496 | id == 496
496 | category_id == 28
496 | category_order == 25
496 | category_name == Joint Inflammation
496 | category_color == #C47AC0
496 | slug == RAD51B-rheumatoid-arthritis
496 | title == What is the Role of DNA Repair in Rheumatoid Arthritis? (RAD51B)
496 | meta_description == RAD51B encodes a DNA-repair protein called RAD51 paralog B. What is its role in rheumatoid arthritis? Read on to learn more.
496 | summary == <p><strong><em>RAD51B </em>encodes a DNA-repair protein called RAD51 paralog B. What is its role in rheumatoid arthritis? Read on to learn more.</strong></p>
496 | overall_score_text == Your Rheumatoid Arthritis Score (based on RAD51B)
496 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/RAD51B-Rheumatoid-arthritis.jpg
496 | author_id == 1
496 | author_name == Jasmine Foster
496 | author_title == BSc, BEd
496 | author_order == 36
496 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
496 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
496 | reviewer == None
496 | medical_reviewer_id == 11
496 | medical_reviewer_name == Puya Yazdi
496 | medical_reviewer_title == MD
496 | publish_date == 2020
496 | publish_date == 11
496 | publish_date == 20
496 | avg_rating == 5.0
496 | tags_id == 33
496 | tags_name == Autoimmunity
496 | tags_id == 750
496 | tags_name == DNA Damage
496 | tags_id == 40
496 | tags_name == DNA Repair
496 | tags_id == 95
496 | tags_name == Immune System
496 | tags_id == 24
496 | tags_name == Inflammation
496 | tags_id == 962
496 | tags_name == RAD51B Gene
496 | tags_id == 82
496 | tags_name == Rheumatoid Arthritis
496 | permissions_favorite == False
496 | permissions_rate == False
496 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">RAD51B</span></em><span style="font-weight: 400;"> encodes RAD51 paralog B, a DNA repair protein. Variants of </span><em><span style="font-weight: 400;">RAD51B</span></em><span style="font-weight: 400;"> may play a role in rheumatoid arthritis by preventing DNA repair. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by reducing DNA damage and enhancing DNA repair.</span></p> <h2><strong><em>RAD51B</em></strong><strong> and Rheumatoid Arthritis</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/rad51b/"><em><span style="font-weight: 400;">RAD51B</span></em></a><span style="font-weight: 400;"> gene encodes a DNA repair protein called RAD51 paralog B. Along with other related RAD51 proteins, RAD51B helps sense DNA damage and stops compromised cells from reproducing [</span><a href="https://www.ncbi.nlm.nih.gov/gene?Db=gene&amp;Cmd=DetailsSearch&amp;Term=5890"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Low levels of RAD51B may lead to compromised cells multiplying out of control, which in turn may cause the formation of tumors. Research suggests that people with higher than normal RAD51B expression may have better protection from cancer than those with lower RAD51B [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342748/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710938/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Through a similar protective mechanism, high RAD51B activity may prevent immune cells from attacking the body&rsquo;s own tissues, thereby suppressing autoimmunity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Multiple studies have found associations between </span><em><span style="font-weight: 400;">RAD51B</span></em><span style="font-weight: 400;"> variants and rheumatoid arthritis. Variants that produce lower levels or loss of function of RAD51B have been linked to both increased rates of the disease and intensity of symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034583/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710800/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374468/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">RAD51B</span></em><span style="font-weight: 400;"> encodes a DNA repair protein that helps protect against many diseases, including cancer and rheumatoid arthritis.</span></span></p> <h2><strong>Your </strong><strong><em>RAD51B</em></strong><strong> Results for Rheumatoid Arthritis</strong></h2> <p>*7649762197187959*</p> <p><a href="https://selfdecode.com/gene/rad51b/"><strong>RAD51B</strong></a> <a href="https://selfdecode.com/snp/rs911263/"><strong>rs911263</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively higher rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Possibly protective against rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may increase RAD51B expression, leading to lower levels of potentially damaging cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342748/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710938/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/rad51b/"><strong>RAD51B</strong></a> <a href="https://selfdecode.com/snp/rs1950897/"><strong>rs1950897</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively higher rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Possibly protective against rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may increase RAD51B expression, leading to lower levels of potentially damaging cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342748/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710938/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*6754691648729476*</p> <h2><strong>Recommendations for Reducing Arthritic Inflammation</strong></h2> <p>*8845351347422403*</p> <h3><strong>Avoid Cigarette Smoke</strong></h3> <p><span style="font-weight: 400;">Exposure to cigarette smoke is well-known to increase the rate of DNA damage and reduce DNA repair capacity. People with potentially detrimental </span><em><span style="font-weight: 400;">RAD51B</span></em><span style="font-weight: 400;"> alleles may already have reduced DNA repair, so cigarette smoke is especially dangerous [</span><a href="https://www.pnas.org/content/115/7/E1560"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749693/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Smoking is one of the strongest environmental risk factors for developing rheumatoid arthritis. In one study, 88% of smokers tested positive for </span><a href="https://selfhacked.com/blog/rheumatoid-factor/"><span style="font-weight: 400;">rheumatoid factor</span></a><span style="font-weight: 400;"> over a period of 10 years [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898190/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11085797"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9833699"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Other studies have reported up to 4 times higher odds of having elevated rheumatoid factor in smokers&nbsp; [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1004225/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16403829"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9306868"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10743800"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11085797"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Cigarette smoke increases DNA damage and reduces DNA repair capacity, which can be especially dangerous for people with harmful </span><em><span style="font-weight: 400;">RAD51B</span></em><span style="font-weight: 400;"> alleles.</span></span></p> <h3><strong>Mediterranean Diet</strong></h3> <p><span style="font-weight: 400;">Many active compounds found in plant-based foods have been found to increase the rate and efficiency of DNA repair mechanisms and to prevent DNA damage in the first place. These compounds are common in the Mediterranean diet, which is rich in fruits, vegetables, whole grains, and olive oil [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412605/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The Mediterranean diet is a popular anti-inflammatory diet that may reduce swelling and pain in arthritic joints [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23975674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to one study of 51 patients, those eating a Mediterranean diet had significantly higher vitality scores (a measurement of energy, quality of life, and general function) than those eating a typical western diet [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23975674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The anti-inflammatory effect of the Mediterranean diet may be due to its high content of </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">. In fact, people whose diets include a lot of olive oil are significantly less likely to develop rheumatoid arthritis than those who use other types of cooking oils [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10584053/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1771399/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet is rich in active compounds that may prevent DNA damage and enhance DNA repair. It is also a broadly anti-inflammatory diet that may help improve rheumatoid arthritis.</span></p> <h3><strong>Borage</strong></h3> <p><a href="https://www.selfhacked.com/blog/borage/"><span style="font-weight: 400;">Borage</span></a><span style="font-weight: 400;"> is a flowering herb whose oil is especially rich in the omega-6 PUFA gamma-linolenic acid (</span><a href="https://selfhacked.com/blog/gamma-linolenic-acid/"><span style="font-weight: 400;">GLA</span></a><span style="font-weight: 400;">). Borage oil may reduce DNA damage and enhance DNA repair. Researchers attribute this effect to its high content of GLA [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584109/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In 2 trials of 187 people with rheumatoid arthritis, taking borage seed oil capsules for up to 18 months reduced the symptoms [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8214997/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977504/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Several studies demonstrated that borage seed oil reduced inflammation in the lining of joints (synovitis), thus reducing the need for anti-inflammatory drugs [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10617996/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/2171540/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9732298/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis concluded that GLA may reduce pain and disability in people suffering from rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21328257"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Borage oil is rich in gamma linolenic acid (GLA), which may reduce DNA damage and enhance DNA repair. Both borage oil and GLA itself reduced the symptoms of rheumatoid arthritis in clinical trials.</span></p>
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496 | content_learn_more_6754691648729476_text == Based on the variants we looked at, your RAD51B gene is somewhat associated with reduced DNA repair capacity. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. A Mediterranean diet, borage oil, and avoiding cigarette smoke may help. Keep scrolling to find out more.
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rsIDs = rs1950897,rs911263
rsStatus = rs1950897,RAD51B,chr14,68293424,C,G,T,,29,0,Normal
rsStatus = rs911263,RAD51B,chr14,68286876,C,A,T,,29,0,Normal
