498 | id == 498
498 | category_id == 28
498 | category_order == 25
498 | category_name == Joint Inflammation
498 | category_color == #C47AC0
498 | slug == TNFAIP3-rheumatoid-arthritis
498 | title == Inflammatory Protein Modulation & Rheumatoid Arthritis (TNFAIP3)
498 | meta_description == TNFAIP3 helps modulate protein activity. Variants of TNFAIP3 have been associated with rheumatoid arthritis. Read more here.
498 | summary == <p style="text-align:justify"><strong><em>TNFAIP3</em> may help modulate protein breakdown, location, activity, and interactions&hellip; but how might <em>TNFAIP3</em> variants increase the risk of rheumatoid arthritis? Read more to find out.</strong></p>
498 | overall_score_text == Your Rheumatoid Arthritis Score (based on TNFAIP3 gene)
498 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TNFAIP3-PERP-Rheumatoid-arthritis.jpg
498 | author_id == 14
498 | author_name == Shany Lahan
498 | author_title == MS (Neuroscience)
498 | author_order == 5
498 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
498 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
498 | reviewer == None
498 | medical_reviewer_id == 11
498 | medical_reviewer_name == Puya Yazdi
498 | medical_reviewer_title == MD
498 | publish_date == 2020
498 | publish_date == 11
498 | publish_date == 23
498 | avg_rating == 5.0
498 | tags_id == 972
498 | tags_name == A20
498 | tags_id == 926
498 | tags_name == Autoantibodies
498 | tags_id == 33
498 | tags_name == Autoimmunity
498 | tags_id == 768
498 | tags_name == Cell Death
498 | tags_id == 369
498 | tags_name == NF-κB
498 | tags_id == 964
498 | tags_name == TNFAIP3 Gene
498 | tags_id == 841
498 | tags_name == Ubiquitin
498 | tags_id == 843
498 | tags_name == Ubiquitination
498 | permissions_favorite == False
498 | permissions_rate == False
498 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">TNFAIP3 </span></em><span style="font-weight: 400;">gene encodes A20, an enzyme involved in modulating the activity of the inflammatory protein NF-kB. Variants of </span><em><span style="font-weight: 400;">TNFAIP3 </span></em><span style="font-weight: 400;">may play a role in rheumatoid arthritis by decreasing the production or activity of A20. Supplement modifications may counteract the effects of these variants by increasing A20 production or activity.</span></span></p> <h2 style="text-align: justify;"><strong><em>TNFAIP3</em></strong><strong> and Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/tnfaip3/"><em><span style="font-weight: 400;">TNFAIP3</span></em></a> <span style="font-weight: 400;">gene codes for A20. This enzyme is involved in modulating the attachment of ubiquitin molecules to proteins, and protecting against cell death [</span><a href="https://www.ncbi.nlm.nih.gov/gene/7128"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Ubiquitin attachment and removal may alter protein breakdown, activity, location, and interactions. A20 may specifically be involved in suppressing the activity of protein </span><a href="https://selfhack.com/blog/nuclear-factor-kappa-b/"><span style="font-weight: 400;">NF-kB</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7923371/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32334614/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">NF-kB has the potential to stimulate the release of inflammatory proteins, as well as promote the formation of antibodies that recognize the body&rsquo;s own tissues (autoantibodies). In this manner, NF-kB may play a major role in the development of autoimmune disorders, such as rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882124/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18613848/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">TNFAIP3 </span></em><span style="font-weight: 400;">have been associated with rheumatoid arthritis. These variants may decrease the production or activity of A20, which may lead to excess production of NF-kB, inflammatory protein release, autoantibody formation, and cell death [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582399/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21841782/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/20453842"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26546613"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605761/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>TNFAIP3 </em></strong><strong>Results for Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*5203343080039713*</p> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Primary SNP</strong></span></p> <p style="text-align: justify;"><strong><em>TNFAIP3 </em></strong><a href="https://selfdecode.com/snp/rs17264332/"><strong>rs17264332</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/article/med/20453842"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26546613"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with rheumatoid arthritis</span></li> </ul> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Other Important SNPs</strong></span></p> <p style="text-align: justify;"><strong><em>TNFAIP3 </em></strong><a href="https://selfdecode.com/snp/rs6920220/"><strong>rs6920220</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605761/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with rheumatoid arthritis</span></li> </ul> <p style="text-align: justify;"><strong><em>TNFAIP3 </em></strong><a href="https://selfdecode.com/snp/rs7752903/"><strong>rs7752903</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with rheumatoid arthritis</span></li> </ul> <p style="text-align: justify;"><strong><em>TNFAIP3 </em></strong><a href="https://selfdecode.com/snp/rs58721818/"><strong>rs58721818</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with rheumatoid arthritis</span></li> </ul> <p style="text-align: justify;">*9199949081892551*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*2627348939422449*</p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Vitamin E</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Various forms of </span><a href="https://selfhacked.com/blog/vitamin-e-can-help-fertility-pregnancy/"><span style="font-weight: 400;">vitamin E</span></a><span style="font-weight: 400;"> have been reported to increase the production of A20 and suppress NF-kB [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30471562/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26002975/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689338/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">One study found that vitamin E supplements (600 mg twice a day for twelve weeks) added to conventional rheumatoid arthritis therapy improved pain but not inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1752293/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In multiple studies of animals with rheumatoid arthritis, vitamin E slowed the progression of joint destruction [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25114906/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10613412/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11840456/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Vitamin E may help manage rheumatoid arthritis by increasing production of A20 and suppressing NF-kB.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Resveratrol</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/top-15-scientific-health-benefits-of-resveratrol-with-references/"><span style="font-weight: 400;">Resveratrol</span></a><span style="font-weight: 400;"> is an antioxidant and anti-inflammatory substance found in grapes and wine. It is also available in supplement form.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Resveratrol was found to lower inflammation in rats by suppressing NF-kB. This effect was attributed to increased production and activity of A20 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31846697/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a study of 100 rheumatoid arthritis patients, 1 g of resveratrol per day significantly improved swelling, tenderness, and disease activity scores. Resveratrol also decreased lab markers of inflammation and disease severity. The authors suggested that resveratrol could make a good addition to conventional treatment plans [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29611086/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Resveratrol may help manage rheumatoid arthritis by increasing production and activity of A20 and suppressing NF-kB.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Sesamin</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Sesamin is an active compound found in sesame, camphor, and other plants.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Similar to resveratrol, sesamin lowered inflammation in rats by increasing the production and activity of A20 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/33182047/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a study of 44 rheumatoid arthritis patients, sesamin supplements reduced joint pain and tenderness, and improved lab markers of inflammation [</span><a href="https://pubchem.ncbi.nlm.nih.gov/compound/sesamin"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31309643/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Sesamin may help manage rheumatoid arthritis by increasing production and activity of A20.</span></p>
498 | content_snp_table_5203343080039713_key == 5203343080039713
498 | content_snp_table_5203343080039713_blur == True
498 | content_snp_table_5203343080039713_hidden == False
498 | content_learn_more_9199949081892551_key == 9199949081892551
498 | content_learn_more_9199949081892551_blur == True
498 | content_learn_more_9199949081892551_hidden == False
498 | content_learn_more_9199949081892551_text == Based on the variants we looked at, your TNFAIP3 gene makes you somewhat more likely to develop rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Vitamin E, resveratrol, and sesamin supplements may help. Keep scrolling to find out more.
498 | content_recommendation_2627348939422449_key == 2627348939422449
498 | content_recommendation_2627348939422449_blur == True
498 | content_recommendation_2627348939422449_hidden == False
rsIDs = rs6920220,rs7752903,rs17264332,rs58721818
rsStatus = rs6920220,,chr6,137685367,G,A,,,23,1,HET
rsStatus = rs7752903,,chr6,137906227,T,G,,,40,0,Normal
rsStatus = rs17264332,,chr6,137684378,A,G,T,,23,0,Normal
rsStatus = rs58721818,,chr6,137922602,C,G,T,,38,0,Normal
