497 | id == 497
497 | category_id == 28
497 | category_order == 25
497 | category_name == Joint Inflammation
497 | category_color == #C47AC0
497 | slug == EOMES-rheumatoid-arthritis
497 | title == Surprising Genetic Factor for Joint Inflammation (EOMES)
497 | meta_description == The EOMES gene enables the development of pro-inflammatory T immune cells. Learn about its link with rheumatoid arthritis.
497 | summary == <p style="text-align:justify"><strong>There&rsquo;s a hidden genetic link between immune cell development and rheumatoid arthritis! This post explains how the <em>EOMES</em> gene impacts joint inflammation and gives personalized recommendations.</strong></p>
497 | overall_score_text == Your Rheumatoid Arthritis Score (based on EOMES gene)
497 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/EOMES-Rheumatoid-arthritis.jpg
497 | author_id == 9
497 | author_name == Aleksa Ristic
497 | author_title == MS (Pharmacy)
497 | author_order == 45
497 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
497 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
497 | reviewer == None
497 | medical_reviewer_id == 11
497 | medical_reviewer_name == Puya Yazdi
497 | medical_reviewer_title == MD
497 | publish_date == 2020
497 | publish_date == 11
497 | publish_date == 22
497 | avg_rating == 5.0
497 | tags_id == 33
497 | tags_name == Autoimmunity
497 | tags_id == 963
497 | tags_name == EOMES gene
497 | tags_id == 24
497 | tags_name == Inflammation
497 | tags_id == 82
497 | tags_name == Rheumatoid Arthritis
497 | tags_id == 442
497 | tags_name == T Cells
497 | permissions_favorite == False
497 | permissions_rate == False
497 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The EOMES gene enables the development of cytotoxic T cells, which can cause joint inflammation.<br /><br /></strong><strong>Specific gene variants may increase EOMES activity and correlate with higher odds of rheumatoid arthritis.<br /><br /></strong><strong>This post reveals potential ways to improve joint health by targeting EOMES variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>EOMES, T Cells &amp; Rheumatoid Arthritis</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/eomes/"><span style="font-weight: 400;">EOMES</span></a><span style="font-weight: 400;"> gene helps make a protein that enables the development of cytotoxic T cells, which kill microbes and cause inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/gene?Db=gene&amp;Cmd=DetailsSearch&amp;Term=8320"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18362944/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374745/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In rheumatoid arthritis, overactive T cells attack the joints and stimulate the production of inflammatory proteins such as </span><a href="https://selfdecode.com/blog/article/tnf-longevity-86"><span style="font-weight: 400;">TNF</span></a><a href="http://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">-alpha</span></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/interleukin-6/"><span style="font-weight: 400;">IL-6</span></a><span style="font-weight: 400;">, and IL-17 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25370956/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your EOMES Results for Rheumatoid Arthritis</strong></h2> <p>*5426254288466588*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs3806624/"><strong>rs3806624</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with higher odds of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - not associated with rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele likely increases EOMES activity and joint inflammation</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs9880772/"><strong>rs9880772</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele likely increases EOMES activity and joint inflammation</span></li> </ul> <p>*7762641410146922*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Rheumatoid Arthritis</strong></h2> <p>*1765058775528425*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Avoid Cigarette Smoke</strong></h4> <p><span style="font-weight: 400;">In one animal study, cigarette smoke activated the inflammatory pathway that increases EOMES activity. Cells treated with tobacco cigarette smoke extract had significantly higher EOMES activity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868633/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433280/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Smoking is one of the strongest environmental risk factors for developing rheumatoid arthritis. In one study, 88% of smokers tested positive for </span><a href="https://selfhacked.com/blog/rheumatoid-factor/"><span style="font-weight: 400;">rheumatoid factor</span></a><span style="font-weight: 400;"> in 10 years [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898190/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11085797"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9833699"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Other studies have reported up to 4 times higher odds of having elevated rheumatoid factor in smokers [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1004225/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16403829"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9306868"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10743800"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11085797"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Avoid cigarette smoke to lessen the impact of your gene variants on joint health.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Lactobacillus Casei</strong></h4> <p><span style="font-weight: 400;">By boosting </span><a href="http://selfhacked.com/blog/treg/"><span style="font-weight: 400;">regulatory T cells</span></a><span style="font-weight: 400;">, probiotics may reduce inflammation and suppress cytotoxic T cells activated by EOMES [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276397/table/t1-11_311_issazadeh-navikas/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196311/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613231/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In two clinical trials, supplementation with a </span><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">probiotic</span></a><span style="font-weight: 400;"> strain </span><a href="http://selfhacked.com/blog/l-casei/"><em><span style="font-weight: 400;">Lactobacillus casei</span></em></a> <span style="font-weight: 400;">improved rheumatoid arthritis by reducing inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24355439/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24673738/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This strain also relieved rheumatoid arthritis in animal studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21810608/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20838859/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18804867/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em>Lactobacillus casei</em> probiotic may improve rheumatoid arthritis by targeting your EOMES variants.</span></p>
497 | content_snp_table_5426254288466588_key == 5426254288466588
497 | content_snp_table_5426254288466588_blur == True
497 | content_snp_table_5426254288466588_hidden == False
497 | content_learn_more_7762641410146922_key == 7762641410146922
497 | content_learn_more_7762641410146922_blur == True
497 | content_learn_more_7762641410146922_hidden == False
497 | content_learn_more_7762641410146922_text == Based on the variants we looked at, your EOMES gene is associated with slightly higher odds of rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Avoid cigarette smoke to improve joint health by targeting your variants. Keep reading to learn more.
497 | content_recommendation_1765058775528425_key == 1765058775528425
497 | content_recommendation_1765058775528425_blur == True
497 | content_recommendation_1765058775528425_hidden == False
rsIDs = rs9880772,rs3806624
rsStatus = rs9880772,,chr3,27736288,G,A,C,,36,0,Normal
