495 | id == 495
495 | category_id == 28
495 | category_order == 25
495 | category_name == Joint Inflammation
495 | category_color == #C47AC0
495 | slug == CEP57-rheumatoid-arthritis
495 | title == A Crucial Gene for Joint Health (CEP57)
495 | meta_description == The CEP57 gene supports bone and cartilage formation. Click to learn about its link with rheumatoid arthritis.
495 | summary == <p style="text-align:justify"><strong>Genes can have a major impact on your joint health! This post explains the link between <em>CEP57</em> and rheumatoid arthritis and provides gene-based solutions.</strong></p>
495 | overall_score_text == Your Rheumatoid Arthritis Score (based on CEP57 gene)
495 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CEP57-SESN3-Rheumatoid-arthritis.jpg
495 | author_id == 9
495 | author_name == Aleksa Ristic
495 | author_title == MS (Pharmacy)
495 | author_order == 45
495 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
495 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
495 | reviewer == None
495 | medical_reviewer_id == 11
495 | medical_reviewer_name == Puya Yazdi
495 | medical_reviewer_title == MD
495 | publish_date == 2020
495 | publish_date == 11
495 | publish_date == 20
495 | avg_rating == 5.0
495 | tags_id == 960
495 | tags_name == CEP57
495 | tags_id == 207
495 | tags_name == Exercise
495 | tags_id == 961
495 | tags_name == FGF-2
495 | tags_id == 74
495 | tags_name == Joint Disorders
495 | tags_id == 82
495 | tags_name == Rheumatoid Arthritis
495 | permissions_favorite == False
495 | permissions_rate == False
495 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The </strong><strong><em>CEP57</em></strong><strong> gene supports joint health by boosting FGF-2, which is crucial for bone and cartilage formation.<br /><br /></strong><strong>One gene variant may reduce CEP57 activity. It&rsquo;s been associated with higher odds of rheumatoid arthritis.<br /><br /></strong><strong>Simple lifestyle changes and supplements may improve joint health by targeting the CEP57 variant.</strong></span></p> <p>&nbsp;</p> <h2><strong>CEP57 and Joint Health</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/cep57/"><em><span style="font-weight: 400;">CEP57</span></em></a><span style="font-weight: 400;"> gene helps make a protein that maintains cell structure and function in different tissues [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063474/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In the joints, CEP57 activates FGF-2, a crucial factor for bone and cartilage formation. Animals lacking this gene have severe bone and joint deformities [</span><a href="https://www.ncbi.nlm.nih.gov/gene/9702"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your CEP57 Results for Rheumatoid Arthritis</strong></h2> <p>*8179840801462701*</p> <p><strong>Primary SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs4409785/"><strong>rs4409785</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with higher odds of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele likely reduces CEP57 activity and FGF-2 levels</span></li> </ul> <p>*2321465363806087*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Joint Health</strong></h2> <p>*9087632314899019*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Massage</strong></h4> <p><span style="font-weight: 400;">In animal studies, </span><a href="https://selfhacked.com/blog/massage-health-benefits/"><span style="font-weight: 400;">massage</span></a><span style="font-weight: 400;"> promoted skin and cartilage repair by boosting FGF-2 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29770958/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037120/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to one clinical review, massage therapy may reduce </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> and increase function in joints affected by rheumatoid arthritis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28177937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">As part of a broader physical therapy regimen, practitioners use massage to improve flexibility and function in arthritic joints [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1395797/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Massage may improve joint health by targeting your gene variant.</span></p> <h4><strong>Aquatic Exercise</strong></h4> <p><span style="font-weight: 400;">In one animal study, a combination of massage and </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> yielded the best results for cartilage repair and FGF-2 increase. Exercise also raised brain FGF-2 levels in rats [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037120/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9295187/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Aquatic exercise describes any type of physical activity that takes place either partially or fully submerged in water. These activities can allow people to maintain physical fitness and reap the benefits of exercise even if they are not fully mobile out of the water [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931167/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In two clinical trials comparing different types of physical activity, aquatic exercise produced the most significant pain reduction in people with rheumatoid arthritis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8971230/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821024/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Practice aquatic exercise to lessen the impact of your CEP57 gene on the joints.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Fish Oil</strong></h4> <p><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">Fish oil</span></a><span style="font-weight: 400;"> supplementation increased FGF-2 levels in one clinical trial [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551834/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Fish oil may improve different inflammatory and autoimmune conditions, including rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12480795"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11802309"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a meta-analysis of 17 trials, supplemental fish oil reduced joint </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> from rheumatoid arthritis and other inflammatory conditions [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17335973"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Fish oil may improve rheumatoid arthritis by targeting your CEP57 variant.</span></p>
495 | content_snp_table_8179840801462701_key == 8179840801462701
495 | content_snp_table_8179840801462701_blur == True
495 | content_snp_table_8179840801462701_hidden == False
495 | content_learn_more_2321465363806087_key == 2321465363806087
495 | content_learn_more_2321465363806087_blur == True
495 | content_learn_more_2321465363806087_hidden == False
495 | content_learn_more_2321465363806087_text == Based on the variant we looked at, your CEP57 gene is associated with slightly higher odds of rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Practice aquatic exercise and massage, and consider supplementing with fish oil to improve joint health. Keep reading to learn more.
495 | content_recommendation_9087632314899019_key == 9087632314899019
495 | content_recommendation_9087632314899019_blur == True
495 | content_recommendation_9087632314899019_hidden == False
rsIDs = rs4409785
rsStatus = rs4409785,,chr11,95578258,T,C,,,29,0,Normal
