493 | id == 493
493 | category_id == 28
493 | category_order == 25
493 | category_name == Joint Inflammation
493 | category_color == #C47AC0
493 | slug == RUNX1-rheumatoid-arthritis
493 | title == A Protein Regulator & Its Role in Rheumatoid Arthritis (RUNX1)
493 | meta_description == RUNX1 helps regulate immune cell development. Variants of RUNX1 are linked to rheumatoid arthritis. Read more here.
493 | summary == <p style="text-align:justify"><strong><em>RUNX1</em> codes for a protein that helps regulate the development of immune cells. How might variants of <em>RUNX1 </em>increase the risk of rheumatoid arthritis? Read more to find out.&nbsp;</strong></p>
493 | overall_score_text == Your Rheumatoid Arthritis Score (based on RUNX1 gene)
493 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/RUNX1-Rheumatoid-arthritis.jpg
493 | author_id == 14
493 | author_name == Shany Lahan
493 | author_title == MS (Neuroscience)
493 | author_order == 5
493 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
493 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
493 | reviewer == None
493 | medical_reviewer_id == 11
493 | medical_reviewer_name == Puya Yazdi
493 | medical_reviewer_title == MD
493 | publish_date == 2020
493 | publish_date == 11
493 | publish_date == 19
493 | avg_rating == 5.0
493 | tags_id == 33
493 | tags_name == Autoimmunity
493 | tags_id == 955
493 | tags_name == RASGRP1 Gene
493 | tags_id == 958
493 | tags_name == RUNX1 Gene
493 | tags_id == 442
493 | tags_name == T Cells
493 | tags_id == 957
493 | tags_name == T Cell Selection
493 | tags_id == 435
493 | tags_name == Th1 Cells
493 | permissions_favorite == False
493 | permissions_rate == False
493 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">RUNX1 helps regulate the development of immune cells. Variants of </span><em><span style="font-weight: 400;">RUNX1 </span></em><span style="font-weight: 400;">may play a role in rheumatoid arthritis by dysregulating RUNX1 production. Diet and supplement modifications may counteract the effects of these variants by modulating levels of pro- and anti-inflammatory immune cells or proteins.</span></span></p> <h2 style="text-align: justify;"><strong><em>RUNX1</em></strong><strong> and Rheumatoid Arthritis&nbsp;</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">RUNX1 regulates the production of proteins involved in T cell development and activation, including </span><a href="https://selfdecode.com/blog/article/RASGRP1-rheumatoid-arthritis-492/"><span style="font-weight: 400;">RAS guanyl-releasing protein 1</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/gene/861"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/33065764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26714738/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11017103/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">More specifically, RAS guanyl-releasing protein 1 may be necessary for promoting the survival of T cells that are unresponsive to the body&rsquo;s own tissues [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10700232/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11017103/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26714738/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The survival of these T cells is crucial for preventing autoimmunity, or immune reactions that target parts of the body. In the autoimmune disorder rheumatoid arthritis, aberrant immune reactions target the body&rsquo;s joints [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10700232/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Although this protein may play a role in preventing autoimmunity, RUNX1 may also be involved in the development of pro-inflammatory </span><a href="https://selfhacked.com/blog/supplements-foods-exercise-right-type-th1-vs-th2-dominance/#Overview"><span style="font-weight: 400;">T helper type 1</span></a><span style="font-weight: 400;"> (</span><a href="https://selfhacked.com/blog/supplements-foods-exercise-right-type-th1-vs-th2-dominance/#Overview"><span style="font-weight: 400;">Th1</span></a><span style="font-weight: 400;">) cells. Multiple studies have provided evidence that a </span><a href="https://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1-dominant</span></a><span style="font-weight: 400;"> immune response may underlie rheumatoid arthritis progression [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12835475/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11812015/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18063670/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><a href="https://selfdecode.com/gene/runx1/" target="_blank" rel="noopener"><em><span style="font-weight: 400;">RUNX1</span></em></a> <span style="font-weight: 400;">have been associated with rheumatoid arthritis. These variants may dysregulate the production of RUNX1, which may result in the development of T cells that are reactive to joints, as well as the development of pro-inflammatory Th1 cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605761/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26546613"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>RUNX1 </em></strong><strong>Results for Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*2185817722404077*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>RUNX1 </em></strong><a href="https://selfdecode.com/snp/rs9979383/"><strong>rs9979383</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605761/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26546613"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with rheumatoid arthritis</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs:</strong></p> <p style="text-align: justify;"><strong><em>RUNX1 </em></strong><a href="https://selfdecode.com/snp/rs8133843/"><strong>rs8133843</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of rheumatoid arthritis&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with rheumatoid arthritis</span></li> </ul> <p style="text-align: justify;">*7150832417702735*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*4117315547058888*</p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Mediterranean Diet</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The Mediterranean diet is a popular anti-inflammatory diet that may reduce swelling and pain in arthritic joints [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23975674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">According to one study of 51 patients, those eating a Mediterranean diet had significantly higher vitality scores (a measurement of energy, quality of life, and general function) than those eating a typical western diet [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23975674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The anti-inflammatory effect of the Mediterranean diet may be due to its high content of </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">. In fact, people whose diets include a lot of olive oil are significantly less likely to develop rheumatoid arthritis than those who use other types of cooking oils [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10584053/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1771399/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Olive oil contains the compound pentanal. Pentanal was reported to increase the production of RAS guanyl-releasing protein 1 in human cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26079696/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet may help manage rheumatoid arthritis by increasing the production of RAS guanyl-releasing protein 1 and lowering levels of Th1-related inflammatory proteins.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>CBD Oil</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Multiple cell- and animal-based studies have found decreases in the number of Th1 cells and levels of Th1-related proteins after treatment with <a href="https://selfhacked.com/blog/cbd-oil-for-arthritis/" target="_blank" rel="noopener">CBD oil</a>. Some of these studies also noted increases in the amount of anti-inflammatory cells and immune proteins [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085417/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31497013/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10920191/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32440886/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a small study of 58 rheumatoid arthritis patients, a </span><a href="https://selfhack.com/blog/top-6-unique-super-effective-ways-counteract-negative-performance-effects-cannabismarijuana/"><span style="font-weight: 400;">cannabis</span></a><span style="font-weight: 400;"> extract containing both </span><span style="font-weight: 400;">CBD</span><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/tetrahydrocannabinol-thc/"><span style="font-weight: 400;">THC</span></a><span style="font-weight: 400;"> significantly reduced pain and increased quality of sleep. Some research suggests that the combination of CBD and THC is more effective than CBD alone; however, CBD oil is much more readily available and considered non-psychoactive [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16282192/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In mice with this condition, oral and injected CBD relieved inflammation and slowed the joint damage progression. CBD also prevented T cells and joint cells (synoviocytes) from reproducing and releasing pro-inflammatory immune proteins [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16904/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Similarly, a topical CBD gel reduced joint swelling, pain, and the levels of inflammatory markers (such as TNF-alpha) in the nerves of rats with rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851925/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Additionally, synthetic CBD-like compounds reduced inflammation, pain perception, and joint damage in mice and rats with this type of arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21683763"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15022343"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576666/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Two studies in humans and dogs found that animals with rheumatoid arthritis or osteoarthritis had higher levels of both CBD receptors and several </span><a href="https://selfhacked.com/blog/49-ways-increase-natural-cannabinoids-without-smoking-pot-including-ways-decrease-cannabinoids/"><span style="font-weight: 400;">cannabinoids</span></a><span style="font-weight: 400;"> in the joints. This suggests that the body activates the endocannabinoid system to fight arthritis. In line with this, increasing cannabinoids may be a good therapeutic strategy [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453762/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674828/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><em><span style="font-weight: 400;">If you&rsquo;re unsure whether CBD oil is legal in your place of residence, check out </span></em><a href="https://selfhacked.com/blog/cbd-oil/#Is_CBD_Oil_Legal"><em><span style="font-weight: 400;">this post</span></em></a><em><span style="font-weight: 400;">.&nbsp;</span></em></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">CBD oil may help manage rheumatoid arthritis by reducing the number of Th1-related cells and proteins, while increasing the number of anti-inflammatory cells and proteins.</span></p> <h4 style="text-align: justify;"><strong>Black Seed Oil</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Thymoquinone, an active component of </span><a href="http://selfhacked.com/blog/top-28-scientific-benefits-of-the-panacea-black-cumin-seed-nigella-sativa/"><span style="font-weight: 400;">black seed</span></a><span style="font-weight: 400;">, reduced symptoms of rheumatoid arthritis in a study of 40 female patients (at a dose of 500 mg, taken twice per day). Women who took black seed oil experienced reduced overall symptoms, joint stiffness, and swelling [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22162258"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In rats with arthritis, thymoquinone lowered numerous pro-inflammatory Th1 proteins while increasing anti-inflammatory ones [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22450443"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642442/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Black seed oil may help manage rheumatoid arthritis by lowering levels of pro-inflammatory (Th1) proteins while increasing levels of anti-inflammatory ones.</span></p> <h4 style="text-align: justify;"><strong>Bromelain</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/bromelain-benefits/"><span style="font-weight: 400;">Bromelain</span></a><span style="font-weight: 400;"> is an enzyme found in pineapples. In 77 patients with rheumatoid arthritis or osteoarthritis, bromelain (400 mg) improved overall symptoms, reduced stiffness, and improved physical function [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12587686"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Similar to thymoquinone of black seed, bromelain lowered Th1 inflammatory proteins and increased anti-inflammatory ones in colon biopsies derived from patients with ulcerative colitis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2269703/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Bromelain may help manage rheumatoid arthritis by lowering levels of pro-inflammatory (Th1) proteins while increasing levels of anti-inflammatory ones.</span></p>
493 | content_snp_table_2185817722404077_key == 2185817722404077
493 | content_snp_table_2185817722404077_blur == True
493 | content_snp_table_2185817722404077_hidden == False
493 | content_learn_more_7150832417702735_key == 7150832417702735
493 | content_learn_more_7150832417702735_blur == True
493 | content_learn_more_7150832417702735_hidden == False
493 | content_learn_more_7150832417702735_text == Based on the variants we looked at, your RUNX1 gene makes you somewhat more likely to develop rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. The Mediterranean diet, CBD oil, black seed oil, and bromelain may help. Keep scrolling to find out more.
493 | content_recommendation_4117315547058888_key == 4117315547058888
493 | content_recommendation_4117315547058888_blur == True
493 | content_recommendation_4117315547058888_hidden == False
rsIDs = rs9979383,rs8133843
rsStatus = rs9979383,,chr21,35343463,C,G,T,,35,0,Normal
rsStatus = rs8133843,,chr21,35365944,G,A,C,T,12,10,HET
