492 | id == 492
492 | category_id == 28
492 | category_order == 25
492 | category_name == Joint Inflammation
492 | category_color == #C47AC0
492 | slug == RASGRP1-rheumatoid-arthritis
492 | title == How Might Immune Cell Development Go Awry in Rheumatoid Arthritis? (RASGRP1)
492 | meta_description == RASGRP1 promotes immune cell development. Variants of RASGRP1 have been associated with rheumatoid arthritis. Read more here.
492 | summary == <p style="text-align:justify"><strong><em>RASGRP1</em> codes for a protein that helps immune cells develop properly. How might immune cell development go awry in rheumatoid arthritis? Read more to find out.</strong></p>
492 | overall_score_text == Your Rheumatoid Arthritis Score (based on RASGRP1 gene)
492 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/RASGRP1-C15orf53-Rheumatoid-arthritis.jpg
492 | author_id == 14
492 | author_name == Shany Lahan
492 | author_title == MS (Neuroscience)
492 | author_order == 5
492 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
492 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
492 | reviewer == None
492 | medical_reviewer_id == 11
492 | medical_reviewer_name == Puya Yazdi
492 | medical_reviewer_title == MD
492 | publish_date == 2020
492 | publish_date == 11
492 | publish_date == 19
492 | avg_rating == 5.0
492 | tags_id == 33
492 | tags_name == Autoimmunity
492 | tags_id == 955
492 | tags_name == RASGRP1 Gene
492 | tags_id == 442
492 | tags_name == T Cells
492 | tags_id == 957
492 | tags_name == T Cell Selection
492 | permissions_favorite == False
492 | permissions_rate == False
492 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">RASGRP1</span></em><span style="font-weight: 400;"> gene encodes RAS guanyl-releasing protein 1, a protein necessary for the development of immune cells. Variants of </span><em><span style="font-weight: 400;">RASGRP1 </span></em><span style="font-weight: 400;">may play a role in rheumatoid arthritis by lowering the production of RAS guanyl-releasing protein 1. Diet and supplement modifications may counteract the effects of these variants by increasing RAS guanyl-releasing protein 1 production or activity.</span></span></p> <h2 style="text-align: justify;"><strong><em>RASGRP1</em></strong><strong> and Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/rasgrp1/"><em><span style="font-weight: 400;">RASGRP1</span></em></a> <span style="font-weight: 400;">gene codes for RAS guanyl-releasing protein 1, a protein involved in T cell development [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26714738/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11017103/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">During their development, T cells must undergo a series of examinations termed </span><em><span style="font-weight: 400;">selection</span></em><span style="font-weight: 400;">. These examinations are conducted in order to </span><em><span style="font-weight: 400;">select </span></em><span style="font-weight: 400;">for T cells that are unresponsive to the body&rsquo;s own tissues [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10700232/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Studies have shown that the survival of these T cells is dependent on the activity of RAS guanyl-releasing protein 1 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11017103/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26714738/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">T cell selection is crucial for preventing autoimmunity, or immune reactions that target parts of the body. In the autoimmune disorder rheumatoid arthritis, aberrant immune reactions target the body&rsquo;s joints [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10700232/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">RASGRP1 </span></em><span style="font-weight: 400;">have been associated with rheumatoid arthritis. These variants may lower the production of RAS guanyl-releasing protein 1, which may promote the development of T cells that are reactive to joints [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605761/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26714738/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>RASGRP1 </em></strong><strong>Results for Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*3195164387876719*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>RASGRP1 </em></strong><a href="https://selfdecode.com/snp/rs8032939/"><strong>rs8032939</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased risk of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with rheumatoid arthritis</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNP:</strong></p> <p style="text-align: justify;"><strong><em>RASGRP1 </em></strong><a href="https://selfdecode.com/snp/rs8043085/"><strong>rs8043085</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605761/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with rheumatoid arthritis</span></li> </ul> <p style="text-align: justify;">*4894103792092663*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*3404136886843252*</p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Mediterranean Diet</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The Mediterranean diet is a popular anti-inflammatory diet that may reduce swelling and pain in arthritic joints [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23975674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">According to one study of 51 patients, those eating a Mediterranean diet had significantly higher vitality scores (a measurement of energy, quality of life, and general function) than those eating a typical western diet [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23975674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The anti-inflammatory effect of the Mediterranean diet may be due to its high content of </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">. In fact, people whose diets include a lot of olive oil are significantly less likely to develop rheumatoid arthritis than those who use other types of cooking oils [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10584053/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1771399/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Olive oil contains the compound pentanal. Pentanal was reported to increase the production of RAS guanyl-releasing protein 1 in human cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26079696/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet may help manage rheumatoid arthritis by increasing production of RAS guanyl-releasing protein 1.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Increased Omega-3 Intake</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Studies suggest that increased dietary intake of </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">omega-3</span></a><span style="font-weight: 400;"> fatty acids (such as EPA and DHA) may protect against rheumatoid arthritis. In a meta-analysis of 20 clinical trials, higher omega-3 consumption improved rheumatoid arthritis symptoms and lab markers [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634864/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28965775/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">DHA was reported to activate RAS guanyl-releasing protein 1 in a study of human T cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/14583629/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Good dietary omega-3 sources include [</span><a href="https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Fish and seafood</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/flaxseed-oil-benefits/"><span style="font-weight: 400;">Flaxseed</span></a></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Chia seeds</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Walnuts</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/hemp-seeds/"><span style="font-weight: 400;">Hemp seeds</span></a></li> </ul> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Increased omega-3 intake may help manage rheumatoid arthritis by increasing the activity of RAS guanyl-releasing protein 1.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Fish Oil&nbsp;</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Individuals carrying risk variants of <em>RASGRP1</em> may choose to supplement with omega-3-rich </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;">, if they aren&rsquo;t able to get enough omega-3 fatty acids in their diet. Supplementation with fish oil may lower the activity of chronic inflammatory and autoimmune diseases, including rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12480795"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11802309"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A meta-analysis of 17 trials found that supplemental fish oil reduced inflammatory joint pain from rheumatoid arthritis and other inflammatory conditions [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17335973"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In one study of 250 patients, fish oil was as effective as ibuprofen in reducing pain caused by arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16531187"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Resolvins found in EPA and DHA appear to prevent certain inflammatory proteins such as TNF-&alpha; from inducing pain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20383154/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Fish oil may help manage rheumatoid arthritis by increasing the activity of RAS guanyl-releasing protein 1.</span></p>
492 | content_snp_table_3195164387876719_key == 3195164387876719
492 | content_snp_table_3195164387876719_blur == True
492 | content_snp_table_3195164387876719_hidden == False
492 | content_learn_more_4894103792092663_key == 4894103792092663
492 | content_learn_more_4894103792092663_blur == True
492 | content_learn_more_4894103792092663_hidden == False
492 | content_learn_more_4894103792092663_text == Based on the variants we looked at, your RASGRP1 gene makes you somewhat more likely to develop rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Adhering to the Mediterranean diet, increasing omega-3 intake, and supplementing with fish oil may help. Keep scrolling to find out more.
492 | content_recommendation_3404136886843252_key == 3404136886843252
492 | content_recommendation_3404136886843252_blur == True
492 | content_recommendation_3404136886843252_hidden == False
rsIDs = rs8032939,rs8043085
rsStatus = rs8032939,RASGRP1,chr15,38541832,T,C,,,31,0,Normal
rsStatus = rs8043085,RASGRP1,chr15,38535939,G,T,,,34,0,Normal
