated with autoimmune inflammation. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Fish oil, thunder god vine, and mangiferin may help. Keep scrolling to find out more.
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rsIDs = rs4936059,rs73013527
rsStatus = rs4936059,,chr11,128632601,A,G,T,,36,0,Normal
rsStatus = rs73013527,,chr11,128627057,C,T,,,11,29,HET
